Gs - TRH1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 A 133 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 A 133 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 130 34x50 G.H5 R 380 G.H5.12
Polar TM5 D 226 5x73 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM5 D 226 5x73 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM5 D 226 5x73 G.h4s6 G 355 G.h4s6.11
Polar C-term S 355 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term S 355 - G.h2s4 D 240 G.h2s4.03
Van-der-waals H8 K 326 8x49 G.H5 Q 390 G.H5.22
Polar C-term K 358 - G.HN K 34 G.HN.51
Van-der-waals C-term K 358 - G.HN K 34 G.HN.51
Polar H8 K 326 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 K 326 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 K 326 8x49 G.H5 E 392 G.H5.24
Polar TM3 I 127 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 127 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 127 3x54 G.H5 Q 384 G.H5.16
Hydrophobic C-term A 351 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term A 351 - G.h3s5 T 284 G.h3s5.02
Hydrophobic C-term Y 354 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term Y 354 - G.h2s4 D 240 G.h2s4.03
Hydrophobic ICL2 Q 134 34x54 G.hns1 R 38 G.hns1.02
Ionic TM5 K 228 5x75 G.h4s6 D 354 G.h4s6.10
Polar TM5 K 228 5x75 G.h4s6 D 354 G.h4s6.10
Hydrophobic TM5 K 228 5x75 G.h4s6 D 354 G.h4s6.10
Van-der-waals TM5 K 228 5x75 G.h4s6 D 354 G.h4s6.10
Polar ICL2 P 130 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 130 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 130 34x50 G.H5 H 387 G.H5.19
Ionic C-term E 359 - G.hns1 R 38 G.hns1.02
Polar C-term E 359 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term E 359 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term E 359 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 I 223 5x70 G.H5 L 388 G.H5.20
Polar TM5 D 226 5x73 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 D 226 5x73 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 D 226 5x73 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 E 122 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 122 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 218 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 218 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM6 S 260 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 S 260 6x29 G.H5 L 394 G.H5.26
Polar C-term N 353 - G.h3s5 T 284 G.h3s5.02
Hydrophobic C-term N 353 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term N 353 - G.h3s5 T 284 G.h3s5.02
Hydrophobic TM3 R 123 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 135 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 K 228 5x75 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM5 K 228 5x75 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM6 V 264 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 264 6x33 G.H5 L 393 G.H5.25
Ionic C-term K 358 - G.h2s4 D 240 G.h2s4.03
Polar C-term K 358 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term K 358 - G.h2s4 D 240 G.h2s4.03
Hydrophobic TM6 L 268 6x37 G.H5 L 393 G.H5.25
Polar TM2 T 60 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 60 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 60 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 127 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 130 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 P 227 5x74 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 P 227 5x74 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 I 131 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 I 131 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM3 I 127 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 127 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 I 131 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM3 F 119 3x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 I 131 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 I 131 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 I 223 5x70 G.H5 D 381 G.H5.13
Van-der-waals TM5 I 223 5x70 G.H5 D 381 G.H5.13
Hydrophobic TM5 P 224 5x71 G.H5 D 381 G.H5.13
Polar H8 S 324 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 324 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 324 8x47 G.H5 E 392 G.H5.24
Polar TM5 K 228 5x75 G.h4s6 G 353 G.h4s6.09
Hydrophobic TM5 K 228 5x75 G.h4s6 G 353 G.h4s6.09
Van-der-waals TM5 K 228 5x75 G.h4s6 G 353 G.h4s6.09
Polar H8 K 326 8x49 G.H5 R 389 G.H5.21
Hydrophobic H8 K 326 8x49 G.H5 R 389 G.H5.21
Van-der-waals H8 K 326 8x49 G.H5 R 389 G.H5.21
Polar C-term K 358 - G.hns1 Y 37 G.hns1.01
Van-der-waals C-term K 358 - G.hns1 Y 37 G.hns1.01
Hydrophobic TM3 A 126 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 126 3x53 G.H5 Y 391 G.H5.23
Polar TM3 A 126 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 126 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 126 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 217 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 I 217 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 P 224 5x71 G.S6 Y 360 G.S6.02
Van-der-waals TM5 P 224 5x71 G.S6 Y 360 G.S6.02
Hydrophobic TM5 I 223 5x70 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 223 5x70 G.H5 R 385 G.H5.17
Polar ICL2 Q 134 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 Q 134 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 Q 134 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 Q 134 34x54 G.H5 H 387 G.H5.19
Polar C-term S 349 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term S 349 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM6 M 267 6x36 G.H5 L 393 G.H5.25
Polar TM5 P 224 5x71 G.H5 R 385 G.H5.17
Hydrophobic TM5 P 224 5x71 G.H5 R 385 G.H5.17
Van-der-waals TM5 P 224 5x71 G.H5 R 385 G.H5.17
Hydrophobic ICL2 I 131 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 I 131 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 130 34x50 G.H5 Q 384 G.H5.16
Polar TM2 T 60 2x39 G.H5 Q 390 G.H5.22
Polar ICL3 S 250 - G.hgh4 E 322 G.hgh4.12
Polar TM3 R 123 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Q 134 34x54 G.H5 I 383 G.H5.15
Van-der-waals ICL2 Q 134 34x54 G.H5 I 383 G.H5.15
Hydrophobic ICL2 F 135 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic TM4 T 138 4x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 T 138 4x38 G.hns1 R 38 G.hns1.02