Gq - OR51E1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 85.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 Y 62 2x40 G.H5 L 358 G.H5.25
Van-der-waals TM2 Y 62 2x40 G.H5 L 358 G.H5.25
Hydrophobic TM6 K 237 6x32 G.H5 V 359 G.H5.26
Polar ICL2 T 136 34x55 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 T 136 34x55 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 T 136 34x55 G.s2s3 S 198 G.s2s3.02
Polar TM6 K 237 6x32 G.H5 N 357 G.H5.24
Hydrophobic TM6 K 237 6x32 G.H5 N 357 G.H5.24
Van-der-waals TM6 K 237 6x32 G.H5 N 357 G.H5.24
Polar ICL1 H 58 12x51 G.hns1 R 37 G.hns1.02
Van-der-waals ICL1 H 58 12x51 G.hns1 R 37 G.hns1.02
Hydrophobic TM5 L 230 5x68 G.H5 Q 350 G.H5.17
Van-der-waals TM5 L 230 5x68 G.H5 Q 350 G.H5.17
Polar ICL1 H 55 12x48 G.HN R 30 G.HN.48
Hydrophobic ICL1 H 55 12x48 G.HN R 30 G.HN.48
Hydrophobic H8 K 298 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 K 298 8x48 G.H5 V 359 G.H5.26
Polar TM3 R 124 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 128 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 128 3x54 G.H5 L 353 G.H5.20
Polar TM6 K 237 6x32 G.H5 K 354 G.H5.21
Hydrophobic TM6 K 237 6x32 G.H5 K 354 G.H5.21
Van-der-waals TM6 K 237 6x32 G.H5 K 354 G.H5.21
Polar H8 T 297 8x47 G.H5 L 358 G.H5.25
Hydrophobic H8 T 297 8x47 G.H5 L 358 G.H5.25
Van-der-waals H8 T 297 8x47 G.H5 L 358 G.H5.25
Polar ICL1 S 56 12x49 G.hns1 R 37 G.hns1.02
Van-der-waals ICL1 S 56 12x49 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 A 127 3x53 G.H5 L 353 G.H5.20
Van-der-waals TM3 A 127 3x53 G.H5 L 353 G.H5.20
Hydrophobic ICL2 L 132 34x51 G.S1 L 40 G.S1.02
Polar ICL2 R 133 34x52 G.s2s3 Q 197 G.s2s3.01
Hydrophobic ICL2 R 133 34x52 G.s2s3 Q 197 G.s2s3.01
Van-der-waals ICL2 R 133 34x52 G.s2s3 Q 197 G.s2s3.01
Hydrophobic TM2 E 59 2x37 G.H5 Y 356 G.H5.23
Van-der-waals TM2 E 59 2x37 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.H5 L 349 G.H5.16
Van-der-waals ICL2 L 132 34x51 G.H5 L 349 G.H5.16
Hydrophobic TM6 G 240 6x35 G.H5 V 359 G.H5.26
Hydrophobic ICL2 L 132 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 L 132 34x51 G.H5 K 345 G.H5.12
Polar TM2 Y 62 2x40 G.H5 N 357 G.H5.24
Van-der-waals TM2 Y 62 2x40 G.H5 N 357 G.H5.24
Hydrophobic ICL2 P 131 34x50 G.H5 L 349 G.H5.16
Van-der-waals ICL2 P 131 34x50 G.H5 L 349 G.H5.16
Ionic TM2 E 59 2x37 G.hns1 R 37 G.hns1.02
Polar TM2 E 59 2x37 G.hns1 R 37 G.hns1.02
Hydrophobic TM2 E 59 2x37 G.hns1 R 37 G.hns1.02
Van-der-waals TM2 E 59 2x37 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 A 234 6x29 G.H5 K 354 G.H5.21
Hydrophobic ICL2 A 135 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM2 M 61 2x39 G.H5 L 358 G.H5.25
Van-der-waals TM7 K 296 7x56 G.H5 L 358 G.H5.25
Polar ICL2 R 133 34x52 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 R 133 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM7 Y 293 7x53 G.H5 L 358 G.H5.25
Polar ICL1 H 55 12x48 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 P 131 34x50 G.H5 L 353 G.H5.20
Van-der-waals ICL2 P 131 34x50 G.H5 L 353 G.H5.20
Hydrophobic ICL2 L 132 34x51 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM4 T 139 4x38 G.hns1 R 38 G.hns1.03
Van-der-waals TM4 T 139 4x38 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 L 132 34x51 G.S2 L 196 G.S2.08
Van-der-waals ICL2 L 132 34x51 G.S2 L 196 G.S2.08
Hydrophobic TM6 T 241 6x36 G.H5 V 359 G.H5.26
Polar ICL2 T 136 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 T 136 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 T 136 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 L 132 34x51 G.S3 F 201 G.S3.03
Van-der-waals ICL2 L 132 34x51 G.S3 F 201 G.S3.03
Hydrophobic TM3 R 124 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 241 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM4 L 140 4x39 G.HN R 34 G.HN.52
Van-der-waals TM4 L 140 4x39 G.HN R 34 G.HN.52
Hydrophobic ICL2 L 132 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 L 132 34x51 G.S3 V 199 G.S3.01
Ionic TM6 E 233 6x28 G.H5 K 354 G.H5.21
Polar TM6 E 233 6x28 G.H5 K 354 G.H5.21
Hydrophobic TM6 E 233 6x28 G.H5 K 354 G.H5.21
Polar ICL2 A 135 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 A 135 34x54 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 A 135 34x54 G.hns1 R 38 G.hns1.03