Go - TPRA1 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 69.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL1 K 71 - G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL1 K 71 - G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL1 K 71 - G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 E 143 - G.H5 D 341 G.H5.13
Van-der-waals ICL2 E 143 - G.H5 D 341 G.H5.13
Hydrophobic TM3 F 139 3x57 G.H5 Y 354 G.H5.26
Polar C-term I 290 - G.S1 K 35 G.S1.03
Hydrophobic C-term I 290 - G.S1 K 35 G.S1.03
Van-der-waals C-term I 290 - G.S1 K 35 G.S1.03
Polar C-term F 292 - G.H2 C 215 G.H2.10
Hydrophobic C-term F 292 - G.H2 C 215 G.H2.10
Van-der-waals C-term F 292 - G.H2 C 215 G.H2.10
Hydrophobic C-term P 288 - G.hns1 A 30 G.hns1.01
Polar C-term C 296 - G.H2 S 207 G.H2.02
Hydrophobic C-term C 296 - G.H2 S 207 G.H2.02
Van-der-waals C-term C 296 - G.H2 S 207 G.H2.02
Polar ICL1 T 75 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL1 T 75 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL1 T 75 - G.s2s3 K 193 G.s2s3.01
Polar C-term P 288 - G.HN S 29 G.HN.53
Hydrophobic C-term P 288 - G.HN S 29 G.HN.53
Van-der-waals C-term P 288 - G.HN S 29 G.HN.53
Polar C-term Y 294 - G.H2 W 212 G.H2.07
Aromatic C-term Y 294 - G.H2 W 212 G.H2.07
Hydrophobic C-term Y 294 - G.H2 W 212 G.H2.07
Van-der-waals C-term Y 294 - G.H2 W 212 G.H2.07
Polar C-term S 293 - G.H2 C 215 G.H2.10
Hydrophobic C-term S 293 - G.H2 C 215 G.H2.10
Van-der-waals C-term S 293 - G.H2 C 215 G.H2.10
Ionic C-term E 287 - G.hns1 K 32 G.hns1.03
Polar C-term E 287 - G.hns1 K 32 G.hns1.03
Van-der-waals C-term E 287 - G.hns1 K 32 G.hns1.03
Ionic C-term D 299 - G.H2 K 210 G.H2.05
Polar C-term D 299 - G.H2 K 210 G.H2.05
Hydrophobic C-term D 299 - G.H2 K 210 G.H2.05
Van-der-waals C-term D 299 - G.H2 K 210 G.H2.05
Hydrophobic C-term F 292 - G.h2s4 F 216 G.h2s4.01
Van-der-waals C-term F 292 - G.h2s4 F 216 G.h2s4.01
Hydrophobic C-term Y 294 - G.hfs2 G 184 G.hfs2.07
Van-der-waals C-term Y 294 - G.hfs2 G 184 G.hfs2.07
Hydrophobic TM2 F 80 2x39 G.H5 F 336 G.H5.08
Hydrophobic C-term L 291 - G.S3 F 200 G.S3.06
Van-der-waals C-term D 299 - G.H2 R 206 G.H2.01
Hydrophobic ICL2 H 141 - G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term F 292 - G.h2s4 V 219 G.h2s4.04
Van-der-waals C-term F 292 - G.h2s4 V 219 G.h2s4.04
Hydrophobic C-term L 308 - H.HA V 72 H.HA.10
Van-der-waals C-term L 308 - H.HA V 72 H.HA.10
Polar ICL1 K 71 - G.S3 H 196 G.S3.02
Hydrophobic ICL1 K 71 - G.S3 H 196 G.S3.02
Van-der-waals ICL1 K 71 - G.S3 H 196 G.S3.02
Hydrophobic TM2 I 79 2x38 G.H5 I 344 G.H5.16
Hydrophobic C-term G 282 - G.S3 L 195 G.S3.01
Van-der-waals C-term G 282 - G.S3 L 195 G.S3.01
Ionic C-term D 305 - G.hfs2 K 181 G.hfs2.04
Polar C-term D 305 - G.hfs2 K 181 G.hfs2.04
Hydrophobic C-term D 305 - G.hfs2 K 181 G.hfs2.04
Van-der-waals C-term D 305 - G.hfs2 K 181 G.hfs2.04
Hydrophobic C-term I 290 - G.h2s4 E 217 G.h2s4.02
Polar ICL1 S 76 - G.H5 Q 333 G.H5.05
Hydrophobic ICL1 S 76 - G.H5 Q 333 G.H5.05
Van-der-waals ICL1 S 76 - G.H5 Q 333 G.H5.05
Hydrophobic ICL2 G 140 - G.H5 D 341 G.H5.13
Van-der-waals ICL2 G 140 - G.H5 D 341 G.H5.13
Polar C-term I 290 - G.S3 R 198 G.S3.04
Hydrophobic C-term I 290 - G.S3 R 198 G.S3.04
Van-der-waals C-term I 290 - G.S3 R 198 G.S3.04
Polar C-term P 288 - G.S1 D 33 G.S1.01
Hydrophobic C-term P 288 - G.S1 D 33 G.S1.01
Van-der-waals C-term P 288 - G.S1 D 33 G.S1.01
Hydrophobic TM2 F 80 2x39 G.H5 T 340 G.H5.12
Van-der-waals TM2 F 80 2x39 G.H5 T 340 G.H5.12
Polar C-term Y 312 - H.HA E 64 H.HA.02
Hydrophobic C-term Y 312 - H.HA E 64 H.HA.02
Van-der-waals C-term Y 312 - H.HA E 64 H.HA.02
Polar C-term S 293 - G.H2 H 214 G.H2.09
Hydrophobic C-term S 293 - G.H2 H 214 G.H2.09
Van-der-waals C-term S 293 - G.H2 H 214 G.H2.09
Polar C-term P 288 - G.S3 R 198 G.S3.04
Hydrophobic C-term P 288 - G.S3 R 198 G.S3.04
Van-der-waals C-term P 288 - G.S3 R 198 G.S3.04
Polar C-term F 283 - G.s2s3 N 194 G.s2s3.02
Hydrophobic C-term F 283 - G.s2s3 N 194 G.s2s3.02
Van-der-waals C-term F 283 - G.s2s3 N 194 G.s2s3.02
Hydrophobic C-term Y 294 - G.H2 K 211 G.H2.06
Van-der-waals C-term Y 294 - G.H2 K 211 G.H2.06
Hydrophobic C-term F 292 - G.S3 F 200 G.S3.06
Van-der-waals C-term F 292 - G.S3 F 200 G.S3.06
Polar C-term L 291 - G.S1 K 35 G.S1.03
Hydrophobic C-term L 291 - G.S1 K 35 G.S1.03
Hydrophobic C-term F 292 - G.S2 I 185 G.S2.01
Van-der-waals C-term F 292 - G.S2 I 185 G.S2.01
Polar C-term R 281 - G.HN K 24 G.HN.48
Polar C-term Y 294 - G.H2 C 215 G.H2.10
Hydrophobic C-term Y 294 - G.H2 C 215 G.H2.10
Van-der-waals C-term Y 294 - G.H2 C 215 G.H2.10
Hydrophobic C-term F 284 - G.s2s3 N 194 G.s2s3.02
Van-der-waals C-term F 284 - G.s2s3 N 194 G.s2s3.02
Hydrophobic C-term V 306 - H.hbhc T 117 H.hbhc.05
Hydrophobic C-term I 290 - G.h2s4 D 218 G.h2s4.03
Van-der-waals C-term I 290 - G.h2s4 D 218 G.h2s4.03
Hydrophobic C-term K 295 - G.H2 K 210 G.H2.05
Van-der-waals C-term K 295 - G.H2 K 210 G.H2.05
Hydrophobic C-term L 308 - G.hfs2 V 180 G.hfs2.03
Van-der-waals C-term L 308 - G.hfs2 V 180 G.hfs2.03
Hydrophobic C-term F 292 - G.S1 K 35 G.S1.03
Van-der-waals C-term F 292 - G.S1 K 35 G.S1.03
Hydrophobic ICL1 I 74 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL1 I 74 - G.s2s3 K 193 G.s2s3.01
Hydrophobic C-term Y 294 - G.S2 I 185 G.S2.01
Van-der-waals C-term Y 294 - G.S2 I 185 G.S2.01
Polar C-term G 285 - G.HN S 29 G.HN.53
Hydrophobic C-term G 285 - G.HN S 29 G.HN.53
Van-der-waals C-term G 285 - G.HN S 29 G.HN.53
Polar C-term G 282 - G.hns1 K 32 G.hns1.03
Hydrophobic C-term G 282 - G.hns1 K 32 G.hns1.03
Van-der-waals C-term G 282 - G.hns1 K 32 G.hns1.03
Hydrophobic C-term K 295 - G.H2 I 213 G.H2.08
Ionic C-term E 303 - H.HA R 86 H.HA.24
Polar C-term K 289 - G.S3 R 198 G.S3.04
Hydrophobic C-term K 289 - G.S3 R 198 G.S3.04
Van-der-waals C-term K 289 - G.S3 R 198 G.S3.04
Polar C-term K 295 - G.H2 K 211 G.H2.06
Hydrophobic C-term K 295 - G.H2 K 211 G.H2.06
Van-der-waals C-term K 295 - G.H2 K 211 G.H2.06
Hydrophobic C-term G 285 - G.HN I 28 G.HN.52
Van-der-waals C-term G 285 - G.HN I 28 G.HN.52
Polar C-term C 296 - G.H2 E 208 G.H2.03
Hydrophobic C-term C 296 - G.H2 E 208 G.H2.03
Van-der-waals C-term C 296 - G.H2 E 208 G.H2.03
Polar ICL1 S 76 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL1 S 76 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL1 S 76 - G.s2s3 K 193 G.s2s3.01
Hydrophobic C-term P 304 - H.hbhc M 114 H.hbhc.02
Hydrophobic TM5 V 209 5x58 G.H5 L 353 G.H5.25
Van-der-waals TM5 V 209 5x58 G.H5 L 353 G.H5.25
Polar C-term Y 294 - G.s3h2 G 203 G.s3h2.01
Hydrophobic C-term Y 294 - G.s3h2 G 203 G.s3h2.01
Van-der-waals C-term Y 294 - G.s3h2 G 203 G.s3h2.01
Polar C-term C 296 - G.H2 K 211 G.H2.06
Hydrophobic C-term C 296 - G.H2 K 211 G.H2.06
Van-der-waals C-term C 296 - G.H2 K 211 G.H2.06
Hydrophobic TM5 V 208 5x57 G.H5 L 353 G.H5.25
Van-der-waals TM5 V 208 5x57 G.H5 L 353 G.H5.25
Hydrophobic C-term K 295 - G.H2 H 214 G.H2.09
Van-der-waals C-term K 295 - G.H2 H 214 G.H2.09
Hydrophobic ICL1 I 74 - G.S2 F 192 G.S2.08
Van-der-waals ICL1 I 74 - G.S2 F 192 G.S2.08
Polar C-term D 299 - G.H2 S 207 G.H2.02
Hydrophobic C-term D 299 - G.H2 S 207 G.H2.02
Van-der-waals C-term D 299 - G.H2 S 207 G.H2.02
Van-der-waals C-term Q 297 - G.H2 S 207 G.H2.02
Ionic C-term D 305 - G.hfs2 R 179 G.hfs2.02
Polar C-term D 305 - G.hfs2 R 179 G.hfs2.02
Polar C-term Q 297 - G.H2 K 210 G.H2.05
Hydrophobic C-term Q 297 - G.H2 K 210 G.H2.05
Van-der-waals C-term Q 297 - G.H2 K 210 G.H2.05
Hydrophobic C-term R 281 - G.HN I 28 G.HN.52
Van-der-waals C-term R 281 - G.HN I 28 G.HN.52
Hydrophobic ICL2 E 143 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 E 143 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 E 143 - G.H5 D 337 G.H5.09
Van-der-waals ICL2 E 143 - G.H5 D 337 G.H5.09
Hydrophobic TM3 G 136 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 G 136 3x54 G.H5 L 348 G.H5.20
Polar C-term H 307 - G.hfs2 T 183 G.hfs2.06
Hydrophobic C-term H 307 - G.hfs2 T 183 G.hfs2.06
Van-der-waals C-term H 307 - G.hfs2 T 183 G.hfs2.06
Hydrophobic ICL1 K 71 - G.s2s3 K 193 G.s2s3.01
Ionic C-term E 287 - G.S3 H 196 G.S3.02
Polar C-term E 287 - G.S3 H 196 G.S3.02
Hydrophobic C-term E 287 - G.S3 H 196 G.S3.02
Van-der-waals C-term E 287 - G.S3 H 196 G.S3.02
Hydrophobic C-term I 290 - G.S3 F 200 G.S3.06
Van-der-waals C-term I 290 - G.S3 F 200 G.S3.06
Polar C-term F 284 - G.hns1 K 32 G.hns1.03
Hydrophobic C-term F 284 - G.hns1 K 32 G.hns1.03
Van-der-waals C-term F 284 - G.hns1 K 32 G.hns1.03
Hydrophobic C-term F 283 - G.s2s3 K 193 G.s2s3.01
Van-der-waals C-term F 283 - G.s2s3 K 193 G.s2s3.01
Hydrophobic C-term F 283 - G.S3 L 195 G.S3.01
Hydrophobic C-term S 286 - G.S3 H 196 G.S3.02
Van-der-waals C-term S 286 - G.S3 H 196 G.S3.02
Polar C-term E 287 - G.S1 D 33 G.S1.01
Hydrophobic C-term E 287 - G.S1 D 33 G.S1.01
Van-der-waals C-term E 287 - G.S1 D 33 G.S1.01
Polar C-term Y 294 - G.H2 E 208 G.H2.03
Hydrophobic C-term Y 294 - G.H2 E 208 G.H2.03
Van-der-waals C-term Y 294 - G.H2 E 208 G.H2.03
Polar C-term S 286 - G.hns1 K 32 G.hns1.03
Hydrophobic C-term S 286 - G.hns1 K 32 G.hns1.03
Van-der-waals C-term S 286 - G.hns1 K 32 G.hns1.03
Hydrophobic C-term Y 294 - G.H2 H 214 G.H2.09
Hydrophobic C-term F 283 - G.H5 F 336 G.H5.08
Hydrophobic C-term S 293 - G.S2 I 185 G.S2.01
Van-der-waals C-term S 293 - G.S2 I 185 G.S2.01
Polar C-term Y 294 - G.S3 V 202 G.S3.08
Hydrophobic C-term Y 294 - G.S3 V 202 G.S3.08
Van-der-waals C-term Y 294 - G.S3 V 202 G.S3.08
Hydrophobic C-term F 283 - G.hns1 K 32 G.hns1.03
Van-der-waals C-term F 283 - G.hns1 K 32 G.hns1.03
Polar C-term S 286 - G.HN I 28 G.HN.52
Polar C-term G 285 - G.hns1 K 32 G.hns1.03
Hydrophobic C-term G 285 - G.hns1 K 32 G.hns1.03
Van-der-waals C-term G 285 - G.hns1 K 32 G.hns1.03
Hydrophobic C-term G 282 - G.hns1 A 31 G.hns1.02
Van-der-waals C-term G 282 - G.hns1 A 31 G.hns1.02
Hydrophobic C-term F 292 - G.H2 H 214 G.H2.09
Hydrophobic C-term F 292 - G.S3 V 202 G.S3.08
Polar ICL2 H 141 - G.H5 D 341 G.H5.13
Hydrophobic ICL1 S 77 - G.H5 F 336 G.H5.08
Polar C-term E 287 - G.HN S 29 G.HN.53
Van-der-waals C-term E 287 - G.HN S 29 G.HN.53
Hydrophobic C-term F 292 - G.S1 L 37 G.S1.05
Van-der-waals C-term F 292 - G.S1 L 37 G.S1.05
Hydrophobic ICL1 K 71 - G.S2 T 191 G.S2.07
Van-der-waals ICL1 K 71 - G.S2 T 191 G.S2.07
Hydrophobic ICL1 T 75 - G.H5 F 336 G.H5.08
Hydrophobic C-term S 286 - G.HN S 29 G.HN.53
Van-der-waals C-term S 286 - G.HN S 29 G.HN.53