G12 - NPBW1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 17.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 I 76 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 I 76 2x43 G.H5 L 380 G.H5.25
Polar H8 S 313 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 S 313 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 G 149 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 G 149 - G.hns1 R 55 G.hns1.02
Hydrophobic TM7 A 308 7x54 G.H5 L 380 G.H5.25
Hydrophobic ICL2 S 144 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 S 144 - G.H5 K 367 G.H5.12
Hydrophobic TM3 V 138 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 138 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 V 249 6x33 G.H5 L 375 G.H5.20
Polar ICL2 R 145 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 145 - G.H5 N 374 G.H5.19
Hydrophobic TM3 V 137 3x53 G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 145 - G.H5 I 370 G.H5.15
Hydrophobic TM5 L 230 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 V 249 6x33 G.H5 I 378 G.H5.23
Van-der-waals TM6 V 249 6x33 G.H5 I 378 G.H5.23
Polar ICL2 R 146 - G.h3s5 N 288 G.h3s5.02
Van-der-waals ICL2 R 146 - G.h3s5 N 288 G.h3s5.02
Hydrophobic ICL2 R 145 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 145 - G.hns1 R 56 G.hns1.03
Hydrophobic TM5 W 199 5x35 G.HN M 1 G.HN.01
Hydrophobic TM6 R 248 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 248 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM6 L 242 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 L 242 6x26 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 S 144 - G.H5 I 370 G.H5.15
Hydrophobic TM3 V 137 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 137 3x53 G.H5 I 378 G.H5.23
Ionic ICL2 R 150 - G.H5 D 377 G.H5.22
Polar ICL2 R 150 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 150 - G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 150 - G.H5 D 377 G.H5.22
Hydrophobic TM2 T 72 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 T 141 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 T 141 - G.H5 L 371 G.H5.16
Polar ICL2 A 148 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 A 148 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 A 148 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 T 141 - G.H5 L 375 G.H5.20
Hydrophobic TM6 A 239 6x23 G.H5 D 368 G.H5.13
Van-der-waals TM6 A 239 6x23 G.H5 D 368 G.H5.13
Hydrophobic TM6 L 242 6x26 G.H5 L 375 G.H5.20
Van-der-waals TM6 L 242 6x26 G.H5 L 375 G.H5.20
Hydrophobic TM7 Y 307 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 307 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM5 M 233 5x68 G.H5 L 371 G.H5.16
Polar TM2 T 72 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 T 72 2x39 G.H5 D 377 G.H5.22
Ionic ICL3 D 236 - G.H5 H 364 G.H5.09
Polar ICL3 D 236 - G.H5 H 364 G.H5.09
Hydrophobic ICL3 D 236 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 D 236 - G.H5 H 364 G.H5.09
Polar H8 D 311 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 D 311 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 D 311 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM6 L 242 6x26 G.H5 L 371 G.H5.16
Van-der-waals TM6 L 242 6x26 G.H5 L 371 G.H5.16
Hydrophobic ICL3 L 235 - G.H5 L 371 G.H5.16
Hydrophobic TM6 V 249 6x33 G.H5 M 379 G.H5.24
Polar ICL2 T 141 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 T 141 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 T 141 - G.H5 N 374 G.H5.19
Hydrophobic H8 S 313 8x49 G.H5 Q 381 G.H5.26
Polar ICL2 R 146 - G.h2s4 I 245 G.h2s4.04
Ionic ICL2 R 146 - G.H5 E 373 G.H5.18
Hydrophobic ICL2 V 147 - G.H5 N 374 G.H5.19
Hydrophobic TM6 A 245 6x29 G.H5 L 375 G.H5.20
Hydrophobic TM6 K 246 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM3 V 137 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 V 137 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 L 242 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM2 N 73 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 73 2x40 G.H5 L 380 G.H5.25
Polar TM3 R 134 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 R 146 - G.h2s4 T 246 G.h2s4.05
Polar H8 D 311 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 D 311 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 D 311 8x47 G.H5 L 380 G.H5.25