Ggust - OPN5 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 V 233 5x72 G.H5 A 338 G.H5.10
Hydrophobic ICL2 V 142 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 V 142 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 250 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 250 6x33 G.H5 L 348 G.H5.20
Hydrophobic C-term F 332 - G.h4s6 L 310 G.h4s6.01
Van-der-waals C-term F 332 - G.h4s6 L 310 G.h4s6.01
Polar TM6 R 239 6x22 G.H4 N 301 G.H4.08
Van-der-waals TM6 R 239 6x22 G.H4 N 301 G.H4.08
Polar ICL2 S 139 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic H8 F 313 8x50 G.H5 G 352 G.H5.24
Hydrophobic TM5 E 232 5x71 G.H5 D 337 G.H5.09
Polar ICL3 D 237 - G.S6 S 321 G.S6.03
Hydrophobic ICL3 D 237 - G.S6 S 321 G.S6.03
Van-der-waals ICL3 D 237 - G.S6 S 321 G.S6.03
Van-der-waals TM6 K 249 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 135 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 V 233 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 V 233 5x72 G.S6 Y 320 G.S6.02
Ionic TM3 K 134 3x53 G.H5 D 350 G.H5.22
Polar TM3 K 134 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 K 134 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 K 134 3x53 G.H5 D 350 G.H5.22
Polar TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 351 G.H5.23
Polar TM5 S 230 5x69 G.H5 D 341 G.H5.13
Ionic TM4 K 145 4x38 G.HN E 28 G.HN.52
Polar TM4 K 145 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 K 145 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 K 145 4x38 G.HN E 28 G.HN.52
Polar TM4 K 145 4x38 G.HN Q 24 G.HN.48
Hydrophobic TM4 K 145 4x38 G.HN Q 24 G.HN.48
Van-der-waals TM4 K 145 4x38 G.HN Q 24 G.HN.48
Polar TM6 R 239 6x22 G.H4 N 305 G.H4.13
Hydrophobic TM6 R 239 6x22 G.H4 N 305 G.H4.13
Van-der-waals TM6 R 239 6x22 G.H4 N 305 G.H4.13
Hydrophobic TM6 L 250 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 250 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 233 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 233 5x72 G.H5 D 341 G.H5.13
Polar TM6 S 242 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 242 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 242 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 V 233 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM5 V 226 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 142 34x54 G.HN E 28 G.HN.52
Van-der-waals ICL2 V 142 34x54 G.HN E 28 G.HN.52
Hydrophobic TM6 L 246 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 253 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 253 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 142 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 V 142 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 S 229 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 229 5x68 G.H5 I 344 G.H5.16
Aromatic ICL3 F 236 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 F 236 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 F 236 - G.H5 F 334 G.H5.06
Hydrophobic TM3 I 135 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 138 34x50 G.S3 L 194 G.S3.01
Hydrophobic TM3 I 135 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 135 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 F 236 - G.H5 K 333 G.H5.05
Hydrophobic TM3 I 135 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 138 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 K 225 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 225 5x64 G.H5 I 344 G.H5.16
Ionic ICL1 R 66 12x51 G.H5 D 350 G.H5.22
Polar ICL1 R 66 12x51 G.H5 D 350 G.H5.22
Van-der-waals ICL1 R 66 12x51 G.H5 D 350 G.H5.22
Hydrophobic H8 F 313 8x50 G.H5 K 349 G.H5.21
Van-der-waals H8 F 313 8x50 G.H5 K 349 G.H5.21
Polar TM3 K 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 134 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic H8 F 313 8x50 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 138 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 138 34x50 G.H5 I 343 G.H5.15
Polar ICL3 F 236 - G.S6 H 322 G.S6.04
Aromatic ICL3 F 236 - G.S6 H 322 G.S6.04
Hydrophobic ICL3 F 236 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 F 236 - G.S6 H 322 G.S6.04
Hydrophobic TM6 L 246 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 L 246 6x29 G.H5 K 345 G.H5.17
Polar H8 D 310 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 310 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM7 I 309 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 I 309 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 I 240 6x23 G.S6 Y 320 G.S6.02
Van-der-waals TM6 I 240 6x23 G.S6 Y 320 G.S6.02
Hydrophobic TM5 V 226 5x65 G.H5 L 348 G.H5.20
Van-der-waals C-term W 353 - G.H3 S 252 G.H3.11
Hydrophobic TM3 K 134 3x53 G.H5 C 351 G.H5.23
Ionic ICL3 D 237 - G.H4 K 304 G.H4.12
Polar ICL3 D 237 - G.H4 K 304 G.H4.12
Hydrophobic ICL3 D 237 - G.H4 K 304 G.H4.12
Van-der-waals ICL3 D 237 - G.H4 K 304 G.H4.12
Hydrophobic TM6 L 246 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 246 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 222 5x61 G.H5 L 348 G.H5.20
Polar TM5 S 229 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 S 229 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 229 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 I 257 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.25
Polar ICL2 S 139 34x51 G.s2s3 D 193 G.s2s3.02
Aromatic C-term W 353 - G.H3 H 256 G.H3.15
Hydrophobic C-term W 353 - G.H3 H 256 G.H3.15
Van-der-waals C-term W 353 - G.H3 H 256 G.H3.15
Hydrophobic ICL2 L 138 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM6 R 239 6x22 G.H4 K 304 G.H4.12