Gi1 - TAS2R16 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 S 280 8x47 G.H5 G 352 G.H5.24
Ionic TM5 H 210 5x72 G.H5 D 341 G.H5.13
Polar TM5 H 210 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 210 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 210 5x72 G.H5 D 341 G.H5.13
Hydrophobic ICL2 F 110 34x45 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 110 34x45 G.S3 L 194 G.S3.01
Polar ICL2 L 116 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 116 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 116 34x51 G.hns1 R 32 G.hns1.03
Polar TM4 R 124 4x40 G.HN R 24 G.HN.48
Hydrophobic TM4 R 124 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 R 124 4x40 G.HN R 24 G.HN.48
Hydrophobic TM5 Q 206 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 S 218 6x27 G.S6 Y 320 G.S6.02
Hydrophobic TM6 L 229 6x38 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 110 34x45 G.H5 I 344 G.H5.16
Polar ICL2 W 120 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 W 120 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 W 120 34x55 G.HN E 28 G.HN.52
Hydrophobic TM6 P 217 6x26 G.S6 Y 320 G.S6.02
Van-der-waals TM6 P 217 6x26 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 L 116 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 116 34x51 G.S3 L 194 G.S3.01
Polar TM6 A 225 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 225 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 225 6x34 G.H5 L 353 G.H5.25
Ionic TM6 R 222 6x31 G.H5 D 341 G.H5.13
Polar TM6 R 222 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 222 6x31 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 222 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM2 V 45 2x39 G.H5 C 351 G.H5.23
Polar TM3 K 106 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 106 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 106 3x53 G.H5 N 347 G.H5.19
Polar TM3 Y 103 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 103 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 103 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 A 221 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 221 6x30 G.H5 F 354 G.H5.26
Ionic TM4 R 124 4x40 G.HN E 28 G.HN.52
Polar TM4 R 124 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 R 124 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 R 124 4x40 G.HN E 28 G.HN.52
Hydrophobic TM3 F 102 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 232 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 222 6x31 G.H5 L 348 G.H5.20
Ionic H8 R 285 8x52 G.h3s5 D 261 G.h3s5.02
Hydrophobic TM3 V 107 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 107 3x54 G.H5 L 348 G.H5.20
Polar TM6 S 218 6x27 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 218 6x27 G.H5 D 341 G.H5.13
Van-der-waals TM6 S 218 6x27 G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 116 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 L 116 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 W 120 34x55 G.HN K 29 G.HN.53
Van-der-waals ICL2 W 120 34x55 G.HN K 29 G.HN.53
Hydrophobic H8 P 281 8x48 G.H5 G 352 G.H5.24
Hydrophobic ICL2 W 120 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 W 120 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 P 217 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 P 217 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 K 106 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 106 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM4 R 124 4x40 G.HN E 25 G.HN.49
Van-der-waals TM4 R 124 4x40 G.HN E 25 G.HN.49
Hydrophobic TM6 S 228 6x37 G.H5 L 353 G.H5.25
Ionic ICL2 H 113 34x48 G.s2s3 D 193 G.s2s3.02
Polar ICL2 H 113 34x48 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 H 113 34x48 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 H 113 34x48 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 L 203 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 221 6x30 G.H5 K 345 G.H5.17
Hydrophobic ICL2 F 110 34x45 G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 110 34x45 G.H5 T 340 G.H5.12
Hydrophobic TM5 H 210 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM3 Y 103 3x50 G.H5 L 353 G.H5.25
Aromatic ICL2 W 120 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 W 120 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 120 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 116 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 116 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM6 T 224 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 T 224 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 225 6x34 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 225 6x34 G.H5 L 348 G.H5.20
Hydrophobic ICL2 F 110 34x45 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 110 34x45 G.H5 I 343 G.H5.15
Polar TM7 S 279 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 S 279 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 S 279 7x56 G.H5 G 352 G.H5.24
Polar ICL2 W 117 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 W 117 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 117 34x52 G.hns1 R 32 G.hns1.03
Ionic TM3 K 106 3x53 G.H5 D 350 G.H5.22
Polar TM3 K 106 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 K 106 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 K 106 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM4 L 123 4x39 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 L 123 4x39 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 A 221 6x30 G.H5 L 348 G.H5.20
Polar ICL2 R 119 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 119 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 F 110 34x45 G.H5 N 347 G.H5.19
Polar ICL2 R 119 34x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 R 119 34x54 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 119 34x54 G.H5 N 347 G.H5.19