Gq - P2Y13 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 148 34x50 G.H5 L 349 G.H5.16
Polar TM7 F 319 7x55 G.H5 N 357 G.H5.24
Hydrophobic TM3 I 145 3x54 G.H5 L 358 G.H5.25
Hydrophobic H8 K 322 8x48 G.H5 N 357 G.H5.24
Van-der-waals H8 K 322 8x48 G.H5 N 357 G.H5.24
Hydrophobic C-term I 351 - G.H3 Y 261 G.H3.15
Van-der-waals C-term I 351 - G.H3 Y 261 G.H3.15
Polar TM5 S 238 5x68 G.H5 Q 350 G.H5.17
Hydrophobic TM5 S 238 5x68 G.H5 Q 350 G.H5.17
Van-der-waals TM5 S 238 5x68 G.H5 Q 350 G.H5.17
Polar ICL3 S 242 - G.H5 Q 350 G.H5.17
Polar ICL2 N 151 34x53 G.HN D 35 G.HN.53
Hydrophobic ICL2 N 151 34x53 G.HN D 35 G.HN.53
Van-der-waals ICL2 N 151 34x53 G.HN D 35 G.HN.53
Polar TM3 R 147 3x56 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 L 149 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 L 149 34x51 G.S3 V 199 G.S3.01
Polar ICL2 L 149 34x51 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 L 149 34x51 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 L 149 34x51 G.s2s3 S 198 G.s2s3.02
Polar ICL2 R 150 34x52 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 R 150 34x52 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 R 150 34x52 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 L 149 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 L 149 34x51 G.S1 L 40 G.S1.02
Polar ICL2 P 148 34x50 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 P 148 34x50 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 P 148 34x50 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 P 148 34x50 G.S3 V 199 G.S3.01
Van-der-waals ICL2 P 148 34x50 G.S3 V 199 G.S3.01
Hydrophobic ICL2 K 155 34x57 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 K 155 34x57 G.hns1 R 38 G.hns1.03
Polar TM3 R 141 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 R 141 3x50 G.H5 N 357 G.H5.24
Hydrophobic TM3 K 144 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM4 P 157 4x39 G.HN R 34 G.HN.52
Van-der-waals TM4 P 157 4x39 G.HN R 34 G.HN.52
Van-der-waals TM4 V 158 4x40 G.HN R 34 G.HN.52
Hydrophobic ICL2 L 149 34x51 G.S3 I 200 G.S3.02
Van-der-waals ICL2 L 149 34x51 G.S3 I 200 G.S3.02
Polar TM5 S 238 5x68 G.H5 D 346 G.H5.13
Hydrophobic TM5 S 238 5x68 G.H5 D 346 G.H5.13
Hydrophobic TM6 V 257 6x38 G.H5 V 359 G.H5.26
Van-der-waals TM6 V 257 6x38 G.H5 V 359 G.H5.26
Hydrophobic C-term L 353 - G.H3 Y 261 G.H3.15
Van-der-waals C-term L 353 - G.H3 Y 261 G.H3.15
Hydrophobic C-term L 353 - G.H3 T 257 G.H3.11
Polar ICL2 N 151 34x53 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 N 151 34x53 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 N 151 34x53 G.hns1 R 38 G.hns1.03
Hydrophobic TM5 V 235 5x65 G.H5 V 359 G.H5.26
Van-der-waals TM5 V 235 5x65 G.H5 V 359 G.H5.26
Polar ICL2 N 151 34x53 G.HN R 34 G.HN.52
Hydrophobic ICL2 N 151 34x53 G.HN R 34 G.HN.52
Van-der-waals ICL2 N 151 34x53 G.HN R 34 G.HN.52
Hydrophobic TM3 R 141 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 141 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM3 I 145 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM4 K 156 4x38 G.HN R 34 G.HN.52
Polar TM7 L 320 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 L 320 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 L 320 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM3 I 146 3x55 G.s2s3 S 198 G.s2s3.02
Van-der-waals TM3 I 146 3x55 G.s2s3 S 198 G.s2s3.02
Polar ICL1 S 75 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL1 S 75 - G.hns1 R 37 G.hns1.02
Hydrophobic TM3 K 144 3x53 G.H5 L 353 G.H5.20
Hydrophobic TM3 K 144 3x53 G.H5 L 358 G.H5.25
Van-der-waals TM3 K 144 3x53 G.H5 L 358 G.H5.25
Hydrophobic ICL3 K 241 - G.H5 D 346 G.H5.13
Van-der-waals ICL3 K 241 - G.H5 D 346 G.H5.13
Polar ICL2 I 152 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 I 152 34x54 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 I 152 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 E 254 6x35 G.H5 V 359 G.H5.26
Van-der-waals TM6 E 254 6x35 G.H5 V 359 G.H5.26
Hydrophobic TM6 V 257 6x38 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 257 6x38 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 149 34x51 G.S1 E 39 G.S1.01
Hydrophobic ICL2 L 149 34x51 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 L 149 34x51 G.hns1 R 38 G.hns1.03
Polar ICL2 P 148 34x50 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 P 148 34x50 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 P 148 34x50 G.hns1 R 38 G.hns1.03