Gs - P2RY8 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term R 322 - G.H3 W 281 G.H3.17
Polar TM3 E 120 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 120 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 120 3x49 G.H5 Y 391 G.H5.23
Polar TM4 R 136 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 R 136 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 R 136 4x38 G.HN Q 35 G.HN.52
Polar H8 S 297 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 297 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 297 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 129 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 129 34x51 G.H5 I 383 G.H5.15
Hydrophobic C-term L 318 - G.H3 R 280 G.H3.16
Polar ICL2 K 132 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 K 132 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 132 34x54 G.hns1 R 38 G.hns1.02
Polar TM3 G 124 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 G 124 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM6 Q 231 6x30 G.H5 L 388 G.H5.20
Polar ICL2 K 132 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 K 132 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 K 132 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 129 34x51 G.H5 C 379 G.H5.11
Polar ICL3 H 227 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 H 227 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 H 227 - G.H5 R 385 G.H5.17
Hydrophobic TM7 Y 293 7x53 G.H5 L 394 G.H5.26
Van-der-waals TM7 Y 293 7x53 G.H5 L 394 G.H5.26
Polar C-term R 322 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term R 322 - G.h3s5 T 284 G.h3s5.02
Hydrophobic ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Van-der-waals TM6 Q 231 6x30 G.H5 R 389 G.H5.21
Hydrophobic ICL3 E 225 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 E 225 - G.H5 D 381 G.H5.13
Ionic ICL3 E 225 - G.H5 R 380 G.H5.12
Hydrophobic C-term F 326 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term F 326 - G.h2s4 D 240 G.h2s4.03
Hydrophobic ICL2 L 129 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 129 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM2 V 59 2x40 G.H5 L 394 G.H5.26
Van-der-waals TM2 V 59 2x40 G.H5 L 394 G.H5.26
Polar ICL2 K 132 34x54 G.S1 T 40 G.S1.01
Van-der-waals ICL2 K 132 34x54 G.S1 T 40 G.S1.01
Hydrophobic TM3 V 125 3x54 G.H5 L 388 G.H5.20
Polar TM4 R 138 4x40 G.HN Q 35 G.HN.52
Hydrophobic TM4 R 138 4x40 G.HN Q 35 G.HN.52
Van-der-waals TM4 R 138 4x40 G.HN Q 35 G.HN.52
Polar C-term F 359 - G.H3 N 279 G.H3.15
Van-der-waals C-term F 359 - G.H3 N 279 G.H3.15
Hydrophobic C-term L 318 - G.H3 W 281 G.H3.17
Hydrophobic ICL2 R 133 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM6 R 232 6x31 G.H5 L 388 G.H5.20
Hydrophobic TM2 M 62 2x43 G.H5 L 394 G.H5.26
Van-der-waals TM2 M 62 2x43 G.H5 L 394 G.H5.26
Hydrophobic C-term L 325 - G.H3 W 281 G.H3.17
Van-der-waals C-term L 325 - G.H3 W 281 G.H3.17
Polar TM3 V 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 125 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 125 3x54 G.H5 Q 384 G.H5.16
Polar ICL3 H 227 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 H 227 - G.S6 C 359 G.S6.01
Polar TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Polar TM3 R 121 3x50 G.H5 L 394 G.H5.26
Van-der-waals TM3 R 121 3x50 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 129 34x51 G.S3 V 217 G.S3.01
Hydrophobic C-term R 321 - G.H3 W 281 G.H3.17
Hydrophobic TM2 S 58 2x39 G.H5 L 394 G.H5.26
Hydrophobic ICL1 M 52 - G.H5 L 394 G.H5.26
Van-der-waals ICL1 M 52 - G.H5 L 394 G.H5.26
Polar TM3 G 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 G 124 3x53 G.H5 H 387 G.H5.19
Ionic ICL3 E 225 - G.H5 R 385 G.H5.17
Ionic TM6 R 234 6x33 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 234 6x33 G.H5 E 392 G.H5.24
Hydrophobic TM4 R 136 4x38 G.hns1 R 38 G.hns1.02
Polar H8 S 297 8x47 G.H5 L 393 G.H5.25
Hydrophobic H8 S 297 8x47 G.H5 L 393 G.H5.25
Van-der-waals H8 S 297 8x47 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 129 34x51 G.S3 F 219 G.S3.03
Hydrophobic C-term R 322 - G.h3s5 I 285 G.h3s5.03
Van-der-waals C-term R 322 - G.h3s5 I 285 G.h3s5.03
Hydrophobic H8 E 299 8x49 G.H5 L 393 G.H5.25
Van-der-waals H8 E 299 8x49 G.H5 L 393 G.H5.25
Polar TM6 R 232 6x31 G.H5 Q 384 G.H5.16
Polar TM4 R 136 4x38 G.HN K 34 G.HN.51
Hydrophobic ICL2 S 130 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 P 128 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 125 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM2 S 56 2x37 G.H5 L 394 G.H5.26
Van-der-waals TM2 S 56 2x37 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 220 5x65 G.H5 L 388 G.H5.20
Polar TM6 Q 231 6x30 G.H5 E 392 G.H5.24
Hydrophobic TM6 Q 231 6x30 G.H5 E 392 G.H5.24
Van-der-waals TM6 Q 231 6x30 G.H5 E 392 G.H5.24
Polar ICL2 L 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 129 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic H8 R 298 8x48 G.H5 L 393 G.H5.25
Van-der-waals H8 R 298 8x48 G.H5 L 393 G.H5.25
Hydrophobic C-term F 326 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term F 326 - G.h2s4 N 239 G.h2s4.02
Hydrophobic ICL2 L 129 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM6 A 235 6x34 G.H5 L 388 G.H5.20
Ionic TM6 R 232 6x31 G.H5 D 381 G.H5.13
Polar TM6 R 232 6x31 G.H5 D 381 G.H5.13
Van-der-waals TM6 R 232 6x31 G.H5 D 381 G.H5.13
Ionic C-term D 316 - G.h3s5 R 283 G.h3s5.01
Ionic C-term D 316 - G.h4s6 R 356 G.h4s6.12
Polar C-term D 316 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term D 316 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term D 316 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term F 359 - G.H2 R 231 G.H2.04
Van-der-waals C-term F 359 - G.H2 R 231 G.H2.04
Hydrophobic ICL2 P 128 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 128 34x50 G.H5 R 380 G.H5.12
Polar ICL2 R 135 34x57 G.H5 H 387 G.H5.19
Aromatic ICL2 R 135 34x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 135 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 135 34x57 G.H5 H 387 G.H5.19