Gi1 - XCR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 85.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term Y 327 - G.H3 W 258 G.H3.17
Hydrophobic C-term Y 327 - G.H3 W 258 G.H3.17
Van-der-waals C-term Y 327 - G.H3 W 258 G.H3.17
Hydrophobic ICL2 L 138 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM6 I 227 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 134 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 134 34x50 G.H5 T 340 G.H5.12
Aromatic C-term F 325 - G.H3 W 258 G.H3.17
Hydrophobic C-term F 325 - G.H3 W 258 G.H3.17
Van-der-waals C-term F 325 - G.H3 W 258 G.H3.17
Polar TM3 H 126 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 H 126 3x49 G.H5 C 351 G.H5.23
Ionic H8 K 293 8x49 G.H5 D 350 G.H5.22
Polar H8 K 293 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 K 293 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 293 8x49 G.H5 D 350 G.H5.22
Polar C-term Y 333 - G.H2 R 205 G.H2.01
Hydrophobic C-term Y 333 - G.H2 R 205 G.H2.01
Van-der-waals C-term Y 333 - G.H2 R 205 G.H2.01
Polar TM2 T 66 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 66 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 R 219 6x29 G.h4s6 T 316 G.h4s6.10
Van-der-waals TM6 R 219 6x29 G.h4s6 T 316 G.h4s6.10
Polar C-term F 332 - G.H2 R 208 G.H2.04
Hydrophobic C-term F 332 - G.H2 R 208 G.H2.04
Van-der-waals C-term F 332 - G.H2 R 208 G.H2.04
Polar TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 C 351 G.H5.23
Polar ICL2 L 135 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 V 131 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 131 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 127 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 141 34x57 G.HN R 24 G.HN.48
Hydrophobic ICL2 P 134 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 226 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 226 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 Y 205 5x58 G.H5 L 353 G.H5.25
Polar TM3 S 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 130 3x53 G.H5 N 347 G.H5.19
Polar H8 V 292 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 V 292 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 V 292 8x48 G.H5 F 354 G.H5.26
Polar TM6 R 222 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 222 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 222 6x32 G.H5 F 354 G.H5.26
Hydrophobic C-term F 332 - G.H2 W 211 G.H2.07
Hydrophobic ICL3 R 216 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 216 - G.h4s6 E 318 G.h4s6.12
Polar ICL2 V 140 34x56 G.HN R 24 G.HN.48
Hydrophobic ICL2 V 140 34x56 G.HN R 24 G.HN.48
Van-der-waals ICL2 V 140 34x56 G.HN R 24 G.HN.48
Polar ICL2 P 134 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 L 226 6x36 G.H5 G 352 G.H5.24
Hydrophobic C-term F 332 - G.H2 I 212 G.H2.08
Hydrophobic ICL2 L 135 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 135 34x51 G.s2s3 K 192 G.s2s3.01
Polar ICL3 R 216 - G.S6 T 321 G.S6.03
Hydrophobic ICL2 L 135 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 135 34x51 G.S3 L 194 G.S3.01
Polar TM2 T 66 2x39 G.H5 D 350 G.H5.22
Polar TM6 K 218 6x28 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 K 218 6x28 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 K 218 6x28 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 K 218 6x28 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 P 134 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 134 34x50 G.H5 I 343 G.H5.15
Polar ICL3 R 216 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 216 - G.H5 D 341 G.H5.13
Hydrophobic TM6 I 230 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 212 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 212 5x65 G.H5 L 348 G.H5.20
Polar TM6 T 223 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 223 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 223 6x33 G.H5 L 353 G.H5.25
Polar C-term S 331 - G.H3 S 252 G.H3.11
Hydrophobic C-term Y 333 - G.s3h2 Q 204 G.s3h2.03
Polar C-term Y 333 - G.H2 R 208 G.H2.04
Hydrophobic C-term Y 333 - G.H2 R 208 G.H2.04
Van-der-waals C-term Y 333 - G.H2 R 208 G.H2.04
Hydrophobic TM6 R 219 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 219 6x29 G.H5 F 354 G.H5.26
Hydrophobic C-term F 332 - G.h2s4 F 215 G.h2s4.01
Van-der-waals C-term F 332 - G.h2s4 F 215 G.h2s4.01
Polar ICL3 S 217 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 S 217 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 S 217 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 L 212 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 131 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL3 R 216 - G.S6 Y 320 G.S6.02
Polar C-term Y 327 - G.H3 K 257 G.H3.16
Hydrophobic C-term Y 327 - G.H3 K 257 G.H3.16
Van-der-waals C-term Y 327 - G.H3 K 257 G.H3.16
Hydrophobic H8 G 291 8x47 G.H5 G 352 G.H5.24
Hydrophobic C-term F 332 - G.H3 I 253 G.H3.12
Van-der-waals C-term F 332 - G.H3 I 253 G.H3.12
Ionic ICL2 R 139 34x55 G.HN E 28 G.HN.52
Polar ICL2 R 139 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 139 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 139 34x55 G.HN E 28 G.HN.52
Polar ICL2 T 137 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 T 137 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 T 211 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 135 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 L 138 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 138 34x54 G.S3 L 194 G.S3.01
Polar C-term Y 333 - G.H3 E 245 G.H3.04
Hydrophobic C-term Y 333 - G.H3 E 245 G.H3.04
Van-der-waals C-term Y 333 - G.H3 E 245 G.H3.04
Hydrophobic TM5 S 215 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 215 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 T 223 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 139 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 138 34x54 G.hns1 R 32 G.hns1.03
Polar TM3 S 130 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 130 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM4 T 142 4x38 G.HN R 24 G.HN.48
Van-der-waals TM4 T 142 4x38 G.HN R 24 G.HN.48
Hydrophobic ICL2 L 138 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 138 34x54 G.hns1 A 31 G.hns1.02
Polar C-term Y 327 - G.H3 N 256 G.H3.15
Hydrophobic C-term Y 327 - G.H3 N 256 G.H3.15
Van-der-waals C-term Y 327 - G.H3 N 256 G.H3.15