Gz - P2Y4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 144 34x54 G.H5 I 344 G.H5.15
Polar ICL2 G 147 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic C-term L 335 - G.H3 N 257 G.H3.15
Van-der-waals C-term L 335 - G.H3 N 257 G.H3.15
Ionic TM6 R 240 6x31 G.H5 D 342 G.H5.13
Polar TM6 R 240 6x31 G.H5 D 342 G.H5.13
Hydrophobic TM6 R 240 6x31 G.H5 D 342 G.H5.13
Van-der-waals TM6 R 240 6x31 G.H5 D 342 G.H5.13
Hydrophobic C-term L 335 - G.H3 W 259 G.H3.17
Polar TM6 S 243 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 243 6x34 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 243 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 133 3x50 G.H5 L 354 G.H5.25
Polar TM6 S 237 6x28 G.H5 Q 346 G.H5.17
Van-der-waals TM6 S 237 6x28 G.H5 Q 346 G.H5.17
Hydrophobic TM5 R 226 5x64 G.H5 I 345 G.H5.16
Polar TM3 R 133 3x50 G.H5 G 353 G.H5.24
Van-der-waals TM3 R 133 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM6 S 234 6x25 G.S6 Y 321 G.S6.02
Polar TM3 R 133 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM6 A 235 6x26 G.h4s6 E 319 G.h4s6.12
Polar TM6 S 238 6x29 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 S 238 6x29 G.h4s6 E 316 G.h4s6.09
Hydrophobic C-term A 332 - G.H3 W 259 G.H3.17
Van-der-waals C-term A 332 - G.H3 W 259 G.H3.17
Hydrophobic TM5 L 227 5x65 G.H5 I 345 G.H5.16
Hydrophobic TM3 I 137 3x54 G.H5 I 352 G.H5.23
Hydrophobic ICL2 P 140 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 140 34x50 G.H5 T 341 G.H5.12
Polar TM4 R 148 4x38 G.HN Q 28 G.HN.52
Hydrophobic TM4 R 148 4x38 G.HN Q 28 G.HN.52
Van-der-waals TM4 R 148 4x38 G.HN Q 28 G.HN.52
Hydrophobic C-term L 337 - G.H3 I 254 G.H3.12
Hydrophobic ICL3 L 231 - G.H5 D 338 G.H5.09
Van-der-waals ICL3 L 231 - G.H5 D 338 G.H5.09
Hydrophobic TM3 I 137 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 137 3x54 G.H5 L 349 G.H5.20
Polar TM6 S 239 6x30 G.H5 Q 346 G.H5.17
Hydrophobic TM6 S 239 6x30 G.H5 Q 346 G.H5.17
Van-der-waals TM6 S 239 6x30 G.H5 Q 346 G.H5.17
Hydrophobic C-term W 348 - G.hgh4 P 289 G.hgh4.03
Van-der-waals C-term W 348 - G.hgh4 P 289 G.hgh4.03
Hydrophobic C-term L 340 - G.H3 R 249 G.H3.07
Van-der-waals C-term L 340 - G.H3 R 249 G.H3.07
Hydrophobic TM5 L 227 5x65 G.H5 L 349 G.H5.20
Ionic ICL2 R 145 34x55 G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 145 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 R 145 34x55 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 145 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL3 L 231 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 L 231 - G.H5 D 342 G.H5.13
Hydrophobic C-term L 337 - G.H3 L 250 G.H3.08
Hydrophobic ICL2 L 141 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM3 I 137 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 I 137 3x54 G.H5 I 345 G.H5.16
Hydrophobic C-term L 337 - G.H3 S 253 G.H3.11
Van-der-waals C-term L 337 - G.H3 S 253 G.H3.11
Polar TM6 S 237 6x28 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 S 237 6x28 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 S 237 6x28 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 I 137 3x54 G.H5 L 354 G.H5.25
Hydrophobic C-term W 348 - G.hgh4 E 290 G.hgh4.04
Polar TM6 S 239 6x30 G.H5 C 355 G.H5.26
Hydrophobic TM6 S 239 6x30 G.H5 C 355 G.H5.26
Van-der-waals TM6 S 239 6x30 G.H5 C 355 G.H5.26
Polar TM3 G 136 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 G 136 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 G 136 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 140 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 140 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM7 T 309 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 T 309 7x56 G.H5 G 353 G.H5.24
Ionic TM6 R 240 6x31 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 240 6x31 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 240 6x31 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 S 243 6x34 G.H5 L 349 G.H5.20
Van-der-waals TM6 S 243 6x34 G.H5 L 349 G.H5.20
Hydrophobic TM6 I 247 6x38 G.H5 L 354 G.H5.25
Polar TM2 D 68 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM2 D 68 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 D 68 2x37 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 L 141 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 141 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 P 140 34x50 G.H5 I 345 G.H5.16
Hydrophobic C-term L 337 - G.h2s4 F 216 G.h2s4.01
Polar ICL3 G 233 - G.S6 S 322 G.S6.03
Hydrophobic ICL2 L 144 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 L 144 34x54 G.hns1 R 31 G.hns1.02
Polar TM6 T 246 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 246 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 246 6x37 G.H5 L 354 G.H5.25
Polar C-term S 333 - G.H3 N 258 G.H3.16
Van-der-waals C-term S 333 - G.H3 N 258 G.H3.16
Hydrophobic C-term V 338 - G.H2 K 210 G.H2.05
Polar TM6 S 234 6x25 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 S 234 6x25 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 S 234 6x25 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 R 145 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 145 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic C-term L 335 - G.H2 I 213 G.H2.08
Van-der-waals C-term L 335 - G.H2 I 213 G.H2.08
Hydrophobic ICL2 L 141 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 141 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM3 H 132 3x49 G.H5 I 352 G.H5.23
Hydrophobic C-term V 338 - G.H2 R 209 G.H2.04
Van-der-waals C-term V 338 - G.H2 R 209 G.H2.04
Hydrophobic C-term L 335 - G.h2s4 F 216 G.h2s4.01
Polar TM6 R 242 6x33 G.H5 C 355 G.H5.26
Hydrophobic TM6 R 242 6x33 G.H5 C 355 G.H5.26
Van-der-waals TM6 R 242 6x33 G.H5 C 355 G.H5.26