G12 - PKR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 97 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM5 P 265 5x71 G.H5 A 365 G.H5.10
Ionic TM6 R 279 6x30 G.H5 D 368 G.H5.13
Polar TM6 R 279 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 279 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 279 6x30 G.H5 D 368 G.H5.13
Polar TM5 F 267 5x73 G.S6 H 348 G.S6.03
Hydrophobic TM5 F 267 5x73 G.S6 H 348 G.S6.03
Van-der-waals TM5 F 267 5x73 G.S6 H 348 G.S6.03
Polar TM3 V 167 3x55 G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 169 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 169 - G.H5 K 367 G.H5.12
Hydrophobic TM7 V 345 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 V 345 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM3 R 162 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 162 3x50 G.H5 I 378 G.H5.23
Polar TM6 Q 271 6x22 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 Q 271 6x22 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 Q 271 6x22 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 I 166 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM7 C 341 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 C 341 7x52 G.H5 L 380 G.H5.25
Hydrophobic TM3 A 165 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 165 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 170 - G.H5 K 367 G.H5.12
Polar TM6 T 282 6x33 G.H5 Q 381 G.H5.26
Polar H8 N 347 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 347 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM5 V 264 5x70 G.H5 D 368 G.H5.13
Van-der-waals TM5 V 264 5x70 G.H5 D 368 G.H5.13
Polar ICL2 R 173 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 R 173 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 173 - G.H5 N 374 G.H5.19
Hydrophobic TM5 P 265 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 P 265 5x71 G.H5 H 364 G.H5.09
Hydrophobic ICL3 T 269 - G.S6 H 348 G.S6.03
Polar TM6 Q 271 6x22 G.h4s6 R 339 G.h4s6.08
Van-der-waals TM6 Q 271 6x22 G.h4s6 R 339 G.h4s6.08
Polar TM6 Q 271 6x22 G.h4s6 R 342 G.h4s6.11
Hydrophobic TM6 Q 271 6x22 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 Q 271 6x22 G.h4s6 R 342 G.h4s6.11
Hydrophobic TM6 T 282 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 282 6x33 G.H5 M 379 G.H5.24
Ionic ICL2 R 173 - G.H5 D 377 G.H5.22
Polar ICL2 R 173 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 173 - G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 173 - G.H5 D 377 G.H5.22
Hydrophobic TM4 C 176 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 C 176 4x39 G.HN R 52 G.HN.52
Polar TM6 C 278 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 C 278 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 C 278 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM5 G 266 5x72 G.H5 F 361 G.H5.06
Van-der-waals TM5 G 266 5x72 G.H5 F 361 G.H5.06
Hydrophobic TM6 R 275 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 R 275 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 L 170 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 170 - G.H5 F 363 G.H5.08
Hydrophobic TM6 R 279 6x30 G.H5 L 375 G.H5.20
Polar ICL4 K 346 - G.H5 L 380 G.H5.25
Hydrophobic ICL4 K 346 - G.H5 L 380 G.H5.25
Van-der-waals ICL4 K 346 - G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 169 - G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 170 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 170 - G.H5 I 370 G.H5.15
Hydrophobic C-term L 392 - G.H3 T 279 G.H3.11
Polar ICL2 P 169 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 169 - G.H5 N 374 G.H5.19
Hydrophobic TM6 I 272 6x23 G.S6 F 347 G.S6.02
Polar TM6 R 279 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 279 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM5 V 264 5x70 G.S6 F 347 G.S6.02
Van-der-waals TM5 V 264 5x70 G.S6 F 347 G.S6.02
Hydrophobic H8 N 347 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 347 8x47 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 170 - G.S1 V 58 G.S1.02
Ionic TM5 E 258 5x64 G.H5 K 367 G.H5.12
Polar TM5 E 258 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 E 258 5x64 G.H5 K 367 G.H5.12
Ionic TM6 R 275 6x26 G.H5 D 368 G.H5.13
Polar TM6 R 275 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 275 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM5 L 259 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM6 I 272 6x23 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 I 272 6x23 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 I 166 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 162 3x50 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 170 - G.H5 V 366 G.H5.11
Hydrophobic TM4 K 175 4x38 G.HN R 52 G.HN.52
Hydrophobic ICL2 L 170 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 170 - G.S3 I 221 G.S3.01
Hydrophobic TM6 T 282 6x33 G.H5 L 375 G.H5.20
Polar ICL4 K 346 - G.H5 D 377 G.H5.22
Van-der-waals ICL4 K 346 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 P 169 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 169 - G.H5 I 370 G.H5.15
Polar TM6 Q 271 6x22 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM6 Q 271 6x22 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 Q 271 6x22 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM5 L 259 5x65 G.H5 L 375 G.H5.20
Polar TM3 A 165 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 165 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 165 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 R 173 - G.H5 I 378 G.H5.23
Van-der-waals ICL2 R 173 - G.H5 I 378 G.H5.23
Hydrophobic TM7 F 342 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 342 7x53 G.H5 L 380 G.H5.25
Polar TM6 Q 271 6x22 G.S6 L 346 G.S6.01
Van-der-waals TM6 Q 271 6x22 G.S6 L 346 G.S6.01
Hydrophobic ICL2 P 172 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 172 - G.hns1 R 56 G.hns1.03
Hydrophobic TM5 P 265 5x71 G.H5 F 361 G.H5.06
Hydrophobic TM6 R 279 6x30 G.H5 L 371 G.H5.16
Hydrophobic TM6 R 275 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 275 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 L 286 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 286 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM6 V 285 6x36 G.H5 M 379 G.H5.24