Gt1 - OR51M1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 H 140 3x56 G.hns1 A 27 G.hns1.02
Hydrophobic TM3 H 140 3x56 G.hns1 A 27 G.hns1.02
Van-der-waals TM3 H 140 3x56 G.hns1 A 27 G.hns1.02
Hydrophobic TM6 A 249 6x33 G.H5 L 349 G.H5.25
Van-der-waals TM6 A 249 6x33 G.H5 L 349 G.H5.25
Hydrophobic ICL2 L 142 34x51 G.S3 L 190 G.S3.01
Polar ICL2 R 143 34x52 G.S1 T 29 G.S1.01
Hydrophobic ICL2 R 143 34x52 G.S1 T 29 G.S1.01
Van-der-waals ICL2 R 143 34x52 G.S1 T 29 G.S1.01
Hydrophobic TM3 I 138 3x54 G.H5 L 344 G.H5.20
Ionic ICL2 R 143 34x52 G.hns1 D 26 G.hns1.01
Polar ICL2 R 143 34x52 G.hns1 D 26 G.hns1.01
Hydrophobic ICL2 R 143 34x52 G.hns1 D 26 G.hns1.01
Van-der-waals ICL2 R 143 34x52 G.hns1 D 26 G.hns1.01
Hydrophobic ICL2 P 141 34x50 G.H5 N 343 G.H5.19
Van-der-waals ICL2 P 141 34x50 G.H5 N 343 G.H5.19
Polar ICL2 L 142 34x51 G.h2s4 T 215 G.h2s4.05
Hydrophobic ICL2 L 142 34x51 G.h2s4 T 215 G.h2s4.05
Van-der-waals ICL2 L 142 34x51 G.h2s4 T 215 G.h2s4.05
Hydrophobic TM3 A 137 3x53 G.H5 L 349 G.H5.25
Van-der-waals TM3 A 137 3x53 G.H5 L 349 G.H5.25
Polar ICL2 L 142 34x51 G.H5 N 343 G.H5.19
Hydrophobic ICL2 L 142 34x51 G.H5 N 343 G.H5.19
Van-der-waals ICL2 L 142 34x51 G.H5 N 343 G.H5.19
Hydrophobic TM3 H 140 3x56 G.HN E 24 G.HN.52
Hydrophobic TM3 R 134 3x50 G.H5 L 349 G.H5.25
Hydrophobic ICL2 Y 144 34x53 G.H5 C 347 G.H5.23
Van-der-waals ICL2 Y 144 34x53 G.H5 C 347 G.H5.23
Hydrophobic TM5 L 240 5x68 G.H5 I 340 G.H5.16
Polar TM3 H 140 3x56 G.hns1 R 28 G.hns1.03
Hydrophobic TM3 H 140 3x56 G.hns1 R 28 G.hns1.03
Van-der-waals TM3 H 140 3x56 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 P 141 34x50 G.H5 C 347 G.H5.23
Polar TM6 T 252 6x36 G.H5 L 349 G.H5.25
Hydrophobic TM6 T 252 6x36 G.H5 L 349 G.H5.25
Van-der-waals TM6 T 252 6x36 G.H5 L 349 G.H5.25
Polar TM3 A 137 3x53 G.H5 C 347 G.H5.23
Hydrophobic TM3 A 137 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 A 137 3x53 G.H5 C 347 G.H5.23
Van-der-waals H8 K 309 8x48 G.H5 F 350 G.H5.26
Hydrophobic TM3 I 138 3x54 G.H5 L 349 G.H5.25
Van-der-waals TM3 I 138 3x54 G.H5 L 349 G.H5.25
Hydrophobic ICL2 R 143 34x52 G.hns1 A 27 G.hns1.02
Polar TM6 T 252 6x36 G.H5 F 350 G.H5.26
Hydrophobic TM6 C 253 6x37 G.H5 L 349 G.H5.25
Van-der-waals TM6 C 253 6x37 G.H5 L 349 G.H5.25
Hydrophobic ICL2 V 146 34x55 G.h2s4 G 213 G.h2s4.03
Van-der-waals ICL2 V 146 34x55 G.h2s4 G 213 G.h2s4.03
Hydrophobic TM6 E 245 6x29 G.H5 I 340 G.H5.16
Ionic ICL1 R 66 12x49 G.h4s6 D 311 G.h4s6.09
Polar ICL1 R 66 12x49 G.h4s6 D 311 G.h4s6.09
Hydrophobic ICL1 R 66 12x49 G.h4s6 D 311 G.h4s6.09
Van-der-waals ICL1 R 66 12x49 G.h4s6 D 311 G.h4s6.09
Polar TM3 R 134 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM6 A 249 6x33 G.H5 L 344 G.H5.20
Polar ICL2 Y 144 34x53 G.H5 D 346 G.H5.22
Hydrophobic ICL2 Y 144 34x53 G.H5 D 346 G.H5.22
Van-der-waals ICL2 Y 144 34x53 G.H5 D 346 G.H5.22
Hydrophobic ICL2 L 142 34x51 G.S1 T 29 G.S1.01
Van-der-waals ICL2 L 142 34x51 G.S1 T 29 G.S1.01
Hydrophobic ICL2 L 142 34x51 G.S1 V 30 G.S1.02
Van-der-waals ICL2 L 142 34x51 G.S1 V 30 G.S1.02
Hydrophobic TM6 R 248 6x32 G.H5 F 350 G.H5.26
Van-der-waals TM6 R 248 6x32 G.H5 F 350 G.H5.26
Hydrophobic TM6 T 252 6x36 G.H5 G 348 G.H5.24
Van-der-waals TM6 T 252 6x36 G.H5 G 348 G.H5.24
Hydrophobic ICL2 L 142 34x51 G.H5 I 339 G.H5.15
Van-der-waals ICL2 L 142 34x51 G.H5 I 339 G.H5.15
Polar TM3 R 134 3x50 G.H5 G 348 G.H5.24
Hydrophobic TM3 R 134 3x50 G.H5 G 348 G.H5.24
Van-der-waals TM3 R 134 3x50 G.H5 G 348 G.H5.24