G12 - PAR4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 182 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 182 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM3 A 177 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 177 3x53 G.H5 I 378 G.H5.23
Polar ICL2 R 188 34x57 G.H5 N 374 G.H5.19
Hydrophobic TM2 L 115 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 182 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 182 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM1 L 102 1x57 G.H5 L 380 G.H5.25
Polar H8 S 344 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 344 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 344 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 271 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 A 281 6x34 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 182 34x51 G.S1 V 58 G.S1.02
Polar ICL2 R 185 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 185 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 185 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic H8 E 346 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 E 346 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM6 Y 278 6x31 G.H5 L 375 G.H5.20
Van-der-waals TM6 Y 278 6x31 G.H5 L 375 G.H5.20
Polar H8 S 344 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 S 344 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 344 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM3 L 178 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 R 185 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM4 R 191 4x40 G.HN A 48 G.HN.48
Van-der-waals TM4 R 191 4x40 G.HN A 48 G.HN.48
Hydrophobic ICL2 L 182 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 182 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 P 181 34x50 G.H5 L 371 G.H5.16
Polar ICL3 R 277 - G.h4s6 S 343 G.h4s6.12
Hydrophobic TM7 Y 341 7x54 G.H5 L 380 G.H5.25
Polar ICL2 R 185 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 185 34x54 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 185 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic TM6 L 284 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM2 L 109 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 L 109 2x37 G.H5 D 377 G.H5.22
Polar TM2 S 111 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 111 2x39 G.H5 D 377 G.H5.22
Polar ICL2 R 188 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 181 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 181 34x50 G.H5 I 370 G.H5.15
Polar TM3 A 177 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 177 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 177 3x53 G.H5 N 374 G.H5.19
Ionic ICL2 R 188 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 188 34x57 G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 188 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 188 34x57 G.H5 D 377 G.H5.22
Hydrophobic TM3 L 178 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 178 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 A 186 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 Y 278 6x31 G.H5 L 371 G.H5.16
Van-der-waals TM6 Y 278 6x31 G.H5 L 371 G.H5.16
Polar TM6 Y 278 6x31 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Y 278 6x31 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Y 278 6x31 G.H5 Q 372 G.H5.17
Polar TM6 Y 278 6x31 G.H5 D 368 G.H5.13
Hydrophobic TM6 Y 278 6x31 G.H5 D 368 G.H5.13
Van-der-waals TM6 Y 278 6x31 G.H5 D 368 G.H5.13
Polar ICL2 R 185 34x54 G.S1 L 57 G.S1.01
Hydrophobic ICL2 R 188 34x57 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 181 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 181 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM2 S 111 2x39 G.H5 I 378 G.H5.23
Polar ICL3 R 277 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 R 277 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 R 277 - G.H5 Q 372 G.H5.17
Polar ICL2 P 181 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM6 H 280 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 H 280 6x33 G.H5 M 379 G.H5.24
Polar TM3 R 174 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 174 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 174 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 182 34x51 G.H5 K 367 G.H5.12
Polar H8 S 344 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 344 8x47 G.H5 Q 381 G.H5.26
Ionic ICL2 R 185 34x54 G.H5 E 373 G.H5.18
Hydrophobic H8 F 347 8x50 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 182 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM6 A 281 6x34 G.H5 L 375 G.H5.20
Hydrophobic ICL3 R 277 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 R 277 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 L 178 3x54 G.H5 I 378 G.H5.23