Gq - P2Y14 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 T 129 34x53 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 T 129 34x53 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 T 129 34x53 G.hns1 R 37 G.hns1.02
Hydrophobic TM2 F 56 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 F 56 2x39 G.H5 E 355 G.H5.22
Polar TM6 K 230 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM6 K 230 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 230 6x33 G.H5 V 359 G.H5.26
Hydrophobic ICL2 P 126 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 126 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM6 V 227 6x30 G.H5 V 359 G.H5.26
Van-der-waals TM6 V 227 6x30 G.H5 V 359 G.H5.26
Polar TM7 F 297 7x55 G.H5 N 357 G.H5.24
Hydrophobic TM7 F 297 7x55 G.H5 N 357 G.H5.24
Van-der-waals TM7 F 297 7x55 G.H5 N 357 G.H5.24
Polar TM6 S 231 6x34 G.H5 L 358 G.H5.25
Hydrophobic TM6 S 231 6x34 G.H5 L 358 G.H5.25
Van-der-waals TM6 S 231 6x34 G.H5 L 358 G.H5.25
Hydrophobic TM5 S 216 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 S 216 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM7 L 298 7x56 G.H5 N 357 G.H5.24
Ionic TM3 K 122 3x53 G.H5 E 355 G.H5.22
Polar TM3 K 122 3x53 G.H5 E 355 G.H5.22
Van-der-waals TM3 K 122 3x53 G.H5 E 355 G.H5.22
Hydrophobic ICL2 L 127 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 L 127 34x51 G.S1 L 40 G.S1.02
Polar C-term N 318 - G.h4s6 D 319 G.h4s6.10
Van-der-waals C-term N 318 - G.h4s6 D 319 G.h4s6.10
Polar TM3 K 122 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 K 122 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 K 122 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 127 34x51 G.S3 V 199 G.S3.01
Polar TM3 R 119 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 123 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 123 3x54 G.H5 L 349 G.H5.16
Polar C-term Q 317 - G.h4s6 D 321 G.h4s6.12
Hydrophobic ICL2 P 126 34x50 G.H5 K 345 G.H5.12
Hydrophobic TM3 I 123 3x54 G.H5 L 353 G.H5.20
Polar ICL2 T 129 34x53 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 T 129 34x53 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 T 129 34x53 G.hns1 R 38 G.hns1.03
Polar ICL2 W 128 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 W 128 34x52 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 W 128 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM3 I 123 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 123 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 127 34x51 G.H5 K 345 G.H5.12
Hydrophobic TM5 K 212 5x64 G.H5 L 349 G.H5.16
Aromatic TM2 F 56 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 F 56 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 F 56 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM5 I 209 5x61 G.H5 L 358 G.H5.25
Polar TM3 D 118 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 118 3x49 G.H5 Y 356 G.H5.23
Polar TM3 K 122 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 K 122 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 K 122 3x53 G.H5 N 352 G.H5.19
Polar TM5 S 216 5x68 G.H5 Q 350 G.H5.17
Polar TM4 S 134 4x38 G.HN R 34 G.HN.52
Hydrophobic ICL2 P 126 34x50 G.H5 L 349 G.H5.16
Hydrophobic TM4 Y 137 4x41 G.HN R 34 G.HN.52
Van-der-waals TM4 Y 137 4x41 G.HN R 34 G.HN.52
Polar H8 R 303 8x51 G.H5 N 357 G.H5.24
Hydrophobic H8 R 303 8x51 G.H5 N 357 G.H5.24
Van-der-waals H8 R 303 8x51 G.H5 N 357 G.H5.24
Polar TM6 N 234 6x37 G.H5 N 357 G.H5.24
Van-der-waals TM6 N 234 6x37 G.H5 N 357 G.H5.24
Hydrophobic ICL2 L 127 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 127 34x51 G.H5 I 348 G.H5.15
Polar TM5 S 216 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 S 216 5x68 G.H5 D 346 G.H5.13
Hydrophobic TM6 I 235 6x38 G.H5 L 358 G.H5.25
Van-der-waals TM6 I 235 6x38 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 127 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 127 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM5 I 213 5x65 G.H5 L 358 G.H5.25
Hydrophobic TM5 I 213 5x65 G.H5 L 353 G.H5.20
Van-der-waals TM5 I 213 5x65 G.H5 L 353 G.H5.20
Ionic TM2 K 54 2x37 G.H5 E 355 G.H5.22
Polar TM2 K 54 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 K 54 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 K 54 2x37 G.H5 E 355 G.H5.22