G12 - NTS2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 292 6x30 G.H5 L 375 G.H5.20
Van-der-waals H8 S 363 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM6 L 299 6x37 G.H5 M 379 G.H5.24
Polar TM6 S 295 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 S 295 6x33 G.H5 Q 381 G.H5.26
Polar ICL2 P 140 34x50 G.H5 N 374 G.H5.19
Hydrophobic H8 F 365 8x50 G.H5 L 380 G.H5.25
Polar ICL3 K 284 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 K 284 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 K 284 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 L 141 34x51 G.H5 K 367 G.H5.12
Ionic TM6 R 288 6x26 G.H5 D 368 G.H5.13
Polar TM6 R 288 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 288 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM2 R 67 2x38 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 236 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 L 236 5x68 G.H5 L 371 G.H5.16
Polar H8 S 363 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 S 363 8x48 G.H5 L 380 G.H5.25
Polar ICL2 S 145 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 145 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 145 34x55 G.hns1 R 56 G.hns1.03
Polar H8 S 364 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 S 364 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 137 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 141 34x51 G.S1 V 58 G.S1.02
Hydrophobic ICL2 R 144 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL1 R 64 - G.h3s5 N 288 G.h3s5.02
Van-der-waals ICL1 R 64 - G.h3s5 N 288 G.h3s5.02
Hydrophobic TM6 S 295 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 295 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM4 T 148 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 T 148 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 L 233 5x65 G.H5 M 379 G.H5.24
Van-der-waals TM5 L 233 5x65 G.H5 M 379 G.H5.24
Hydrophobic TM7 V 361 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 V 361 7x56 G.H5 M 379 G.H5.24
Polar TM3 A 136 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 136 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 136 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 141 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 141 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM3 A 136 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 136 3x53 G.H5 I 378 G.H5.23
Polar TM2 R 67 2x38 G.H5 N 374 G.H5.19
Polar TM6 S 291 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 S 291 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 S 291 6x29 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 140 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 S 145 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 L 233 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL3 K 284 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 L 141 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL2 L 141 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 141 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL1 A 65 - G.H5 D 377 G.H5.22
Van-der-waals ICL1 A 65 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 P 140 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 140 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 L 141 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 141 34x51 G.S3 I 221 G.S3.01
Polar TM6 R 288 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 R 288 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 288 6x26 G.H5 Q 372 G.H5.17
Ionic TM2 R 67 2x38 G.H5 D 377 G.H5.22
Polar TM2 R 67 2x38 G.H5 D 377 G.H5.22
Hydrophobic TM2 R 67 2x38 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 67 2x38 G.H5 D 377 G.H5.22
Hydrophobic TM2 L 68 2x39 G.H5 I 378 G.H5.23
Polar ICL2 R 144 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 144 34x54 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 144 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic TM4 R 151 4x41 G.HN R 52 G.HN.52
Van-der-waals TM4 R 151 4x41 G.HN R 52 G.HN.52
Hydrophobic TM3 L 129 3x46 G.H5 I 378 G.H5.23
Polar TM2 G 66 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 G 66 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM3 V 137 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 137 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL3 G 247 - G.H4 R 329 G.H4.09
Hydrophobic ICL2 L 147 34x57 G.H5 I 378 G.H5.23
Ionic ICL1 R 64 - G.H5 E 373 G.H5.18
Polar ICL1 R 64 - G.H5 E 373 G.H5.18
Polar ICL2 R 144 34x54 G.S1 L 57 G.S1.01
Polar H8 S 362 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 362 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 362 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM2 L 68 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 68 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 140 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 140 34x50 G.H5 I 370 G.H5.15
Polar TM3 R 133 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 I 378 G.H5.23