Ggust - OR51B4 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 23.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 122 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 A 122 3x53 G.H5 L 348 G.H5.20
Polar TM6 T 237 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 237 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 237 6x36 G.H5 L 353 G.H5.25
Van-der-waals ICL1 S 52 12x49 G.H5 D 350 G.H5.22
Polar TM2 Y 58 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 Y 58 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 Y 58 2x40 G.H5 G 352 G.H5.24
Polar TM4 S 136 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 S 136 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 S 136 4x40 G.HN E 28 G.HN.52
Polar ICL2 L 127 34x51 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 127 34x51 G.H5 I 344 G.H5.16
Van-der-waals ICL2 L 127 34x51 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 126 34x50 G.H5 L 348 G.H5.20
Van-der-waals ICL2 P 126 34x50 G.H5 L 348 G.H5.20
Hydrophobic ICL2 C 131 34x55 G.H5 I 344 G.H5.16
Van-der-waals ICL2 C 131 34x55 G.H5 I 344 G.H5.16
Hydrophobic TM2 M 57 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 M 57 2x39 G.H5 G 352 G.H5.24
Hydrophobic ICL2 R 128 34x52 G.S3 L 194 G.S3.01
Hydrophobic TM3 A 122 3x53 G.H5 L 353 G.H5.25
Polar TM4 S 136 4x40 G.HN Q 24 G.HN.48
Hydrophobic ICL2 P 126 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 126 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM2 M 57 2x39 G.H5 L 353 G.H5.25
Van-der-waals TM2 M 57 2x39 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 129 34x53 G.H5 I 344 G.H5.16
Van-der-waals ICL2 Y 129 34x53 G.H5 I 344 G.H5.16
Hydrophobic TM3 C 119 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 128 34x52 G.H5 I 344 G.H5.16
Hydrophobic TM4 R 137 4x41 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 R 137 4x41 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 126 34x50 G.H5 K 345 G.H5.17
Van-der-waals ICL2 P 126 34x50 G.H5 K 345 G.H5.17
Hydrophobic TM6 K 233 6x32 G.H5 K 349 G.H5.21
Hydrophobic TM6 S 234 6x33 G.H5 F 354 G.H5.26
Ionic ICL2 R 128 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 128 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 128 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 128 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 L 127 34x51 G.H5 I 343 G.H5.15
Ionic TM6 E 230 6x29 G.H5 K 345 G.H5.17
Polar H8 Q 295 8x49 G.H5 F 354 G.H5.26
Hydrophobic H8 Q 295 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 Q 295 8x49 G.H5 F 354 G.H5.26
Van-der-waals ICL2 L 127 34x51 G.H5 K 345 G.H5.17
Hydrophobic ICL2 N 130 34x54 G.H5 N 347 G.H5.19
Van-der-waals ICL2 N 130 34x54 G.H5 N 347 G.H5.19
Hydrophobic H8 Q 295 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 Q 295 8x49 G.H5 G 352 G.H5.24
Hydrophobic TM2 P 56 2x38 G.H5 C 351 G.H5.23
Van-der-waals TM2 P 56 2x38 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 118 3x49 G.H5 L 353 G.H5.25
Van-der-waals TM3 D 118 3x49 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 127 34x51 G.S3 F 196 G.S3.03
Hydrophobic ICL2 Y 129 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 129 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 126 34x50 G.H5 D 341 G.H5.13
Van-der-waals ICL2 P 126 34x50 G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 127 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 127 34x51 G.S3 L 194 G.S3.01
Polar ICL2 R 128 34x52 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 R 128 34x52 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 R 128 34x52 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 Y 129 34x53 G.H5 L 353 G.H5.25
Van-der-waals ICL2 Y 129 34x53 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 129 34x53 G.H5 L 348 G.H5.20
Van-der-waals ICL2 Y 129 34x53 G.H5 L 348 G.H5.20
Hydrophobic TM4 T 134 4x38 G.hns1 A 31 G.hns1.02
Hydrophobic TM2 E 55 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 L 127 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 L 127 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 N 130 34x54 G.H5 I 344 G.H5.16
Van-der-waals ICL2 N 130 34x54 G.H5 I 344 G.H5.16
Polar ICL2 C 131 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 C 131 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 C 131 34x55 G.hns1 R 32 G.hns1.03
Ionic TM6 K 233 6x32 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 233 6x32 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 233 6x32 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 Y 58 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 Y 58 2x40 G.H5 C 351 G.H5.23
Polar H8 Q 295 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 Q 295 8x49 G.H5 K 349 G.H5.21
Polar ICL2 N 130 34x54 G.H5 C 351 G.H5.23
Hydrophobic ICL2 N 130 34x54 G.H5 C 351 G.H5.23
Van-der-waals ICL2 N 130 34x54 G.H5 C 351 G.H5.23
Polar ICL2 N 130 34x54 G.H5 L 348 G.H5.20
Ionic H8 R 298 8x52 G.h4s6 D 316 G.h4s6.10
Polar H8 R 298 8x52 G.h4s6 D 316 G.h4s6.10
Van-der-waals H8 R 298 8x52 G.h4s6 D 316 G.h4s6.10
Hydrophobic ICL2 C 131 34x55 G.S3 L 194 G.S3.01
Van-der-waals ICL2 C 131 34x55 G.S3 L 194 G.S3.01
Polar ICL2 L 127 34x51 G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 127 34x51 G.H5 D 341 G.H5.13
Van-der-waals ICL2 L 127 34x51 G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 127 34x51 G.s2s3 K 192 G.s2s3.01
Polar TM2 E 55 2x37 G.H5 C 351 G.H5.23
Hydrophobic TM2 E 55 2x37 G.H5 C 351 G.H5.23
Van-der-waals TM2 E 55 2x37 G.H5 C 351 G.H5.23
Polar ICL2 C 131 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 C 131 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 C 131 34x55 G.hns1 A 31 G.hns1.02