Gs - OPN1MW complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 24.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 262 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM3 V 154 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 151 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 151 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL3 E 255 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 E 255 - G.hgh4 D 323 G.hgh4.13
Hydrophobic C-term L 347 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term L 347 - G.h4s6 R 356 G.h4s6.12
Polar TM3 R 151 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 151 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 151 3x50 G.H5 Y 391 G.H5.23
Polar C-term T 353 - G.h2s4 N 239 G.h2s4.02
Polar H8 Q 328 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 Q 328 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 328 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM3 K 157 3x56 G.H5 Q 384 G.H5.16
Polar ICL2 N 161 34x53 G.hns1 A 39 G.hns1.03
Polar ICL3 E 255 - G.H4 Y 339 G.H4.08
Hydrophobic TM3 V 154 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 V 154 3x53 G.H5 H 387 G.H5.19
Ionic ICL3 E 255 - G.H4 R 342 G.H4.12
Polar ICL3 E 255 - G.H4 R 342 G.H4.12
Polar ICL3 E 255 - G.hgh4 T 325 G.hgh4.15
Hydrophobic ICL3 E 255 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 E 255 - G.hgh4 T 325 G.hgh4.15
Polar C-term G 344 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term G 344 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term G 344 - G.h4s6 R 356 G.h4s6.12
Polar C-term G 344 - G.H5 R 389 G.H5.21
Van-der-waals C-term L 347 - G.H3 R 280 G.H3.16
Hydrophobic TM2 L 88 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 L 88 2x39 G.H5 Y 391 G.H5.23
Polar TM6 T 259 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 T 259 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM3 V 155 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 155 3x54 G.H5 L 388 G.H5.20
Polar H8 N 326 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 326 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 326 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 K 157 3x56 G.H5 I 383 G.H5.15
Van-der-waals TM3 K 157 3x56 G.H5 I 383 G.H5.15
Polar TM3 E 150 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 150 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 150 3x49 G.H5 Y 391 G.H5.23
Polar H8 R 327 8x48 G.H5 E 392 G.H5.24
Polar ICL2 N 161 34x53 G.S1 H 41 G.S1.02
Hydrophobic ICL2 N 161 34x53 G.S1 H 41 G.S1.02
Van-der-waals ICL2 N 161 34x53 G.S1 H 41 G.S1.02
Van-der-waals C-term E 346 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term L 347 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term L 347 - G.h3s5 T 284 G.h3s5.02
Polar TM3 V 155 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 155 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 155 3x54 G.H5 Q 384 G.H5.16
Polar C-term D 343 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term D 343 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term D 343 - G.h4s6 R 356 G.h4s6.12
Polar TM3 K 157 3x56 G.H5 R 380 G.H5.12
Hydrophobic TM3 K 157 3x56 G.H5 R 380 G.H5.12
Hydrophobic TM6 M 269 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 269 6x36 G.H5 L 393 G.H5.25
Polar TM6 S 258 6x25 G.H5 R 385 G.H5.17
Van-der-waals TM6 S 258 6x25 G.H5 R 385 G.H5.17
Polar TM2 N 89 2x40 G.H5 E 392 G.H5.24
Van-der-waals TM2 N 89 2x40 G.H5 E 392 G.H5.24
Polar ICL2 R 163 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 163 34x55 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 163 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic C-term L 347 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term L 347 - G.h3s5 R 283 G.h3s5.01
Polar H8 F 329 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 F 329 8x50 G.H5 E 392 G.H5.24
Polar TM2 H 86 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 H 86 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 H 86 2x37 G.H5 Q 390 G.H5.22