Gi2 - P2Y13 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 231 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 I 231 5x61 G.H5 L 354 G.H5.25
Hydrophobic C-term L 353 - G.H3 L 250 G.H3.08
Van-der-waals C-term L 353 - G.H3 L 250 G.H3.08
Hydrophobic TM4 P 157 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 P 157 4x39 G.HN R 24 G.HN.48
Hydrophobic TM3 I 145 3x54 G.H5 L 354 G.H5.25
Van-der-waals TM3 I 145 3x54 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 149 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 149 34x51 G.H5 I 344 G.H5.15
Polar C-term G 354 - G.H2 R 209 G.H2.04
Van-der-waals C-term G 354 - G.H2 R 209 G.H2.04
Hydrophobic ICL2 L 149 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 149 34x51 G.S3 L 195 G.S3.01
Ionic ICL3 K 241 - G.H5 D 342 G.H5.13
Polar ICL3 K 241 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 K 241 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 K 241 - G.H5 D 342 G.H5.13
Ionic TM6 K 251 6x32 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 251 6x32 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 K 251 6x32 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 K 251 6x32 G.h4s6 E 319 G.h4s6.12
Ionic H8 K 322 8x48 G.h3s5 D 262 G.h3s5.02
Polar TM6 K 256 6x37 G.H5 G 353 G.H5.24
Hydrophobic TM6 K 256 6x37 G.H5 G 353 G.H5.24
Van-der-waals TM6 K 256 6x37 G.H5 G 353 G.H5.24
Hydrophobic TM3 I 145 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 149 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic C-term L 353 - G.H3 I 254 G.H3.12
Hydrophobic TM5 V 235 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 V 235 5x65 G.H5 L 349 G.H5.20
Polar TM6 N 249 6x30 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM6 F 258 6x39 G.H5 L 354 G.H5.25
Hydrophobic TM6 V 257 6x38 G.H5 C 352 G.H5.23
Van-der-waals TM6 V 257 6x38 G.H5 C 352 G.H5.23
Polar TM3 R 141 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 141 3x50 G.H5 C 352 G.H5.23
Polar C-term G 354 - G.H2 R 206 G.H2.01
Hydrophobic C-term G 354 - G.H2 R 206 G.H2.01
Van-der-waals C-term G 354 - G.H2 R 206 G.H2.01
Polar ICL2 N 151 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 151 34x53 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 151 34x53 G.hns1 R 32 G.hns1.03
Polar TM3 K 144 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 K 144 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 K 144 3x53 G.H5 N 348 G.H5.19
Aromatic TM6 K 245 6x26 G.S6 H 323 G.S6.04
Hydrophobic C-term L 353 - G.H2 R 209 G.H2.04
Van-der-waals C-term L 353 - G.H2 R 209 G.H2.04
Hydrophobic C-term L 353 - G.H2 W 212 G.H2.07
Van-der-waals C-term L 353 - G.H2 W 212 G.H2.07
Hydrophobic TM6 K 251 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 251 6x32 G.H5 F 355 G.H5.26
Van-der-waals C-term I 351 - G.H3 S 253 G.H3.11
Polar TM6 V 257 6x38 G.H5 G 353 G.H5.24
Van-der-waals TM6 V 257 6x38 G.H5 G 353 G.H5.24
Polar TM3 R 141 3x50 G.H5 D 351 G.H5.22
Van-der-waals TM3 R 141 3x50 G.H5 D 351 G.H5.22
Polar ICL2 P 148 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 148 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 148 34x50 G.H5 N 348 G.H5.19
Hydrophobic TM6 L 253 6x34 G.H5 L 354 G.H5.25
Ionic C-term D 349 - G.H3 K 258 G.H3.16
Polar C-term D 349 - G.H3 K 258 G.H3.16
Van-der-waals C-term D 349 - G.H3 K 258 G.H3.16
Polar TM6 E 254 6x35 G.H5 L 354 G.H5.25
Hydrophobic TM6 E 254 6x35 G.H5 L 354 G.H5.25
Van-der-waals TM6 E 254 6x35 G.H5 L 354 G.H5.25
Hydrophobic ICL1 S 75 - G.HN R 24 G.HN.48
Polar TM6 K 245 6x26 G.S6 T 322 G.S6.03
Hydrophobic TM6 K 245 6x26 G.S6 T 322 G.S6.03
Van-der-waals TM6 K 245 6x26 G.S6 T 322 G.S6.03
Hydrophobic TM6 V 257 6x38 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 257 6x38 G.H5 L 354 G.H5.25
Hydrophobic TM7 L 320 7x56 G.H5 G 353 G.H5.24
Ionic ICL2 R 150 34x52 G.s2s3 D 194 G.s2s3.02
Polar ICL2 R 150 34x52 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 R 150 34x52 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 R 150 34x52 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 P 148 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 148 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM7 L 320 7x56 G.H5 C 352 G.H5.23
Van-der-waals TM7 L 320 7x56 G.H5 C 352 G.H5.23
Hydrophobic C-term I 351 - G.H3 N 257 G.H3.15
Van-der-waals C-term I 351 - G.H3 N 257 G.H3.15
Hydrophobic TM5 V 235 5x65 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 148 34x50 G.H5 I 344 G.H5.15
Van-der-waals TM4 K 156 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 149 34x51 G.H5 T 341 G.H5.12
Hydrophobic TM5 K 234 5x64 G.H5 I 345 G.H5.16
Hydrophobic C-term I 351 - G.h2s4 F 216 G.h2s4.01
Van-der-waals C-term I 351 - G.h2s4 F 216 G.h2s4.01
Hydrophobic TM4 P 157 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 P 157 4x39 G.HN E 28 G.HN.52
Polar ICL2 N 151 34x53 G.HN E 28 G.HN.52
Polar ICL3 S 242 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 S 242 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 S 242 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 I 145 3x54 G.H5 C 352 G.H5.23
Hydrophobic TM3 K 144 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM6 E 254 6x35 G.H5 F 355 G.H5.26
Hydrophobic TM6 E 254 6x35 G.H5 G 353 G.H5.24
Van-der-waals TM6 E 254 6x35 G.H5 G 353 G.H5.24