G13 - TAS1R1 complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 T 664 - G.s2s3 K 214 G.s2s3.01
Van-der-waals ICL2 T 664 - G.s2s3 K 214 G.s2s3.01
Van-der-waals ICL2 P 667 - G.HN T 43 G.HN.52
Polar H8 Q 828 8x55 G.H5 D 369 G.H5.18
Hydrophobic H8 Q 828 8x55 G.H5 D 369 G.H5.18
Van-der-waals H8 Q 828 8x55 G.H5 D 369 G.H5.18
Hydrophobic C-term G 839 - G.s2s3 K 214 G.s2s3.01
Van-der-waals C-term G 839 - G.s2s3 K 214 G.s2s3.01
Polar ICL2 V 674 - G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 V 674 - G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 V 674 - G.hns1 K 46 G.hns1.02
Polar ICL2 H 671 - G.HN Y 44 G.HN.53
Hydrophobic ICL2 H 671 - G.HN Y 44 G.HN.53
Van-der-waals ICL2 H 671 - G.HN Y 44 G.HN.53
Hydrophobic ICL3 Y 756 - G.H5 M 375 G.H5.24
Van-der-waals ICL3 Y 756 - G.H5 M 375 G.H5.24
Hydrophobic ICL3 Y 756 - G.H5 L 371 G.H5.20
Polar TM3 R 652 3x50 G.H5 M 375 G.H5.24
Hydrophobic TM3 R 652 3x50 G.H5 M 375 G.H5.24
Van-der-waals TM3 R 652 3x50 G.H5 M 375 G.H5.24
Hydrophobic ICL2 Y 670 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 Y 670 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 H 671 - G.S3 P 217 G.S3.02
Polar ICL2 P 667 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 P 667 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 P 667 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 Y 670 - G.hns1 K 46 G.hns1.02
Polar C-term R 836 - G.H5 D 364 G.H5.13
Polar ICL2 S 663 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 S 663 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 S 663 - G.hns1 R 47 G.hns1.03
Hydrophobic C-term T 835 - G.H5 K 363 G.H5.12
Hydrophobic C-term R 836 - G.H5 R 360 G.H5.09
Hydrophobic ICL1 R 598 12x51 G.H5 L 376 G.H5.25
Van-der-waals ICL1 R 598 12x51 G.H5 L 376 G.H5.25
Hydrophobic TM3 I 659 3x57 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 659 3x57 G.H5 L 371 G.H5.20
Hydrophobic TM3 F 660 3x58 G.H5 L 371 G.H5.20
Van-der-waals TM3 F 660 3x58 G.H5 L 371 G.H5.20
Polar ICL2 H 671 - G.hns1 R 47 G.hns1.03
Aromatic ICL2 H 671 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 H 671 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 H 671 - G.hns1 R 47 G.hns1.03
Hydrophobic TM3 I 659 3x57 G.H5 M 375 G.H5.24
Polar ICL3 Y 756 - G.H5 H 368 G.H5.17
Aromatic ICL3 Y 756 - G.H5 H 368 G.H5.17
Hydrophobic ICL3 Y 756 - G.H5 H 368 G.H5.17
Van-der-waals ICL3 Y 756 - G.H5 H 368 G.H5.17
Polar H8 T 824 8x51 G.H5 K 372 G.H5.21
Hydrophobic H8 T 824 8x51 G.H5 K 372 G.H5.21
Van-der-waals H8 T 824 8x51 G.H5 K 372 G.H5.21
Polar ICL2 S 663 - G.S3 V 216 G.S3.01
Hydrophobic ICL2 S 663 - G.S3 V 216 G.S3.01
Van-der-waals ICL2 S 663 - G.S3 V 216 G.S3.01
Hydrophobic ICL2 H 671 - G.hns1 K 46 G.hns1.02
Hydrophobic TM4 Q 675 4x28 G.hns1 K 46 G.hns1.02
Polar C-term C 838 - G.s2s3 K 214 G.s2s3.01
Van-der-waals C-term C 838 - G.s2s3 K 214 G.s2s3.01
Hydrophobic ICL2 H 671 - G.HN R 40 G.HN.49
Van-der-waals ICL2 H 671 - G.HN R 40 G.HN.49
Hydrophobic ICL1 S 599 12x52 G.H5 M 375 G.H5.24
Van-der-waals ICL1 S 599 12x52 G.H5 M 375 G.H5.24
Hydrophobic TM3 L 656 3x54 G.H5 M 375 G.H5.24
Van-der-waals TM3 L 656 3x54 G.H5 M 375 G.H5.24
Hydrophobic H8 F 827 8x54 G.H5 K 372 G.H5.21
Polar C-term T 835 - G.H5 D 364 G.H5.13
Hydrophobic C-term T 835 - G.H5 D 364 G.H5.13
Van-der-waals C-term T 835 - G.H5 D 364 G.H5.13
Ionic C-term R 836 - G.H5 D 361 G.H5.10
Polar C-term R 836 - G.H5 D 361 G.H5.10
Hydrophobic C-term R 836 - G.H5 D 361 G.H5.10
Van-der-waals C-term R 836 - G.H5 D 361 G.H5.10
Van-der-waals H8 Q 828 8x55 G.H5 K 372 G.H5.21
Hydrophobic TM4 Q 675 4x28 G.HN T 43 G.HN.52
Van-der-waals TM4 Q 675 4x28 G.HN T 43 G.HN.52
Polar TM4 Q 675 4x28 G.HN K 42 G.HN.51
Hydrophobic TM4 Q 675 4x28 G.HN K 42 G.HN.51
Van-der-waals TM4 Q 675 4x28 G.HN K 42 G.HN.51
Van-der-waals ICL2 Y 670 - G.H5 L 374 G.H5.23
Polar ICL2 F 662 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 F 662 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 F 662 - G.hns1 R 47 G.hns1.03
Polar ICL3 Y 756 - G.H5 K 372 G.H5.21
Polar ICL2 T 664 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 T 668 - G.HN R 40 G.HN.49
Hydrophobic C-term Q 832 - G.H5 D 364 G.H5.13
Van-der-waals C-term Q 832 - G.H5 D 364 G.H5.13
Polar C-term Q 832 - G.H5 T 365 G.H5.14
Van-der-waals C-term Q 832 - G.H5 T 365 G.H5.14
Polar C-term T 835 - G.s2s3 K 214 G.s2s3.01
Van-der-waals C-term T 835 - G.s2s3 K 214 G.s2s3.01
Polar H8 Q 828 8x55 G.H5 T 365 G.H5.14
Hydrophobic H8 Q 828 8x55 G.H5 T 365 G.H5.14
Van-der-waals H8 Q 828 8x55 G.H5 T 365 G.H5.14
Hydrophobic ICL2 T 664 - G.s2s3 N 215 G.s2s3.02
Van-der-waals ICL2 T 664 - G.s2s3 N 215 G.s2s3.02
Polar H8 F 827 8x54 G.H5 H 368 G.H5.17
Hydrophobic H8 F 827 8x54 G.H5 H 368 G.H5.17
Van-der-waals H8 F 827 8x54 G.H5 H 368 G.H5.17
Hydrophobic ICL2 S 663 - G.s2s3 N 215 G.s2s3.02
Van-der-waals ICL2 S 663 - G.s2s3 N 215 G.s2s3.02
Polar ICL2 T 668 - G.HN T 43 G.HN.52
Hydrophobic ICL2 V 674 - G.H5 L 374 G.H5.23
Polar H8 Q 828 8x55 G.S6 Y 343 G.S6.02
Hydrophobic H8 Q 828 8x55 G.S6 Y 343 G.S6.02
Van-der-waals H8 Q 828 8x55 G.S6 Y 343 G.S6.02
Hydrophobic C-term I 831 - G.H5 H 368 G.H5.17
Van-der-waals C-term I 831 - G.H5 H 368 G.H5.17
Polar ICL2 V 666 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 V 666 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 V 666 - G.hns1 R 47 G.hns1.03
Hydrophobic C-term I 831 - G.H5 D 364 G.H5.13
Van-der-waals C-term I 831 - G.H5 D 364 G.H5.13
Polar C-term Q 832 - G.H5 D 361 G.H5.10
Polar ICL2 H 671 - G.HN T 43 G.HN.52
Hydrophobic ICL2 H 671 - G.HN T 43 G.HN.52
Van-der-waals ICL2 H 671 - G.HN T 43 G.HN.52
Hydrophobic ICL2 T 664 - G.S3 V 216 G.S3.01
Hydrophobic H8 E 825 8x52 G.h4s6 P 341 G.h4s6.20
Van-der-waals H8 E 825 8x52 G.h4s6 P 341 G.h4s6.20
Polar H8 Q 828 8x55 G.H5 H 368 G.H5.17
Hydrophobic H8 Q 828 8x55 G.H5 H 368 G.H5.17
Van-der-waals H8 Q 828 8x55 G.H5 H 368 G.H5.17
Hydrophobic C-term I 831 - G.H5 L 371 G.H5.20
Van-der-waals C-term I 831 - G.H5 L 371 G.H5.20