Go - PAR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PAR1 66.7
Gαo 87.4
Gβ1 94.0
Gγ2 85.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM7 A 374 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 A 374 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 A 374 7x56 G.H5 G 352 G.H5.24
Polar TM6 K 307 6x30 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 307 6x30 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 307 6x30 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 310 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 310 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 V 302 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 V 302 - G.S6 Y 320 G.S6.02
Polar C-term L 423 - G.H3 S 253 G.H3.11
Van-der-waals TM7 Y 373 7x55 G.H5 G 352 G.H5.24
Hydrophobic ICL3 V 302 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 V 302 - G.H5 D 341 G.H5.13
Hydrophobic TM3 A 203 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 203 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 M 208 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 M 208 34x51 G.S1 V 34 G.S1.02
Polar TM3 A 203 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 203 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 203 3x53 G.H5 N 347 G.H5.19
Hydrophobic C-term L 415 - G.s4h3 T 240 G.s4h3.13
Hydrophobic TM6 A 311 6x34 G.H5 L 353 G.H5.25
Hydrophobic C-term Y 420 - G.s4h3 T 241 G.s4h3.14
Hydrophobic C-term L 423 - G.H3 L 250 G.H3.08
Hydrophobic TM2 K 135 2x37 G.H5 G 350 G.H5.22
Van-der-waals TM2 K 135 2x37 G.H5 G 350 G.H5.22
Polar TM3 D 199 3x49 G.H5 C 351 G.H5.23
Polar ICL2 R 214 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 214 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 214 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM6 K 307 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 297 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 M 208 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 M 208 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM3 V 204 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 204 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM2 A 137 2x39 G.H5 C 351 G.H5.23
Hydrophobic C-term Y 420 - G.s4h3 L 235 G.s4h3.08
Van-der-waals C-term Y 420 - G.s4h3 L 235 G.s4h3.08
Polar ICL3 S 300 - G.H5 D 341 G.H5.13
Polar ICL2 R 214 34x57 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 214 34x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 207 34x50 G.H5 I 343 G.H5.15
Polar H8 R 380 8x52 G.h4s6 N 316 G.h4s6.10
Hydrophobic C-term I 419 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term I 419 - G.s4h3 E 237 G.s4h3.10
Hydrophobic TM7 A 374 7x56 G.H5 C 351 G.H5.23
Van-der-waals TM7 A 374 7x56 G.H5 C 351 G.H5.23
Polar ICL2 P 207 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 207 34x50 G.H5 N 347 G.H5.19
Hydrophobic C-term L 424 - G.H3 M 249 G.H3.07
Hydrophobic TM3 V 204 3x54 G.H5 L 353 G.H5.25
Hydrophobic C-term L 423 - G.H2 R 209 G.H2.04
Polar C-term N 417 - G.s4h3 D 238 G.s4h3.11
Hydrophobic C-term N 417 - G.s4h3 D 238 G.s4h3.11
Van-der-waals C-term N 417 - G.s4h3 D 238 G.s4h3.11
Polar TM6 R 310 6x33 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 310 6x33 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 310 6x33 G.H5 Y 354 G.H5.26
Polar C-term Y 420 - G.H3 E 246 G.H3.04
Hydrophobic C-term Y 420 - G.H3 E 246 G.H3.04
Van-der-waals C-term Y 420 - G.H3 E 246 G.H3.04
Polar TM3 R 200 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 200 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 M 208 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 208 34x51 G.H5 I 343 G.H5.15
Polar C-term T 425 - G.H2 K 210 G.H2.05
Hydrophobic C-term T 425 - G.H2 K 210 G.H2.05
Hydrophobic ICL2 S 212 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 R 200 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 314 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 207 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 207 34x50 G.H5 I 344 G.H5.16
Polar H8 S 375 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 375 8x47 G.H5 G 352 G.H5.24
Ionic TM6 K 307 6x30 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 307 6x30 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 307 6x30 G.h4s6 E 318 G.h4s6.12