Gs -
NPS receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | M | 154 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Polar | TM5 | Y | 244 | 5x72 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | Y | 244 | 5x72 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | Y | 244 | 5x72 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | N | 250 | 5x78 | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM5 | N | 250 | 5x78 | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | TM5 | N | 250 | 5x78 | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM2 | M | 83 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | M | 83 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | I | 150 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Polar | ICL3 | N | 261 | - | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL3 | N | 261 | - | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | ICL3 | N | 261 | - | G.H5 | R | 385 | G.H5.17 |
Polar | TM3 | D | 145 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | D | 145 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | D | 145 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | R | 146 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 146 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 146 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL3 | Y | 260 | - | G.S6 | C | 359 | G.S6.01 |
Hydrophobic | ICL3 | Y | 260 | - | G.S6 | C | 359 | G.S6.01 |
Van-der-waals | ICL3 | Y | 260 | - | G.S6 | C | 359 | G.S6.01 |
Hydrophobic | ICL2 | L | 157 | - | G.hns1 | A | 39 | G.hns1.03 |
Ionic | TM5 | K | 240 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | K | 240 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | K | 240 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL3 | Y | 260 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | ICL3 | Y | 260 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL2 | F | 156 | 34x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | F | 156 | 34x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Van-der-waals | ICL2 | M | 154 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Polar | TM5 | C | 251 | 5x79 | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM5 | C | 251 | 5x79 | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | TM5 | C | 251 | 5x79 | G.hgh4 | D | 323 | G.hgh4.13 |
Aromatic | ICL2 | F | 156 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | F | 156 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | F | 156 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM2 | M | 83 | 2x39 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | M | 83 | 2x39 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | I | 265 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | I | 265 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL2 | P | 153 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM6 | L | 264 | 6x25 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | L | 264 | 6x25 | G.h4s6 | Y | 358 | G.h4s6.20 |
Ionic | TM1 | R | 77 | 1x60 | G.H5 | E | 392 | G.H5.24 |
Polar | TM1 | R | 77 | 1x60 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM1 | R | 77 | 1x60 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM1 | R | 77 | 1x60 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | N | 261 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | ICL3 | N | 261 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | ICL3 | Y | 260 | - | G.h4s6 | S | 349 | G.h4s6.02 |
Hydrophobic | ICL3 | Y | 260 | - | G.h4s6 | S | 349 | G.h4s6.02 |
Van-der-waals | ICL3 | Y | 260 | - | G.h4s6 | S | 349 | G.h4s6.02 |
Hydrophobic | TM2 | M | 83 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | M | 83 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Polar | TM5 | K | 240 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | K | 240 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | K | 240 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Van-der-waals | ICL2 | M | 154 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Hydrophobic | TM5 | C | 251 | 5x79 | G.hgh4 | E | 322 | G.hgh4.12 |
Hydrophobic | ICL2 | P | 153 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | P | 153 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | TM6 | K | 271 | 6x32 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | M | 154 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM6 | L | 264 | 6x25 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | L | 264 | 6x25 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | R | 146 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | N | 250 | 5x78 | G.hgh4 | E | 322 | G.hgh4.12 |
Van-der-waals | TM5 | N | 250 | 5x78 | G.hgh4 | E | 322 | G.hgh4.12 |
Hydrophobic | ICL2 | L | 157 | - | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | L | 157 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL3 | Y | 260 | - | G.H4 | L | 346 | G.H4.16 |
Hydrophobic | ICL2 | Q | 158 | - | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 158 | - | G.hns1 | A | 39 | G.hns1.03 |
Polar | TM3 | A | 149 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 149 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 149 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM6 | Y | 275 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | L | 264 | 6x25 | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | TM6 | L | 264 | 6x25 | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | TM3 | A | 149 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | A | 149 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM5 | S | 252 | 5x80 | G.hgh4 | E | 322 | G.hgh4.12 |
Hydrophobic | TM5 | S | 252 | 5x80 | G.hgh4 | E | 322 | G.hgh4.12 |
Van-der-waals | TM5 | S | 252 | 5x80 | G.hgh4 | E | 322 | G.hgh4.12 |
Hydrophobic | TM3 | I | 150 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | I | 150 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | M | 154 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM5 | I | 237 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | I | 237 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | L | 157 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | L | 157 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM6 | A | 272 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | P | 153 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | P | 153 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM2 | S | 81 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL3 | L | 256 | - | G.H4 | R | 347 | G.H4.17 |
Hydrophobic | ICL2 | P | 153 | 34x50 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | P | 153 | 34x50 | G.H5 | H | 387 | G.H5.19 |
Polar | TM3 | I | 150 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 150 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 150 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Polar | H8 | S | 334 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | S | 334 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | S | 334 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL3 | D | 253 | - | G.hgh4 | E | 322 | G.hgh4.12 |
Hydrophobic | ICL3 | D | 253 | - | G.hgh4 | E | 322 | G.hgh4.12 |
Van-der-waals | ICL3 | D | 253 | - | G.hgh4 | E | 322 | G.hgh4.12 |
Hydrophobic | ICL3 | Y | 260 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | ICL2 | M | 154 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | M | 154 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM6 | A | 268 | 6x29 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | A | 268 | 6x29 | G.H5 | L | 393 | G.H5.25 |
Polar | TM6 | K | 271 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | K | 271 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | K | 271 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | A | 268 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | A | 268 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL3 | Y | 260 | - | G.H3 | W | 277 | G.H3.13 |
Van-der-waals | ICL3 | Y | 260 | - | G.H3 | W | 277 | G.H3.13 |
Ionic | TM4 | E | 160 | 4x39 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM4 | E | 160 | 4x39 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM4 | E | 160 | 4x39 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM4 | E | 160 | 4x39 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM5 | Y | 244 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Aromatic | TM5 | Y | 244 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Polar | TM7 | Y | 330 | 7x53 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM7 | Y | 330 | 7x53 | G.H5 | E | 392 | G.H5.24 |