Gi3 - OPN4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 74.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM7 T 353 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 T 353 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 T 353 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 269 5x72 G.H5 D 337 G.H5.09
Hydrophobic ICL2 L 176 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 F 179 34x54 G.h2s4 T 219 G.h2s4.05
Hydrophobic TM3 I 172 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 172 3x54 G.H5 L 348 G.H5.20
Polar ICL2 A 177 34x52 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM5 C 275 5x78 G.S6 F 323 G.S6.05
Van-der-waals TM5 C 275 5x78 G.S6 F 323 G.S6.05
Polar ICL3 W 283 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 W 283 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 W 283 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 F 179 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 F 179 34x54 G.hns1 A 31 G.hns1.02
Polar C-term Y 385 - G.h2s4 E 216 G.h2s4.02
Hydrophobic C-term Y 385 - G.h2s4 E 216 G.h2s4.02
Van-der-waals C-term Y 385 - G.h2s4 E 216 G.h2s4.02
Hydrophobic C-term W 420 - G.H3 L 249 G.H3.08
Hydrophobic TM3 R 168 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 168 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 298 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 179 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 F 179 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 F 179 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 F 179 34x54 G.S1 V 34 G.S1.02
Hydrophobic TM3 I 172 3x54 G.H5 L 353 G.H5.25
Hydrophobic C-term W 420 - G.H3 S 252 G.H3.11
Van-der-waals C-term W 420 - G.H3 S 252 G.H3.11
Hydrophobic TM5 I 262 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 T 265 5x68 G.H5 I 344 G.H5.16
Polar TM6 K 293 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 293 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 293 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM3 I 172 3x54 G.H5 I 344 G.H5.16
Hydrophobic C-term W 420 - G.H2 R 208 G.H2.04
Hydrophobic C-term P 383 - G.H3 W 258 G.H3.17
Hydrophobic TM5 T 265 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 T 265 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 M 294 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 M 294 6x33 G.H5 L 348 G.H5.20
Ionic C-term E 424 - G.H3 K 257 G.H3.16
Polar C-term E 424 - G.H3 K 257 G.H3.16
Van-der-waals C-term E 424 - G.H3 K 257 G.H3.16
Hydrophobic ICL2 A 177 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 P 175 34x50 G.H5 T 340 G.H5.12
Polar C-term Y 385 - G.h2s4 F 215 G.h2s4.01
Hydrophobic C-term Y 385 - G.h2s4 F 215 G.h2s4.01
Van-der-waals C-term Y 385 - G.h2s4 F 215 G.h2s4.01
Hydrophobic ICL2 P 175 34x50 G.H5 I 343 G.H5.15
Polar TM5 C 275 5x78 G.H4 Y 296 G.H4.03
Hydrophobic TM5 C 275 5x78 G.H4 Y 296 G.H4.03
Hydrophobic ICL2 L 176 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 176 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 Y 255 5x58 G.H5 L 353 G.H5.25
Hydrophobic C-term H 378 - G.h4s6 T 316 G.h4s6.10
Polar TM3 V 171 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 171 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 171 3x53 G.H5 N 347 G.H5.19
Hydrophobic C-term L 400 - H.HA Q 68 H.HA.06
Van-der-waals C-term L 400 - H.HA Q 68 H.HA.06
Hydrophobic TM5 I 262 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 G 180 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic TM6 M 294 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 294 6x33 G.H5 L 353 G.H5.25
Polar C-term Y 382 - G.h3s5 E 261 G.h3s5.02
Hydrophobic C-term Y 382 - G.h3s5 E 261 G.h3s5.02
Van-der-waals C-term Y 382 - G.h3s5 E 261 G.h3s5.02
Hydrophobic TM5 L 269 5x72 G.S6 H 322 G.S6.04
Polar TM3 R 168 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 168 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 168 3x50 G.H5 C 351 G.H5.23
Polar ICL2 G 180 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 G 180 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 G 180 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 176 34x51 G.H5 T 340 G.H5.12
Ionic H8 K 356 8x49 G.H5 E 350 G.H5.22
Polar H8 K 356 8x49 G.H5 E 350 G.H5.22
Van-der-waals H8 K 356 8x49 G.H5 E 350 G.H5.22
Polar H8 H 354 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 H 354 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 F 179 34x54 G.H5 I 343 G.H5.15
Polar TM6 Q 286 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 Q 286 6x25 G.h4s6 K 314 G.h4s6.08
Aromatic TM5 F 272 5x75 G.H5 F 334 G.H5.06
Hydrophobic TM5 F 272 5x75 G.H5 F 334 G.H5.06
Van-der-waals TM5 F 272 5x75 G.H5 F 334 G.H5.06
Ionic TM6 R 287 6x26 G.H5 D 341 G.H5.13
Polar TM6 R 287 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 287 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 287 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM5 L 269 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 L 269 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 L 269 5x72 G.H5 A 338 G.H5.10
Polar H8 H 354 8x47 G.H5 E 350 G.H5.22
Hydrophobic H8 H 354 8x47 G.H5 E 350 G.H5.22
Van-der-waals H8 H 354 8x47 G.H5 E 350 G.H5.22
Hydrophobic ICL2 V 181 34x56 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 V 181 34x56 G.hns1 K 32 G.hns1.03
Hydrophobic C-term Y 385 - G.H3 W 258 G.H3.17
Van-der-waals C-term Y 385 - G.H3 W 258 G.H3.17
Hydrophobic ICL2 P 175 34x50 G.H5 I 344 G.H5.16
Polar H8 H 354 8x47 G.H5 K 349 G.H5.21
Hydrophobic TM5 L 269 5x72 G.H5 D 341 G.H5.13
Polar TM4 S 183 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 S 183 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 S 183 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 I 297 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 179 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 179 34x54 G.S3 L 194 G.S3.01
Hydrophobic H8 P 355 8x48 G.H5 G 352 G.H5.24
Hydrophobic ICL2 F 179 34x54 G.S1 E 33 G.S1.01
Hydrophobic ICL2 L 176 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 176 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 L 176 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 176 34x51 G.S3 L 194 G.S3.01
Hydrophobic C-term W 420 - G.H3 I 253 G.H3.12