Golf - OR51B2 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 87.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 128 34x51 G.S3 F 206 G.S3.03
Hydrophobic ICL2 A 131 34x54 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 A 131 34x54 G.hns1 K 40 G.hns1.02
Hydrophobic TM6 C 239 6x37 G.H5 L 380 G.H5.25
Van-der-waals TM6 C 239 6x37 G.H5 L 380 G.H5.25
Hydrophobic TM3 A 123 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 A 123 3x53 G.H5 Y 378 G.H5.23
Polar TM6 K 234 6x32 G.H5 L 381 G.H5.26
Hydrophobic TM6 K 234 6x32 G.H5 L 381 G.H5.26
Van-der-waals TM6 K 234 6x32 G.H5 L 381 G.H5.26
Hydrophobic TM5 I 226 5x68 G.H5 Q 371 G.H5.16
Van-der-waals TM5 I 226 5x68 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 R 129 34x52 G.s2s3 K 203 G.s2s3.02
Hydrophobic ICL2 P 127 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 127 34x50 G.H5 I 370 G.H5.15
Polar ICL2 Y 130 34x53 G.H5 Y 378 G.H5.23
Hydrophobic TM4 T 135 4x38 G.HN L 37 G.HN.52
Van-der-waals TM4 T 135 4x38 G.HN L 37 G.HN.52
Polar TM6 T 238 6x36 G.H5 E 379 G.H5.24
Hydrophobic TM6 T 238 6x36 G.H5 E 379 G.H5.24
Van-der-waals TM6 T 238 6x36 G.H5 E 379 G.H5.24
Polar TM5 I 226 5x68 G.H5 R 372 G.H5.17
Hydrophobic TM5 I 226 5x68 G.H5 R 372 G.H5.17
Van-der-waals TM5 I 226 5x68 G.H5 R 372 G.H5.17
Hydrophobic TM7 K 293 7x56 G.H5 E 379 G.H5.24
Van-der-waals TM7 K 293 7x56 G.H5 E 379 G.H5.24
Polar TM3 I 124 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM3 I 124 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 I 124 3x54 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 P 127 34x50 G.H5 H 374 G.H5.19
Van-der-waals TM6 T 238 6x36 G.H5 Y 378 G.H5.23
Polar TM6 A 235 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 235 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 A 235 6x33 G.H5 L 380 G.H5.25
Polar TM3 C 120 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM3 C 120 3x50 G.H5 Y 378 G.H5.23
Van-der-waals TM3 C 120 3x50 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 P 127 34x50 G.H5 R 367 G.H5.12
Van-der-waals ICL2 P 127 34x50 G.H5 R 367 G.H5.12
Hydrophobic ICL2 S 132 34x55 G.hns1 A 41 G.hns1.03
Hydrophobic TM3 I 124 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 124 3x54 G.H5 L 375 G.H5.20
Polar ICL2 L 128 34x51 G.S1 H 43 G.S1.02
Hydrophobic ICL2 L 128 34x51 G.S1 H 43 G.S1.02
Van-der-waals ICL2 L 128 34x51 G.S1 H 43 G.S1.02
Hydrophobic TM5 T 222 5x64 G.H5 Q 371 G.H5.16
Van-der-waals TM5 T 222 5x64 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 A 131 34x54 G.hns1 A 41 G.hns1.03
Hydrophobic ICL2 L 128 34x51 G.H5 R 367 G.H5.12
Hydrophobic TM3 I 124 3x54 G.H5 L 380 G.H5.25
Van-der-waals TM3 I 124 3x54 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 127 34x50 G.H5 Q 371 G.H5.16
Ionic H8 K 295 8x48 G.H5 E 379 G.H5.24
Polar H8 K 295 8x48 G.H5 E 379 G.H5.24
Hydrophobic H8 K 295 8x48 G.H5 E 379 G.H5.24
Van-der-waals H8 K 295 8x48 G.H5 E 379 G.H5.24
Polar TM6 E 231 6x29 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM6 E 231 6x29 G.h4s6 Y 345 G.h4s6.20
Ionic TM2 E 55 2x37 G.hns1 K 40 G.hns1.02
Polar TM3 A 123 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 A 123 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 A 123 3x53 G.H5 H 374 G.H5.19
Hydrophobic ICL2 L 128 34x51 G.H5 I 370 G.H5.15
Aromatic ICL2 Y 130 34x53 G.H5 H 374 G.H5.19
Hydrophobic ICL2 Y 130 34x53 G.H5 H 374 G.H5.19
Hydrophobic ICL2 R 129 34x52 G.S3 V 204 G.S3.01
Van-der-waals ICL2 R 129 34x52 G.S3 V 204 G.S3.01
Hydrophobic ICL2 L 128 34x51 G.H5 C 366 G.H5.11
Hydrophobic TM5 V 223 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 V 223 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 128 34x51 G.S3 V 204 G.S3.01
Van-der-waals ICL2 L 128 34x51 G.S3 V 204 G.S3.01
Hydrophobic TM6 E 231 6x29 G.H5 L 381 G.H5.26
Van-der-waals TM6 E 231 6x29 G.H5 L 381 G.H5.26
Ionic TM6 K 234 6x32 G.H5 E 379 G.H5.24
Polar TM6 K 234 6x32 G.H5 E 379 G.H5.24
Hydrophobic TM6 K 234 6x32 G.H5 E 379 G.H5.24
Hydrophobic ICL3 A 227 - G.H5 L 381 G.H5.26
Polar TM3 D 119 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM3 D 119 3x49 G.H5 Y 378 G.H5.23
Van-der-waals TM3 D 119 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM3 C 120 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM5 I 219 5x61 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 128 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 128 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM6 T 238 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 238 6x36 G.H5 L 380 G.H5.25
Ionic TM6 E 231 6x29 G.H5 R 372 G.H5.17
Polar TM6 E 231 6x29 G.H5 R 372 G.H5.17
Van-der-waals TM6 E 231 6x29 G.H5 R 372 G.H5.17
Hydrophobic H8 T 294 8x47 G.H5 E 379 G.H5.24
Hydrophobic TM2 M 57 2x39 G.H5 Y 378 G.H5.23
Van-der-waals TM2 M 57 2x39 G.H5 Y 378 G.H5.23
Polar TM2 E 55 2x37 G.H5 Q 377 G.H5.22
Van-der-waals TM2 E 55 2x37 G.H5 Q 377 G.H5.22
Hydrophobic TM5 I 226 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 I 226 5x68 G.H5 D 368 G.H5.13