G13 - TAS2R8 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 24.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 T 220 - G.H4 R 331 G.H4.16
Hydrophobic ICL3 T 220 - G.H4 R 331 G.H4.16
Van-der-waals ICL3 T 220 - G.H4 R 331 G.H4.16
Polar ICL1 K 40 - G.HN K 42 G.HN.51
Hydrophobic ICL1 K 40 - G.HN K 42 G.HN.51
Van-der-waals ICL1 K 40 - G.HN K 42 G.HN.51
Hydrophobic ICL2 K 123 34x54 G.H5 L 367 G.H5.16
Hydrophobic TM3 I 111 3x54 G.H5 M 375 G.H5.24
Van-der-waals TM3 I 111 3x54 G.H5 M 375 G.H5.24
Polar H8 N 289 8x47 G.H5 M 375 G.H5.24
Hydrophobic ICL2 W 124 34x55 G.S3 P 217 G.S3.02
Van-der-waals ICL2 W 124 34x55 G.S3 P 217 G.S3.02
Hydrophobic TM3 I 111 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM6 S 226 6x27 G.S6 Y 343 G.S6.02
Van-der-waals TM6 S 226 6x27 G.S6 Y 343 G.S6.02
Polar TM5 H 211 5x68 G.H5 T 365 G.H5.14
Hydrophobic TM4 M 128 4x40 G.hns1 R 47 G.hns1.03
Van-der-waals TM4 M 128 4x40 G.hns1 R 47 G.hns1.03
Polar TM5 Y 218 5x75 G.S6 H 344 G.S6.03
Hydrophobic TM5 Y 218 5x75 G.S6 H 344 G.S6.03
Van-der-waals TM5 Y 218 5x75 G.S6 H 344 G.S6.03
Polar ICL2 W 124 34x55 G.hns1 R 47 G.hns1.03
Aromatic ICL2 W 124 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 W 124 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 W 124 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 L 120 34x51 G.s2s3 K 214 G.s2s3.01
Van-der-waals ICL2 L 120 34x51 G.s2s3 K 214 G.s2s3.01
Hydrophobic TM5 I 215 5x72 G.S6 Y 343 G.S6.02
Hydrophobic ICL3 G 221 - G.H4 R 331 G.H4.16
Hydrophobic TM2 V 44 2x39 G.H5 L 374 G.H5.23
Polar ICL2 W 124 34x55 G.s2s3 N 215 G.s2s3.02
Hydrophobic ICL2 W 124 34x55 G.s2s3 N 215 G.s2s3.02
Van-der-waals ICL2 W 124 34x55 G.s2s3 N 215 G.s2s3.02
Hydrophobic TM5 L 208 5x65 G.H5 H 368 G.H5.17
Van-der-waals TM5 L 208 5x65 G.H5 H 368 G.H5.17
Hydrophobic ICL1 K 40 - G.hns1 K 46 G.hns1.02
Van-der-waals ICL1 K 40 - G.hns1 K 46 G.hns1.02
Hydrophobic TM6 D 224 6x25 G.h4s6 P 341 G.h4s6.20
Van-der-waals TM6 D 224 6x25 G.h4s6 P 341 G.h4s6.20
Hydrophobic ICL2 L 120 34x51 G.H5 K 363 G.H5.12
Hydrophobic TM6 P 225 6x26 G.h4s6 K 340 G.h4s6.19
Van-der-waals TM6 P 225 6x26 G.h4s6 K 340 G.h4s6.19
Hydrophobic H8 K 291 8x49 G.H5 Q 377 G.H5.26
Van-der-waals H8 K 291 8x49 G.H5 Q 377 G.H5.26
Hydrophobic TM6 V 229 6x30 G.H5 K 372 G.H5.21
Van-der-waals TM6 V 229 6x30 G.H5 K 372 G.H5.21
Polar TM3 I 111 3x54 G.H5 H 368 G.H5.17
Hydrophobic TM3 I 111 3x54 G.H5 H 368 G.H5.17
Van-der-waals TM3 I 111 3x54 G.H5 H 368 G.H5.17
Polar TM5 Q 214 5x71 G.H5 D 361 G.H5.10
Hydrophobic TM5 Q 214 5x71 G.H5 D 361 G.H5.10
Van-der-waals TM5 Q 214 5x71 G.H5 D 361 G.H5.10
Hydrophobic TM3 Y 107 3x50 G.H5 M 375 G.H5.24
Van-der-waals TM3 Y 107 3x50 G.H5 M 375 G.H5.24
Hydrophobic TM5 Y 218 5x75 G.S6 H 345 G.S6.04
Hydrophobic ICL2 W 124 34x55 G.S3 V 216 G.S3.01
Van-der-waals ICL2 W 124 34x55 G.S3 V 216 G.S3.01
Hydrophobic TM6 P 225 6x26 G.h4s6 Q 338 G.h4s6.12
Van-der-waals TM6 P 225 6x26 G.h4s6 Q 338 G.h4s6.12
Hydrophobic ICL2 K 123 34x54 G.H5 L 371 G.H5.20
Ionic TM4 D 127 4x39 G.hns1 R 47 G.hns1.03
Hydrophobic TM4 D 127 4x39 G.hns1 R 47 G.hns1.03
Van-der-waals TM4 D 127 4x39 G.hns1 R 47 G.hns1.03
Hydrophobic TM6 S 226 6x27 G.h4s6 P 341 G.h4s6.20
Van-der-waals TM6 S 226 6x27 G.h4s6 P 341 G.h4s6.20
Hydrophobic H8 N 290 8x48 G.H5 L 376 G.H5.25
Van-der-waals H8 N 290 8x48 G.H5 L 376 G.H5.25
Polar H8 K 291 8x49 G.H5 L 376 G.H5.25
Polar ICL1 I 41 - G.hns1 K 46 G.hns1.02
Van-der-waals ICL1 I 41 - G.hns1 K 46 G.hns1.02
Hydrophobic TM5 A 219 5x76 G.S6 H 344 G.S6.03
Polar ICL2 S 115 34x46 G.s2s3 K 214 G.s2s3.01
Van-der-waals ICL2 S 115 34x46 G.s2s3 K 214 G.s2s3.01
Hydrophobic ICL2 W 124 34x55 G.S2 E 212 G.S2.07
Van-der-waals ICL2 W 124 34x55 G.S2 E 212 G.S2.07
Hydrophobic ICL2 S 113 34x44 G.H5 D 364 G.H5.13
Van-der-waals ICL2 S 113 34x44 G.H5 D 364 G.H5.13
Polar TM6 H 230 6x31 G.H5 H 368 G.H5.17
Aromatic TM6 H 230 6x31 G.H5 H 368 G.H5.17
Hydrophobic TM6 H 230 6x31 G.H5 H 368 G.H5.17
Van-der-waals TM6 H 230 6x31 G.H5 H 368 G.H5.17
Hydrophobic TM6 P 225 6x26 G.h4s6 Q 339 G.h4s6.13
Van-der-waals TM6 P 225 6x26 G.h4s6 Q 339 G.h4s6.13
Hydrophobic TM6 P 225 6x26 G.h4s6 P 341 G.h4s6.20
Van-der-waals TM6 P 225 6x26 G.h4s6 P 341 G.h4s6.20
Polar TM6 S 226 6x27 G.H5 K 372 G.H5.21
Van-der-waals ICL2 W 121 34x52 G.s2s3 N 215 G.s2s3.02
Hydrophobic TM3 K 110 3x53 G.H5 L 371 G.H5.20
Van-der-waals TM3 K 110 3x53 G.H5 L 371 G.H5.20
Hydrophobic TM6 V 229 6x30 G.H5 L 376 G.H5.25