Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 11272103 | 123856 | 0 | None | -37 | 8 | Human | 11.0 | pIC50 | = | 11 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL363840 | 123856 | 0 | None | -37 | 8 | Human | 11.0 | pIC50 | = | 11 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| 11272103 | 123856 | 0 | None | -37 | 8 | Human | 11.0 | pIC50 | = | 11 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL363840 | 123856 | 0 | None | -37 | 8 | Human | 11.0 | pIC50 | = | 11 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 11272103 | 123856 | 0 | None | -37 | 8 | Human | 11.0 | pIC50 | = | 11 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL363840 | 123856 | 0 | None | -37 | 8 | Human | 11.0 | pIC50 | = | 11 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 11272103 | 123856 | 0 | None | -37 | 8 | Human | 11.0 | pIC50 | = | 11 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL363840 | 123856 | 0 | None | -37 | 8 | Human | 11.0 | pIC50 | = | 11 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11272103 | 123856 | 0 | None | -37 | 8 | Human | 11.0 | pIC50 | = | 11 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL363840 | 123856 | 0 | None | -37 | 8 | Human | 11.0 | pIC50 | = | 11 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 44455820 | 94998 | 0 | None | - | 1 | Human | 11.0 | pIC50 | = | 11.0 | Functional | ChEMBL | 551 | 11 | 3 | 7 | 4.9 | CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL257074 | 94998 | 0 | None | - | 1 | Human | 11.0 | pIC50 | = | 11.0 | Functional | ChEMBL | 551 | 11 | 3 | 7 | 4.9 | CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 10458976 | 94569 | 0 | None | - | 1 | Human | 10.9 | pIC50 | = | 10.9 | Functional | ChEMBL | 509 | 9 | 3 | 7 | 3.4 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL254930 | 94569 | 0 | None | - | 1 | Human | 10.9 | pIC50 | = | 10.9 | Functional | ChEMBL | 509 | 9 | 3 | 7 | 3.4 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44455711 | 168168 | 0 | None | - | 1 | Human | 10.9 | pIC50 | = | 10.9 | Functional | ChEMBL | 509 | 9 | 3 | 7 | 3.8 | CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL437031 | 168168 | 0 | None | - | 1 | Human | 10.9 | pIC50 | = | 10.9 | Functional | ChEMBL | 509 | 9 | 3 | 7 | 3.8 | CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11340670 | 126712 | 0 | None | - | 1 | Human | 10.8 | pIC50 | = | 10.8 | Functional | ChEMBL | 483 | 7 | 2 | 3 | 5.8 | CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F | 10.1021/jm049530m | ||
| CHEMBL365820 | 126712 | 0 | None | - | 1 | Human | 10.8 | pIC50 | = | 10.8 | Functional | ChEMBL | 483 | 7 | 2 | 3 | 5.8 | CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F | 10.1021/jm049530m | ||
| 11328714 | 78588 | 0 | None | - | 1 | Human | 10.8 | pIC50 | = | 10.8 | Functional | ChEMBL | 462 | 6 | 3 | 2 | 5.9 | O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL2113074 | 78588 | 0 | None | - | 1 | Human | 10.8 | pIC50 | = | 10.8 | Functional | ChEMBL | 462 | 6 | 3 | 2 | 5.9 | O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44455686 | 95048 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 523 | 9 | 3 | 7 | 4.3 | CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL257293 | 95048 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 523 | 9 | 3 | 7 | 4.3 | CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455869 | 97096 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 507 | 9 | 2 | 7 | 4.1 | CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL270582 | 97096 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 507 | 9 | 2 | 7 | 4.1 | CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455509 | 165873 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 493 | 9 | 2 | 6 | 4.4 | CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL427728 | 165873 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 493 | 9 | 2 | 6 | 4.4 | CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455485 | 154960 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 507 | 9 | 2 | 6 | 5.0 | CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL404122 | 154960 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 507 | 9 | 2 | 6 | 5.0 | CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11329244 | 70772 | 10 | None | 20 | 7 | Human | 10.5 | pIC50 | = | 10.5 | Functional | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL195433 | 70772 | 10 | None | 20 | 7 | Human | 10.5 | pIC50 | = | 10.5 | Functional | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 11329244 | 70772 | 10 | None | 20 | 7 | Human | 10.5 | pIC50 | = | 10.5 | Functional | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | ||
| CHEMBL195433 | 70772 | 10 | None | 20 | 7 | Human | 10.5 | pIC50 | = | 10.5 | Functional | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | ||
| 11227406 | 93909 | 1 | None | 107 | 4 | Human | 10.5 | pIC50 | = | 10.5 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL250689 | 93909 | 1 | None | 107 | 4 | Human | 10.5 | pIC50 | = | 10.5 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| 11227406 | 93909 | 1 | None | 107 | 4 | Human | 10.5 | pIC50 | = | 10.5 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm300682j | ||
| CHEMBL250689 | 93909 | 1 | None | 107 | 4 | Human | 10.5 | pIC50 | = | 10.5 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm300682j | ||
| 11227406 | 93909 | 1 | None | 107 | 4 | Human | 10.5 | pIC50 | = | 10.5 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL250689 | 93909 | 1 | None | 107 | 4 | Human | 10.5 | pIC50 | = | 10.5 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11227406 | 93909 | 1 | None | 107 | 4 | Human | 10.5 | pIC50 | = | 10.5 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL250689 | 93909 | 1 | None | 107 | 4 | Human | 10.5 | pIC50 | = | 10.5 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 10050884 | 154115 | 10 | None | -1 | 3 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL399495 | 154115 | 10 | None | -1 | 3 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.087 | ||
| 11227406 | 93909 | 1 | None | 107 | 4 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL250689 | 93909 | 1 | None | 107 | 4 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 10050884 | 154115 | 10 | None | -1 | 3 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL399495 | 154115 | 10 | None | -1 | 3 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11169258 | 140366 | 0 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 587 | 8 | 2 | 10 | 3.8 | Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1021/jm049530m | ||
| CHEMBL382108 | 140366 | 0 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 587 | 8 | 2 | 10 | 3.8 | Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1021/jm049530m | ||
| 11488078 | 78591 | 0 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL2113077 | 78591 | 0 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44455683 | 154549 | 0 | None | - | 1 | Human | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 531 | 9 | 3 | 7 | 4.4 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL401879 | 154549 | 0 | None | - | 1 | Human | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 531 | 9 | 3 | 7 | 4.4 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455745 | 154762 | 0 | None | - | 1 | Human | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 559 | 8 | 3 | 7 | 4.0 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL402983 | 154762 | 0 | None | - | 1 | Human | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 559 | 8 | 3 | 7 | 4.0 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455793 | 94783 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 483 | 9 | 3 | 5 | 4.4 | CC(=O)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL256068 | 94783 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 483 | 9 | 3 | 5 | 4.4 | CC(=O)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11397114 | 132948 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL3706810 | 132948 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44455766 | 95241 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 479 | 8 | 2 | 6 | 4.3 | C[C@H](C[C@@H](C)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL258156 | 95241 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 479 | 8 | 2 | 6 | 4.3 | C[C@H](C[C@@H](C)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11953409 | 93781 | 0 | None | 7 | 4 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 529 | 7 | 2 | 6 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249854 | 93781 | 0 | None | 7 | 4 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 529 | 7 | 2 | 6 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445847 | 93988 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 487 | 7 | 3 | 6 | 3.8 | CC(=O)c1sc(NC(=O)N[C@@H]2CNCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251079 | 93988 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 487 | 7 | 3 | 6 | 3.8 | CC(=O)c1sc(NC(=O)N[C@@H]2CNCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 11214474 | 71009 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 514 | 6 | 2 | 4 | 6.7 | O=C(Nc1nc2c(Cl)cccc2s1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL195790 | 71009 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 514 | 6 | 2 | 4 | 6.7 | O=C(Nc1nc2c(Cl)cccc2s1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44445845 | 93807 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 487 | 7 | 3 | 6 | 3.8 | CC(=O)c1sc(NC(=O)N[C@@H]2CCNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL250056 | 93807 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 487 | 7 | 3 | 6 | 3.8 | CC(=O)c1sc(NC(=O)N[C@@H]2CCNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44455845 | 97010 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 537 | 10 | 3 | 7 | 4.5 | CC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL270146 | 97010 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 537 | 10 | 3 | 7 | 4.5 | CC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455846 | 97011 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 515 | 9 | 2 | 6 | 5.1 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL270147 | 97011 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 515 | 9 | 2 | 6 | 5.1 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455458 | 166897 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 533 | 9 | 3 | 7 | 5.3 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ccon2)cc(-c2ccon2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL429846 | 166897 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 533 | 9 | 3 | 7 | 5.3 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ccon2)cc(-c2ccon2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11454941 | 70798 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL195555 | 70798 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 10050884 | 154115 | 10 | None | 1 | 3 | Crab-eating macaque | 9.8 | pIC50 | = | 9.8 | Functional | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL399495 | 154115 | 10 | None | 1 | 3 | Crab-eating macaque | 9.8 | pIC50 | = | 9.8 | Functional | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455459 | 94648 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 467 | 9 | 2 | 4 | 5.1 | CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL255398 | 94648 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 467 | 9 | 2 | 4 | 5.1 | CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 10140602 | 166065 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 479 | 7 | 2 | 6 | 3.4 | C[C@H](CC(=O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL428071 | 166065 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 479 | 7 | 2 | 6 | 3.4 | C[C@H](CC(=O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11398022 | 98178 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 | 10.1021/jm049530m | ||
| CHEMBL277131 | 98178 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 | 10.1021/jm049530m | ||
| 44455484 | 166852 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 493 | 9 | 2 | 6 | 4.6 | CC(C)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL429604 | 166852 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 493 | 9 | 2 | 6 | 4.6 | CC(C)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455483 | 97380 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 537 | 10 | 3 | 7 | 3.8 | Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)(C)C(=O)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL272068 | 97380 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 537 | 10 | 3 | 7 | 3.8 | Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)(C)C(=O)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11385766 | 132275 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL370082 | 132275 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 11236950 | 94326 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 479 | 9 | 2 | 6 | 4.3 | CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL253210 | 94326 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 479 | 9 | 2 | 6 | 4.3 | CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 71460523 | 81082 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 423 | 7 | 3 | 4 | 3.7 | O=C(Nc1ccccc1OCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160099 | 81082 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 423 | 7 | 3 | 4 | 3.7 | O=C(Nc1ccccc1OCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 44455817 | 154639 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 538 | 9 | 3 | 8 | 3.6 | CNC(=O)O[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL402331 | 154639 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 538 | 9 | 3 | 8 | 3.6 | CNC(=O)O[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| 10050884 | 154115 | 10 | None | -1 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL399495 | 154115 | 10 | None | -1 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44445854 | 93649 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 522 | 7 | 2 | 7 | 3.3 | CC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249057 | 93649 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 522 | 7 | 2 | 7 | 3.3 | CC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 45267588 | 194360 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 501 | 5 | 2 | 4 | 4.5 | Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c(O)c1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL560275 | 194360 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 501 | 5 | 2 | 4 | 4.5 | Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c(O)c1 | 10.1016/j.bmc.2009.06.066 | ||
| 44512617 | 193668 | 0 | None | 79 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 487 | 5 | 2 | 4 | 4.2 | O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL551735 | 193668 | 0 | None | 79 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 487 | 5 | 2 | 4 | 4.2 | O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 44455658 | 166720 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 479 | 8 | 3 | 5 | 4.4 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL429323 | 166720 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 479 | 8 | 3 | 5 | 4.4 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44289715 | 169668 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 465 | 8 | 2 | 6 | 3.8 | Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL444568 | 169668 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 465 | 8 | 2 | 6 | 3.8 | Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11272103 | 123856 | 0 | None | -37 | 8 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL363840 | 123856 | 0 | None | -37 | 8 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 11363006 | 70092 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 | 10.1021/jm049530m | ||
| CHEMBL194601 | 70092 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 | 10.1021/jm049530m | ||
| 44455539 | 166429 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 465 | 8 | 2 | 6 | 3.9 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL428775 | 166429 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 465 | 8 | 2 | 6 | 3.9 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 45271892 | 193670 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 515 | 5 | 1 | 5 | 4.3 | O=C(C=C1CCN(C(=O)c2ccc3c(c2)OCO3)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL551739 | 193670 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 515 | 5 | 1 | 5 | 4.3 | O=C(C=C1CCN(C(=O)c2ccc3c(c2)OCO3)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 71460523 | 81082 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 423 | 7 | 3 | 4 | 3.7 | O=C(Nc1ccccc1OCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160099 | 81082 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 423 | 7 | 3 | 4 | 3.7 | O=C(Nc1ccccc1OCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 45271891 | 193669 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 501 | 6 | 1 | 4 | 4.5 | COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)cc1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL551738 | 193669 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 501 | 6 | 1 | 4 | 4.5 | COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)cc1 | 10.1016/j.bmc.2009.06.066 | ||
| 11363005 | 60182 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL175634 | 60182 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11329244 | 70772 | 10 | None | -20 | 7 | Mouse | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | ||
| CHEMBL195433 | 70772 | 10 | None | -20 | 7 | Mouse | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | ||
| 45269392 | 194352 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 374 | 5 | 1 | 2 | 4.4 | O=C(/C=C/c1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL560198 | 194352 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 374 | 5 | 1 | 2 | 4.4 | O=C(/C=C/c1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 71449694 | 81086 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 437 | 8 | 3 | 4 | 3.9 | O=C(Nc1ccccc1COCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160102 | 81086 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 437 | 8 | 3 | 4 | 3.9 | O=C(Nc1ccccc1COCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 70694703 | 75794 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 578 | 5 | 2 | 3 | 6.1 | O=C(Nc1cccc(Br)c1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057764 | 75794 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 578 | 5 | 2 | 3 | 6.1 | O=C(Nc1cccc(Br)c1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| 44451981 | 160724 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 454 | 6 | 1 | 3 | 6.2 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL412061 | 160724 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 454 | 6 | 1 | 3 | 6.2 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1cccc(Oc2ccccc2)c1 | 10.1016/j.bmc.2007.10.003 | ||
| 44282031 | 119310 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 488 | 8 | 2 | 5 | 3.2 | CC(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)N1CCCC1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL34839 | 119310 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 488 | 8 | 2 | 5 | 3.2 | CC(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)N1CCCC1 | 10.1016/s0960-894x(01)00249-9 | ||
| 11363005 | 60182 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL175634 | 60182 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44281673 | 109867 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 572 | 10 | 3 | 5 | 5.6 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@H](C(=O)Nc1ccccc1)c1ccccc1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL32410 | 109867 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 572 | 10 | 3 | 5 | 5.6 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@H](C(=O)Nc1ccccc1)c1ccccc1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| 76331527 | 102888 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 486 | 6 | 1 | 3 | 6.6 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1OC1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084575 | 102888 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 486 | 6 | 1 | 3 | 6.6 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1OC1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| 71458677 | 81058 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 423 | 7 | 3 | 4 | 3.7 | O=C(Nc1ccc(OCCO)cc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2159868 | 81058 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 423 | 7 | 3 | 4 | 3.7 | O=C(Nc1ccc(OCCO)cc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 76316939 | 102892 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 513 | 5 | 1 | 3 | 5.9 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084579 | 102892 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 513 | 5 | 1 | 3 | 5.9 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| 45270978 | 194839 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 489 | 5 | 1 | 3 | 4.7 | O=C(C=C1CCN(C(=O)c2cccc(F)c2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL563536 | 194839 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 489 | 5 | 1 | 3 | 4.7 | O=C(C=C1CCN(C(=O)c2cccc(F)c2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 44282048 | 111146 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 520 | 9 | 3 | 5 | 4.2 | COc1ccccc1NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(C#N)cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL32852 | 111146 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 520 | 9 | 3 | 5 | 4.2 | COc1ccccc1NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(C#N)cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| 44282385 | 99621 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 562 | 7 | 1 | 6 | 6.1 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1nc(C(=O)N2CCc3ccccc3C2)cs1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL287320 | 99621 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 562 | 7 | 1 | 6 | 6.1 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1nc(C(=O)N2CCc3ccccc3C2)cs1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| 76327878 | 102884 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 500 | 5 | 1 | 4 | 4.9 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccncc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084571 | 102884 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 500 | 5 | 1 | 4 | 4.9 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccncc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| 70686358 | 75793 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 578 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1Br)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057763 | 75793 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 578 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccccc1Br)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| 70682102 | 75796 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 518 | 5 | 2 | 3 | 5.4 | O=C(Nc1ccccc1F)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057766 | 75796 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 518 | 5 | 2 | 3 | 5.4 | O=C(Nc1ccccc1F)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| 2729098 | 80084 | 2 | None | -11 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 362 | 4 | 1 | 2 | 4.4 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL214726 | 80084 | 2 | None | -11 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 362 | 4 | 1 | 2 | 4.4 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| 76309741 | 102893 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 500 | 5 | 1 | 4 | 4.9 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ncccc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084580 | 102893 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 500 | 5 | 1 | 4 | 4.9 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ncccc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| 44399469 | 165573 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL426089 | 165573 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| 71449677 | 81053 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 448 | 5 | 2 | 4 | 2.3 | CS(=O)(=O)N1CCC(NC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2159863 | 81053 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 448 | 5 | 2 | 4 | 2.3 | CS(=O)(=O)N1CCC(NC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 | 10.1016/j.bmcl.2012.09.035 | ||
| 45271843 | 194696 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 517 | 6 | 2 | 5 | 4.2 | COc1ccc(O)c(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL562574 | 194696 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 517 | 6 | 2 | 5 | 4.2 | COc1ccc(O)c(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1 | 10.1016/j.bmc.2009.06.066 | ||
| 45267629 | 194676 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 424 | 5 | 1 | 2 | 5.7 | O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL562475 | 194676 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 424 | 5 | 1 | 2 | 5.7 | O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| 23509697 | 193281 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 440 | 6 | 2 | 4 | 3.6 | COc1cccc(NC(=O)N2CCNC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL54273 | 193281 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 440 | 6 | 2 | 4 | 3.6 | COc1cccc(NC(=O)N2CCNC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44282006 | 123130 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 525 | 10 | 3 | 5 | 4.3 | COc1ccc(C[C@H](NC(=O)c2cccc3ccccc23)C(=O)N[C@@H](C)C(=O)Nc2ccccc2OC)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL36195 | 123130 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 525 | 10 | 3 | 5 | 4.3 | COc1ccc(C[C@H](NC(=O)c2cccc3ccccc23)C(=O)N[C@@H](C)C(=O)Nc2ccccc2OC)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 44440402 | 93484 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 596 | 8 | 0 | 5 | 5.9 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL248179 | 93484 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 596 | 8 | 0 | 5 | 5.9 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44440402 | 93484 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 596 | 8 | 0 | 5 | 5.9 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL248179 | 93484 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 596 | 8 | 0 | 5 | 5.9 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 45270977 | 193481 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 409 | 4 | 1 | 3 | 3.2 | CC(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL550255 | 193481 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 409 | 4 | 1 | 3 | 3.2 | CC(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 | 10.1016/j.bmc.2009.06.066 | ||
| 70682100 | 75787 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 568 | 4 | 1 | 3 | 5.9 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCN(C(=O)c2c(Cl)cccc2Cl)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057757 | 75787 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 568 | 4 | 1 | 3 | 5.9 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCN(C(=O)c2c(Cl)cccc2Cl)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| 11430170 | 123315 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 423 | 6 | 2 | 2 | 5.5 | O=C(Nc1ccccc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL362466 | 123315 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 423 | 6 | 2 | 2 | 5.5 | O=C(Nc1ccccc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 45271911 | 193387 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 362 | 5 | 1 | 2 | 3.9 | O=C(Cc1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL549514 | 193387 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 362 | 5 | 1 | 2 | 3.9 | O=C(Cc1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 44452250 | 95787 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 362 | 4 | 1 | 2 | 4.8 | O=C(Nc1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL260900 | 95787 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 362 | 4 | 1 | 2 | 4.8 | O=C(Nc1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2007.10.003 | ||
| 44281793 | 99652 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 414 | 7 | 1 | 5 | 4.7 | CCn1ccnc1[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL287538 | 99652 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 414 | 7 | 1 | 5 | 4.7 | CCn1ccnc1[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| 70688459 | 75786 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 568 | 5 | 1 | 3 | 6.7 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(Cc2c(Cl)cccc2Cl)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057756 | 75786 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 568 | 5 | 1 | 3 | 6.7 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(Cc2c(Cl)cccc2Cl)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| 44281891 | 125187 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 474 | 8 | 2 | 6 | 4.7 | CCNC(=O)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL36473 | 125187 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 474 | 8 | 2 | 6 | 4.7 | CCNC(=O)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 | 10.1016/s0960-894x(01)00249-9 | ||
| 44281612 | 109137 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 510 | 9 | 3 | 5 | 4.2 | C[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccccc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL32224 | 109137 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 510 | 9 | 3 | 5 | 4.2 | C[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccccc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 10194663 | 81088 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 423 | 7 | 3 | 4 | 3.7 | O=C(Nc1cccc(OCCO)c1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160104 | 81088 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 423 | 7 | 3 | 4 | 3.7 | O=C(Nc1cccc(OCCO)c1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 70692659 | 75732 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 499 | 7 | 1 | 3 | 5.5 | O=C(NCCCN1CCC(C(c2ccccc2)c2ccccc2)CC1)N1CCc2cc(F)ccc2C1=O | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057490 | 75732 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 499 | 7 | 1 | 3 | 5.5 | O=C(NCCCN1CCC(C(c2ccccc2)c2ccccc2)CC1)N1CCc2cc(F)ccc2C1=O | 10.1016/j.bmcl.2012.06.042 | ||
| 11409583 | 69439 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 507 | 8 | 2 | 4 | 5.9 | CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1021/jm049530m | ||
| CHEMBL193575 | 69439 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 507 | 8 | 2 | 4 | 5.9 | CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1021/jm049530m | ||
| 11454941 | 70798 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL195555 | 70798 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 11328714 | 78588 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 462 | 6 | 3 | 2 | 5.9 | O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL2113074 | 78588 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 462 | 6 | 3 | 2 | 5.9 | O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11488078 | 78591 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL2113077 | 78591 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11169258 | 140366 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 587 | 8 | 2 | 10 | 3.8 | Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1021/jm049530m | ||
| CHEMBL382108 | 140366 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 587 | 8 | 2 | 10 | 3.8 | Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1021/jm049530m | ||
| 44401328 | 70752 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 462 | 6 | 3 | 2 | 5.9 | O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL195348 | 70752 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 462 | 6 | 3 | 2 | 5.9 | O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 71460525 | 81095 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 526 | 6 | 3 | 5 | 3.4 | O=C(NC1CCN(S(=O)(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160111 | 81095 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 526 | 6 | 3 | 5 | 3.4 | O=C(NC1CCN(S(=O)(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 44290039 | 178224 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL46905 | 178224 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 11953409 | 93781 | 0 | None | 7 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 529 | 7 | 2 | 6 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249854 | 93781 | 0 | None | 7 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 529 | 7 | 2 | 6 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44447144 | 168207 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 483 | 11 | 3 | 7 | 3.0 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL437396 | 168207 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 483 | 11 | 3 | 7 | 3.0 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 10474776 | 113158 | 36 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33227 | 113158 | 36 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 44281975 | 99168 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 491 | 8 | 2 | 6 | 3.9 | C[C@@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OC(C)(C)C | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL284166 | 99168 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 491 | 8 | 2 | 6 | 3.9 | C[C@@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OC(C)(C)C | 10.1016/s0960-894x(01)00249-9 | ||
| 44452168 | 95407 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 464 | 5 | 1 | 2 | 6.6 | O=C(NC1C[C@@H]2CC[C@@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL258996 | 95407 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 464 | 5 | 1 | 2 | 6.6 | O=C(NC1C[C@@H]2CC[C@@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| 24882359 | 192445 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 464 | 5 | 1 | 2 | 6.6 | O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL522295 | 192445 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 464 | 5 | 1 | 2 | 6.6 | O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2008.08.006 | ||
| 70696744 | 75733 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 464 | 5 | 1 | 2 | 6.6 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057491 | 75733 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 464 | 5 | 1 | 2 | 6.6 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2012.06.042 | ||
| 24882359 | 192445 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 464 | 5 | 1 | 2 | 6.6 | O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL522295 | 192445 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 464 | 5 | 1 | 2 | 6.6 | O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| 3492 | 685 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O | 10.1016/s0960-894x(02)00206-8 | ||
| 9868459 | 685 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50593 | 685 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O | 10.1016/s0960-894x(02)00206-8 | ||
| 11272103 | 123856 | 0 | None | -1995 | 8 | Mouse | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL363840 | 123856 | 0 | None | -1995 | 8 | Mouse | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 22393339 | 186154 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 410 | 7 | 2 | 3 | 4.7 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(Cl)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL48873 | 186154 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 410 | 7 | 2 | 3 | 4.7 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(Cl)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 23509693 | 190897 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 540 | 6 | 1 | 5 | 5.2 | COc1cccc(NC(=O)N2CCN(C(=O)OC(C)(C)C)C(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51937 | 190897 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 540 | 6 | 1 | 5 | 5.2 | COc1cccc(NC(=O)N2CCN(C(=O)OC(C)(C)C)C(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 71462227 | 81092 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 466 | 4 | 0 | 3 | 6.6 | O=C1OC2(CCN(Cc3ccc4cc(F)ccc4c3)CC2)c2ccccc2N1Cc1ccccc1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160108 | 81092 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 466 | 4 | 0 | 3 | 6.6 | O=C1OC2(CCN(Cc3ccc4cc(F)ccc4c3)CC2)c2ccccc2N1Cc1ccccc1 | 10.1016/j.bmcl.2012.09.035 | ||
| 45270135 | 193597 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 441 | 5 | 2 | 4 | 3.6 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)NS(=O)(=O)c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL551205 | 193597 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 441 | 5 | 2 | 4 | 3.6 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)NS(=O)(=O)c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| 45268444 | 194344 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 458 | 6 | 1 | 3 | 5.6 | O=C(C=C1CCC(Oc2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL560135 | 194344 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 458 | 6 | 1 | 3 | 5.6 | O=C(C=C1CCC(Oc2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 44282030 | 111142 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 461 | 8 | 1 | 7 | 3.5 | CCOC(=O)C1COC([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)=N1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL32850 | 111142 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 461 | 8 | 1 | 7 | 3.5 | CCOC(=O)C1COC([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)=N1 | 10.1016/s0960-894x(01)00249-9 | ||
| 76320670 | 102887 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 454 | 5 | 1 | 4 | 5.1 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-n1ccnc1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084574 | 102887 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 454 | 5 | 1 | 4 | 5.1 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-n1ccnc1 | 10.1016/j.bmc.2008.08.006 | ||
| 45270980 | 193506 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 489 | 5 | 1 | 3 | 4.7 | O=C(C=C1CCN(C(=O)c2ccc(F)cc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL550464 | 193506 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 489 | 5 | 1 | 3 | 4.7 | O=C(C=C1CCN(C(=O)c2ccc(F)cc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 44447361 | 94512 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 453 | 9 | 4 | 8 | 1.8 | C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL254503 | 94512 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 453 | 9 | 4 | 8 | 1.8 | C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 23509695 | 189147 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 441 | 6 | 1 | 4 | 4.0 | COc1cccc(NC(=O)N2CCOC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51584 | 189147 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 441 | 6 | 1 | 4 | 4.0 | COc1cccc(NC(=O)N2CCOC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 76331526 | 102879 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 453 | 5 | 1 | 3 | 5.7 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-n1cccc1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084566 | 102879 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 453 | 5 | 1 | 3 | 5.7 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-n1cccc1 | 10.1016/j.bmc.2008.08.006 | ||
| 76327880 | 102891 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 485 | 5 | 1 | 3 | 5.1 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084578 | 102891 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 485 | 5 | 1 | 3 | 5.1 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| 44281943 | 99769 | 0 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 387 | 6 | 1 | 5 | 4.5 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1cnco1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL288554 | 99769 | 0 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 387 | 6 | 1 | 5 | 4.5 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1cnco1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| 71453334 | 81080 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 407 | 6 | 2 | 3 | 4.5 | COCc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160097 | 81080 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 407 | 6 | 2 | 3 | 4.5 | COCc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 76316938 | 102880 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 499 | 5 | 1 | 3 | 5.5 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084567 | 102880 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 499 | 5 | 1 | 3 | 5.5 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| 44512619 | 102894 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 516 | 5 | 1 | 4 | 4.2 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084581 | 102894 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 516 | 5 | 1 | 4 | 4.2 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| 45270199 | 194744 | 0 | None | 47 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 516 | 5 | 1 | 4 | 4.2 | O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL562897 | 194744 | 0 | None | 47 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 516 | 5 | 1 | 4 | 4.2 | O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2009.06.066 | ||
| 44401561 | 123602 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL363373 | 123602 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 45271882 | 193589 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 366 | 4 | 1 | 2 | 4.1 | O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccc(F)cc1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL551134 | 193589 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 366 | 4 | 1 | 2 | 4.1 | O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccc(F)cc1 | 10.1016/j.bmc.2009.06.066 | ||
| 71455029 | 81059 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 464 | 7 | 2 | 4 | 3.8 | CN(C)C(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2159869 | 81059 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 464 | 7 | 2 | 4 | 3.8 | CN(C)C(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 70696753 | 75792 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 500 | 5 | 2 | 3 | 5.3 | O=C(Nc1ccccc1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057762 | 75792 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 500 | 5 | 2 | 3 | 5.3 | O=C(Nc1ccccc1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| 44452009 | 95501 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 392 | 5 | 1 | 3 | 4.4 | COc1ccc(C(=O)NC2CCN(Cc3ccc4cc(F)ccc4c3)CC2)cc1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL259409 | 95501 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 392 | 5 | 1 | 3 | 4.4 | COc1ccc(C(=O)NC2CCN(Cc3ccc4cc(F)ccc4c3)CC2)cc1 | 10.1016/j.bmc.2007.10.003 | ||
| 10474776 | 113158 | 36 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33227 | 113158 | 36 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 71453337 | 81094 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 540 | 5 | 2 | 5 | 3.8 | O=C(NC1CCN(S(=O)(=O)c2ccccc2O)CC1)N1CCCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160110 | 81094 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 540 | 5 | 2 | 5 | 3.8 | O=C(NC1CCN(S(=O)(=O)c2ccccc2O)CC1)N1CCCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmcl.2012.09.035 | ||
| 44290039 | 178224 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL46905 | 178224 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44282005 | 123236 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 520 | 9 | 3 | 5 | 4.2 | COc1ccc(C[C@H](NC(=O)c2cccc3ccccc23)C(=O)N[C@@H](C)C(=O)Nc2ccc(C#N)cc2)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL36223 | 123236 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 520 | 9 | 3 | 5 | 4.2 | COc1ccc(C[C@H](NC(=O)c2cccc3ccccc23)C(=O)N[C@@H](C)C(=O)Nc2ccc(C#N)cc2)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 45269291 | 194766 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 427 | 5 | 2 | 4 | 3.2 | O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)NS(=O)(=O)c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL563019 | 194766 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 427 | 5 | 2 | 4 | 3.2 | O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)NS(=O)(=O)c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| 45269385 | 194806 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 424 | 5 | 1 | 2 | 5.7 | O=C(N[C@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL563319 | 194806 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 424 | 5 | 1 | 2 | 5.7 | O=C(N[C@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| 44281668 | 109933 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 500 | 8 | 3 | 4 | 4.4 | C[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1cccnc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL32451 | 109933 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 500 | 8 | 3 | 4 | 4.4 | C[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1cccnc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 44452168 | 95407 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 464 | 5 | 1 | 2 | 6.6 | O=C(NC1C[C@@H]2CC[C@@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL258996 | 95407 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 464 | 5 | 1 | 2 | 6.6 | O=C(NC1C[C@@H]2CC[C@@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| 76320671 | 102889 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 471 | 5 | 1 | 3 | 5.9 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084576 | 102889 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 471 | 5 | 1 | 3 | 5.9 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| 71456839 | 81084 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 467 | 10 | 3 | 5 | 3.8 | O=C(Nc1ccccc1OCCOCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160100 | 81084 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 467 | 10 | 3 | 5 | 3.8 | O=C(Nc1ccccc1OCCOCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 44452220 | 160729 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 452 | 5 | 1 | 2 | 6.4 | CC1(NC(=O)c2ccccc2-c2ccccc2)CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL412072 | 160729 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 452 | 5 | 1 | 2 | 6.4 | CC1(NC(=O)c2ccccc2-c2ccccc2)CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2007.10.003 | ||
| 76313428 | 102877 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 465 | 5 | 1 | 3 | 6.0 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cccnc1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084564 | 102877 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 465 | 5 | 1 | 3 | 6.0 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cccnc1 | 10.1016/j.bmc.2008.08.006 | ||
| 70688469 | 75834 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 534 | 5 | 2 | 3 | 5.9 | O=C(Nc1ccccc1Cl)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2058070 | 75834 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 534 | 5 | 2 | 3 | 5.9 | O=C(Nc1ccccc1Cl)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| 44452119 | 95907 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 380 | 4 | 1 | 2 | 4.5 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1F | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL261574 | 95907 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 380 | 4 | 1 | 2 | 4.5 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1F | 10.1016/j.bmc.2007.10.003 | ||
| 44281859 | 109337 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 463 | 9 | 2 | 6 | 3.2 | CCOC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL32334 | 109337 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 463 | 9 | 2 | 6 | 3.2 | CCOC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| 44289926 | 176985 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 453 | 9 | 2 | 4 | 4.7 | CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL46404 | 176985 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 453 | 9 | 2 | 4 | 4.7 | CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44289927 | 167764 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL43423 | 167764 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 45268462 | 194541 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 517 | 6 | 2 | 5 | 4.2 | COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c(O)c1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL561535 | 194541 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 517 | 6 | 2 | 5 | 4.2 | COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c(O)c1 | 10.1016/j.bmc.2009.06.066 | ||
| 45269302 | 194442 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 531 | 7 | 1 | 5 | 4.5 | COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)cc1OC | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL560995 | 194442 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 531 | 7 | 1 | 5 | 4.5 | COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)cc1OC | 10.1016/j.bmc.2009.06.066 | ||
| 70688470 | 75837 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 542 | 6 | 2 | 3 | 6.4 | CC(C)c1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2058073 | 75837 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 542 | 6 | 2 | 3 | 6.4 | CC(C)c1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| 9892753 | 16323 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 516 | 8 | 3 | 4 | 5.5 | CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm049530m | ||
| CHEMBL123611 | 16323 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 516 | 8 | 3 | 4 | 5.5 | CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm049530m | ||
| 44281667 | 115161 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 524 | 10 | 3 | 5 | 3.9 | CC(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)NCc1ccccc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL33537 | 115161 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 524 | 10 | 3 | 5 | 3.9 | CC(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)NCc1ccccc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 45273705 | 194125 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 376 | 5 | 1 | 2 | 4.3 | O=C(Cc1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL557936 | 194125 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 376 | 5 | 1 | 2 | 4.3 | O=C(Cc1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2009.06.066 | ||
| 10050884 | 154115 | 10 | None | -204 | 3 | Mouse | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL399495 | 154115 | 10 | None | -204 | 3 | Mouse | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| 70684230 | 75836 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 530 | 6 | 2 | 4 | 5.3 | COc1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2058072 | 75836 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 530 | 6 | 2 | 4 | 5.3 | COc1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| 70682099 | 75782 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 532 | 4 | 1 | 3 | 5.2 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057752 | 75782 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 532 | 4 | 1 | 3 | 5.2 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| 10474776 | 113158 | 36 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33227 | 113158 | 36 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 45268519 | 194599 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 409 | 5 | 0 | 2 | 6.4 | O=C(c1ccccc1-c1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL561941 | 194599 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 409 | 5 | 0 | 2 | 6.4 | O=C(c1ccccc1-c1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 44281966 | 99351 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 403 | 6 | 1 | 5 | 4.9 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1nccs1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL285444 | 99351 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 403 | 6 | 1 | 5 | 4.9 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1nccs1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| 44452361 | 96061 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 338 | 5 | 1 | 2 | 3.7 | O=C(NC1CCN(C/C=C/c2ccc(F)cc2)CC1)c1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL262588 | 96061 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 338 | 5 | 1 | 2 | 3.7 | O=C(NC1CCN(C/C=C/c2ccc(F)cc2)CC1)c1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| 10474776 | 113158 | 36 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33227 | 113158 | 36 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 11442439 | 123539 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 455 | 6 | 2 | 2 | 5.9 | Cc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1F | 10.1021/jm049530m | ||
| CHEMBL363166 | 123539 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 455 | 6 | 2 | 2 | 5.9 | Cc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1F | 10.1021/jm049530m | ||
| 44386406 | 62158 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 461 | 9 | 2 | 6 | 3.3 | C=C(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OCC | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL178019 | 62158 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 461 | 9 | 2 | 6 | 3.3 | C=C(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OCC | 10.1016/s0960-894x(01)00249-9 | ||
| 6918497 | 112931 | 1 | None | -213 | 4 | Mouse | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| CHEMBL277930 | 112931 | 1 | None | -213 | 4 | Mouse | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| CHEMBL331897 | 112931 | 1 | None | -213 | 4 | Mouse | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| 44452044 | 155546 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 392 | 5 | 1 | 3 | 4.4 | COc1cccc(C(=O)NC2CCN(Cc3ccc4cc(F)ccc4c3)CC2)c1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL406296 | 155546 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 392 | 5 | 1 | 3 | 4.4 | COc1cccc(C(=O)NC2CCN(Cc3ccc4cc(F)ccc4c3)CC2)c1 | 10.1016/j.bmc.2007.10.003 | ||
| 70690518 | 75778 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 555 | 4 | 1 | 4 | 5.0 | CN1CN(c2ccccc2)C2(CCN(C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)CC2)C1=O | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057748 | 75778 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 555 | 4 | 1 | 4 | 5.0 | CN1CN(c2ccccc2)C2(CCN(C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)CC2)C1=O | 10.1016/j.bmcl.2012.06.042 | ||
| 10474776 | 113158 | 36 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33227 | 113158 | 36 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 44451928 | 158617 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 438 | 5 | 1 | 2 | 6.0 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL409830 | 158617 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 438 | 5 | 1 | 2 | 6.0 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| 44451928 | 158617 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 438 | 5 | 1 | 2 | 6.0 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL409830 | 158617 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 438 | 5 | 1 | 2 | 6.0 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| 45268458 | 195068 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 517 | 6 | 2 | 5 | 4.2 | COc1cccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1O | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL565165 | 195068 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 517 | 6 | 2 | 5 | 4.2 | COc1cccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1O | 10.1016/j.bmc.2009.06.066 | ||
| 71460524 | 81093 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 474 | 5 | 1 | 3 | 4.9 | O=C(NC1CCN(Cc2ccccc2)CC1)N1CCCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160109 | 81093 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 474 | 5 | 1 | 3 | 4.9 | O=C(NC1CCN(Cc2ccccc2)CC1)N1CCCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmcl.2012.09.035 | ||
| 70686357 | 75783 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 529 | 4 | 2 | 4 | 4.6 | Nc1ccc(C(=O)N2CCCN(C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)CC2)cc1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057753 | 75783 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 529 | 4 | 2 | 4 | 4.6 | Nc1ccc(C(=O)N2CCCN(C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)CC2)cc1 | 10.1016/j.bmcl.2012.06.042 | ||
| 44282280 | 119887 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 463 | 9 | 2 | 6 | 3.2 | CCOC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL35341 | 119887 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 463 | 9 | 2 | 6 | 3.2 | CCOC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| 11329244 | 70772 | 10 | None | 20 | 7 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | ||
| CHEMBL195433 | 70772 | 10 | None | 20 | 7 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | ||
| 11340670 | 126712 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 483 | 7 | 2 | 3 | 5.8 | CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F | 10.1021/jm049530m | ||
| CHEMBL365820 | 126712 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 483 | 7 | 2 | 3 | 5.8 | CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F | 10.1021/jm049530m | ||
| 11397114 | 132948 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL3706810 | 132948 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44401123 | 135757 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 516 | 7 | 2 | 5 | 4.9 | N#CC1=CC(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)CC=C1n1cccn1 | 10.1021/jm049530m | ||
| CHEMBL373347 | 135757 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 516 | 7 | 2 | 5 | 4.9 | N#CC1=CC(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)CC=C1n1cccn1 | 10.1021/jm049530m | ||
| 9847583 | 194792 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 471 | 5 | 1 | 3 | 4.5 | O=C(C=C1CCN(C(=O)c2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL563189 | 194792 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 471 | 5 | 1 | 3 | 4.5 | O=C(C=C1CCN(C(=O)c2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 45273624 | 193994 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 489 | 5 | 1 | 3 | 4.7 | O=C(C=C1CCN(C(=O)c2ccccc2F)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL556500 | 193994 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 489 | 5 | 1 | 3 | 4.7 | O=C(C=C1CCN(C(=O)c2ccccc2F)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 70696765 | 75835 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 545 | 6 | 2 | 5 | 5.2 | O=C(Nc1ccccc1[N+](=O)[O-])[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2058071 | 75835 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 545 | 6 | 2 | 5 | 5.2 | O=C(Nc1ccccc1[N+](=O)[O-])[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| 25024651 | 115536 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355956 | 115536 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44281706 | 111070 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 496 | 9 | 3 | 5 | 3.8 | O=C(CNC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)Nc1ccccc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL32806 | 111070 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 496 | 9 | 3 | 5 | 3.8 | O=C(CNC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)Nc1ccccc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 11227406 | 93909 | 1 | None | -107 | 4 | Mouse | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL250689 | 93909 | 1 | None | -107 | 4 | Mouse | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| 71460504 | 81054 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 369 | 4 | 2 | 2 | 4.2 | O=C(NC1CCCCC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2159864 | 81054 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 369 | 4 | 2 | 2 | 4.2 | O=C(NC1CCCCC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 11227406 | 93909 | 1 | None | -107 | 4 | Mouse | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL250689 | 93909 | 1 | None | -107 | 4 | Mouse | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 71456816 | 81056 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 407 | 6 | 3 | 3 | 3.9 | O=C(Nc1ccccc1CCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2159866 | 81056 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 407 | 6 | 3 | 3 | 3.9 | O=C(Nc1ccccc1CCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 71455044 | 81089 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 450 | 8 | 2 | 4 | 4.3 | CN(C)CCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160105 | 81089 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 450 | 8 | 2 | 4 | 4.3 | CN(C)CCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 71453336 | 81090 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 7 | 3 | 4 | 3.2 | NC(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160106 | 81090 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 7 | 3 | 4 | 3.2 | NC(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 76327879 | 102890 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 527 | 6 | 1 | 3 | 6.3 | CN(C(=O)c1ccccc1C(=O)N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)C1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084577 | 102890 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 527 | 6 | 1 | 3 | 6.3 | CN(C(=O)c1ccccc1C(=O)N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)C1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| 70682098 | 75780 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 545 | 4 | 2 | 4 | 5.3 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC(n2c(=O)[nH]c3c(F)cccc32)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057750 | 75780 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 545 | 4 | 2 | 4 | 5.3 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC(n2c(=O)[nH]c3c(F)cccc32)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| 70682101 | 75788 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 530 | 4 | 2 | 4 | 4.7 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccc(O)cc2)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057758 | 75788 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 530 | 4 | 2 | 4 | 4.7 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccc(O)cc2)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| 44281852 | 99221 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 511 | 8 | 3 | 3 | 5.1 | Cc1ccc(C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](C)C(=O)Nc2ccc(Cl)cc2)c(C)c1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL284531 | 99221 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 511 | 8 | 3 | 3 | 5.1 | Cc1ccc(C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](C)C(=O)Nc2ccc(Cl)cc2)c(C)c1 | 10.1016/s0960-894x(01)00249-9 | ||
| 44281944 | 121279 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 529 | 9 | 3 | 4 | 5.0 | COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)c2cccc3ccccc23)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL35896 | 121279 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 529 | 9 | 3 | 4 | 5.0 | COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)c2cccc3ccccc23)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 70692666 | 75790 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 554 | 5 | 1 | 3 | 5.5 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)C2(c3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057760 | 75790 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 554 | 5 | 1 | 3 | 5.5 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)C2(c3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| 45273639 | 194751 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 517 | 6 | 2 | 5 | 4.2 | COc1cccc(O)c1C(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL562922 | 194751 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 517 | 6 | 2 | 5 | 4.2 | COc1cccc(O)c1C(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 | 10.1016/j.bmc.2009.06.066 | ||
| 44452172 | 95408 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 378 | 4 | 1 | 3 | 5.2 | O=C(Nc1ccccc1)OC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL258997 | 95408 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 378 | 4 | 1 | 3 | 5.2 | O=C(Nc1ccccc1)OC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2007.10.003 | ||
| 76324312 | 102881 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 514 | 5 | 1 | 4 | 4.3 | CN1CCN(C(=O)c2ccccc2C(=O)N[C@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084568 | 102881 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 514 | 5 | 1 | 4 | 4.3 | CN1CCN(C(=O)c2ccccc2C(=O)N[C@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2008.08.006 | ||
| 10474776 | 113158 | 36 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL33227 | 113158 | 36 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| 9957612 | 162711 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 8 | 3 | 3 | 5.0 | C[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccccc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL418588 | 162711 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 8 | 3 | 3 | 5.0 | C[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccccc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 45273632 | 194030 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 487 | 5 | 2 | 4 | 4.2 | O=C(C=C1CCN(C(=O)c2cccc(O)c2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL556916 | 194030 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 487 | 5 | 2 | 4 | 4.2 | O=C(C=C1CCN(C(=O)c2cccc(O)c2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 44455847 | 154907 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 501 | 9 | 2 | 6 | 4.7 | O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL403839 | 154907 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 501 | 9 | 2 | 6 | 4.7 | O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 45272697 | 193948 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 501 | 6 | 1 | 4 | 4.5 | COc1ccccc1C(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL556227 | 193948 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 501 | 6 | 1 | 4 | 4.5 | COc1ccccc1C(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 | 10.1016/j.bmc.2009.06.066 | ||
| 45273698 | 194752 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 487 | 5 | 2 | 4 | 4.2 | O=C(C=C1CCN(C(=O)c2ccc(O)cc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL562923 | 194752 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 487 | 5 | 2 | 4 | 4.2 | O=C(C=C1CCN(C(=O)c2ccc(O)cc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 45273689 | 194053 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 501 | 6 | 1 | 4 | 4.5 | COc1cccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL557118 | 194053 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 501 | 6 | 1 | 4 | 4.5 | COc1cccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1 | 10.1016/j.bmc.2009.06.066 | ||
| 71455028 | 81055 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 363 | 4 | 2 | 2 | 4.4 | O=C(Nc1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2159865 | 81055 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 363 | 4 | 2 | 2 | 4.4 | O=C(Nc1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 71453335 | 81087 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 437 | 8 | 3 | 4 | 4.1 | O=C(Nc1ccccc1OCCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160103 | 81087 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 437 | 8 | 3 | 4 | 4.1 | O=C(Nc1ccccc1OCCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 11179592 | 69249 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 501 | 6 | 2 | 2 | 6.2 | O=C(Nc1ccc(Br)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL193442 | 69249 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 501 | 6 | 2 | 2 | 6.2 | O=C(Nc1ccc(Br)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11316656 | 69919 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 441 | 6 | 2 | 2 | 5.6 | O=C(Nc1ccc(F)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL194141 | 69919 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 441 | 6 | 2 | 2 | 5.6 | O=C(Nc1ccc(F)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44281755 | 99226 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 502 | 9 | 3 | 6 | 3.8 | COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2cscn2)NC(=O)c2cccc3ccccc23)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL284576 | 99226 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 502 | 9 | 3 | 6 | 3.8 | COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2cscn2)NC(=O)c2cccc3ccccc23)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 44281999 | 121343 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 459 | 8 | 1 | 7 | 4.6 | CCOC(=O)c1coc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL35900 | 121343 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 459 | 8 | 1 | 7 | 4.6 | CCOC(=O)c1coc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 | 10.1016/s0960-894x(01)00249-9 | ||
| 71462226 | 81081 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 421 | 7 | 3 | 3 | 4.3 | O=C(Nc1ccccc1CCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160098 | 81081 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 421 | 7 | 3 | 3 | 4.3 | O=C(Nc1ccccc1CCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 70694702 | 75785 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 548 | 4 | 2 | 4 | 4.9 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2c(O)cccc2F)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057755 | 75785 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 548 | 4 | 2 | 4 | 4.9 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2c(O)cccc2F)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| 70690519 | 75779 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 527 | 4 | 2 | 4 | 5.2 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057749 | 75779 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 527 | 4 | 2 | 4 | 5.2 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| 10474776 | 113158 | 36 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33227 | 113158 | 36 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 45271905 | 193351 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 438 | 5 | 1 | 2 | 6.0 | O=C(NC1CCCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL549302 | 193351 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 438 | 5 | 1 | 2 | 6.0 | O=C(NC1CCCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2009.06.066 | ||
| 70690520 | 75791 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 550 | 5 | 1 | 4 | 4.6 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(S(=O)(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057761 | 75791 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 550 | 5 | 1 | 4 | 4.6 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(S(=O)(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| 9952288 | 110015 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 389 | 6 | 1 | 5 | 3.5 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C1=NCCO1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL32493 | 110015 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 389 | 6 | 1 | 5 | 3.5 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C1=NCCO1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| 76324313 | 102886 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 465 | 5 | 1 | 3 | 6.0 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccn1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084573 | 102886 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 465 | 5 | 1 | 3 | 6.0 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccn1 | 10.1016/j.bmc.2008.08.006 | ||
| 70690517 | 75777 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 541 | 4 | 2 | 4 | 4.6 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057747 | 75777 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 541 | 4 | 2 | 4 | 4.6 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2012.06.042 | ||
| 45268467 | 194568 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 505 | 5 | 2 | 4 | 4.4 | O=C(C=C1CCN(C(=O)c2ccc(F)cc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL561740 | 194568 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 505 | 5 | 2 | 4 | 4.4 | O=C(C=C1CCN(C(=O)c2ccc(F)cc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 6918497 | 112931 | 1 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| CHEMBL277930 | 112931 | 1 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| CHEMBL331897 | 112931 | 1 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| 44455872 | 154977 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 467 | 9 | 2 | 4 | 5.1 | CC(=O)c1cc(NC(=O)N[C@@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL404202 | 154977 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 467 | 9 | 2 | 4 | 5.1 | CC(=O)c1cc(NC(=O)N[C@@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44281987 | 99187 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 542 | 9 | 3 | 4 | 5.4 | C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccc(-c2ccccc2)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL284313 | 99187 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 542 | 9 | 3 | 4 | 5.4 | C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccc(-c2ccccc2)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 44281794 | 167448 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 524 | 9 | 2 | 5 | 4.3 | C[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)N(C)c1ccccc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL432088 | 167448 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 524 | 9 | 2 | 5 | 4.3 | C[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)N(C)c1ccccc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 44452304 | 157303 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 348 | 5 | 1 | 2 | 4.7 | Fc1ccc2cc(CN3CCC(NCc4ccccc4)CC3)ccc2c1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL408368 | 157303 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 348 | 5 | 1 | 2 | 4.7 | Fc1ccc2cc(CN3CCC(NCc4ccccc4)CC3)ccc2c1 | 10.1016/j.bmc.2007.10.003 | ||
| 71449695 | 81091 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 416 | 5 | 0 | 2 | 5.0 | O=C1N(CCc2ccccc2)CCC12CCN(Cc1ccc3cc(F)ccc3c1)CC2 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160107 | 81091 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 416 | 5 | 0 | 2 | 5.0 | O=C1N(CCc2ccccc2)CCC12CCN(Cc1ccc3cc(F)ccc3c1)CC2 | 10.1016/j.bmcl.2012.09.035 | ||
| 9826988 | 75731 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 492 | 7 | 0 | 7 | 4.2 | Cc1nnc2n(CCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)c(=O)c3ccccc3n12 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057489 | 75731 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 492 | 7 | 0 | 7 | 4.2 | Cc1nnc2n(CCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)c(=O)c3ccccc3n12 | 10.1016/j.bmcl.2012.06.042 | ||
| 76320667 | 102876 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 465 | 5 | 1 | 3 | 6.0 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccncc1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084563 | 102876 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 465 | 5 | 1 | 3 | 6.0 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccncc1 | 10.1016/j.bmc.2008.08.006 | ||
| 24882359 | 192445 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 464 | 5 | 1 | 2 | 6.6 | O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL522295 | 192445 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 464 | 5 | 1 | 2 | 6.6 | O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmc.2008.08.006 | ||
| 70694701 | 75784 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 582 | 4 | 1 | 3 | 6.3 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2c(Cl)cccc2Cl)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057754 | 75784 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 582 | 4 | 1 | 3 | 6.3 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2c(Cl)cccc2Cl)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| 70696752 | 75789 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 530 | 4 | 2 | 4 | 4.7 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccccc2O)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057759 | 75789 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 530 | 4 | 2 | 4 | 4.7 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccccc2O)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| 44452086 | 157345 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 380 | 4 | 1 | 2 | 4.5 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL408407 | 157345 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 380 | 4 | 1 | 2 | 4.5 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2007.10.003 | ||
| 44452086 | 157345 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 380 | 4 | 1 | 2 | 4.5 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL408407 | 157345 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 380 | 4 | 1 | 2 | 4.5 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2009.06.066 | ||
| 44281775 | 115064 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 524 | 9 | 2 | 5 | 4.6 | C[C@@H](C(=O)Nc1ccccc1)N(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL33534 | 115064 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 524 | 9 | 2 | 5 | 4.6 | C[C@@H](C(=O)Nc1ccccc1)N(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| 44281951 | 119722 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 475 | 8 | 1 | 7 | 5.1 | CCOC(=O)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL35217 | 119722 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 475 | 8 | 1 | 7 | 5.1 | CCOC(=O)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 | 10.1016/s0960-894x(01)00249-9 | ||
| 44281686 | 111534 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 462 | 9 | 3 | 5 | 2.7 | CCNC(=O)C(C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL32895 | 111534 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 462 | 9 | 3 | 5 | 2.7 | CCNC(=O)C(C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00249-9 | ||
| 44452120 | 155688 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 380 | 4 | 1 | 2 | 4.5 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1cccc(F)c1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL406468 | 155688 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 380 | 4 | 1 | 2 | 4.5 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1cccc(F)c1 | 10.1016/j.bmc.2007.10.003 | ||
| 76313429 | 102882 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 501 | 5 | 1 | 4 | 4.4 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCOCC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084569 | 102882 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 501 | 5 | 1 | 4 | 4.4 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCOCC1 | 10.1016/j.bmc.2008.08.006 | ||
| 11953409 | 93781 | 0 | None | -7 | 4 | Mouse | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 529 | 7 | 2 | 6 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249854 | 93781 | 0 | None | -7 | 4 | Mouse | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 529 | 7 | 2 | 6 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 45269320 | 194917 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 521 | 5 | 2 | 4 | 4.9 | O=C(C=C1CCN(C(=O)c2ccc(Cl)cc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL564022 | 194917 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 521 | 5 | 2 | 4 | 4.9 | O=C(C=C1CCN(C(=O)c2ccc(Cl)cc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 44281774 | 116167 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 501 | 9 | 3 | 4 | 5.1 | COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](CC2CCCCC2)NC(=O)c2cccc3ccccc23)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL33708 | 116167 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 501 | 9 | 3 | 4 | 5.1 | COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](CC2CCCCC2)NC(=O)c2cccc3ccccc23)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 71456840 | 81085 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 437 | 8 | 2 | 4 | 4.4 | COCCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2160101 | 81085 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 437 | 8 | 2 | 4 | 4.4 | COCCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 44387842 | 130779 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 369 | 5 | 2 | 3 | 4.2 | CC(=O)c1cccc(NC(=O)NN2CCCCC2Cc2ccc(F)cc2)c1 | 10.1021/jm049530m | ||
| CHEMBL368683 | 130779 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 369 | 5 | 2 | 3 | 4.2 | CC(=O)c1cccc(NC(=O)NN2CCCCC2Cc2ccc(F)cc2)c1 | 10.1021/jm049530m | ||
| 44452083 | 95730 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 392 | 5 | 1 | 3 | 4.4 | COc1ccccc1C(=O)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL260649 | 95730 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 392 | 5 | 1 | 3 | 4.4 | COc1ccccc1C(=O)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2007.10.003 | ||
| 44281872 | 108870 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 522 | 8 | 2 | 6 | 6.2 | O=C(Nc1ccccc1)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL32191 | 108870 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 522 | 8 | 2 | 6 | 6.2 | O=C(Nc1ccccc1)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 | 10.1016/s0960-894x(01)00249-9 | ||
| 70684221 | 75776 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 461 | 3 | 1 | 2 | 5.4 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCc2cc(F)ccc2C1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057746 | 75776 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 461 | 3 | 1 | 2 | 5.4 | O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCc2cc(F)ccc2C1 | 10.1016/j.bmcl.2012.06.042 | ||
| 11227406 | 93909 | 1 | None | 107 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL250689 | 93909 | 1 | None | 107 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| 70696751 | 75781 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 542 | 4 | 3 | 5 | 4.7 | Nc1ccc2c(c1)[nH]c(=O)n2C1CCN(C(=O)NC2C[C@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057751 | 75781 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 542 | 4 | 3 | 5 | 4.7 | Nc1ccc2c(c1)[nH]c(=O)n2C1CCN(C(=O)NC2C[C@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmcl.2012.06.042 | ||
| 11227406 | 93909 | 1 | None | 107 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL250689 | 93909 | 1 | None | 107 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 44512617 | 193668 | 0 | None | 79 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 487 | 5 | 2 | 4 | 4.2 | O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL551735 | 193668 | 0 | None | 79 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 487 | 5 | 2 | 4 | 4.2 | O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 22393430 | 168137 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL43677 | 168137 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44281754 | 112679 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 506 | 8 | 3 | 5 | 4.4 | C[C@H](NC(=O)[C@H](Cc1cscn1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccc(Cl)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL33144 | 112679 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 506 | 8 | 3 | 5 | 4.4 | C[C@H](NC(=O)[C@H](Cc1cscn1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccc(Cl)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 44452248 | 95785 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 376 | 4 | 0 | 2 | 4.7 | CN(C(=O)c1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL260899 | 95785 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 376 | 4 | 0 | 2 | 4.7 | CN(C(=O)c1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2007.10.003 | ||
| 44295672 | 188170 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 439 | 6 | 1 | 3 | 5.0 | COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50535 | 188170 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 439 | 6 | 1 | 3 | 5.0 | COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44452280 | 95366 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 398 | 5 | 1 | 3 | 3.9 | O=S(=O)(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL258790 | 95366 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 398 | 5 | 1 | 3 | 3.9 | O=S(=O)(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| 76313430 | 102885 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 500 | 5 | 1 | 4 | 4.9 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cnccc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084572 | 102885 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 500 | 5 | 1 | 4 | 4.9 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cnccc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| 76320668 | 102878 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 471 | 5 | 1 | 4 | 6.0 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1nccs1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084565 | 102878 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 471 | 5 | 1 | 4 | 6.0 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1nccs1 | 10.1016/j.bmc.2008.08.006 | ||
| 71451489 | 81057 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 451 | 9 | 3 | 4 | 4.5 | O=C(Nc1ccccc1OCCCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| CHEMBL2159867 | 81057 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 451 | 9 | 3 | 4 | 4.5 | O=C(Nc1ccccc1OCCCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmcl.2012.09.035 | ||
| 44282047 | 162617 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 520 | 9 | 3 | 5 | 4.2 | COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)c2cccc3ccccc23)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| CHEMBL418041 | 162617 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 520 | 9 | 3 | 5 | 4.2 | COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)c2cccc3ccccc23)cc1 | 10.1016/s0960-894x(01)00249-9 | ||
| 45273619 | 194804 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 485 | 6 | 1 | 3 | 4.8 | O=C(/C=C/C1CCN(C(=O)c2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL563303 | 194804 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 485 | 6 | 1 | 3 | 4.8 | O=C(/C=C/C1CCN(C(=O)c2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 70688460 | 75795 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 578 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccc(Br)cc1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| CHEMBL2057765 | 75795 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 578 | 5 | 2 | 3 | 6.1 | O=C(Nc1ccc(Br)cc1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 | 10.1016/j.bmcl.2012.06.042 | ||
| 76313415 | 105906 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 466 | 5 | 1 | 4 | 5.4 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cncnc1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084359 | 105906 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 466 | 5 | 1 | 4 | 5.4 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cncnc1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3139342 | 105906 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 466 | 5 | 1 | 4 | 5.4 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cncnc1 | 10.1016/j.bmc.2008.08.006 | ||
| 3536 | 3843 | 0 | None | -9 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 515 | 5 | 1 | 2 | 7.3 | CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 | 10.1021/jm300682j | ||
| 44560289 | 3843 | 0 | None | -9 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 515 | 5 | 1 | 2 | 7.3 | CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 | 10.1021/jm300682j | ||
| CHEMBL1186993 | 3843 | 0 | None | -9 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 515 | 5 | 1 | 2 | 7.3 | CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 | 10.1021/jm300682j | ||
| 44451983 | 158815 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 454 | 6 | 1 | 3 | 6.2 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1Oc1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL410041 | 158815 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 454 | 6 | 1 | 3 | 6.2 | O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1Oc1ccccc1 | 10.1016/j.bmc.2007.10.003 | ||
| 44452198 | 157429 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 388 | 5 | 1 | 2 | 4.8 | O=C(/C=C/c1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2007.10.003 | ||
| CHEMBL408486 | 157429 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 388 | 5 | 1 | 2 | 4.8 | O=C(/C=C/c1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2007.10.003 | ||
| 44452198 | 157429 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 388 | 5 | 1 | 2 | 4.8 | O=C(/C=C/c1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL408486 | 157429 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 388 | 5 | 1 | 2 | 4.8 | O=C(/C=C/c1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 | 10.1016/j.bmc.2009.06.066 | ||
| 76320669 | 102883 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 500 | 5 | 1 | 4 | 4.9 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cccnc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| CHEMBL3084570 | 102883 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 500 | 5 | 1 | 4 | 4.9 | O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cccnc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2008.08.006 | ||
| 11753159 | 542 | 3 | None | 4 | 2 | Human | 7.0 | pKd | = | 7 | Functional | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 7679 | 542 | 3 | None | 4 | 2 | Human | 7.0 | pKd | = | 7 | Functional | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2158814 | 542 | 3 | None | 4 | 2 | Human | 7.0 | pKd | = | 7 | Functional | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 16040671 | 80867 | 0 | None | - | 0 | Human | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 502 | 8 | 1 | 4 | 5.4 | Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158791 | 80867 | 0 | None | - | 0 | Human | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 502 | 8 | 1 | 4 | 5.4 | Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 16681693 | 82160 | 1 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 487 | 5 | 1 | 5 | 3.6 | Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)nn1 | 10.1021/jm300682j | ||
| CHEMBL2178580 | 82160 | 1 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 487 | 5 | 1 | 5 | 3.6 | Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)nn1 | 10.1021/jm300682j | ||
| 44399573 | 67694 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 465 | 6 | 1 | 3 | 5.4 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)C1CCCCC1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL191418 | 67694 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 465 | 6 | 1 | 3 | 5.4 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)C1CCCCC1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399538 | 67196 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 524 | 7 | 1 | 4 | 5.7 | O=C(NCC1CCCN(C2CCN(CCc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL189680 | 67196 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 524 | 7 | 1 | 4 | 5.7 | O=C(NCC1CCCN(C2CCN(CCc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399469 | 165573 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL426089 | 165573 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399385 | 67285 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 498 | 6 | 2 | 3 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2[nH]ccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL190436 | 67285 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 498 | 6 | 2 | 3 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2[nH]ccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| 11540776 | 69118 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2cccnc12 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL193354 | 69118 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2cccnc12 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399272 | 67132 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1nccc2ccccc12 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL189206 | 67132 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1nccc2ccccc12 | 10.1016/j.bmcl.2005.04.054 | ||
| 11540776 | 69118 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2cccnc12 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL193354 | 69118 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2cccnc12 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399482 | 165475 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 498 | 6 | 2 | 3 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2[nH]ccc12 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL425548 | 165475 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 498 | 6 | 2 | 3 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2[nH]ccc12 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399443 | 68838 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3cc(Cl)ccc3Cl)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL192584 | 68838 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3cc(Cl)ccc3Cl)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399574 | 67449 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3cc(Cl)cc(Cl)c3)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL190894 | 67449 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3cc(Cl)cc(Cl)c3)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399389 | 126984 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 499 | 6 | 2 | 4 | 5.0 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2[nH]cnc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL366143 | 126984 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 499 | 6 | 2 | 4 | 5.0 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2[nH]cnc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399331 | 126995 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 509 | 6 | 1 | 3 | 6.3 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL366199 | 126995 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 509 | 6 | 1 | 3 | 6.3 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399395 | 67250 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 524 | 6 | 1 | 4 | 6.0 | CC1(N2CCCC(CNC(=O)c3ccc4ncccc4c3)C2)CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL190149 | 67250 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 524 | 6 | 1 | 4 | 6.0 | CC1(N2CCCC(CNC(=O)c3ccc4ncccc4c3)C2)CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399552 | 67121 | 0 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 397 | 5 | 1 | 3 | 3.8 | CC(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL189158 | 67121 | 0 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 397 | 5 | 1 | 3 | 3.8 | CC(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399524 | 134993 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 509 | 6 | 1 | 3 | 6.3 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2ccccc12 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL372868 | 134993 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 509 | 6 | 1 | 3 | 6.3 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2ccccc12 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399368 | 66858 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 473 | 6 | 1 | 3 | 5.4 | Cc1ccccc1C(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL187779 | 66858 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 473 | 6 | 1 | 3 | 5.4 | Cc1ccccc1C(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399303 | 67749 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 524 | 6 | 1 | 4 | 5.9 | CC1CN(Cc2ccc(Cl)c(Cl)c2)CCC1N1CCCC(CNC(=O)c2ccc3ncccc3c2)C1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL191464 | 67749 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 524 | 6 | 1 | 4 | 5.9 | CC1CN(Cc2ccc(Cl)c(Cl)c2)CCC1N1CCCC(CNC(=O)c2ccc3ncccc3c2)C1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399332 | 68940 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 524 | 6 | 1 | 4 | 6.2 | CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCC(CNC(=O)c3ccc4ncccc4c3)C2)CC1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL192757 | 68940 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 524 | 6 | 1 | 4 | 6.2 | CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCC(CNC(=O)c3ccc4ncccc4c3)C2)CC1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399290 | 67270 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 538 | 6 | 1 | 4 | 5.2 | O=C(NCC1CCCN(C2CCN(C(=O)Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL190312 | 67270 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 538 | 6 | 1 | 4 | 5.2 | O=C(NCC1CCCN(C2CCN(C(=O)Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399567 | 67434 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccnc2ccccc12 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL190852 | 67434 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 510 | 6 | 1 | 4 | 5.6 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccnc2ccccc12 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399407 | 67227 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 487 | 7 | 1 | 3 | 5.3 | Cc1ccccc1CC(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL189917 | 67227 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 487 | 7 | 1 | 3 | 5.3 | Cc1ccccc1CC(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399442 | 67312 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 489 | 7 | 1 | 4 | 5.1 | COc1ccccc1C(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL190646 | 67312 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 489 | 7 | 1 | 4 | 5.1 | COc1ccccc1C(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399537 | 67277 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 476 | 6 | 1 | 4 | 5.0 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)cc3)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL190362 | 67277 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 476 | 6 | 1 | 4 | 5.0 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)cc3)CC2)C1)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2005.04.054 | ||
| 44399479 | 67240 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 511 | 6 | 1 | 5 | 5.0 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cnnc2ccccc12 | 10.1016/j.bmcl.2005.04.054 | ||
| CHEMBL190048 | 67240 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 511 | 6 | 1 | 5 | 5.0 | O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cnnc2ccccc12 | 10.1016/j.bmcl.2005.04.054 | ||
| 3536 | 3843 | 0 | None | -9 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | Guide to Pharmacology | 515 | 5 | 1 | 2 | 7.3 | CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 | 10854442 | ||
| 44560289 | 3843 | 0 | None | -9 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | Guide to Pharmacology | 515 | 5 | 1 | 2 | 7.3 | CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 | 10854442 | ||
| CHEMBL1186993 | 3843 | 0 | None | -9 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | Guide to Pharmacology | 515 | 5 | 1 | 2 | 7.3 | CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 | 10854442 | ||
| 4382 | 820 | 0 | None | 25 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | None | None | None | None | 23951310 | ||||
| 9680 | 1867 | 4 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | 450 | 7 | 3 | 4 | 2.8 | O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl | 22931505 | ||
| 9825034 | 1867 | 4 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | 450 | 7 | 3 | 4 | 2.8 | O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl | 22931505 | ||
| CHEMBL2178574 | 1867 | 4 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | 450 | 7 | 3 | 4 | 2.8 | O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl | 22931505 | ||
| 776 | 840 | 0 | None | -1 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 10488147 | ||||
| 776 | 840 | 0 | None | -1 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 15207250 | ||||
| 776 | 840 | 0 | None | -1 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 16339911 | ||||
| 754 | 817 | 0 | None | 5 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | None | None | None | None | 9346309 | ||||
| 775 | 837 | 0 | None | 316 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 15207250 | ||||
| 775 | 837 | 0 | None | 316 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 16339911 | ||||
| 769 | 813 | 0 | None | 14 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | None | None | None | None | 10488147 | ||||
| 769 | 813 | 0 | None | 14 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | None | None | None | None | 10854442 | ||||
| 769 | 813 | 0 | None | 14 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | None | None | None | None | 12761559 | ||||
| 769 | 813 | 0 | None | 14 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | None | None | None | None | 16339911 | ||||
| 769 | 813 | 0 | None | 14 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | None | None | None | None | 9276730 | ||||
| 770 | 815 | 0 | None | 7 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Functional | Guide to Pharmacology | None | None | None | None | 16339911 | ||||
| 770 | 815 | 0 | None | 7 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Functional | Guide to Pharmacology | None | None | None | None | 9276730 | ||||
| 773 | 1906 | 0 | None | -12 | 2 | Human | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | None | None | None | None | 9789057 | ||||
| 10098735 | 3291 | 0 | None | - | 1 | Human | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | 537 | 10 | 2 | 5 | 6.1 | COc1cc(NC(=O)N[C@H](C(C)C)CN2CCC(CC2)Cc2ccc(c(c2)Cl)Cl)cc(c1OC)OC | 12070060 | ||
| 789 | 3291 | 0 | None | - | 1 | Human | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | 537 | 10 | 2 | 5 | 6.1 | COc1cc(NC(=O)N[C@H](C(C)C)CN2CCC(CC2)Cc2ccc(c(c2)Cl)Cl)cc(c1OC)OC | 12070060 | ||
| 11556309 | 4057 | 0 | None | - | 1 | Human | 7.9 | pIC50 | None | 7.9 | Functional | Guide to Pharmacology | 502 | 5 | 2 | 5 | 3.9 | O=C(C=C1CCN(CC1)C(=O)c1ncc(cc1O)C)N[C@@H]1CCN(C1)Cc1ccc2c(c1)ccc(c2)F | 16339911 | ||
| 793 | 4057 | 0 | None | - | 1 | Human | 7.9 | pIC50 | None | 7.9 | Functional | Guide to Pharmacology | 502 | 5 | 2 | 5 | 3.9 | O=C(C=C1CCN(CC1)C(=O)c1ncc(cc1O)C)N[C@@H]1CCN(C1)Cc1ccc2c(c1)ccc(c2)F | 16339911 | ||
| 788 | 2458 | 0 | None | - | 1 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 10640766 | ||||
| 10304110 | 3297 | 0 | None | - | 1 | Human | 8.3 | pIC50 | None | 8.3 | Functional | Guide to Pharmacology | 560 | 11 | 2 | 7 | 5.3 | COc1cc(ccc1OC)c1cnc(nc1)SCC(=O)NCC[C@H]1NC[C@@H](C1)Cc1ccc(c(c1)Cl)Cl | 12070060 | ||
| 792 | 3297 | 0 | None | - | 1 | Human | 8.3 | pIC50 | None | 8.3 | Functional | Guide to Pharmacology | 560 | 11 | 2 | 7 | 5.3 | COc1cc(ccc1OC)c1cnc(nc1)SCC(=O)NCC[C@H]1NC[C@@H](C1)Cc1ccc(c(c1)Cl)Cl | 12070060 | ||
| 10255622 | 3295 | 0 | None | - | 1 | Human | 8.4 | pIC50 | None | 8.4 | Functional | Guide to Pharmacology | 505 | 10 | 3 | 6 | 4.2 | COc1cc(NC(=O)N[C@H](C(O)C)CN2CCC(CC2)Cc2ccc(cc2)Cl)cc(c1OC)OC | 12070060 | ||
| 791 | 3295 | 0 | None | - | 1 | Human | 8.4 | pIC50 | None | 8.4 | Functional | Guide to Pharmacology | 505 | 10 | 3 | 6 | 4.2 | COc1cc(NC(=O)N[C@H](C(O)C)CN2CCC(CC2)Cc2ccc(cc2)Cl)cc(c1OC)OC | 12070060 | ||
| 790 | 3292 | 0 | None | - | 1 | Human | 9.0 | pIC50 | None | 9 | Functional | Guide to Pharmacology | 552 | 10 | 2 | 4 | 6.3 | COc1cc(NC(=O)N[C@H](C(C)C)C[N+]2(C)CCC(CC2)Cc2ccc(c(c2)Cl)Cl)cc(c1OC)OC | 12070060 | ||
| 9915610 | 3292 | 0 | None | - | 1 | Human | 9.0 | pIC50 | None | 9 | Functional | Guide to Pharmacology | 552 | 10 | 2 | 4 | 6.3 | COc1cc(NC(=O)N[C@H](C(C)C)C[N+]2(C)CCC(CC2)Cc2ccc(c(c2)Cl)Cl)cc(c1OC)OC | 12070060 | ||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 38347547 | 145922 | 5 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 430 | 11 | 0 | 7 | 4.5 | C=CCc1cc(OC)c(O[C@@H](C)[C@H](OC(C)=O)c2ccc(OC)c(OC)c2)c(OC)c1 | 10.1021/acs.jnatprod.6b00262 | ||
| CHEMBL3922119 | 145922 | 5 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 430 | 11 | 0 | 7 | 4.5 | C=CCc1cc(OC)c(O[C@@H](C)[C@H](OC(C)=O)c2ccc(OC)c(OC)c2)c(OC)c1 | 10.1021/acs.jnatprod.6b00262 | ||
| 25751147 | 149428 | 2 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 404 | 10 | 2 | 7 | 3.7 | C=CCc1cc(OC)c(O[C@H](C)[C@@H](O)c2cc(OC)c(O)c(OC)c2)c(OC)c1 | 10.1021/acs.jnatprod.6b00262 | ||
| CHEMBL3949874 | 149428 | 2 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 404 | 10 | 2 | 7 | 3.7 | C=CCc1cc(OC)c(O[C@H](C)[C@@H](O)c2cc(OC)c(O)c(OC)c2)c(OC)c1 | 10.1021/acs.jnatprod.6b00262 | ||
| 124396489 | 143931 | 2 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 356 | 5 | 1 | 5 | 4.7 | C/C=C/c1cc(OC)c2c(c1)[C@@H](C)[C@H](c1cc(OC)c(O)c(OC)c1)O2 | 10.1021/acs.jnatprod.6b00262 | ||
| CHEMBL3906647 | 143931 | 2 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 356 | 5 | 1 | 5 | 4.7 | C/C=C/c1cc(OC)c2c(c1)[C@@H](C)[C@H](c1cc(OC)c(O)c(OC)c1)O2 | 10.1021/acs.jnatprod.6b00262 | ||
| 10474776 | 113158 | 36 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1021/acs.jnatprod.6b00262 | ||
| CHEMBL33227 | 113158 | 36 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1021/acs.jnatprod.6b00262 | ||
| 11272103 | 123856 | 0 | None | - | 0 | Rat | 11.0 | pIC50 | = | 11 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL363840 | 123856 | 0 | None | - | 0 | Rat | 11.0 | pIC50 | = | 11 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 44570583 | 190348 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 550 | 7 | 2 | 8 | 3.3 | CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL505914 | 190348 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 550 | 7 | 2 | 8 | 3.3 | CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL518571 | 190348 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 550 | 7 | 2 | 8 | 3.3 | CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| 44570583 | 190348 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 550 | 7 | 2 | 8 | 3.3 | CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL505914 | 190348 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 550 | 7 | 2 | 8 | 3.3 | CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL518571 | 190348 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 550 | 7 | 2 | 8 | 3.3 | CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| 44593547 | 176292 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 538 | 10 | 2 | 8 | 3.3 | CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL461445 | 176292 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 538 | 10 | 2 | 8 | 3.3 | CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2008.11.002 | ||
| 44447136 | 94116 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 469 | 11 | 3 | 7 | 2.8 | CCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL251837 | 94116 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 469 | 11 | 3 | 7 | 2.8 | CCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447381 | 94450 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 511 | 12 | 3 | 7 | 3.8 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)CCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL254095 | 94450 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 511 | 12 | 3 | 7 | 3.8 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)CCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447137 | 153619 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 483 | 12 | 3 | 7 | 3.2 | CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL398548 | 153619 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 483 | 12 | 3 | 7 | 3.2 | CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44570537 | 177585 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 536 | 7 | 2 | 8 | 2.9 | CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL464902 | 177585 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 536 | 7 | 2 | 8 | 2.9 | CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| 10050884 | 154115 | 10 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL399495 | 154115 | 10 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2008.11.002 | ||
| 44447143 | 94151 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 469 | 11 | 4 | 7 | 2.7 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CNCCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL252035 | 94151 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 469 | 11 | 4 | 7 | 2.7 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CNCCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 10050884 | 154115 | 10 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL399495 | 154115 | 10 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447144 | 168207 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 483 | 11 | 3 | 7 | 3.0 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL437396 | 168207 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 483 | 11 | 3 | 7 | 3.0 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 10050884 | 154115 | 10 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL399495 | 154115 | 10 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455658 | 166720 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 479 | 8 | 3 | 5 | 4.4 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL429323 | 166720 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 479 | 8 | 3 | 5 | 4.4 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11488078 | 78591 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL2113077 | 78591 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44593553 | 177792 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 489 | 6 | 2 | 6 | 3.9 | Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL465272 | 177792 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 489 | 6 | 2 | 6 | 3.9 | Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 | 10.1016/j.bmcl.2008.11.002 | ||
| 44447139 | 94117 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 495 | 12 | 3 | 7 | 3.2 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC1CC1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL251838 | 94117 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 495 | 12 | 3 | 7 | 3.2 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC1CC1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447135 | 94238 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 455 | 10 | 3 | 7 | 2.5 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)CCCc1ccc(F)cc1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL252631 | 94238 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 455 | 10 | 3 | 7 | 2.5 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)CCCc1ccc(F)cc1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447361 | 94512 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 453 | 9 | 4 | 8 | 1.8 | C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL254503 | 94512 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 453 | 9 | 4 | 8 | 1.8 | C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447138 | 154279 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.0 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CC1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL400378 | 154279 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.0 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CC1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447382 | 166060 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 497 | 12 | 3 | 7 | 3.4 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL428062 | 166060 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 497 | 12 | 3 | 7 | 3.4 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 10050884 | 154115 | 10 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL399495 | 154115 | 10 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 481 | 8 | 3 | 7 | 2.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44455841 | 154906 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 509 | 9 | 3 | 7 | 3.8 | CC(C)[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL403838 | 154906 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 509 | 9 | 3 | 7 | 3.8 | CC(C)[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11328714 | 78588 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 462 | 6 | 3 | 2 | 5.9 | O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL2113074 | 78588 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 462 | 6 | 3 | 2 | 5.9 | O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44593547 | 176292 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 538 | 10 | 2 | 8 | 3.3 | CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL461445 | 176292 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 538 | 10 | 2 | 8 | 3.3 | CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2008.11.002 | ||
| 44419331 | 82362 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 453 | 9 | 3 | 4 | 4.7 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL217987 | 82362 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 453 | 9 | 3 | 4 | 4.7 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 25032958 | 94112 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 481 | 10 | 4 | 8 | 2.4 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)[C@@H](C)[C@@H](O)c2ccccc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL251822 | 94112 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 481 | 10 | 4 | 8 | 2.4 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)[C@@H](C)[C@@H](O)c2ccccc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447145 | 94536 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 511 | 13 | 3 | 7 | 3.8 | CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cc(CC)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL254676 | 94536 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 511 | 13 | 3 | 7 | 3.8 | CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cc(CC)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44455744 | 94987 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 495 | 8 | 3 | 7 | 3.5 | Cc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL257029 | 94987 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 495 | 8 | 3 | 7 | 3.5 | Cc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455817 | 154639 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 538 | 9 | 3 | 8 | 3.6 | CNC(=O)O[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL402331 | 154639 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 538 | 9 | 3 | 8 | 3.6 | CNC(=O)O[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455788 | 155078 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 10 | 2 | 7 | 4.3 | CCc1cc(NC(=O)N[C@H](C)C[C@@H](N(C)C)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL404585 | 155078 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 10 | 2 | 7 | 4.3 | CCc1cc(NC(=O)N[C@H](C)C[C@@H](N(C)C)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11329244 | 70772 | 10 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | ||
| CHEMBL195433 | 70772 | 10 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | ||
| 11272103 | 123856 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL363840 | 123856 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 6918497 | 112931 | 1 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL277930 | 112931 | 1 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL331897 | 112931 | 1 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1016/s0960-894x(03)00748-0 | ||
| 6918497 | 112931 | 1 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1016/s0960-894x(01)00176-7 | ||
| CHEMBL277930 | 112931 | 1 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1016/s0960-894x(01)00176-7 | ||
| CHEMBL331897 | 112931 | 1 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1016/s0960-894x(01)00176-7 | ||
| 6918497 | 112931 | 1 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| CHEMBL277930 | 112931 | 1 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| CHEMBL331897 | 112931 | 1 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| 11236950 | 94326 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.3 | CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL253210 | 94326 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.3 | CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447146 | 94537 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 509 | 12 | 3 | 7 | 3.5 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C2CC2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL254677 | 94537 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 509 | 12 | 3 | 7 | 3.5 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C2CC2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447147 | 94563 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 523 | 13 | 3 | 7 | 3.8 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC2CC2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL254881 | 94563 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 523 | 13 | 3 | 7 | 3.8 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC2CC2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44445886 | 93784 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 544 | 7 | 3 | 6 | 3.9 | CNC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249857 | 93784 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 544 | 7 | 3 | 6 | 3.9 | CNC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44455844 | 96966 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 509 | 10 | 3 | 7 | 4.0 | CCC[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL269933 | 96966 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 509 | 10 | 3 | 7 | 4.0 | CCC[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455791 | 155079 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 522 | 9 | 3 | 7 | 3.3 | CC(=O)N[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL404586 | 155079 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 522 | 9 | 3 | 7 | 3.3 | CC(=O)N[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44289927 | 167764 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL43423 | 167764 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11698698 | 122724 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 481 | 8 | 2 | 6 | 4.2 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3cccc(Cl)c3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL361369 | 122724 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 481 | 8 | 2 | 6 | 4.2 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3cccc(Cl)c3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44289927 | 167764 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL43423 | 167764 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44390955 | 123173 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 4.3 | CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CCC2(C)C)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL362179 | 123173 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 4.3 | CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CCC2(C)C)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44419344 | 141241 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 495 | 11 | 2 | 4 | 5.9 | CCCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL386073 | 141241 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 495 | 11 | 2 | 4 | 5.9 | CCCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 11272103 | 123856 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL363840 | 123856 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44445865 | 154316 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 544 | 7 | 3 | 6 | 3.9 | CNC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL400589 | 154316 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 544 | 7 | 3 | 6 | 3.9 | CNC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44455461 | 155082 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 551 | 10 | 3 | 7 | 4.2 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)C(=O)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL404618 | 155082 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 551 | 10 | 3 | 7 | 4.2 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)C(=O)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44390838 | 127988 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.7 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL366710 | 127988 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.7 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 11398022 | 98178 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 | 10.1021/jm049530m | ||
| CHEMBL277131 | 98178 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 | 10.1021/jm049530m | ||
| 11272103 | 123856 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL363840 | 123856 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 11397114 | 132948 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL3706810 | 132948 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 10459751 | 99710 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 533 | 9 | 2 | 10 | 2.7 | Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL288009 | 99710 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 533 | 9 | 2 | 10 | 2.7 | Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44289701 | 100637 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 508 | 9 | 3 | 7 | 2.8 | CNC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL295081 | 100637 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 508 | 9 | 3 | 7 | 2.8 | CNC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44455793 | 94783 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 483 | 9 | 3 | 5 | 4.4 | CC(=O)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL256068 | 94783 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 483 | 9 | 3 | 5 | 4.4 | CC(=O)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455625 | 97141 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 565 | 9 | 3 | 7 | 6.2 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nccs2)cc(-c2nccs2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL270806 | 97141 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 565 | 9 | 3 | 7 | 6.2 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nccs2)cc(-c2nccs2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11227406 | 93909 | 1 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL250689 | 93909 | 1 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 44419295 | 82802 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 497 | 11 | 3 | 5 | 4.4 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCO)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL218568 | 82802 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 497 | 11 | 3 | 5 | 4.4 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCO)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44419298 | 137611 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 509 | 11 | 2 | 5 | 5.0 | CC(=O)CN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL376737 | 137611 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 509 | 11 | 2 | 5 | 5.0 | CC(=O)CN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 11329244 | 70772 | 10 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL195433 | 70772 | 10 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445863 | 94019 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 559 | 9 | 2 | 7 | 3.7 | COCC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251275 | 94019 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 559 | 9 | 2 | 7 | 3.7 | COCC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44445872 | 94077 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 533 | 9 | 2 | 6 | 4.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CCF)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251622 | 94077 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 533 | 9 | 2 | 6 | 4.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CCF)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445868 | 166422 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 567 | 9 | 2 | 7 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(Cc3ccco3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL428761 | 166422 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 567 | 9 | 2 | 7 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(Cc3ccco3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 11329244 | 70772 | 10 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | ||
| CHEMBL195433 | 70772 | 10 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | ||
| 11156406 | 124651 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL364508 | 124651 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44290100 | 178045 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 481 | 9 | 3 | 7 | 3.0 | Cn1nnnc1-c1cc(CO)cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL46747 | 178045 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 481 | 9 | 3 | 7 | 3.0 | Cn1nnnc1-c1cc(CO)cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44419345 | 82741 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 493 | 11 | 2 | 4 | 5.6 | C=CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL218262 | 82741 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 493 | 11 | 2 | 4 | 5.6 | C=CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 11272103 | 123856 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL363840 | 123856 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44445842 | 155037 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 488 | 7 | 2 | 6 | 4.3 | CC(=O)c1sc(NC(=O)N[C@@H]2COCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL404416 | 155037 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 488 | 7 | 2 | 6 | 4.3 | CC(=O)c1sc(NC(=O)N[C@@H]2COCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44455686 | 95048 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 523 | 9 | 3 | 7 | 4.3 | CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL257293 | 95048 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 523 | 9 | 3 | 7 | 4.3 | CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455871 | 97097 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 495 | 9 | 3 | 7 | 3.6 | CC[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL270583 | 97097 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 495 | 9 | 3 | 7 | 3.6 | CC[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11272103 | 123856 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL363840 | 123856 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455511 | 154488 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.0 | CCc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL401545 | 154488 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.0 | CCc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44295462 | 187825 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 519 | 12 | 3 | 7 | 4.3 | CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50194 | 187825 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 519 | 12 | 3 | 7 | 4.3 | CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295536 | 187851 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 479 | 12 | 3 | 4 | 5.3 | CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50233 | 187851 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 479 | 12 | 3 | 4 | 5.3 | CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 9892753 | 16323 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 516 | 8 | 3 | 4 | 5.5 | CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm049530m | ||
| CHEMBL123611 | 16323 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 516 | 8 | 3 | 4 | 5.5 | CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm049530m | ||
| 11213416 | 132950 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2nc[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL3706812 | 132950 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2nc[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11169258 | 140366 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 587 | 8 | 2 | 10 | 3.8 | Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1021/jm049530m | ||
| CHEMBL382108 | 140366 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 587 | 8 | 2 | 10 | 3.8 | Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1021/jm049530m | ||
| 11966688 | 12266 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 518 | 7 | 2 | 4 | 6.0 | CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2C[N+]2(C)CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| CHEMBL1185532 | 12266 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 518 | 7 | 2 | 4 | 6.0 | CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2C[N+]2(C)CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| CHEMBL419599 | 12266 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 518 | 7 | 2 | 4 | 6.0 | CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2C[N+]2(C)CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| 9892753 | 16323 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 516 | 8 | 3 | 4 | 5.5 | CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL123611 | 16323 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 516 | 8 | 3 | 4 | 5.5 | CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 11730796 | 116328 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 499 | 7 | 3 | 4 | 5.2 | CNC(=O)c1cccc(NC(=O)Nc2cccc(C#N)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL337962 | 116328 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 499 | 7 | 3 | 4 | 5.2 | CNC(=O)c1cccc(NC(=O)Nc2cccc(C#N)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 44570617 | 177801 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 531 | 7 | 2 | 7 | 4.1 | CC(=O)c1sc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL465291 | 177801 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 531 | 7 | 2 | 7 | 4.1 | CC(=O)c1sc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2008.11.002 | ||
| 44445885 | 168442 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 558 | 8 | 3 | 6 | 4.3 | CCNC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL439253 | 168442 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 558 | 8 | 3 | 6 | 4.3 | CCNC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44455483 | 97380 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 537 | 10 | 3 | 7 | 3.8 | Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)(C)C(=O)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL272068 | 97380 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 537 | 10 | 3 | 7 | 3.8 | Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)(C)C(=O)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455458 | 166897 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 533 | 9 | 3 | 7 | 5.3 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ccon2)cc(-c2ccon2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL429846 | 166897 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 533 | 9 | 3 | 7 | 5.3 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ccon2)cc(-c2ccon2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44400941 | 68522 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 426 | 6 | 3 | 3 | 3.9 | O=C(NC1C=CC=CN1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL192240 | 68522 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 426 | 6 | 3 | 3 | 3.9 | O=C(NC1C=CC=CN1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11409583 | 69439 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 507 | 8 | 2 | 4 | 5.9 | CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1021/jm049530m | ||
| CHEMBL193575 | 69439 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 507 | 8 | 2 | 4 | 5.9 | CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1021/jm049530m | ||
| 44445901 | 159660 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 501 | 7 | 2 | 6 | 4.2 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL410959 | 159660 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 501 | 7 | 2 | 6 | 4.2 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2008.11.002 | ||
| 44447375 | 94332 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 527 | 12 | 4 | 8 | 2.8 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)[C@@H](O)Cc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL253244 | 94332 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 527 | 12 | 4 | 8 | 2.8 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)[C@@H](O)Cc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44445854 | 93649 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 522 | 7 | 2 | 7 | 3.3 | CC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249057 | 93649 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 522 | 7 | 2 | 7 | 3.3 | CC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445891 | 93984 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 533 | 9 | 2 | 6 | 4.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(CCF)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251044 | 93984 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 533 | 9 | 2 | 6 | 4.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(CCF)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445915 | 154890 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 599 | 8 | 2 | 7 | 4.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CCOCC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL403742 | 154890 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 599 | 8 | 2 | 7 | 4.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CCOCC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445888 | 155118 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 526 | 8 | 2 | 7 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC#N)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL404857 | 155118 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 526 | 8 | 2 | 7 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC#N)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445901 | 159660 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 501 | 7 | 2 | 6 | 4.2 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL410959 | 159660 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 501 | 7 | 2 | 6 | 4.2 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44455818 | 94997 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 523 | 10 | 3 | 7 | 4.2 | CC(C)C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL257073 | 94997 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 523 | 10 | 3 | 7 | 4.2 | CC(C)C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455510 | 95146 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 479 | 8 | 2 | 6 | 4.2 | Cc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL257737 | 95146 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 479 | 8 | 2 | 6 | 4.2 | Cc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455790 | 95278 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 480 | 8 | 3 | 7 | 3.2 | C[C@H](C[C@@H](N)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL258322 | 95278 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 480 | 8 | 3 | 7 | 3.2 | C[C@H](C[C@@H](N)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44289926 | 176985 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 453 | 9 | 2 | 4 | 4.7 | CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL46404 | 176985 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 453 | 9 | 2 | 4 | 4.7 | CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44390883 | 63743 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.8 | CCc1cc(NC(=O)N[C@@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL180746 | 63743 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.8 | CCc1cc(NC(=O)N[C@@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 11167549 | 78590 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 480 | 6 | 2 | 4 | 6.1 | O=C(Nc1ccc2ncsc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL2113076 | 78590 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 480 | 6 | 2 | 4 | 6.1 | O=C(Nc1ccc2ncsc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44290018 | 166151 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 4.0 | CCn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL42826 | 166151 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 4.0 | CCn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44289741 | 170163 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 2 | 6 | 4.5 | Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL44522 | 170163 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 2 | 6 | 4.5 | Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44289926 | 176985 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 453 | 9 | 2 | 4 | 4.7 | CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL46404 | 176985 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 453 | 9 | 2 | 4 | 4.7 | CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44419296 | 140918 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 511 | 12 | 3 | 5 | 4.8 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCCO)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL384199 | 140918 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 511 | 12 | 3 | 5 | 4.8 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCCO)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44445884 | 93782 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 559 | 9 | 2 | 7 | 3.7 | COCC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249855 | 93782 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 559 | 9 | 2 | 7 | 3.7 | COCC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44445867 | 93856 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 526 | 8 | 2 | 7 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC#N)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL250437 | 93856 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 526 | 8 | 2 | 7 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC#N)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 16747712 | 154315 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 529 | 7 | 2 | 6 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(C)=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL400588 | 154315 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 529 | 7 | 2 | 6 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(C)=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445870 | 166711 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 543 | 9 | 2 | 7 | 4.1 | CC(=O)CN1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL429303 | 166711 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 543 | 9 | 2 | 7 | 4.1 | CC(=O)CN1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44455539 | 166429 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.9 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL428775 | 166429 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.9 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 10096657 | 64523 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 479 | 8 | 2 | 6 | 3.9 | CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL182086 | 64523 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 479 | 8 | 2 | 6 | 3.9 | CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 11306550 | 78593 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 497 | 6 | 3 | 3 | 6.0 | O=C(Nc1ccc2[nH]nc(Cl)c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL2113079 | 78593 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 497 | 6 | 3 | 3 | 6.0 | O=C(Nc1ccc2[nH]nc(Cl)c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44419328 | 82895 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 411 | 8 | 3 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL219048 | 82895 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 411 | 8 | 3 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44445895 | 94013 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 584 | 8 | 2 | 7 | 4.7 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C3CCN(C)CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251220 | 94013 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 584 | 8 | 2 | 7 | 4.7 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C3CCN(C)CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44455482 | 97379 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 533 | 9 | 3 | 9 | 3.2 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2ccnn2)cc(-n2ccnn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL272067 | 97379 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 533 | 9 | 3 | 9 | 3.2 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2ccnn2)cc(-n2ccnn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11363005 | 60182 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL175634 | 60182 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11442162 | 70324 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 5.2 | Cc1csc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 | 10.1021/jm049530m | ||
| CHEMBL195044 | 70324 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 5.2 | Cc1csc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 | 10.1021/jm049530m | ||
| 11454941 | 70798 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL195555 | 70798 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 44445864 | 94046 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 558 | 8 | 3 | 6 | 4.3 | CCNC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251446 | 94046 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 558 | 8 | 3 | 6 | 4.3 | CCNC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44445916 | 154891 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 599 | 8 | 2 | 7 | 4.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CCOCC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL403743 | 154891 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 599 | 8 | 2 | 7 | 4.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CCOCC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44455820 | 94998 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 11 | 3 | 7 | 4.9 | CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL257074 | 94998 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 11 | 3 | 7 | 4.9 | CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455869 | 97096 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 507 | 9 | 2 | 7 | 4.1 | CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL270582 | 97096 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 507 | 9 | 2 | 7 | 4.1 | CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44289715 | 169668 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.8 | Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL444568 | 169668 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.8 | Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11340670 | 126712 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 483 | 7 | 2 | 3 | 5.8 | CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F | 10.1021/jm049530m | ||
| CHEMBL365820 | 126712 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 483 | 7 | 2 | 3 | 5.8 | CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F | 10.1021/jm049530m | ||
| 44289715 | 169668 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.8 | Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL444568 | 169668 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.8 | Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44445887 | 93785 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 572 | 9 | 2 | 7 | 3.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)CN(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249858 | 93785 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 572 | 9 | 2 | 7 | 3.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)CN(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445866 | 154424 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 572 | 9 | 2 | 7 | 3.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)CN(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL401159 | 154424 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 572 | 9 | 2 | 7 | 3.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)CN(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44455847 | 154907 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 501 | 9 | 2 | 6 | 4.7 | O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL403839 | 154907 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 501 | 9 | 2 | 6 | 4.7 | O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 10322255 | 62198 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.7 | CCc1cc(NC(=O)NC[C@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL178230 | 62198 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.7 | CCc1cc(NC(=O)NC[C@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44390945 | 62620 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 507 | 9 | 2 | 6 | 4.5 | CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C(C)C)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL178503 | 62620 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 507 | 9 | 2 | 6 | 4.5 | CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C(C)C)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 11154845 | 60393 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 437 | 6 | 2 | 2 | 5.8 | Cc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL176077 | 60393 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 437 | 6 | 2 | 2 | 5.8 | Cc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11454015 | 132951 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 462 | 6 | 3 | 2 | 5.9 | O=C(Nc1ccc2cc[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL3706813 | 132951 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 462 | 6 | 3 | 2 | 5.9 | O=C(Nc1ccc2cc[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 16126667 | 82653 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 425 | 8 | 2 | 3 | 4.9 | CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL218174 | 82653 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 425 | 8 | 2 | 3 | 4.9 | CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44445839 | 154982 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 488 | 7 | 2 | 6 | 4.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCO[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL404213 | 154982 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 488 | 7 | 2 | 6 | 4.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCO[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44455846 | 97011 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 515 | 9 | 2 | 6 | 5.1 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL270147 | 97011 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 515 | 9 | 2 | 6 | 5.1 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455765 | 154821 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 543 | 8 | 2 | 6 | 4.6 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL403331 | 154821 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 543 | 8 | 2 | 6 | 4.6 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11751629 | 78594 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 464 | 6 | 3 | 3 | 5.4 | O=C(Nc1ccc2c(c1)CCN2)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL2113080 | 78594 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 464 | 6 | 3 | 3 | 5.4 | O=C(Nc1ccc2c(c1)CCN2)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 10458976 | 94569 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 509 | 9 | 3 | 7 | 3.4 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL254930 | 94569 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 509 | 9 | 3 | 7 | 3.4 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44445873 | 154425 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 572 | 9 | 2 | 7 | 3.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC(=O)N(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL401160 | 154425 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 572 | 9 | 2 | 7 | 3.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC(=O)N(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44455766 | 95241 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 479 | 8 | 2 | 6 | 4.3 | C[C@H](C[C@@H](C)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL258156 | 95241 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 479 | 8 | 2 | 6 | 4.3 | C[C@H](C[C@@H](C)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455745 | 154762 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 559 | 8 | 3 | 7 | 4.0 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL402983 | 154762 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 559 | 8 | 3 | 7 | 4.0 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455711 | 168168 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 509 | 9 | 3 | 7 | 3.8 | CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL437031 | 168168 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 509 | 9 | 3 | 7 | 3.8 | CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44390938 | 62626 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 483 | 8 | 2 | 6 | 3.8 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3F)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL178506 | 62626 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 483 | 8 | 2 | 6 | 3.8 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3F)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 11351206 | 69080 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 441 | 6 | 2 | 2 | 5.6 | O=C(Nc1ccccc1F)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL193330 | 69080 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 441 | 6 | 2 | 2 | 5.6 | O=C(Nc1ccccc1F)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11477384 | 132949 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 490 | 6 | 3 | 2 | 6.6 | Cc1[nH]c2cc(NC(=O)N[C@@H]3CCCC[C@H]3CN3CCC[C@@H](Cc4ccc(F)cc4)C3)ccc2c1C | 10.1021/jm049530m | ||
| CHEMBL3706811 | 132949 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 490 | 6 | 3 | 2 | 6.6 | Cc1[nH]c2cc(NC(=O)N[C@@H]3CCCC[C@H]3CN3CCC[C@@H](Cc4ccc(F)cc4)C3)ccc2c1C | 10.1021/jm049530m | ||
| 44419301 | 83668 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 491 | 10 | 2 | 4 | 5.1 | C#CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL220765 | 83668 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 491 | 10 | 2 | 4 | 5.1 | C#CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 11953409 | 93781 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 7 | 2 | 6 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249854 | 93781 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 7 | 2 | 6 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445845 | 93807 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 487 | 7 | 3 | 6 | 3.8 | CC(=O)c1sc(NC(=O)N[C@@H]2CCNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL250056 | 93807 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 487 | 7 | 3 | 6 | 3.8 | CC(=O)c1sc(NC(=O)N[C@@H]2CCNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44390837 | 63217 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.0 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL180042 | 63217 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.0 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 11419003 | 70564 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 430 | 6 | 2 | 4 | 4.9 | O=C(Nc1nccs1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL195129 | 70564 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 430 | 6 | 2 | 4 | 4.9 | O=C(Nc1nccs1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44401328 | 70752 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 462 | 6 | 3 | 2 | 5.9 | O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL195348 | 70752 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 462 | 6 | 3 | 2 | 5.9 | O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11373714 | 126653 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 427 | 6 | 2 | 4 | 4.2 | Cn1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 | 10.1021/jm049530m | ||
| CHEMBL365732 | 126653 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 427 | 6 | 2 | 4 | 4.2 | Cn1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 | 10.1021/jm049530m | ||
| 9680 | 1867 | 4 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 450 | 7 | 3 | 4 | 2.8 | O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl | 10.1021/jm300682j | ||
| 9825034 | 1867 | 4 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 450 | 7 | 3 | 4 | 2.8 | O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl | 10.1021/jm300682j | ||
| CHEMBL2178574 | 1867 | 4 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 450 | 7 | 3 | 4 | 2.8 | O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl | 10.1021/jm300682j | ||
| 22393282 | 100736 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL295832 | 100736 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393282 | 100736 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| CHEMBL295832 | 100736 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| 11385178 | 124287 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 441 | 6 | 2 | 2 | 5.6 | O=C(Nc1cccc(F)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL364263 | 124287 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 441 | 6 | 2 | 2 | 5.6 | O=C(Nc1cccc(F)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 22393282 | 100736 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL295832 | 100736 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44440398 | 92901 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 584 | 8 | 0 | 5 | 6.3 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(C2CCCCC2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL245310 | 92901 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 584 | 8 | 0 | 5 | 6.3 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(C2CCCCC2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44440420 | 93099 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 608 | 9 | 0 | 6 | 5.8 | COc1ccc(-n2c(=O)c(CN(CCc3ccc(Cl)cc3)C3CCN(C(=O)c4c(F)cccc4F)CC3)c(C)n2C)cc1 | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL246347 | 93099 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 608 | 9 | 0 | 6 | 5.8 | COc1ccc(-n2c(=O)c(CN(CCc3ccc(Cl)cc3)C3CCN(C(=O)c4c(F)cccc4F)CC3)c(C)n2C)cc1 | 10.1016/j.bmcl.2007.05.035 | ||
| 44440424 | 148728 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 621 | 9 | 0 | 6 | 5.8 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(N(C)C)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL394443 | 148728 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 621 | 9 | 0 | 6 | 5.8 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(N(C)C)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44440426 | 148731 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 613 | 8 | 0 | 6 | 5.8 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2cnccc2Cl)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL394444 | 148731 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 613 | 8 | 0 | 6 | 5.8 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2cnccc2Cl)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44440411 | 149558 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 596 | 8 | 0 | 5 | 5.9 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2cccc(F)c2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL395090 | 149558 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 596 | 8 | 0 | 5 | 5.9 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2cccc(F)c2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44440414 | 150491 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 594 | 8 | 1 | 6 | 5.5 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(O)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL395851 | 150491 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 594 | 8 | 1 | 6 | 5.5 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(O)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44440417 | 150494 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 623 | 9 | 0 | 7 | 5.7 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc([N+](=O)[O-])cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL395852 | 150494 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 623 | 9 | 0 | 7 | 5.7 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc([N+](=O)[O-])cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44295264 | 186892 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 435 | 8 | 2 | 3 | 5.6 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2ccco2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL49404 | 186892 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 435 | 8 | 2 | 3 | 5.6 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2ccco2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295664 | 188110 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 435 | 10 | 2 | 3 | 5.5 | CCC[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50423 | 188110 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 435 | 10 | 2 | 3 | 5.5 | CCC[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295405 | 188493 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 435 | 8 | 3 | 3 | 4.7 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2ncc[nH]2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50988 | 188493 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 435 | 8 | 3 | 3 | 4.7 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2ncc[nH]2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393436 | 188721 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 375 | 7 | 2 | 2 | 4.1 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NC1CCCCC1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51229 | 188721 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 375 | 7 | 2 | 2 | 4.1 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NC1CCCCC1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295567 | 190059 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 465 | 10 | 3 | 4 | 4.7 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](O)C(C)C)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51815 | 190059 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 465 | 10 | 3 | 4 | 4.7 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](O)C(C)C)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 9979012 | 79392 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 411 | 7 | 1 | 5 | 4.4 | O=C(CSc1nc2ccccc2s1)NCC1CCCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(01)00176-7 | ||
| CHEMBL21199 | 79392 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 411 | 7 | 1 | 5 | 4.4 | O=C(CSc1nc2ccccc2s1)NCC1CCCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(01)00176-7 | ||
| 44273640 | 98471 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 417 | 7 | 1 | 5 | 4.8 | O=C(CSc1nc2ccccc2s1)NCC1CCCN(CC2CCCCC2)C1 | 10.1016/s0960-894x(01)00176-7 | ||
| CHEMBL279450 | 98471 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 417 | 7 | 1 | 5 | 4.8 | O=C(CSc1nc2ccccc2s1)NCC1CCCN(CC2CCCCC2)C1 | 10.1016/s0960-894x(01)00176-7 | ||
| 57401421 | 67523 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 486 | 6 | 1 | 3 | 5.1 | O=C(NCCCN1CCC(c2ccc(F)cc2)CC1)C1=Cc2cc(Br)ccc2OCC1 | 10.1016/j.bmcl.2011.09.013 | ||
| CHEMBL1910161 | 67523 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 486 | 6 | 1 | 3 | 5.1 | O=C(NCCCN1CCC(c2ccc(F)cc2)CC1)C1=Cc2cc(Br)ccc2OCC1 | 10.1016/j.bmcl.2011.09.013 | ||
| 44440435 | 93006 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 563 | 8 | 0 | 6 | 4.6 | Cc1c(CN(CCc2ccccn2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL245956 | 93006 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 563 | 8 | 0 | 6 | 4.6 | Cc1c(CN(CCc2ccccn2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44295529 | 186717 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 368 | 8 | 1 | 2 | 4.3 | O=C(NCCCCN1CCC(Cc2ccccc2)CC1)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL49296 | 186717 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 368 | 8 | 1 | 2 | 4.3 | O=C(NCCCCN1CCC(Cc2ccccc2)CC1)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44349617 | 117615 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 336 | 4 | 0 | 2 | 4.0 | Fc1ccc(CCCN2CCC3C(C2)c2cccc4c2N3CC4)cc1 | 10.1021/jm0201767 | ||
| CHEMBL340770 | 117615 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 336 | 4 | 0 | 2 | 4.0 | Fc1ccc(CCCN2CCC3C(C2)c2cccc4c2N3CC4)cc1 | 10.1021/jm0201767 | ||
| 5481702 | 204109 | 1 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 556 | 8 | 0 | 4 | 5.3 | CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 | 10.1016/s0960-894x(00)00639-9 | ||
| CHEMBL83338 | 204109 | 1 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 556 | 8 | 0 | 4 | 5.3 | CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 | 10.1016/s0960-894x(00)00639-9 | ||
| 44442590 | 93339 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 606 | 11 | 6 | 5 | 3.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | ||
| CHEMBL247455 | 93339 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 606 | 11 | 6 | 5 | 3.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | ||
| 44295435 | 189061 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 415 | 6 | 1 | 4 | 2.7 | O=S(=O)(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51512 | 189061 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 415 | 6 | 1 | 4 | 2.7 | O=S(=O)(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44346194 | 15373 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 501 | 9 | 2 | 5 | 5.4 | COc1cc(NC(=O)N[C@H](C)CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)cc(OC)c1OC | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL121905 | 15373 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 501 | 9 | 2 | 5 | 5.4 | COc1cc(NC(=O)N[C@H](C)CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)cc(OC)c1OC | 10.1016/s0960-894x(03)00748-0 | ||
| 11006582 | 11351 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 483 | 6 | 2 | 4 | 5.5 | C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL1180359 | 11351 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 483 | 6 | 2 | 4 | 5.5 | C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL123616 | 11351 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 483 | 6 | 2 | 4 | 5.5 | C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 11059789 | 16593 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 472 | 7 | 3 | 4 | 5.3 | N#Cc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL124438 | 16593 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 472 | 7 | 3 | 4 | 5.3 | N#Cc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 10983981 | 16669 | 1 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 505 | 8 | 2 | 5 | 5.7 | COC(=O)c1cccc(NC(=O)Nc2cccc(OC)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124821 | 16669 | 1 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 505 | 8 | 2 | 5 | 5.7 | COC(=O)c1cccc(NC(=O)Nc2cccc(OC)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 10895831 | 117909 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 461 | 8 | 2 | 3 | 6.0 | COc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL341074 | 117909 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 461 | 8 | 2 | 3 | 6.0 | COc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 44295486 | 101029 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 502 | 5 | 2 | 3 | 4.0 | O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1cccc(I)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL297945 | 101029 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 502 | 5 | 2 | 3 | 4.0 | O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1cccc(I)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 20576924 | 188650 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 364 | 5 | 0 | 3 | 4.0 | O=C(CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51163 | 188650 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 364 | 5 | 0 | 3 | 4.0 | O=C(CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 45270199 | 194744 | 0 | None | - | 0 | Mouse | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 516 | 5 | 1 | 4 | 4.2 | O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL562897 | 194744 | 0 | None | - | 0 | Mouse | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 516 | 5 | 1 | 4 | 4.2 | O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 | 10.1016/j.bmc.2009.06.066 | ||
| 44295408 | 188213 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 3.7 | O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)C1CCCCC1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50591 | 188213 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 3.7 | O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)C1CCCCC1 | 10.1016/s0960-894x(02)00206-8 | ||
| 11101888 | 112807 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 421 | 5 | 2 | 2 | 6.0 | O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(c2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL331530 | 112807 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 421 | 5 | 2 | 2 | 6.0 | O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(c2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 10983308 | 17794 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 454 | 7 | 3 | 4 | 5.1 | N#Cc1cccc(NC(=O)Nc2cc(CO)ccc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL126174 | 17794 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 454 | 7 | 3 | 4 | 5.1 | N#Cc1cccc(NC(=O)Nc2cc(CO)ccc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| 57392726 | 67529 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 490 | 8 | 0 | 5 | 4.2 | COc1ccc(OC)c(S(=O)(=O)N2CCC(CN3CCC(Cc4ccc(F)cc4)CC3)CC2)c1 | 10.1016/j.bmcl.2011.09.013 | ||
| CHEMBL1910167 | 67529 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 490 | 8 | 0 | 5 | 4.2 | COc1ccc(OC)c(S(=O)(=O)N2CCC(CN3CCC(Cc4ccc(F)cc4)CC3)CC2)c1 | 10.1016/j.bmcl.2011.09.013 | ||
| 44346153 | 15328 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 519 | 8 | 3 | 5 | 4.1 | C[C@H](O)[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL121637 | 15328 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 519 | 8 | 3 | 5 | 4.1 | C[C@H](O)[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 | 10.1016/s0960-894x(03)00748-0 | ||
| 44346154 | 168096 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 489 | 7 | 2 | 4 | 4.7 | C[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL436363 | 168096 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 489 | 7 | 2 | 4 | 4.7 | C[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 | 10.1016/s0960-894x(03)00748-0 | ||
| 44440437 | 145930 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 600 | 9 | 0 | 8 | 4.9 | Cc1ccnc(C)c1C(=O)N1CCC(N(CCc2ccc([N+](=O)[O-])cc2)Cc2c(C)n(C)n(-c3ccc(F)cc3)c2=O)CC1 | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL392218 | 145930 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 600 | 9 | 0 | 8 | 4.9 | Cc1ccnc(C)c1C(=O)N1CCC(N(CCc2ccc([N+](=O)[O-])cc2)Cc2c(C)n(C)n(-c3ccc(F)cc3)c2=O)CC1 | 10.1016/j.bmcl.2007.05.035 | ||
| 23657036 | 145931 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 572 | 9 | 0 | 8 | 4.3 | Cc1c(CN(CCc2ccc([N+](=O)[O-])cc2)C2CCN(C(=O)c3ccccn3)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL392219 | 145931 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 572 | 9 | 0 | 8 | 4.3 | Cc1c(CN(CCc2ccc([N+](=O)[O-])cc2)C2CCN(C(=O)c3ccccn3)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44390848 | 121875 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.7 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3cccc(F)c3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL360062 | 121875 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.7 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3cccc(F)c3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 9868532 | 60164 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| CHEMBL175502 | 60164 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| 11396995 | 69959 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 459 | 6 | 2 | 2 | 5.7 | O=C(Nc1ccc(F)c(F)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL194384 | 69959 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 459 | 6 | 2 | 2 | 5.7 | O=C(Nc1ccc(F)c(F)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44387837 | 123314 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 448 | 6 | 2 | 3 | 5.3 | N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| CHEMBL362465 | 123314 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 448 | 6 | 2 | 3 | 5.3 | N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| 44419303 | 141315 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 517 | 11 | 2 | 4 | 5.7 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)F)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL386493 | 141315 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 517 | 11 | 2 | 4 | 5.7 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)F)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44390843 | 63848 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 477 | 9 | 2 | 7 | 3.5 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(OC)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL180860 | 63848 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 477 | 9 | 2 | 7 | 3.5 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(OC)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44295374 | 101120 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 404 | 9 | 2 | 3 | 4.8 | N#Cc1cccc(NC(=O)NCCCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL298681 | 101120 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 404 | 9 | 2 | 3 | 4.8 | N#Cc1cccc(NC(=O)NCCCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295352 | 188099 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 380 | 9 | 1 | 3 | 4.2 | COc1cccc(C(=O)NCCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50400 | 188099 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 380 | 9 | 1 | 3 | 4.2 | COc1cccc(C(=O)NCCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295372 | 188574 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 419 | 7 | 2 | 2 | 5.2 | O=C(NCCCN1CCC(Cc2ccccc2)CC1)Nc1ccc(C(F)(F)F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51113 | 188574 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 419 | 7 | 2 | 2 | 5.2 | O=C(NCCCN1CCC(Cc2ccccc2)CC1)Nc1ccc(C(F)(F)F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 10623381 | 16722 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 448 | 8 | 2 | 3 | 5.3 | NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL125111 | 16722 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 448 | 8 | 2 | 3 | 5.3 | NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 44349204 | 17026 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 350 | 5 | 0 | 2 | 3.8 | CC1C2=C(CC=CC2)C(=O)N1CC1CCN(CCc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL125643 | 17026 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 350 | 5 | 0 | 2 | 3.8 | CC1C2=C(CC=CC2)C(=O)N1CC1CCN(CCc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 11037869 | 16544 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 459 | 7 | 2 | 3 | 6.1 | CC(=O)c1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| CHEMBL124317 | 16544 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 459 | 7 | 2 | 3 | 6.1 | CC(=O)c1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| 11037869 | 16544 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 459 | 7 | 2 | 3 | 6.1 | CC(=O)c1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL124317 | 16544 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 459 | 7 | 2 | 3 | 6.1 | CC(=O)c1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 44419314 | 82888 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 376 | 7 | 3 | 3 | 4.1 | N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL218997 | 82888 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 376 | 7 | 3 | 3 | 4.1 | N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44593553 | 177792 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 489 | 6 | 2 | 6 | 3.9 | Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL465272 | 177792 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 489 | 6 | 2 | 6 | 3.9 | Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 | 10.1016/j.bmcl.2008.11.002 | ||
| 44390891 | 63643 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 437 | 7 | 2 | 6 | 3.1 | Cn1nnnc1-c1cccc(NC(=O)NC[C@H]2CCCN(CCc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL180694 | 63643 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 437 | 7 | 2 | 6 | 3.1 | Cn1nnnc1-c1cccc(NC(=O)NC[C@H]2CCCN(CCc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44295544 | 188343 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 375 | 8 | 1 | 3 | 4.0 | N#Cc1ccc(C(=O)NCCCCN2CCC(Cc3ccccc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50801 | 188343 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 375 | 8 | 1 | 3 | 4.0 | N#Cc1ccc(C(=O)NCCCCN2CCC(Cc3ccccc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 11826382 | 17090 | 1 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 443 | 8 | 2 | 3 | 5.5 | COc1ccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)cc1 | 10.1021/jm0201767 | ||
| CHEMBL125695 | 17090 | 1 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 443 | 8 | 2 | 3 | 5.5 | COc1ccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)cc1 | 10.1021/jm0201767 | ||
| 44419305 | 82219 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 535 | 10 | 2 | 4 | 6.0 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)(F)F)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL217928 | 82219 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 535 | 10 | 2 | 4 | 6.0 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)(F)F)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44390867 | 62250 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 451 | 7 | 2 | 6 | 3.4 | CCc1cc(NC(=O)N[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL178278 | 62250 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 451 | 7 | 2 | 6 | 3.4 | CCc1cc(NC(=O)N[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 11396851 | 60174 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| CHEMBL175559 | 60174 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| 11247999 | 77616 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL2096763 | 77616 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 10972522 | 16949 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 456 | 7 | 2 | 3 | 5.8 | N#Cc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL125549 | 16949 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 456 | 7 | 2 | 3 | 5.8 | N#Cc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 11004663 | 117099 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 438 | 7 | 2 | 3 | 5.7 | N#Cc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL340080 | 117099 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 438 | 7 | 2 | 3 | 5.7 | N#Cc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| 10917990 | 16317 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 491 | 7 | 2 | 5 | 5.7 | COc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| CHEMBL123580 | 16317 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 491 | 7 | 2 | 5 | 5.7 | COc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| 11729258 | 16666 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 409 | 8 | 0 | 3 | 5.1 | N#CC(CCCN1CCN(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL124808 | 16666 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 409 | 8 | 0 | 3 | 5.1 | N#CC(CCCN1CCN(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 44419323 | 83720 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 390 | 8 | 3 | 3 | 4.5 | N#Cc1cccc(NC(=O)NCCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL220800 | 83720 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 390 | 8 | 3 | 3 | 4.5 | N#Cc1cccc(NC(=O)NCCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 11609863 | 16667 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 343 | 6 | 1 | 2 | 4.6 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124813 | 16667 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 343 | 6 | 1 | 2 | 4.6 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 44390851 | 123341 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NC[C@H]2CCCN(CCCc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL362613 | 123341 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NC[C@H]2CCCN(CCCc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44442599 | 93216 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 585 | 9 | 5 | 5 | 3.3 | Cc1cc(Br)ccc1CNC[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1N)C(=O)NC(C)(C)C | 10.1016/j.bmcl.2007.07.028 | ||
| CHEMBL246804 | 93216 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 585 | 9 | 5 | 5 | 3.3 | Cc1cc(Br)ccc1CNC[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1N)C(=O)NC(C)(C)C | 10.1016/j.bmcl.2007.07.028 | ||
| 44295145 | 191001 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 502 | 5 | 2 | 3 | 4.0 | O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1ccc(I)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51953 | 191001 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 502 | 5 | 2 | 3 | 4.0 | O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1ccc(I)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 11059385 | 157851 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 448 | 8 | 1 | 2 | 5.6 | O=C(Cc1ccc(F)cc1)Nc1ccccc1CCN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL409001 | 157851 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 448 | 8 | 1 | 2 | 5.6 | O=C(Cc1ccc(F)cc1)Nc1ccccc1CCN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 44440419 | 93098 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 603 | 8 | 0 | 6 | 5.6 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(C#N)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL246346 | 93098 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 603 | 8 | 0 | 6 | 5.6 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(C#N)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44440393 | 93483 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 586 | 10 | 0 | 5 | 6.8 | Cc1c(CN(CCCCc2ccccc2)C2CCN(C(=O)c3cccc4ccccc34)CC2)c(=O)n(-c2ccccc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL248178 | 93483 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 586 | 10 | 0 | 5 | 6.8 | Cc1c(CN(CCCCc2ccccc2)C2CCN(C(=O)c3cccc4ccccc34)CC2)c(=O)n(-c2ccccc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44445851 | 154044 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 573 | 7 | 2 | 7 | 5.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL399133 | 154044 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 573 | 7 | 2 | 7 | 5.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44295354 | 188572 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 394 | 8 | 2 | 3 | 4.2 | CN(C)c1ccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51110 | 188572 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 394 | 8 | 2 | 3 | 4.2 | CN(C)c1ccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 23509664 | 193277 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 421 | 6 | 1 | 3 | 4.9 | COc1cccc(NC(=O)N2CCC(CN3CCC(Cc4ccccc4)CC3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL54251 | 193277 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 421 | 6 | 1 | 3 | 4.9 | COc1cccc(NC(=O)N2CCC(CN3CCC(Cc4ccccc4)CC3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 9907041 | 167266 | 2 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 363 | 7 | 2 | 5 | 2.2 | CCOC(=O)[C@H](Cc1ccc(O)cc1)NS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL430745 | 167266 | 2 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 363 | 7 | 2 | 5 | 2.2 | CCOC(=O)[C@H](Cc1ccc(O)cc1)NS(=O)(=O)c1ccc(C)cc1 | 10.1016/s0960-894x(01)00248-7 | ||
| 10974378 | 113798 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 664 | 12 | 3 | 4 | 7.4 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL333063 | 113798 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 664 | 12 | 3 | 4 | 7.4 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 71458114 | 79206 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 437 | 8 | 2 | 3 | 4.9 | CC(=O)c1cccc(NC(=O)NCCCN2CC3CCC2[C@@H](Cc2ccc(F)cc2)C3)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL2114958 | 79206 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 437 | 8 | 2 | 3 | 4.9 | CC(=O)c1cccc(NC(=O)NCCCN2CC3CCC2[C@@H](Cc2ccc(F)cc2)C3)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 10983419 | 116958 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 461 | 7 | 3 | 3 | 5.6 | O=C(Nc1ccccc1)Nc1cccc(C(=O)O)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL339884 | 116958 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 461 | 7 | 3 | 3 | 5.6 | O=C(Nc1ccccc1)Nc1cccc(C(=O)O)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 44295480 | 189019 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 439 | 6 | 1 | 3 | 5.2 | COc1cccc(NC(=O)N2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51480 | 189019 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 439 | 6 | 1 | 3 | 5.2 | COc1cccc(NC(=O)N2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 20613253 | 112843 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 446 | 7 | 1 | 2 | 6.4 | Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc1 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL331702 | 112843 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 446 | 7 | 1 | 2 | 6.4 | Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc1 | 10.1016/s0960-894x(03)00748-0 | ||
| 44281525 | 109215 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 314 | 6 | 2 | 5 | 1.7 | CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccn1 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL32282 | 109215 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 314 | 6 | 2 | 5 | 1.7 | CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccn1 | 10.1016/s0960-894x(01)00248-7 | ||
| 10928228 | 16616 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 435 | 6 | 2 | 2 | 6.1 | O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124583 | 16616 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 435 | 6 | 2 | 2 | 6.1 | O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 10874167 | 170275 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 457 | 7 | 2 | 4 | 5.2 | O=C(NCc1ccc2c(c1)OCO2)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL445379 | 170275 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 457 | 7 | 2 | 4 | 5.2 | O=C(NCc1ccc2c(c1)OCO2)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 44281789 | 110862 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 454 | 8 | 1 | 5 | 4.8 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)OCc1ccccc1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL32692 | 110862 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 454 | 8 | 1 | 5 | 4.8 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)OCc1ccccc1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 11026634 | 112832 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 443 | 8 | 2 | 3 | 5.8 | COc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL331634 | 112832 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 443 | 8 | 2 | 3 | 5.8 | COc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| 22022826 | 16272 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 7 | 1 | 2 | 6.5 | Cc1ccc(C(=O)NC(CN2C3CCC2CC(Cc2ccc(Cl)c(Cl)c2)C3)C(C)C)cc1 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL123308 | 16272 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 7 | 1 | 2 | 6.5 | Cc1ccc(C(=O)NC(CN2C3CCC2CC(Cc2ccc(Cl)c(Cl)c2)C3)C(C)C)cc1 | 10.1016/s0960-894x(03)00748-0 | ||
| 44419322 | 83954 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 362 | 6 | 3 | 3 | 3.7 | N#Cc1cccc(NC(=O)NCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL221901 | 83954 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 362 | 6 | 3 | 3 | 3.7 | N#Cc1cccc(NC(=O)NCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 15907328 | 162811 | 31 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 301 | 3 | 1 | 2 | 3.8 | OC1(c2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL419244 | 162811 | 31 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 301 | 3 | 1 | 2 | 3.8 | OC1(c2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 44447374 | 94291 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 499 | 11 | 4 | 8 | 2.2 | CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)[C@@H](O)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL253034 | 94291 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 499 | 11 | 4 | 8 | 2.2 | CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)[C@@H](O)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44289763 | 164499 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 4.3 | N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccc(F)cc3F)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL42264 | 164499 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 4.3 | N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccc(F)cc3F)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 22143196 | 183405 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 509 | 7 | 5 | 6 | 2.0 | CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | ||
| CHEMBL481790 | 183405 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 509 | 7 | 5 | 6 | 2.0 | CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | ||
| 209394 | 116132 | 10 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 297 | 6 | 1 | 3 | 2.6 | CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33693 | 116132 | 10 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 297 | 6 | 1 | 3 | 2.6 | CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| 11814253 | 116455 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 635 | 10 | 3 | 3 | 8.2 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cccc(C(F)(F)F)c1 | 10.1021/jm0201767 | ||
| CHEMBL338624 | 116455 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 635 | 10 | 3 | 3 | 8.2 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cccc(C(F)(F)F)c1 | 10.1021/jm0201767 | ||
| 12000105 | 83826 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 453 | 10 | 2 | 3 | 5.7 | CCCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL221067 | 83826 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 453 | 10 | 2 | 3 | 5.7 | CCCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 11227406 | 93909 | 1 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm300682j | ||
| CHEMBL250689 | 93909 | 1 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm300682j | ||
| 11272103 | 123856 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL363840 | 123856 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2008.11.002 | ||
| 44445876 | 93653 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 501 | 7 | 2 | 6 | 4.2 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249060 | 93653 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 501 | 7 | 2 | 6 | 4.2 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445856 | 93828 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 557 | 8 | 2 | 6 | 4.7 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL250262 | 93828 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 557 | 8 | 2 | 6 | 4.7 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 11227406 | 93909 | 1 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL250689 | 93909 | 1 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44445892 | 93985 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 572 | 9 | 2 | 7 | 3.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC(=O)N(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251045 | 93985 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 572 | 9 | 2 | 7 | 3.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC(=O)N(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445840 | 94015 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 488 | 7 | 2 | 6 | 4.3 | CC(=O)c1sc(NC(=O)N[C@@H]2CCOC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251232 | 94015 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 488 | 7 | 2 | 6 | 4.3 | CC(=O)c1sc(NC(=O)N[C@@H]2CCOC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445894 | 154193 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 612 | 8 | 2 | 7 | 4.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C3CCN(C(C)=O)CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL399893 | 154193 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 612 | 8 | 2 | 7 | 4.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C3CCN(C(C)=O)CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 21362425 | 154464 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 584 | 8 | 2 | 7 | 4.7 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C3CCN(C)CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL401394 | 154464 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 584 | 8 | 2 | 7 | 4.7 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C3CCN(C)CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 11227406 | 93909 | 1 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL250689 | 93909 | 1 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455509 | 165873 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 4.4 | CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL427728 | 165873 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 4.4 | CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455560 | 168713 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 517 | 9 | 2 | 8 | 3.8 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2ccnn2)cc(-n2ccnn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL441334 | 168713 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 517 | 9 | 2 | 8 | 3.8 | C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2ccnn2)cc(-n2ccnn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11363006 | 70092 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 | 10.1021/jm049530m | ||
| CHEMBL194601 | 70092 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 | 10.1021/jm049530m | ||
| 11227406 | 93909 | 1 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL250689 | 93909 | 1 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 44401123 | 135757 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 516 | 7 | 2 | 5 | 4.9 | N#CC1=CC(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)CC=C1n1cccn1 | 10.1021/jm049530m | ||
| CHEMBL373347 | 135757 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 516 | 7 | 2 | 5 | 4.9 | N#CC1=CC(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)CC=C1n1cccn1 | 10.1021/jm049530m | ||
| 11017618 | 11365 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 501 | 6 | 2 | 4 | 5.7 | C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL1180385 | 11365 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 501 | 6 | 2 | 4 | 5.7 | C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124689 | 11365 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 501 | 6 | 2 | 4 | 5.7 | C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 11762511 | 16386 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 474 | 7 | 3 | 3 | 5.3 | CNC(=O)c1cccc(NC(=O)Nc2ccccc2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL123837 | 16386 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 474 | 7 | 3 | 3 | 5.3 | CNC(=O)c1cccc(NC(=O)Nc2ccccc2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 11134936 | 16566 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 504 | 8 | 3 | 4 | 5.3 | CNC(=O)c1cccc(NC(=O)Nc2cccc(OC)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124334 | 16566 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 504 | 8 | 3 | 4 | 5.3 | CNC(=O)c1cccc(NC(=O)Nc2cccc(OC)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 11038430 | 16644 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 502 | 8 | 3 | 4 | 5.2 | CC(=O)c1cccc(NC(=O)Nc2cccc(C(N)=O)c2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL124722 | 16644 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 502 | 8 | 3 | 4 | 5.2 | CC(=O)c1cccc(NC(=O)Nc2cccc(C(N)=O)c2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 44570581 | 177841 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 536 | 10 | 2 | 8 | 3.1 | CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN(CCCc2ccc(F)cc2)C2CC2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL465942 | 177841 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 536 | 10 | 2 | 8 | 3.1 | CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN(CCCc2ccc(F)cc2)C2CC2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| 44445847 | 93988 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 487 | 7 | 3 | 6 | 3.8 | CC(=O)c1sc(NC(=O)N[C@@H]2CNCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251079 | 93988 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 487 | 7 | 3 | 6 | 3.8 | CC(=O)c1sc(NC(=O)N[C@@H]2CNCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445878 | 154061 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 557 | 8 | 2 | 6 | 4.7 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL399150 | 154061 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 557 | 8 | 2 | 6 | 4.7 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445880 | 154697 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 543 | 8 | 2 | 6 | 4.5 | CCC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL402707 | 154697 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 543 | 8 | 2 | 6 | 4.5 | CCC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| 21362416 | 93650 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 612 | 8 | 2 | 7 | 4.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C3CCN(C(C)=O)CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249058 | 93650 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 612 | 8 | 2 | 7 | 4.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C3CCN(C(C)=O)CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44390927 | 62671 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 4.3 | CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2CC)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL178671 | 62671 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 4.3 | CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2CC)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44390894 | 121845 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.0 | CCc1cc(NC(=O)NC[C@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL360039 | 121845 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.0 | CCc1cc(NC(=O)NC[C@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 11179351 | 124094 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 490 | 7 | 2 | 5 | 5.0 | O=C(Nc1ccc(-n2cncn2)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL364068 | 124094 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 490 | 7 | 2 | 5 | 5.0 | O=C(Nc1ccc(-n2cncn2)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44419300 | 83589 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 499 | 11 | 2 | 4 | 5.4 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCF)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL220713 | 83589 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 499 | 11 | 2 | 4 | 5.4 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCF)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 795 | 568 | 3 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 10.1016/s0960-894x(03)00748-0 | ||
| 796 | 568 | 3 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 10.1016/s0960-894x(03)00748-0 | ||
| 9913085 | 568 | 3 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL20921 | 568 | 3 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 10.1016/s0960-894x(03)00748-0 | ||
| 795 | 568 | 3 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 10.1016/s0960-894x(01)00176-7 | ||
| 796 | 568 | 3 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 10.1016/s0960-894x(01)00176-7 | ||
| 9913085 | 568 | 3 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 10.1016/s0960-894x(01)00176-7 | ||
| CHEMBL20921 | 568 | 3 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 10.1016/s0960-894x(01)00176-7 | ||
| 44445875 | 93651 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 531 | 9 | 3 | 7 | 3.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CCO)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249059 | 93651 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 531 | 9 | 3 | 7 | 3.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CCO)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445859 | 154248 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 545 | 7 | 2 | 7 | 4.3 | COC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL400173 | 154248 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 545 | 7 | 2 | 7 | 4.3 | COC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44401561 | 123602 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL363373 | 123602 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 463 | 6 | 3 | 3 | 5.3 | O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11750808 | 125675 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 431 | 6 | 2 | 5 | 4.3 | O=C(Nc1nncs1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL364977 | 125675 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 431 | 6 | 2 | 5 | 4.3 | O=C(Nc1nncs1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44346210 | 167392 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 531 | 10 | 3 | 6 | 4.7 | COc1cc(NC(=O)N[C@@H](CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)[C@H](C)O)cc(OC)c1OC | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL431670 | 167392 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 531 | 10 | 3 | 6 | 4.7 | COc1cc(NC(=O)N[C@@H](CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)[C@H](C)O)cc(OC)c1OC | 10.1016/s0960-894x(03)00748-0 | ||
| 44455845 | 97010 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 537 | 10 | 3 | 7 | 4.5 | CC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL270146 | 97010 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 537 | 10 | 3 | 7 | 4.5 | CC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44289713 | 165555 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 527 | 9 | 2 | 6 | 5.2 | Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2ccccc2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL42599 | 165555 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 527 | 9 | 2 | 6 | 5.2 | Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2ccccc2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44419335 | 83726 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 465 | 10 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC2CC2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL220819 | 83726 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 465 | 10 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC2CC2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44447140 | 94118 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 523 | 11 | 3 | 7 | 4.2 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CCCCC1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL251839 | 94118 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 523 | 11 | 3 | 7 | 4.2 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CCCCC1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447154 | 94254 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 559 | 13 | 3 | 7 | 4.6 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)Cc2ccccc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL252792 | 94254 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 559 | 13 | 3 | 7 | 4.6 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)Cc2ccccc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447380 | 94449 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 483 | 11 | 3 | 7 | 3.2 | CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)CCc1ccc(F)cc1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL254093 | 94449 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 483 | 11 | 3 | 7 | 3.2 | CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)CCc1ccc(F)cc1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44445907 | 94392 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 409 | 7 | 2 | 3 | 4.6 | CC(=O)c1cccc(NC(=O)N/C=C/CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL253676 | 94392 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 409 | 7 | 2 | 3 | 4.6 | CC(=O)c1cccc(NC(=O)N/C=C/CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44445883 | 154698 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 555 | 8 | 2 | 6 | 4.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL402708 | 154698 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 555 | 8 | 2 | 6 | 4.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44290039 | 178224 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL46905 | 178224 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11430170 | 123315 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 423 | 6 | 2 | 2 | 5.5 | O=C(Nc1ccccc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL362466 | 123315 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 423 | 6 | 2 | 2 | 5.5 | O=C(Nc1ccccc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11385766 | 132275 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL370082 | 132275 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 44290039 | 178224 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL46905 | 178224 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 44290039 | 178224 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL46905 | 178224 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44445849 | 94016 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 573 | 7 | 2 | 7 | 5.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251243 | 94016 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 573 | 7 | 2 | 7 | 5.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445889 | 154327 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 567 | 9 | 2 | 7 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(Cc3ccco3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL400649 | 154327 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 567 | 9 | 2 | 7 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(Cc3ccco3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44289919 | 100684 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 493 | 9 | 2 | 7 | 3.7 | CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL295415 | 100684 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 493 | 9 | 2 | 7 | 3.7 | CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455683 | 154549 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 531 | 9 | 3 | 7 | 4.4 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL401879 | 154549 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 531 | 9 | 3 | 7 | 4.4 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455485 | 154960 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 507 | 9 | 2 | 6 | 5.0 | CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL404122 | 154960 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 507 | 9 | 2 | 6 | 5.0 | CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455484 | 166852 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 4.6 | CC(C)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL429604 | 166852 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 4.6 | CC(C)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44387842 | 130779 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 369 | 5 | 2 | 3 | 4.2 | CC(=O)c1cccc(NC(=O)NN2CCCCC2Cc2ccc(F)cc2)c1 | 10.1021/jm049530m | ||
| CHEMBL368683 | 130779 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 369 | 5 | 2 | 3 | 4.2 | CC(=O)c1cccc(NC(=O)NN2CCCCC2Cc2ccc(F)cc2)c1 | 10.1021/jm049530m | ||
| 10457573 | 116547 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 473 | 8 | 2 | 3 | 6.2 | CC(=O)c1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL339110 | 116547 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 473 | 8 | 2 | 3 | 6.2 | CC(=O)c1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 44289919 | 100684 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 493 | 9 | 2 | 7 | 3.7 | CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL295415 | 100684 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 493 | 9 | 2 | 7 | 3.7 | CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44445893 | 153878 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 541 | 9 | 2 | 6 | 5.0 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC3CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL398889 | 153878 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 541 | 9 | 2 | 6 | 5.0 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC3CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44455459 | 94648 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 467 | 9 | 2 | 4 | 5.1 | CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL255398 | 94648 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 467 | 9 | 2 | 4 | 5.1 | CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455460 | 94649 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 533 | 9 | 3 | 7 | 5.3 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ncco2)cc(-c2ncco2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL255399 | 94649 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 533 | 9 | 3 | 7 | 5.3 | C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ncco2)cc(-c2ncco2)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44455767 | 95277 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 483 | 9 | 3 | 5 | 4.4 | CC(=O)c1cc(NC(=O)N[C@@H](C)C[C@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL258309 | 95277 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 483 | 9 | 3 | 5 | 4.4 | CC(=O)c1cc(NC(=O)N[C@@H](C)C[C@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11487192 | 69332 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 428 | 6 | 2 | 4 | 4.8 | Cc1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)no1 | 10.1021/jm049530m | ||
| CHEMBL193526 | 69332 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 428 | 6 | 2 | 4 | 4.8 | Cc1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)no1 | 10.1021/jm049530m | ||
| 44445896 | 153999 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 531 | 9 | 3 | 7 | 3.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(CCO)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL399088 | 153999 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 531 | 9 | 3 | 7 | 3.6 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(CCO)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445855 | 154247 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 583 | 8 | 2 | 6 | 5.3 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CCCC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL400172 | 154247 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 583 | 8 | 2 | 6 | 5.3 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CCCC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 11113940 | 79172 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 509 | 8 | 1 | 6 | 5.9 | CCOc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 | 10.1016/s0960-894x(01)00176-7 | ||
| CHEMBL21143 | 79172 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 509 | 8 | 1 | 6 | 5.9 | CCOc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 | 10.1016/s0960-894x(01)00176-7 | ||
| 44440402 | 93484 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 596 | 8 | 0 | 5 | 5.9 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL248179 | 93484 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 596 | 8 | 0 | 5 | 5.9 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44295648 | 101530 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 437 | 9 | 3 | 4 | 4.1 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](C)O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL301601 | 101530 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 437 | 9 | 3 | 4 | 4.1 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](C)O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295555 | 101584 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 447 | 8 | 2 | 4 | 3.7 | CS(=O)(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL301974 | 101584 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 447 | 8 | 2 | 4 | 3.7 | CS(=O)(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393430 | 168137 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL43677 | 168137 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393339 | 186154 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 410 | 7 | 2 | 3 | 4.7 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(Cl)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL48873 | 186154 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 410 | 7 | 2 | 3 | 4.7 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(Cl)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295306 | 188296 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 415 | 8 | 2 | 3 | 5.0 | CSc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50726 | 188296 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 415 | 8 | 2 | 3 | 5.0 | CSc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393469 | 188785 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51286 | 188785 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295566 | 193047 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 479 | 11 | 3 | 4 | 5.1 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@@H](O)CC(C)C)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL53444 | 193047 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 479 | 11 | 3 | 4 | 5.1 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@@H](O)CC(C)C)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393430 | 168137 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL43677 | 168137 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44440429 | 93210 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 580 | 8 | 0 | 5 | 5.4 | Cc1c(CN(CCc2ccc(F)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL246768 | 93210 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 580 | 8 | 0 | 5 | 5.4 | Cc1c(CN(CCc2ccc(F)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44440445 | 146214 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 577 | 8 | 0 | 6 | 4.3 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3cccc[n+]3[O-])CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL392430 | 146214 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 577 | 8 | 0 | 6 | 4.3 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3cccc[n+]3[O-])CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44295674 | 101162 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 483 | 10 | 2 | 3 | 6.0 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2Cc2ccccc2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL298999 | 101162 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 483 | 10 | 2 | 3 | 6.0 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2Cc2ccccc2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393362 | 101219 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 437 | 7 | 2 | 2 | 5.3 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1C(F)(F)F | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL299385 | 101219 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 437 | 7 | 2 | 2 | 5.3 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1C(F)(F)F | 10.1016/s0960-894x(02)00206-8 | ||
| 9842640 | 166820 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 376 | 7 | 2 | 3 | 4.0 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL42948 | 166820 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 376 | 7 | 2 | 3 | 4.0 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295267 | 187649 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 431 | 8 | 2 | 3 | 4.0 | C[S+]([O-])c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL49938 | 187649 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 431 | 8 | 2 | 3 | 4.0 | C[S+]([O-])c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295406 | 187780 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 451 | 8 | 2 | 3 | 6.0 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2cccs2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50129 | 187780 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 451 | 8 | 2 | 3 | 6.0 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2cccs2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295664 | 188110 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 435 | 10 | 2 | 3 | 5.5 | CCC[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50423 | 188110 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 435 | 10 | 2 | 3 | 5.5 | CCC[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393307 | 188185 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3F)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50557 | 188185 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3F)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295304 | 188539 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 451 | 9 | 3 | 4 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2C(C)(C)O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51052 | 188539 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 451 | 9 | 3 | 4 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2C(C)(C)O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393366 | 191922 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL52094 | 191922 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 9842640 | 166820 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 376 | 7 | 2 | 3 | 4.0 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL42948 | 166820 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 376 | 7 | 2 | 3 | 4.0 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44349614 | 117946 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 402 | 5 | 0 | 3 | 3.6 | O=C1CC2(CCc3ccccc32)C(=O)N1CC1CCN(CCc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL341144 | 117946 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 402 | 5 | 0 | 3 | 3.6 | O=C1CC2(CCc3ccccc32)C(=O)N1CC1CCN(CCc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 44281791 | 115771 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 406 | 7 | 1 | 5 | 4.0 | CC(C)OC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33589 | 115771 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 406 | 7 | 1 | 5 | 4.0 | CC(C)OC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 11103845 | 12020 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 6 | 3 | 3 | 5.5 | C[N+]1(Cc2cc(O)ccc2NC(=O)Nc2cccc(C#N)c2)CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL1184106 | 12020 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 6 | 3 | 3 | 5.5 | C[N+]1(Cc2cc(O)ccc2NC(=O)Nc2cccc(C#N)c2)CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL332591 | 12020 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 6 | 3 | 3 | 5.5 | C[N+]1(Cc2cc(O)ccc2NC(=O)Nc2cccc(C#N)c2)CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 11812807 | 16401 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 477 | 8 | 3 | 4 | 5.5 | COc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL123917 | 16401 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 477 | 8 | 3 | 4 | 5.5 | COc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 44447161 | 94443 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 547 | 12 | 3 | 8 | 2.3 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)S(C)(=O)=O)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL254055 | 94443 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 547 | 12 | 3 | 8 | 2.3 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)S(C)(=O)=O)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447153 | 153398 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 617 | 13 | 3 | 7 | 5.6 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC23CC4CC(CC(C4)C2)C3)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL398344 | 153398 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 617 | 13 | 3 | 7 | 5.6 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC23CC4CC(CC(C4)C2)C3)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44419314 | 82888 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 376 | 7 | 3 | 3 | 4.1 | N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL218997 | 82888 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 376 | 7 | 3 | 3 | 4.1 | N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 11828215 | 113961 | 1 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 613 | 12 | 3 | 3 | 7.1 | O=C(NCCc1ccc(F)cc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL333422 | 113961 | 1 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 613 | 12 | 3 | 3 | 7.1 | O=C(NCCc1ccc(F)cc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 11104005 | 116857 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 602 | 12 | 3 | 4 | 6.2 | O=C(NCCN1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL339752 | 116857 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 602 | 12 | 3 | 4 | 6.2 | O=C(NCCN1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 11813735 | 117642 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 562 | 12 | 3 | 4 | 5.3 | CN(C)CCNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL340797 | 117642 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 562 | 12 | 3 | 4 | 5.3 | CN(C)CCNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 11730610 | 16506 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 485 | 7 | 2 | 5 | 5.7 | CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccccc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| CHEMBL124272 | 16506 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 485 | 7 | 2 | 5 | 5.7 | CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccccc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| 44390949 | 64074 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(CCCc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL181311 | 64074 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(CCCc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44512617 | 193668 | 0 | None | - | 0 | Mouse | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 487 | 5 | 2 | 4 | 4.2 | O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| CHEMBL551735 | 193668 | 0 | None | - | 0 | Mouse | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 487 | 5 | 2 | 4 | 4.2 | O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 | 10.1016/j.bmc.2009.06.066 | ||
| 44295686 | 162451 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 407 | 5 | 1 | 3 | 4.6 | COc1cccc(NC(=O)N2CCC(N3CCC(Cc4ccccc4)CC3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL417547 | 162451 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 407 | 5 | 1 | 3 | 4.6 | COc1cccc(NC(=O)N2CCC(N3CCC(Cc4ccccc4)CC3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 10995218 | 16438 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 549 | 12 | 4 | 4 | 5.1 | O=C(NCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL124127 | 16438 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 549 | 12 | 4 | 4 | 5.1 | O=C(NCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 9982077 | 16410 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 468 | 6 | 2 | 5 | 5.4 | N#Cc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccccc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| CHEMBL123962 | 16410 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 468 | 6 | 2 | 5 | 5.4 | N#Cc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccccc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| 44447373 | 94237 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 453 | 9 | 4 | 8 | 1.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@H](C)[C@@H](O)c1ccccc1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL252628 | 94237 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 453 | 9 | 4 | 8 | 1.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@H](C)[C@@H](O)c1ccccc1 | 10.1016/j.bmcl.2007.11.087 | ||
| 10863252 | 170790 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 447 | 7 | 3 | 3 | 5.5 | O=C(Nc1ccccc1)Nc1ccccc1C(O)CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL446164 | 170790 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 447 | 7 | 3 | 3 | 5.5 | O=C(Nc1ccccc1)Nc1ccccc1C(O)CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 44295479 | 101086 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 425 | 6 | 1 | 3 | 4.6 | COc1cccc(NC(=O)N2CCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL298414 | 101086 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 425 | 6 | 1 | 3 | 4.6 | COc1cccc(NC(=O)N2CCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 11285792 | 866 | 30 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | ||
| 801 | 866 | 30 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | ||
| CHEMBL2110727 | 866 | 30 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | ||
| DB11758 | 866 | 30 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | ||
| 10983106 | 16748 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 443 | 8 | 2 | 3 | 5.5 | COc1cccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL125282 | 16748 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 443 | 8 | 2 | 3 | 5.5 | COc1cccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| 11124782 | 117965 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 587 | 11 | 3 | 3 | 7.3 | O=C(NCC1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL341306 | 117965 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 587 | 11 | 3 | 3 | 7.3 | O=C(NCC1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 22393396 | 167707 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3cccc(F)c3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL43391 | 167707 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3cccc(F)c3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 11732727 | 16471 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 429 | 7 | 3 | 3 | 5.3 | O=C(Nc1ccccc1)Nc1ccccc1C(O)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124206 | 16471 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 429 | 7 | 3 | 3 | 5.3 | O=C(Nc1ccccc1)Nc1ccccc1C(O)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 44440396 | 152533 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 579 | 8 | 0 | 6 | 5.2 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccn2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL397599 | 152533 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 579 | 8 | 0 | 6 | 5.2 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccn2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44440427 | 93209 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 609 | 9 | 0 | 7 | 5.2 | COc1ccncc1-n1c(=O)c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(C)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL246766 | 93209 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 609 | 9 | 0 | 7 | 5.2 | COc1ccncc1-n1c(=O)c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(C)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44295499 | 188768 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 453 | 7 | 1 | 3 | 5.4 | COc1cccc(NC(=O)N2CCCC(CCN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51267 | 188768 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 453 | 7 | 1 | 3 | 5.4 | COc1cccc(NC(=O)N2CCCC(CCN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44440422 | 93100 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 622 | 9 | 1 | 6 | 5.5 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(C(=O)O)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL246348 | 93100 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 622 | 9 | 1 | 6 | 5.5 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(C(=O)O)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44440440 | 93211 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 577 | 8 | 1 | 6 | 4.8 | Cc1c(CN(CCc2ccc(N)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL246769 | 93211 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 577 | 8 | 1 | 6 | 4.8 | Cc1c(CN(CCc2ccc(N)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44440434 | 152829 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 563 | 8 | 0 | 6 | 4.6 | Cc1c(CN(CCc2cccnc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL397853 | 152829 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 563 | 8 | 0 | 6 | 4.6 | Cc1c(CN(CCc2cccnc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44295409 | 101194 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 355 | 5 | 1 | 3 | 3.2 | CC(C)(C)C(=O)NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL299226 | 101194 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 355 | 5 | 1 | 3 | 3.2 | CC(C)(C)C(=O)NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295433 | 186477 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 6 | 1 | 4 | 4.0 | COc1cccc(NC(=O)N2CCO[C@@H](CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL49117 | 186477 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 6 | 1 | 4 | 4.0 | COc1cccc(NC(=O)N2CCO[C@@H](CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 23497297 | 16695 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 483 | 6 | 3 | 5 | 5.4 | O=C(Nc1ccc2c[nH]nc2c1)Nc1cc2c(cc1CN1CCC(Cc3ccccc3)CC1)OCO2 | 10.1021/jm0201767 | ||
| CHEMBL124966 | 16695 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 483 | 6 | 3 | 5 | 5.4 | O=C(Nc1ccc2c[nH]nc2c1)Nc1cc2c(cc1CN1CCC(Cc3ccccc3)CC1)OCO2 | 10.1021/jm0201767 | ||
| 11001953 | 113634 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 327 | 7 | 2 | 4 | 2.2 | CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Cc1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33290 | 113634 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 327 | 7 | 2 | 4 | 2.2 | CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Cc1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| 11825113 | 16707 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 381 | 8 | 3 | 3 | 3.6 | O=C(NCCCO)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL125026 | 16707 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 381 | 8 | 3 | 3 | 3.6 | O=C(NCCCO)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 11762865 | 16384 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 503 | 9 | 2 | 2 | 7.1 | O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL123807 | 16384 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 503 | 9 | 2 | 2 | 7.1 | O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 44570714 | 189202 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 565 | 9 | 5 | 6 | 3.6 | CSc1ccc(C(=O)NC2CCC(NC(C)C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | ||
| CHEMBL516224 | 189202 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 565 | 9 | 5 | 6 | 3.6 | CSc1ccc(C(=O)NC2CCC(NC(C)C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | ||
| 11048458 | 117974 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 440 | 6 | 3 | 4 | 5.4 | N#Cc1cccc(NC(=O)Nc2ccc(O)cc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL341343 | 117974 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 440 | 6 | 3 | 4 | 5.4 | N#Cc1cccc(NC(=O)Nc2ccc(O)cc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| 71449114 | 78537 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 435 | 7 | 2 | 3 | 5.3 | COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCCC(Cc3ccccc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL2112987 | 78537 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 435 | 7 | 2 | 3 | 5.3 | COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCCC(Cc3ccccc3)C2)c1 | 10.1021/jm049530m | ||
| 10928173 | 76190 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.8 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2cccc(Cl)c2)CC1 | 10.1016/s0960-894x(01)00176-7 | ||
| CHEMBL20612 | 76190 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.8 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2cccc(Cl)c2)CC1 | 10.1016/s0960-894x(01)00176-7 | ||
| 10950225 | 116971 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 7 | 2 | 3 | 5.3 | N#Cc1cccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL339934 | 116971 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 7 | 2 | 3 | 5.3 | N#Cc1cccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| 76316987 | 103060 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.9 | Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(CCCCc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL3085295 | 103060 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.9 | Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(CCCCc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 11408397 | 77605 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL2096695 | 77605 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 22393329 | 100657 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL295229 | 100657 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44390970 | 63733 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 533 | 8 | 2 | 6 | 4.4 | CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C(F)(F)F)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL180728 | 63733 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 533 | 8 | 2 | 6 | 4.4 | CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C(F)(F)F)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44390971 | 122605 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 541 | 9 | 2 | 6 | 5.0 | CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2c2ccccc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL361130 | 122605 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 541 | 9 | 2 | 6 | 5.0 | CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2c2ccccc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44387856 | 130920 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 447 | 7 | 2 | 3 | 5.5 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm049530m | ||
| CHEMBL369073 | 130920 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 447 | 7 | 2 | 3 | 5.5 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm049530m | ||
| 11465468 | 166484 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| CHEMBL428881 | 166484 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| 44281521 | 99936 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 370 | 7 | 1 | 5 | 3.1 | CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccc(C)cc1C | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL290104 | 99936 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 370 | 7 | 1 | 5 | 3.1 | CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccc(C)cc1C | 10.1016/s0960-894x(01)00248-7 | ||
| 10255492 | 117658 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 502 | 8 | 3 | 4 | 5.2 | CC(=O)c1cccc(NC(=O)Nc2ccc(C(N)=O)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL340853 | 117658 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 502 | 8 | 3 | 4 | 5.2 | CC(=O)c1cccc(NC(=O)Nc2ccc(C(N)=O)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 11733617 | 160707 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 485 | 7 | 3 | 4 | 4.9 | N#Cc1cccc(NC(=O)Nc2cccc(C(N)=O)c2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL411956 | 160707 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 485 | 7 | 3 | 4 | 4.9 | N#Cc1cccc(NC(=O)Nc2cccc(C(N)=O)c2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 44289910 | 100741 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 529 | 8 | 2 | 6 | 4.2 | Cn1nnnc1-c1cc(Br)cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL295898 | 100741 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 529 | 8 | 2 | 6 | 4.2 | Cn1nnnc1-c1cc(Br)cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44290019 | 100752 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.5 | CC(C)n1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL295970 | 100752 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.5 | CC(C)n1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44447149 | 94503 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 551 | 12 | 3 | 7 | 4.7 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C2CCCCC2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL254470 | 94503 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 551 | 12 | 3 | 7 | 4.7 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C2CCCCC2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44445862 | 94018 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 555 | 8 | 2 | 6 | 4.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251274 | 94018 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 555 | 8 | 2 | 6 | 4.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44390954 | 63537 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 483 | 8 | 2 | 6 | 3.8 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)c(F)c3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL180351 | 63537 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 483 | 8 | 2 | 6 | 3.8 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)c(F)c3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44445861 | 93855 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 8 | 2 | 6 | 4.5 | CCC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL250436 | 93855 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 8 | 2 | 6 | 4.5 | CCC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44447378 | 154301 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 527 | 12 | 4 | 8 | 2.8 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)[C@H](O)Cc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL400467 | 154301 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 527 | 12 | 4 | 8 | 2.8 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)[C@H](O)Cc2ccc(F)cc2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44390838 | 127988 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.7 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL366710 | 127988 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.7 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44419299 | 141158 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 510 | 11 | 3 | 5 | 3.9 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(N)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL385607 | 141158 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 510 | 11 | 3 | 5 | 3.9 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(N)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 11953409 | 93781 | 0 | None | - | 0 | Mouse | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 529 | 7 | 2 | 6 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249854 | 93781 | 0 | None | - | 0 | Mouse | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 529 | 7 | 2 | 6 | 4.1 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44445877 | 93779 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 583 | 8 | 2 | 6 | 5.3 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CCCC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249851 | 93779 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 583 | 8 | 2 | 6 | 5.3 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CCCC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44390964 | 62269 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 8 | 2 | 6 | 4.2 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(Cl)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL178287 | 62269 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 8 | 2 | 6 | 4.2 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(Cl)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44289877 | 165488 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 437 | 8 | 2 | 5 | 4.3 | O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-c2nnco2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL42562 | 165488 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 437 | 8 | 2 | 5 | 4.3 | O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-c2nnco2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 11213457 | 94325 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 9 | 3 | 6 | 3.9 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CNCCCc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL253209 | 94325 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 9 | 3 | 6 | 3.9 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CNCCCc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44390919 | 121539 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 447 | 8 | 2 | 6 | 3.5 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccccc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL359609 | 121539 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 447 | 8 | 2 | 6 | 3.5 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccccc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44419306 | 140855 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 9 | 2 | 4 | 5.0 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C(C)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL383879 | 140855 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 9 | 2 | 4 | 5.0 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C(C)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44295434 | 101097 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 441 | 6 | 1 | 4 | 4.0 | COc1cccc(NC(=O)N2CCO[C@H](CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL298505 | 101097 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 441 | 6 | 1 | 4 | 4.0 | COc1cccc(NC(=O)N2CCO[C@H](CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295362 | 161672 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 369 | 7 | 2 | 2 | 4.3 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL416305 | 161672 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 369 | 7 | 2 | 2 | 4.3 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393419 | 164877 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 399 | 8 | 2 | 3 | 4.3 | COc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL42388 | 164877 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 399 | 8 | 2 | 3 | 4.3 | COc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 23509697 | 193281 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 440 | 6 | 2 | 4 | 3.6 | COc1cccc(NC(=O)N2CCNC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL54273 | 193281 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 440 | 6 | 2 | 4 | 3.6 | COc1cccc(NC(=O)N2CCNC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393419 | 164877 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 399 | 8 | 2 | 3 | 4.3 | COc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL42388 | 164877 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 399 | 8 | 2 | 3 | 4.3 | COc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 9951883 | 168127 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 381 | 8 | 2 | 3 | 4.2 | COc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL43666 | 168127 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 381 | 8 | 2 | 3 | 4.2 | COc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393378 | 188374 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 397 | 9 | 2 | 2 | 4.0 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NCCc1ccccc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50829 | 188374 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 397 | 9 | 2 | 2 | 4.0 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NCCc1ccccc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 9951883 | 168127 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 381 | 8 | 2 | 3 | 4.2 | COc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL43666 | 168127 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 381 | 8 | 2 | 3 | 4.2 | COc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 11734303 | 168012 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 547 | 9 | 3 | 3 | 6.5 | CC(C)(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL435812 | 168012 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 547 | 9 | 3 | 3 | 6.5 | CC(C)(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 11396966 | 78595 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 457 | 6 | 2 | 2 | 6.1 | O=C(Nc1cccc(Cl)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL2113082 | 78595 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 457 | 6 | 2 | 2 | 6.1 | O=C(Nc1cccc(Cl)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44289762 | 165382 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 380 | 7 | 2 | 3 | 3.8 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL42507 | 165382 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 380 | 7 | 2 | 3 | 3.8 | N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 11059280 | 116405 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 442 | 6 | 2 | 3 | 5.8 | N#Cc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL338389 | 116405 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 442 | 6 | 2 | 3 | 5.8 | N#Cc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 11037958 | 75618 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 5.5 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm300682j | ||
| CHEMBL20532 | 75618 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 5.5 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm300682j | ||
| 11037958 | 75618 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 5.5 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/s0960-894x(01)00176-7 | ||
| CHEMBL20532 | 75618 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 5.5 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/s0960-894x(01)00176-7 | ||
| 44440394 | 93290 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 578 | 8 | 0 | 5 | 5.8 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL247160 | 93290 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 578 | 8 | 0 | 5 | 5.8 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 9927733 | 116400 | 1 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 336 | 6 | 2 | 3 | 3.1 | CCOC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33838 | 116400 | 1 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 336 | 6 | 2 | 3 | 3.1 | CCOC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| 9888454 | 101409 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 421 | 6 | 1 | 3 | 4.9 | COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccccc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL300726 | 101409 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 421 | 6 | 1 | 3 | 4.9 | COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccccc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44281522 | 111024 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 391 | 6 | 1 | 4 | 3.2 | CN(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL32784 | 111024 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 391 | 6 | 1 | 4 | 3.2 | CN(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 11133428 | 16549 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 413 | 7 | 2 | 2 | 5.5 | O=C(NCc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124321 | 16549 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 413 | 7 | 2 | 2 | 5.5 | O=C(NCc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 10863284 | 18371 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 449 | 7 | 2 | 2 | 6.1 | O=C(Nc1ccc(F)cc1)Nc1ccccc1CCN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL127590 | 18371 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 449 | 7 | 2 | 2 | 6.1 | O=C(Nc1ccc(F)cc1)Nc1ccccc1CCN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 44390931 | 122417 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 437 | 7 | 2 | 6 | 3.1 | Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(CCc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL360653 | 122417 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 437 | 7 | 2 | 6 | 3.1 | Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(CCc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 76320703 | 103061 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 423 | 6 | 2 | 6 | 3.1 | Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL3085296 | 103061 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 423 | 6 | 2 | 6 | 3.1 | Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 10875472 | 113160 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 568 | 10 | 3 | 4 | 6.6 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccncc1 | 10.1021/jm0201767 | ||
| CHEMBL332277 | 113160 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 568 | 10 | 3 | 4 | 6.6 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccncc1 | 10.1021/jm0201767 | ||
| 9981262 | 64524 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(CCCc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL182087 | 64524 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(CCCc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 10874195 | 163804 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 459 | 8 | 3 | 4 | 5.3 | COc1cccc(NC(=O)Nc2cc(CO)ccc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL421273 | 163804 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 459 | 8 | 3 | 4 | 5.3 | COc1cccc(NC(=O)Nc2cc(CO)ccc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| 11112528 | 16634 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 417 | 6 | 2 | 2 | 5.9 | O=C(Nc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124669 | 16634 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 417 | 6 | 2 | 2 | 5.9 | O=C(Nc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 44295487 | 168597 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 444 | 5 | 2 | 3 | 4.5 | O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1ccc(C(F)(F)F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL440477 | 168597 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 444 | 5 | 2 | 3 | 4.5 | O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1ccc(C(F)(F)F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 11145481 | 113069 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 8 | 2 | 3 | 5.9 | O=C(Nc1cccc(CN2CCC(Cc3ccccc3)CC2)c1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL332227 | 113069 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 8 | 2 | 3 | 5.9 | O=C(Nc1cccc(CN2CCC(Cc3ccccc3)CC2)c1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 22393395 | 168299 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3F)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL43818 | 168299 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 394 | 7 | 2 | 3 | 4.2 | N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3F)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44390857 | 63299 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 490 | 9 | 2 | 7 | 3.6 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(N(C)C)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL180082 | 63299 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 490 | 9 | 2 | 7 | 3.6 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(N(C)C)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 10939210 | 16729 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 445 | 8 | 2 | 2 | 5.6 | O=C(NCCc1ccc(F)cc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL125167 | 16729 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 445 | 8 | 2 | 2 | 5.6 | O=C(NCCc1ccc(F)cc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 11722772 | 98133 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 307 | 7 | 0 | 1 | 5.0 | c1ccc(CCCCN2CCC(Cc3ccccc3)CC2)cc1 | 10.1021/jm0201767 | ||
| CHEMBL276784 | 98133 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 307 | 7 | 0 | 1 | 5.0 | c1ccc(CCCCN2CCC(Cc3ccccc3)CC2)cc1 | 10.1021/jm0201767 | ||
| 77033 | 113296 | 75 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 313 | 6 | 2 | 4 | 2.3 | CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33242 | 113296 | 75 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 313 | 6 | 2 | 4 | 2.3 | CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| 22966052 | 83809 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 376 | 7 | 3 | 3 | 4.1 | N#Cc1cccc(NC(=O)NCCC[C@@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL220866 | 83809 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 376 | 7 | 3 | 3 | 4.1 | N#Cc1cccc(NC(=O)NCCC[C@@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44289959 | 99953 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 437 | 8 | 2 | 3 | 5.0 | CC(=O)c1cccc(NC(=O)NCCCN2CC3(Cc4ccc(F)cc4)CCC2CC3)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL290276 | 99953 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 437 | 8 | 2 | 3 | 5.0 | CC(=O)c1cccc(NC(=O)NCCCN2CC3(Cc4ccc(F)cc4)CCC2CC3)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44290040 | 171898 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL44817 | 171898 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 8 | 2 | 3 | 4.5 | CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44295259 | 162005 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 393 | 6 | 1 | 3 | 3.6 | O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL416835 | 162005 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 393 | 6 | 1 | 3 | 3.6 | O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 9935588 | 16720 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 8 | 2 | 3 | 5.9 | O=C(Nc1ccccc1CN1CCC(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL125108 | 16720 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 8 | 2 | 3 | 5.9 | O=C(Nc1ccccc1CN1CCC(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 10874991 | 163806 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 517 | 9 | 2 | 3 | 6.7 | O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL421274 | 163806 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 517 | 9 | 2 | 3 | 6.7 | O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 44445874 | 94078 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 541 | 9 | 2 | 6 | 5.0 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC3CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251623 | 94078 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 541 | 9 | 2 | 6 | 5.0 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC3CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44455792 | 95279 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.9 | C[C@@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL258323 | 95279 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.9 | C[C@@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 11214474 | 71009 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 6 | 2 | 4 | 6.7 | O=C(Nc1nc2c(Cl)cccc2s1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL195790 | 71009 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 6 | 2 | 4 | 6.7 | O=C(Nc1nc2c(Cl)cccc2s1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 11442439 | 123539 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 455 | 6 | 2 | 2 | 5.9 | Cc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1F | 10.1021/jm049530m | ||
| CHEMBL363166 | 123539 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 455 | 6 | 2 | 2 | 5.9 | Cc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1F | 10.1021/jm049530m | ||
| 9804542 | 129762 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| CHEMBL367992 | 129762 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm049530m | ||
| 44419340 | 83955 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 451 | 10 | 2 | 3 | 5.4 | C=CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL221903 | 83955 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 451 | 10 | 2 | 3 | 5.4 | C=CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 10140602 | 166065 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 479 | 7 | 2 | 6 | 3.4 | C[C@H](CC(=O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL428071 | 166065 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 479 | 7 | 2 | 6 | 3.4 | C[C@H](CC(=O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 20636465 | 83675 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 9 | 4 | 4 | 4.3 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C(=N)N)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL220766 | 83675 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 9 | 4 | 4 | 4.3 | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C(=N)N)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44346153 | 15328 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 519 | 8 | 3 | 5 | 4.1 | C[C@H](O)[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL121637 | 15328 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 519 | 8 | 3 | 5 | 4.1 | C[C@H](O)[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 | 10.1016/s0960-894x(03)00748-0 | ||
| 11259591 | 125003 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 455 | 6 | 2 | 2 | 5.9 | Cc1ccc(F)cc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL364673 | 125003 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 455 | 6 | 2 | 2 | 5.9 | Cc1ccc(F)cc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44346194 | 15373 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 501 | 9 | 2 | 5 | 5.4 | COc1cc(NC(=O)N[C@H](C)CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)cc(OC)c1OC | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL121905 | 15373 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 501 | 9 | 2 | 5 | 5.4 | COc1cc(NC(=O)N[C@H](C)CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)cc(OC)c1OC | 10.1016/s0960-894x(03)00748-0 | ||
| 44445879 | 93780 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 545 | 7 | 2 | 7 | 4.3 | COC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249852 | 93780 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 545 | 7 | 2 | 7 | 4.3 | COC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44440412 | 150489 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 596 | 8 | 0 | 5 | 5.9 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccc2F)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL395850 | 150489 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 596 | 8 | 0 | 5 | 5.9 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccc2F)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44295554 | 187760 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 415 | 8 | 2 | 3 | 5.0 | CSc1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50094 | 187760 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 415 | 8 | 2 | 3 | 5.0 | CSc1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 23509693 | 190897 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 540 | 6 | 1 | 5 | 5.2 | COc1cccc(NC(=O)N2CCN(C(=O)OC(C)(C)C)C(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51937 | 190897 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 540 | 6 | 1 | 5 | 5.2 | COc1cccc(NC(=O)N2CCN(C(=O)OC(C)(C)C)C(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 10029075 | 116332 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 503 | 7 | 2 | 5 | 5.9 | CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| CHEMBL337990 | 116332 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 503 | 7 | 2 | 5 | 5.9 | CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| 44440423 | 146177 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 635 | 9 | 1 | 6 | 5.7 | CC(=O)Nc1ccc(-n2c(=O)c(CN(CCc3ccc(Cl)cc3)C3CCN(C(=O)c4c(F)cccc4F)CC3)c(C)n2C)cc1 | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL392405 | 146177 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 635 | 9 | 1 | 6 | 5.7 | CC(=O)Nc1ccc(-n2c(=O)c(CN(CCc3ccc(Cl)cc3)C3CCN(C(=O)c4c(F)cccc4F)CC3)c(C)n2C)cc1 | 10.1016/j.bmcl.2007.05.035 | ||
| 22393428 | 188069 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 383 | 8 | 2 | 2 | 4.0 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NCc1ccccc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50354 | 188069 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 383 | 8 | 2 | 2 | 4.0 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NCc1ccccc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393333 | 188815 | 4 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 351 | 7 | 2 | 2 | 4.2 | O=C(NCCCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51307 | 188815 | 4 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 351 | 7 | 2 | 2 | 4.2 | O=C(NCCCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44281523 | 99227 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 453 | 8 | 2 | 4 | 4.4 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)NCc1ccccc1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL284577 | 99227 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 453 | 8 | 2 | 4 | 4.4 | O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)NCc1ccccc1)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 11282712 | 78126 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)NC2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL2112049 | 78126 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)NC2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1021/jm049530m | ||
| 22393315 | 168117 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 376 | 7 | 2 | 3 | 4.0 | N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL43655 | 168117 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 376 | 7 | 2 | 3 | 4.0 | N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 11134412 | 164089 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 465 | 7 | 3 | 3 | 5.6 | O=C(Nc1cc(F)ccc1F)Nc1ccccc1C(O)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL421634 | 164089 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 465 | 7 | 3 | 3 | 5.6 | O=C(Nc1cc(F)ccc1F)Nc1ccccc1C(O)CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 10864223 | 16705 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 517 | 8 | 2 | 5 | 5.9 | COC(=O)c1ccc(NC(=O)Nc2cccc(C(C)=O)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL125012 | 16705 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 517 | 8 | 2 | 5 | 5.9 | COC(=O)c1ccc(NC(=O)Nc2cccc(C(C)=O)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 44447142 | 94232 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 589 | 12 | 3 | 7 | 5.0 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC12CC3CC(CC(C3)C1)C2 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL252610 | 94232 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 589 | 12 | 3 | 7 | 5.0 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC12CC3CC(CC(C3)C1)C2 | 10.1016/j.bmcl.2007.11.087 | ||
| 9845853 | 127953 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 435 | 7 | 2 | 3 | 5.3 | COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm049530m | ||
| CHEMBL366654 | 127953 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 435 | 7 | 2 | 3 | 5.3 | COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm049530m | ||
| 44593546 | 178180 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 531 | 6 | 2 | 6 | 4.9 | CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL468695 | 178180 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 531 | 6 | 2 | 6 | 4.9 | CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| 44445853 | 154045 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 473 | 7 | 3 | 6 | 3.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CNC[C@@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL399134 | 154045 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 473 | 7 | 3 | 6 | 3.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CNC[C@@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 11144348 | 16407 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 424 | 6 | 2 | 3 | 5.7 | N#Cc1cccc(NC(=O)Nc2cccc(CN3CCC(Cc4ccccc4)CC3)c2)c1 | 10.1021/jm0201767 | ||
| CHEMBL123957 | 16407 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 424 | 6 | 2 | 3 | 5.7 | N#Cc1cccc(NC(=O)Nc2cccc(CN3CCC(Cc4ccccc4)CC3)c2)c1 | 10.1021/jm0201767 | ||
| 11048445 | 16587 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 439 | 6 | 3 | 3 | 5.7 | O=C(Nc1ccc2[nH]ncc2c1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124390 | 16587 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 439 | 6 | 3 | 3 | 5.7 | O=C(Nc1ccc2[nH]ncc2c1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 11091447 | 168824 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 439 | 6 | 3 | 3 | 5.7 | O=C(Nc1ccc2c[nH]nc2c1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL442210 | 168824 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 439 | 6 | 3 | 3 | 5.7 | O=C(Nc1ccc2c[nH]nc2c1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 6918497 | 112931 | 1 | None | - | 0 | Mouse | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| CHEMBL277930 | 112931 | 1 | None | - | 0 | Mouse | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| CHEMBL331897 | 112931 | 1 | None | - | 0 | Mouse | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| 10916572 | 18331 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 408 | 8 | 0 | 2 | 6.2 | N#CC(CCCN1CCC(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL127395 | 18331 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 408 | 8 | 0 | 2 | 6.2 | N#CC(CCCN1CCC(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 11102400 | 117591 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 449 | 6 | 2 | 3 | 5.7 | O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL340656 | 117591 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 449 | 6 | 2 | 3 | 5.7 | O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 10906911 | 17806 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 477 | 8 | 3 | 4 | 5.4 | COc1cccc(NC(=O)Nc2ccc(CO)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL126220 | 17806 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 477 | 8 | 3 | 4 | 5.4 | COc1cccc(NC(=O)Nc2ccc(CO)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 68826395 | 103031 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 437 | 8 | 2 | 3 | 5.0 | CC(=O)c1cccc(NC(=O)NCCCN2[C@H]3CC[C@@H]2C[C@H](Cc2ccc(F)cc2)C3)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL3085118 | 103031 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 437 | 8 | 2 | 3 | 5.0 | CC(=O)c1cccc(NC(=O)NCCCN2[C@H]3CC[C@@H]2C[C@H](Cc2ccc(F)cc2)C3)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 10984360 | 96501 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 537 | 8 | 1 | 7 | 5.7 | CCOC(=O)c1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 | 10.1016/s0960-894x(01)00176-7 | ||
| CHEMBL266181 | 96501 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 537 | 8 | 1 | 7 | 5.7 | CCOC(=O)c1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 | 10.1016/s0960-894x(01)00176-7 | ||
| 44295375 | 167590 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 419 | 6 | 2 | 4 | 3.5 | CN(C)c1ccc(NC(=O)NCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL433086 | 167590 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 419 | 6 | 2 | 4 | 3.5 | CN(C)c1ccc(NC(=O)NCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 9840971 | 99278 | 41 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 342 | 7 | 1 | 5 | 2.5 | CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL284954 | 99278 | 41 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 342 | 7 | 1 | 5 | 2.5 | CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| 11733139 | 16724 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 454 | 7 | 3 | 4 | 5.2 | N#Cc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL125132 | 16724 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 454 | 7 | 3 | 4 | 5.2 | N#Cc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| 44289699 | 167252 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 409 | 6 | 2 | 3 | 3.9 | CC(=O)c1cccc(NC(=O)NCCCN2C[C@@H]3Cc4ccc(F)cc4C[C@H]3C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL43066 | 167252 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 409 | 6 | 2 | 3 | 3.9 | CC(=O)c1cccc(NC(=O)NCCCN2C[C@@H]3Cc4ccc(F)cc4C[C@H]3C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 10474776 | 113158 | 36 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL33227 | 113158 | 36 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(03)00748-0 | ||
| 44390842 | 123319 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 437 | 7 | 2 | 6 | 3.1 | Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL362490 | 123319 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 437 | 7 | 2 | 6 | 3.1 | Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44295485 | 101402 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 497 | 12 | 3 | 4 | 5.4 | CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccc(F)cc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL300699 | 101402 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 497 | 12 | 3 | 4 | 5.4 | CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccc(F)cc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393287 | 167401 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL43173 | 167401 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 11316656 | 69919 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 441 | 6 | 2 | 2 | 5.6 | O=C(Nc1ccc(F)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL194141 | 69919 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 441 | 6 | 2 | 2 | 5.6 | O=C(Nc1ccc(F)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 10474776 | 113158 | 36 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33227 | 113158 | 36 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 22393287 | 167401 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL43173 | 167401 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 3.5 | Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44593553 | 177792 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 489 | 6 | 2 | 6 | 3.9 | Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL465272 | 177792 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 489 | 6 | 2 | 6 | 3.9 | Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 | 10.1016/j.bmcl.2008.11.002 | ||
| 44593546 | 178180 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 531 | 6 | 2 | 6 | 4.9 | CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL468695 | 178180 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 531 | 6 | 2 | 6 | 4.9 | CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O | 10.1016/j.bmcl.2008.11.002 | ||
| 44390911 | 63476 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 515 | 8 | 2 | 6 | 4.8 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(Cl)cc3Cl)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL180229 | 63476 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 515 | 8 | 2 | 6 | 4.8 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(Cl)cc3Cl)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44390859 | 131268 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.7 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccccc3F)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL369331 | 131268 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 3.7 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccccc3F)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44447369 | 94174 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 453 | 9 | 4 | 8 | 1.8 | C[C@@H]([C@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL252222 | 94174 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 453 | 9 | 4 | 8 | 1.8 | C[C@@H]([C@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44419308 | 140998 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 509 | 10 | 2 | 4 | 5.4 | CCC(=O)N1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL384649 | 140998 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 509 | 10 | 2 | 4 | 5.4 | CCC(=O)N1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44455872 | 154977 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 467 | 9 | 2 | 4 | 5.1 | CC(=O)c1cc(NC(=O)N[C@@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| CHEMBL404202 | 154977 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 467 | 9 | 2 | 4 | 5.1 | CC(=O)c1cc(NC(=O)N[C@@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 | 10.1016/j.bmcl.2007.11.067 | ||
| 44295622 | 101021 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 465 | 10 | 3 | 4 | 4.7 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@@H](O)C(C)C)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL297904 | 101021 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 465 | 10 | 3 | 4 | 4.7 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@@H](O)C(C)C)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295286 | 187715 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 431 | 8 | 2 | 3 | 4.0 | C[S+]([O-])c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50034 | 187715 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 431 | 8 | 2 | 3 | 4.0 | C[S+]([O-])c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295672 | 188170 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 6 | 1 | 3 | 5.0 | COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50535 | 188170 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 6 | 1 | 3 | 5.0 | COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295641 | 188739 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 453 | 9 | 4 | 5 | 3.4 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2C(C)(O)O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51244 | 188739 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 453 | 9 | 4 | 5 | 3.4 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2C(C)(O)O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 23509695 | 189147 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 441 | 6 | 1 | 4 | 4.0 | COc1cccc(NC(=O)N2CCOC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51584 | 189147 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 441 | 6 | 1 | 4 | 4.0 | COc1cccc(NC(=O)N2CCOC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295364 | 193283 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL54290 | 193283 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22257689 | 16404 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 446 | 7 | 1 | 2 | 6.0 | Cc1ccc(C(=O)NC(CN2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc1 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL123943 | 16404 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 446 | 7 | 1 | 2 | 6.0 | Cc1ccc(C(=O)NC(CN2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc1 | 10.1016/s0960-894x(03)00748-0 | ||
| 44346211 | 163341 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 537 | 10 | 2 | 5 | 6.5 | COc1cc(NC(=O)NC(CC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc(OC)c1OC | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL420709 | 163341 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 537 | 10 | 2 | 5 | 6.5 | COc1cc(NC(=O)NC(CC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc(OC)c1OC | 10.1016/s0960-894x(03)00748-0 | ||
| 44295130 | 100727 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 362 | 6 | 2 | 3 | 3.6 | N#Cc1cccc(NC(=O)NCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL295726 | 100727 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 362 | 6 | 2 | 3 | 3.6 | N#Cc1cccc(NC(=O)NCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295528 | 101437 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 336 | 4 | 0 | 2 | 4.0 | Fc1ccc(CCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL300905 | 101437 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 336 | 4 | 0 | 2 | 4.0 | Fc1ccc(CCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393370 | 189263 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 390 | 7 | 2 | 3 | 4.3 | Cc1ccc(CC2CCN(CCCNC(=O)Nc3cccc(C#N)c3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51676 | 189263 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 390 | 7 | 2 | 3 | 4.3 | Cc1ccc(CC2CCN(CCCNC(=O)Nc3cccc(C#N)c3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22393398 | 193248 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 390 | 8 | 2 | 3 | 4.4 | N#Cc1cccc(NC(=O)NCCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL54143 | 193248 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 390 | 8 | 2 | 3 | 4.4 | N#Cc1cccc(NC(=O)NCCCCN2CCC(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 10979426 | 17780 | 1 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 298 | 7 | 3 | 2 | 2.7 | O=C(NCCCO)NC(Cc1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL126106 | 17780 | 1 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 298 | 7 | 3 | 2 | 2.7 | O=C(NCCCO)NC(Cc1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 44295102 | 187368 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 405 | 7 | 1 | 4 | 3.4 | COc1ccc(C(=O)NCCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL49702 | 187368 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 405 | 7 | 1 | 4 | 3.4 | COc1ccc(C(=O)NCCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 10985078 | 114240 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 635 | 10 | 3 | 3 | 8.2 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccc(C(F)(F)F)cc1 | 10.1021/jm0201767 | ||
| CHEMBL333865 | 114240 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 635 | 10 | 3 | 3 | 8.2 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccc(C(F)(F)F)cc1 | 10.1021/jm0201767 | ||
| 11081509 | 18357 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 492 | 6 | 2 | 3 | 6.9 | N#Cc1cccc(NC(=O)Nc2c(CN3CCC(Cc4ccc(F)cc4)CC3)ccc3ccccc23)c1 | 10.1021/jm0201767 | ||
| CHEMBL127534 | 18357 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 492 | 6 | 2 | 3 | 6.9 | N#Cc1cccc(NC(=O)Nc2c(CN3CCC(Cc4ccc(F)cc4)CC3)ccc3ccccc23)c1 | 10.1021/jm0201767 | ||
| 11004826 | 17805 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 447 | 7 | 3 | 3 | 5.4 | O=C(Nc1ccccc1)Nc1cccc(CO)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL126218 | 17805 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 447 | 7 | 3 | 3 | 5.4 | O=C(Nc1ccccc1)Nc1cccc(CO)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 44295470 | 188241 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 425 | 5 | 1 | 3 | 4.8 | COc1cccc(NC(=O)N2CCCC(N3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50645 | 188241 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 425 | 5 | 1 | 3 | 4.8 | COc1cccc(NC(=O)N2CCCC(N3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 22022834 | 112838 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 472 | 7 | 1 | 2 | 6.4 | Cc1ccc(C(=O)NC(CN2CC3CCC2CC3Cc2ccc(Cl)c(Cl)c2)C(C)C)cc1 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL331672 | 112838 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 472 | 7 | 1 | 2 | 6.4 | Cc1ccc(C(=O)NC(CN2CC3CCC2CC3Cc2ccc(Cl)c(Cl)c2)C(C)C)cc1 | 10.1016/s0960-894x(03)00748-0 | ||
| 11072275 | 16618 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 632 | 10 | 3 | 5 | 5.9 | COC(=O)N1CCC(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124585 | 16618 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 632 | 10 | 3 | 5 | 5.9 | COC(=O)N1CCC(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 25024651 | 115536 | 0 | None | 39 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355956 | 115536 | 0 | None | 39 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2014.11.063 | ||
| 10257335 | 99979 | 4 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 565 | 6 | 2 | 4 | 3.5 | CCOC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL290565 | 99979 | 4 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 565 | 6 | 2 | 4 | 3.5 | CCOC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| 11227406 | 93909 | 1 | None | - | 0 | Mouse | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL250689 | 93909 | 1 | None | - | 0 | Mouse | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 465 | 7 | 2 | 3 | 5.7 | CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2007.03.065 | ||
| 44390858 | 63572 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 423 | 6 | 2 | 6 | 3.1 | Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL180534 | 63572 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 423 | 6 | 2 | 6 | 3.1 | Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 10928826 | 17618 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 472 | 7 | 3 | 4 | 5.3 | N#Cc1cccc(NC(=O)Nc2ccc(CO)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL125884 | 17618 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 472 | 7 | 3 | 4 | 5.3 | N#Cc1cccc(NC(=O)Nc2ccc(CO)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 9951882 | 178590 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 381 | 8 | 2 | 3 | 4.2 | COc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL47220 | 178590 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 381 | 8 | 2 | 3 | 4.2 | COc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3)C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44295230 | 188528 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 379 | 5 | 1 | 3 | 3.2 | O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51038 | 188528 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 379 | 5 | 1 | 3 | 3.2 | O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44290041 | 172159 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 409 | 6 | 2 | 3 | 3.9 | CC(=O)c1cccc(NC(=O)NCCCN2C[C@H]3Cc4ccc(F)cc4C[C@H]3C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL45064 | 172159 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 409 | 6 | 2 | 3 | 3.9 | CC(=O)c1cccc(NC(=O)NCCCN2C[C@H]3Cc4ccc(F)cc4C[C@H]3C2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44281790 | 168647 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 420 | 6 | 1 | 5 | 4.4 | CC(C)(C)OC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL440844 | 168647 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 420 | 6 | 1 | 5 | 4.4 | CC(C)(C)OC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 11082578 | 117567 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 603 | 10 | 3 | 3 | 7.5 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cc(F)ccc1F | 10.1021/jm0201767 | ||
| CHEMBL340491 | 117567 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 603 | 10 | 3 | 3 | 7.5 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cc(F)ccc1F | 10.1021/jm0201767 | ||
| 44447366 | 94173 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 453 | 9 | 4 | 8 | 1.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@H](C)[C@H](O)c1ccccc1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL252221 | 94173 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 453 | 9 | 4 | 8 | 1.8 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@H](C)[C@H](O)c1ccccc1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44447141 | 94150 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 523 | 11 | 3 | 7 | 3.4 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC(F)(F)F | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL252034 | 94150 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 523 | 11 | 3 | 7 | 3.4 | C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC(F)(F)F | 10.1016/j.bmcl.2007.11.087 | ||
| 9818195 | 109875 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 311 | 7 | 1 | 3 | 3.0 | CCOC(=O)[C@H](CCc1ccccc1)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL32413 | 109875 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 311 | 7 | 1 | 3 | 3.0 | CCOC(=O)[C@H](CCc1ccccc1)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| 10995329 | 17997 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 563 | 13 | 4 | 4 | 5.5 | O=C(NCCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL126978 | 17997 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 563 | 13 | 4 | 4 | 5.5 | O=C(NCCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 44419327 | 82804 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 393 | 8 | 3 | 3 | 4.4 | CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL218581 | 82804 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 393 | 8 | 3 | 3 | 4.4 | CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44447155 | 154384 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 511 | 11 | 3 | 7 | 2.9 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C(C)=O)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL401002 | 154384 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 511 | 11 | 3 | 7 | 2.9 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C(C)=O)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44445843 | 93806 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 587 | 7 | 2 | 7 | 5.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL250054 | 93806 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 587 | 7 | 2 | 7 | 5.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44390978 | 64241 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 437 | 7 | 2 | 6 | 3.1 | Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(CCc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL181575 | 64241 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 437 | 7 | 2 | 6 | 3.1 | Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(CCc3ccc(F)cc3)C2)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 3492 | 685 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O | 10.1016/s0960-894x(02)00206-8 | ||
| 9868459 | 685 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50593 | 685 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O | 10.1016/s0960-894x(02)00206-8 | ||
| 11179592 | 69249 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 501 | 6 | 2 | 2 | 6.2 | O=C(Nc1ccc(Br)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| CHEMBL193442 | 69249 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 501 | 6 | 2 | 2 | 6.2 | O=C(Nc1ccc(Br)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 | 10.1021/jm049530m | ||
| 44440431 | 145929 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 607 | 9 | 0 | 7 | 5.2 | Cc1c(CN(CCc2ccc([N+](=O)[O-])cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL392217 | 145929 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 607 | 9 | 0 | 7 | 5.2 | Cc1c(CN(CCc2ccc([N+](=O)[O-])cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 44445890 | 154410 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 543 | 9 | 2 | 7 | 4.1 | CC(=O)CN1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL401115 | 154410 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 543 | 9 | 2 | 7 | 4.1 | CC(=O)CN1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 | 10.1016/j.bmcl.2007.03.065 | ||
| 11226588 | 94327 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 547 | 10 | 2 | 6 | 5.2 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN(CCCc2ccc(F)cc2)CC(F)(F)F)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL253211 | 94327 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 547 | 10 | 2 | 6 | 5.2 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN(CCCc2ccc(F)cc2)CC(F)(F)F)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44295201 | 170776 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 479 | 11 | 3 | 4 | 5.1 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](O)CC(C)C)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL446144 | 170776 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 479 | 11 | 3 | 4 | 5.1 | CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](O)CC(C)C)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295328 | 193079 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 437 | 7 | 2 | 2 | 5.3 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc(C(F)(F)F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL53673 | 193079 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 437 | 7 | 2 | 2 | 5.3 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc(C(F)(F)F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 11026367 | 16305 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 429 | 7 | 2 | 3 | 5.8 | COc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL123511 | 16305 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 429 | 7 | 2 | 3 | 5.8 | COc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| 11060510 | 16325 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 533 | 10 | 3 | 3 | 6.1 | CC(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL123622 | 16325 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 533 | 10 | 3 | 3 | 6.1 | CC(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 11004681 | 16653 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 439 | 6 | 3 | 3 | 5.7 | O=C(Nc1cccc(CN2CCC(Cc3ccccc3)CC2)c1)Nc1ccc2[nH]ncc2c1 | 10.1021/jm0201767 | ||
| CHEMBL124748 | 16653 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 439 | 6 | 3 | 3 | 5.7 | O=C(Nc1cccc(CN2CCC(Cc3ccccc3)CC2)c1)Nc1ccc2[nH]ncc2c1 | 10.1021/jm0201767 | ||
| 7072714 | 109967 | 2 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 490 | 11 | 3 | 6 | 3.5 | CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL32468 | 109967 | 2 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 490 | 11 | 3 | 6 | 3.5 | CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| 44440413 | 93155 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 612 | 8 | 0 | 5 | 6.4 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(Cl)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL246549 | 93155 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 612 | 8 | 0 | 5 | 6.4 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(Cl)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 10983980 | 17862 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 505 | 8 | 2 | 5 | 5.7 | COC(=O)c1ccc(NC(=O)Nc2cccc(OC)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL126520 | 17862 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 505 | 8 | 2 | 5 | 5.7 | COC(=O)c1ccc(NC(=O)Nc2cccc(OC)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 44295463 | 161455 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 429 | 7 | 1 | 4 | 3.1 | O=S(=O)(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL415950 | 161455 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 429 | 7 | 1 | 4 | 3.1 | O=S(=O)(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44419314 | 82888 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 376 | 7 | 3 | 3 | 4.1 | N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL218997 | 82888 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 376 | 7 | 3 | 3 | 4.1 | N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44346154 | 168096 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 7 | 2 | 4 | 4.7 | C[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL436363 | 168096 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 7 | 2 | 4 | 4.7 | C[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 | 10.1016/s0960-894x(03)00748-0 | ||
| 11511522 | 67525 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 491 | 8 | 0 | 6 | 3.1 | COc1ccc(OC)c(S(=O)(=O)N2CCC(CN3CCN(Cc4ccc(F)cc4)CC3)CC2)c1 | 10.1016/j.bmcl.2011.09.013 | ||
| CHEMBL1910163 | 67525 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 491 | 8 | 0 | 6 | 3.1 | COc1ccc(OC)c(S(=O)(=O)N2CCC(CN3CCN(Cc4ccc(F)cc4)CC3)CC2)c1 | 10.1016/j.bmcl.2011.09.013 | ||
| 44295407 | 189049 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 433 | 6 | 1 | 3 | 4.3 | O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)C12CC3CC(CC(C3)C1)C2 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51507 | 189049 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 433 | 6 | 1 | 3 | 4.3 | O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)C12CC3CC(CC(C3)C1)C2 | 10.1016/s0960-894x(02)00206-8 | ||
| 9845853 | 127953 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 435 | 7 | 2 | 3 | 5.3 | COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm049530m | ||
| CHEMBL366654 | 127953 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 435 | 7 | 2 | 3 | 5.3 | COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm049530m | ||
| 10929194 | 17791 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 500 | 7 | 2 | 5 | 5.6 | COC(=O)c1ccc(NC(=O)Nc2cccc(C#N)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL126163 | 17791 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 500 | 7 | 2 | 5 | 5.6 | COC(=O)c1ccc(NC(=O)Nc2cccc(C#N)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 44295065 | 183709 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 405 | 7 | 1 | 4 | 3.4 | COc1ccccc1C(=O)NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL48401 | 183709 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 405 | 7 | 1 | 4 | 3.4 | COc1ccccc1C(=O)NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3 | 10.1016/s0960-894x(02)00206-8 | ||
| 10474776 | 113158 | 36 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL33227 | 113158 | 36 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 22966050 | 83721 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 455 | 10 | 3 | 4 | 4.2 | CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCO)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| CHEMBL220801 | 83721 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 455 | 10 | 3 | 4 | 4.2 | CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCO)c1 | 10.1016/j.bmcl.2006.08.012 | ||
| 44295282 | 101187 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 414 | 8 | 2 | 4 | 4.2 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc([N+](=O)[O-])cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL299170 | 101187 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 414 | 8 | 2 | 4 | 4.2 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc([N+](=O)[O-])cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295591 | 187634 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 465 | 11 | 3 | 4 | 4.9 | CCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL49921 | 187634 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 465 | 11 | 3 | 4 | 4.9 | CCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44593555 | 188198 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 642 | 10 | 4 | 6 | 4.9 | CSc1ccc(C(=O)NC2CC(NC(=O)OCc3ccccc3)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | ||
| CHEMBL505722 | 188198 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 642 | 10 | 4 | 6 | 4.9 | CSc1ccc(C(=O)NC2CC(NC(=O)OCc3ccccc3)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | ||
| 10874762 | 16625 | 1 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 500 | 7 | 2 | 5 | 5.6 | COC(=O)c1cccc(NC(=O)Nc2cccc(C#N)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124628 | 16625 | 1 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 500 | 7 | 2 | 5 | 5.6 | COC(=O)c1cccc(NC(=O)Nc2cccc(C#N)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 44290020 | 178448 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 435 | 8 | 2 | 4 | 4.5 | O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-n2ccnc2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL47122 | 178448 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 435 | 8 | 2 | 4 | 4.5 | O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-n2ccnc2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 68826395 | 103031 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 437 | 8 | 2 | 3 | 5.0 | CC(=O)c1cccc(NC(=O)NCCCN2[C@H]3CC[C@@H]2C[C@H](Cc2ccc(F)cc2)C3)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL3085118 | 103031 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 437 | 8 | 2 | 3 | 5.0 | CC(=O)c1cccc(NC(=O)NCCCN2[C@H]3CC[C@@H]2C[C@H](Cc2ccc(F)cc2)C3)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 44445850 | 93648 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 473 | 7 | 3 | 6 | 3.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL249056 | 93648 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 473 | 7 | 3 | 6 | 3.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44390898 | 64234 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.2 | CCc1cc(NC(=O)N[C@@H]2CCCN(CCCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL181528 | 64234 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 479 | 9 | 2 | 6 | 4.2 | CCc1cc(NC(=O)N[C@@H]2CCCN(CCCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44290029 | 178568 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 436 | 8 | 2 | 4 | 4.9 | O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-c2cnco2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL47211 | 178568 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 436 | 8 | 2 | 4 | 4.9 | O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-c2cnco2)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 22393474 | 96102 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 437 | 7 | 2 | 2 | 5.3 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL262918 | 96102 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 437 | 7 | 2 | 2 | 5.3 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295288 | 188759 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 447 | 8 | 2 | 4 | 3.7 | CS(=O)(=O)c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL51259 | 188759 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 447 | 8 | 2 | 4 | 3.7 | CS(=O)(=O)c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44295510 | 101376 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 401 | 5 | 2 | 4 | 3.3 | N#Cc1cccc(NC(=O)NCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL300472 | 101376 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 401 | 5 | 2 | 4 | 3.3 | N#Cc1cccc(NC(=O)NCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 10591473 | 64556 | 10 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 279 | 5 | 0 | 1 | 4.2 | c1ccc(CCN2CCC(Cc3ccccc3)CC2)cc1 | 10.1021/jm0201767 | ||
| CHEMBL18222 | 64556 | 10 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 279 | 5 | 0 | 1 | 4.2 | c1ccc(CCN2CCC(Cc3ccccc3)CC2)cc1 | 10.1021/jm0201767 | ||
| 11812728 | 16572 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 4.8 | O=C(NCc1ccc2c(c1)OCO2)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124336 | 16572 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 4.8 | O=C(NCc1ccc2c(c1)OCO2)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 10000888 | 75624 | 3 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.2 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00176-7 | ||
| CHEMBL20539 | 75624 | 3 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.2 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00176-7 | ||
| 10142792 | 93308 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 521 | 9 | 5 | 5 | 2.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | ||
| CHEMBL247245 | 93308 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 521 | 9 | 5 | 5 | 2.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | ||
| 11069916 | 16381 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 424 | 6 | 2 | 3 | 5.7 | N#Cc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL123791 | 16381 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 424 | 6 | 2 | 3 | 5.7 | N#Cc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| 10993686 | 116437 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 429 | 7 | 2 | 3 | 5.8 | COc1ccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)cc1 | 10.1021/jm0201767 | ||
| CHEMBL338543 | 116437 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 429 | 7 | 2 | 3 | 5.8 | COc1ccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)cc1 | 10.1021/jm0201767 | ||
| 57394442 | 67527 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 407 | 8 | 2 | 3 | 4.2 | O=C(NCCCCN1CCC(Oc2ccc(F)cc2)C1)Nc1ccc(F)c(F)c1 | 10.1016/j.bmcl.2011.09.013 | ||
| CHEMBL1910165 | 67527 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 407 | 8 | 2 | 3 | 4.2 | O=C(NCCCCN1CCC(Oc2ccc(F)cc2)C1)Nc1ccc(F)c(F)c1 | 10.1016/j.bmcl.2011.09.013 | ||
| 11072063 | 16428 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 597 | 11 | 3 | 4 | 7.2 | COc1ccc(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm0201767 | ||
| CHEMBL124084 | 16428 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 597 | 11 | 3 | 4 | 7.2 | COc1ccc(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm0201767 | ||
| 11026461 | 16759 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 434 | 8 | 2 | 3 | 4.7 | O=C(NCCN1CCCCC1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL125325 | 16759 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 434 | 8 | 2 | 3 | 4.7 | O=C(NCCN1CCCCC1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 11005432 | 167795 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 487 | 8 | 2 | 5 | 5.6 | COC(=O)c1ccc(CN2CCC(Cc3ccccc3)CC2)c(NC(=O)Nc2cccc(OC)c2)c1 | 10.1021/jm0201767 | ||
| CHEMBL434437 | 167795 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 487 | 8 | 2 | 5 | 5.6 | COC(=O)c1ccc(CN2CCC(Cc3ccccc3)CC2)c(NC(=O)Nc2cccc(OC)c2)c1 | 10.1021/jm0201767 | ||
| 11385474 | 78127 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1cccc(NC(=O)NC2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL2112050 | 78127 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 453 | 7 | 2 | 3 | 5.5 | COc1cccc(NC(=O)NC2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 | 10.1021/jm049530m | ||
| 44346023 | 14926 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 406 | 7 | 1 | 2 | 5.7 | Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc(C)c(C)c3)CC2)C(C)C)cc1 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL120957 | 14926 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 406 | 7 | 1 | 2 | 5.7 | Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc(C)c(C)c3)CC2)C(C)C)cc1 | 10.1016/s0960-894x(03)00748-0 | ||
| 10873705 | 98877 | 7 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.8 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00176-7 | ||
| CHEMBL282285 | 98877 | 7 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.8 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00176-7 | ||
| 44440421 | 93097 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 593 | 8 | 1 | 6 | 5.3 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(N)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| CHEMBL246339 | 93097 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 593 | 8 | 1 | 6 | 5.3 | Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(N)cc2)n1C | 10.1016/j.bmcl.2007.05.035 | ||
| 3492 | 685 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O | 10.1016/s0960-894x(02)00206-8 | ||
| 9868459 | 685 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50593 | 685 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O | 10.1016/s0960-894x(02)00206-8 | ||
| 9800669 | 109011 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 392 | 7 | 1 | 5 | 3.7 | CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL32210 | 109011 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 392 | 7 | 1 | 5 | 3.7 | CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 11070954 | 16600 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 485 | 7 | 3 | 4 | 4.9 | N#Cc1cccc(NC(=O)Nc2ccc(C(N)=O)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL124473 | 16600 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 485 | 7 | 3 | 4 | 4.9 | N#Cc1cccc(NC(=O)Nc2ccc(C(N)=O)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 10962347 | 18311 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 516 | 8 | 3 | 4 | 5.5 | CNC(=O)c1ccc(NC(=O)Nc2cccc(C(C)=O)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL127281 | 18311 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 516 | 8 | 3 | 4 | 5.5 | CNC(=O)c1ccc(NC(=O)Nc2cccc(C(C)=O)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 | 10.1021/jm0201767 | ||
| 11763035 | 168752 | 1 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 517 | 8 | 2 | 5 | 5.9 | COC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL441656 | 168752 | 1 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 517 | 8 | 2 | 5 | 5.9 | COC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 11753159 | 542 | 3 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1021/jm300682j | ||
| 7679 | 542 | 3 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1021/jm300682j | ||
| CHEMBL2158814 | 542 | 3 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1021/jm300682j | ||
| 44346210 | 167392 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 531 | 10 | 3 | 6 | 4.7 | COc1cc(NC(=O)N[C@@H](CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)[C@H](C)O)cc(OC)c1OC | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL431670 | 167392 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 531 | 10 | 3 | 6 | 4.7 | COc1cc(NC(=O)N[C@@H](CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)[C@H](C)O)cc(OC)c1OC | 10.1016/s0960-894x(03)00748-0 | ||
| 44295536 | 187851 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 479 | 12 | 3 | 4 | 5.3 | CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50233 | 187851 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 479 | 12 | 3 | 4 | 5.3 | CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 9885355 | 99940 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 363 | 6 | 2 | 4 | 3.5 | CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL290119 | 99940 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 363 | 6 | 2 | 4 | 3.5 | CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cccc2ccccc12 | 10.1016/s0960-894x(01)00248-7 | ||
| 44295353 | 188100 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 350 | 8 | 1 | 2 | 4.2 | O=C(NCCCCN1CCC(Cc2ccccc2)CC1)c1ccccc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50401 | 188100 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 350 | 8 | 1 | 2 | 4.2 | O=C(NCCCCN1CCC(Cc2ccccc2)CC1)c1ccccc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 71454583 | 79285 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 437 | 8 | 2 | 3 | 4.9 | CC(=O)c1cccc(NC(=O)NCCCN2CC3CCC2[C@H](Cc2ccc(F)cc2)C3)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| CHEMBL2115412 | 79285 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 437 | 8 | 2 | 3 | 4.9 | CC(=O)c1cccc(NC(=O)NCCCN2CC3CCC2[C@H](Cc2ccc(F)cc2)C3)c1 | 10.1016/j.bmcl.2004.01.059 | ||
| 11015975 | 16319 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 459 | 8 | 3 | 4 | 5.3 | COc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| CHEMBL123585 | 16319 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 459 | 8 | 3 | 4 | 5.3 | COc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm0201767 | ||
| 44295118 | 188456 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 405 | 7 | 1 | 4 | 3.4 | COc1cccc(C(=O)NCCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50937 | 188456 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 405 | 7 | 1 | 4 | 3.4 | COc1cccc(C(=O)NCCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 57398008 | 67526 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 393 | 9 | 2 | 3 | 4.5 | COc1ccc(Cl)cc1NC(=O)NCCCCN(C)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2011.09.013 | ||
| CHEMBL1910164 | 67526 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 393 | 9 | 2 | 3 | 4.5 | COc1ccc(Cl)cc1NC(=O)NCCCCN(C)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2011.09.013 | ||
| 44390893 | 64043 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 515 | 8 | 2 | 6 | 4.5 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(C(F)(F)F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL181302 | 64043 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 515 | 8 | 2 | 6 | 4.5 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(C(F)(F)F)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 132072454 | 179144 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 558 | 6 | 2 | 8 | 4.7 | COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 | 10.1016/j.bmc.2020.115546 | ||
| CHEMBL4744046 | 179144 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 558 | 6 | 2 | 8 | 4.7 | COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 | 10.1016/j.bmc.2020.115546 | ||
| 44295558 | 101493 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 365 | 4 | 1 | 3 | 2.8 | O=C(NCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL301332 | 101493 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 365 | 4 | 1 | 3 | 2.8 | O=C(NCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 | 10.1016/s0960-894x(02)00206-8 | ||
| 10934382 | 16597 | 26 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 265 | 4 | 0 | 1 | 4.1 | c1ccc(CC2CCN(Cc3ccccc3)CC2)cc1 | 10.1021/jm0201767 | ||
| CHEMBL124457 | 16597 | 26 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 265 | 4 | 0 | 1 | 4.1 | c1ccc(CC2CCN(Cc3ccccc3)CC2)cc1 | 10.1021/jm0201767 | ||
| 11828013 | 17225 | 1 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 581 | 11 | 3 | 3 | 6.9 | O=C(NCc1ccccc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL125753 | 17225 | 1 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 581 | 11 | 3 | 3 | 6.9 | O=C(NCc1ccccc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 11049424 | 116604 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 505 | 9 | 3 | 3 | 5.3 | CNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL339349 | 116604 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 505 | 9 | 3 | 3 | 5.3 | CNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 9972570 | 69488 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 308 | 7 | 0 | 2 | 3.8 | c1ccc(CCCCN2CCN(Cc3ccccc3)CC2)cc1 | 10.1021/jm0201767 | ||
| CHEMBL19375 | 69488 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 308 | 7 | 0 | 2 | 3.8 | c1ccc(CCCCN2CCN(Cc3ccccc3)CC2)cc1 | 10.1021/jm0201767 | ||
| 10458117 | 16409 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 486 | 6 | 2 | 5 | 5.5 | N#Cc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| CHEMBL123961 | 16409 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 486 | 6 | 2 | 5 | 5.5 | N#Cc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 | 10.1021/jm0201767 | ||
| 44346178 | 113757 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 423 | 8 | 1 | 4 | 5.0 | Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)C(C)C)cc1 | 10.1016/s0960-894x(03)00748-0 | ||
| CHEMBL333040 | 113757 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 423 | 8 | 1 | 4 | 5.0 | Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)C(C)C)cc1 | 10.1016/s0960-894x(03)00748-0 | ||
| 44447377 | 94390 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 499 | 11 | 4 | 8 | 2.2 | CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)[C@H](O)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL253666 | 94390 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 499 | 11 | 4 | 8 | 2.2 | CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)[C@H](O)Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44295327 | 187799 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 414 | 8 | 2 | 4 | 4.2 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1[N+](=O)[O-] | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL50158 | 187799 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 414 | 8 | 2 | 4 | 4.2 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1[N+](=O)[O-] | 10.1016/s0960-894x(02)00206-8 | ||
| 44447150 | 94504 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 551 | 12 | 3 | 7 | 3.9 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC(F)(F)F)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| CHEMBL254471 | 94504 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 551 | 12 | 3 | 7 | 3.9 | CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC(F)(F)F)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2007.11.087 | ||
| 44295326 | 168510 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 414 | 8 | 2 | 4 | 4.2 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc([N+](=O)[O-])c1 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL439744 | 168510 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 414 | 8 | 2 | 4 | 4.2 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc([N+](=O)[O-])c1 | 10.1016/s0960-894x(02)00206-8 | ||
| 44387850 | 60190 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 430 | 6 | 2 | 3 | 5.2 | N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm049530m | ||
| CHEMBL175679 | 60190 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 430 | 6 | 2 | 3 | 5.2 | N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccccc3)CC2)c1 | 10.1021/jm049530m | ||
| 11236236 | 77606 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 448 | 6 | 2 | 3 | 5.3 | N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL2096696 | 77606 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 448 | 6 | 2 | 3 | 5.3 | N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 11224689 | 77617 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 448 | 6 | 2 | 3 | 5.3 | N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| CHEMBL2096764 | 77617 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 448 | 6 | 2 | 3 | 5.3 | N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | ||
| 10939698 | 161121 | 1 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 475 | 7 | 2 | 4 | 5.7 | COC(=O)c1cccc(NC(=O)Nc2ccccc2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL413113 | 161121 | 1 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 475 | 7 | 2 | 4 | 5.7 | COC(=O)c1cccc(NC(=O)Nc2ccccc2)c1CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1021/jm0201767 | ||
| 44570582 | 177842 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 477 | 10 | 2 | 6 | 3.9 | CCCN(CCCc1ccc(F)cc1)C[C@@H]1OC(=O)N(C)C[C@H]1NC(=O)Nc1nc(C)cs1 | 10.1016/j.bmcl.2008.11.002 | ||
| CHEMBL465943 | 177842 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 477 | 10 | 2 | 6 | 3.9 | CCCN(CCCc1ccc(F)cc1)C[C@@H]1OC(=O)N(C)C[C@H]1NC(=O)Nc1nc(C)cs1 | 10.1016/j.bmcl.2008.11.002 | ||
| 44445846 | 93987 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 587 | 7 | 2 | 7 | 5.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| CHEMBL251078 | 93987 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 587 | 7 | 2 | 7 | 5.5 | CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1016/j.bmcl.2007.03.065 | ||
| 44390882 | 122286 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 461 | 8 | 2 | 6 | 3.8 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(C)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| CHEMBL360529 | 122286 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 461 | 8 | 2 | 6 | 3.8 | CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(C)cc3)C2)cc(-c2nnnn2C)c1 | 10.1016/j.bmcl.2004.11.006 | ||
| 44295543 | 101516 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 427 | 7 | 2 | 2 | 4.7 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NC12CC3CC(CC(C3)C1)C2 | 10.1016/s0960-894x(02)00206-8 | ||
| CHEMBL301503 | 101516 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 427 | 7 | 2 | 2 | 4.7 | O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NC12CC3CC(CC(C3)C1)C2 | 10.1016/s0960-894x(02)00206-8 | ||
| 11811443 | 16439 | 3 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 399 | 6 | 2 | 2 | 5.8 | O=C(Nc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL124134 | 16439 | 3 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 399 | 6 | 2 | 2 | 5.8 | O=C(Nc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 6995527 | 111407 | 6 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 221 | 4 | 1 | 3 | 1.4 | CCOC(=O)[C@H](C)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| CHEMBL32878 | 111407 | 6 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 221 | 4 | 1 | 3 | 1.4 | CCOC(=O)[C@H](C)NC(=O)c1ccccc1 | 10.1016/s0960-894x(01)00248-7 | ||
| 9889700 | 118083 | 13 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL34166 | 118083 | 13 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | ||
| 11762084 | 16735 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 446 | 8 | 2 | 3 | 4.5 | O=C(NCCc1ccc(F)cc1)Nc1ccccc1CN1CCN(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| CHEMBL125220 | 16735 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 446 | 8 | 2 | 3 | 4.5 | O=C(NCCc1ccc(F)cc1)Nc1ccccc1CN1CCN(Cc2ccccc2)CC1 | 10.1021/jm0201767 | ||
| 11060814 | 16991 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 567 | 10 | 3 | 3 | 7.2 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccccc1 | 10.1021/jm0201767 | ||
| CHEMBL125618 | 16991 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 567 | 10 | 3 | 3 | 7.2 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccccc1 | 10.1021/jm0201767 | ||
| 66615627 | 80866 | 0 | None | 158 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 536 | 8 | 1 | 4 | 6.1 | Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158790 | 80866 | 0 | None | 158 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 536 | 8 | 1 | 4 | 6.1 | Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 59296081 | 83669 | 0 | None | 7 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 608 | 9 | 3 | 7 | 2.9 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)N3CCC3)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207654 | 83669 | 0 | None | 7 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 608 | 9 | 3 | 7 | 2.9 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)N3CCC3)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 66615619 | 80859 | 0 | None | 79 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 522 | 8 | 1 | 4 | 5.7 | Cc1c(Cl)ccc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158783 | 80859 | 0 | None | 79 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 522 | 8 | 1 | 4 | 5.7 | Cc1c(Cl)ccc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 12001832 | 80860 | 0 | None | 63 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 522 | 8 | 1 | 4 | 5.7 | Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158784 | 80860 | 0 | None | 63 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 522 | 8 | 1 | 4 | 5.7 | Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 16040671 | 80867 | 0 | None | 56 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 502 | 8 | 1 | 4 | 5.4 | Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158791 | 80867 | 0 | None | 56 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 502 | 8 | 1 | 4 | 5.4 | Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 17963201 | 81854 | 0 | None | 31 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 539 | 5 | 1 | 5 | 5.0 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(C)c4Cl)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171047 | 81854 | 0 | None | 31 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 539 | 5 | 1 | 5 | 5.0 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(C)c4Cl)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 66615702 | 80863 | 0 | None | 100 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 522 | 8 | 1 | 4 | 5.8 | C[C@](Cc1ccc(F)cc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158787 | 80863 | 0 | None | 100 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 522 | 8 | 1 | 4 | 5.8 | C[C@](Cc1ccc(F)cc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 59296033 | 83604 | 0 | None | 15 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 596 | 9 | 3 | 7 | 2.7 | CN(C)S(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207286 | 83604 | 0 | None | 15 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 596 | 9 | 3 | 7 | 2.7 | CN(C)S(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| 59295968 | 83672 | 0 | None | 3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 487 | 7 | 3 | 5 | 3.3 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3c(F)cccc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207657 | 83672 | 0 | None | 3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 487 | 7 | 3 | 5 | 3.3 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3c(F)cccc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 59296099 | 83676 | 0 | None | 50 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 494 | 7 | 3 | 5 | 3.7 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207660 | 83676 | 0 | None | 50 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 494 | 7 | 3 | 5 | 3.7 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| 46931923 | 128752 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 537 | 6 | 1 | 5 | 4.2 | Cc1cc(C(=O)N2CCCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670798 | 128752 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 537 | 6 | 1 | 5 | 4.2 | Cc1cc(C(=O)N2CCCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 59295928 | 83601 | 0 | None | 63 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 581 | 8 | 3 | 7 | 3.2 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccc(S(C)(=O)=O)cc34)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207283 | 83601 | 0 | None | 63 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 581 | 8 | 3 | 7 | 3.2 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccc(S(C)(=O)=O)cc34)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| 66615606 | 80861 | 0 | None | 398 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 513 | 8 | 1 | 5 | 4.9 | Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(C#N)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158785 | 80861 | 0 | None | 398 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 513 | 8 | 1 | 5 | 4.9 | Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(C#N)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 71462100 | 80868 | 0 | None | 39 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 502 | 8 | 1 | 4 | 5.4 | Cc1cc(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158792 | 80868 | 0 | None | 39 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 502 | 8 | 1 | 4 | 5.4 | Cc1cc(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 59295938 | 83680 | 0 | None | 7 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 521 | 7 | 3 | 5 | 3.6 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)cc3C(F)(F)F)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207664 | 83680 | 0 | None | 7 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 521 | 7 | 3 | 5 | 3.6 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)cc3C(F)(F)F)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| 66615691 | 80865 | 0 | None | 125 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 518 | 8 | 1 | 4 | 5.9 | Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158789 | 80865 | 0 | None | 125 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 518 | 8 | 1 | 4 | 5.9 | Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 9870185 | 83682 | 0 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2207666 | 83682 | 0 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 59295931 | 83797 | 0 | None | 5 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 462 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208429 | 83797 | 0 | None | 5 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 462 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296010 | 83799 | 0 | None | 3 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 490 | 7 | 3 | 6 | 2.9 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208431 | 83799 | 0 | None | 3 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 490 | 7 | 3 | 6 | 2.9 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 71459762 | 83677 | 0 | None | 7 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 452 | 8 | 3 | 5 | 3.2 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C1CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207661 | 83677 | 0 | None | 7 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 452 | 8 | 3 | 5 | 3.2 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C1CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 9870185 | 83682 | 0 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207666 | 83682 | 0 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 56967066 | 128777 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 525 | 7 | 1 | 5 | 4.0 | CCN(C)C(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| CHEMBL3670824 | 128777 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 525 | 7 | 1 | 5 | 4.0 | CCN(C)C(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| 66615617 | 80864 | 0 | None | 31 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158788 | 80864 | 0 | None | 31 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 71456722 | 80869 | 0 | None | 39 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 486 | 8 | 1 | 4 | 4.9 | Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158793 | 80869 | 0 | None | 39 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 486 | 8 | 1 | 4 | 4.9 | Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69262172 | 80881 | 1 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.5 | O=C(O)c1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158822 | 80881 | 1 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.5 | O=C(O)c1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 59295935 | 83596 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(F)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207278 | 83596 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(F)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 59295978 | 83671 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2c(F)cccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207656 | 83671 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2c(F)cccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 59296066 | 83679 | 0 | None | 5 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 487 | 7 | 3 | 5 | 3.0 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)cc2C(F)(F)F)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207663 | 83679 | 0 | None | 5 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 487 | 7 | 3 | 5 | 3.0 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)cc2C(F)(F)F)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 69347575 | 80880 | 0 | None | 10 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)[C@@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158821 | 80880 | 0 | None | 10 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)[C@@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072040 | 80895 | 0 | None | 5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 490 | 8 | 1 | 4 | 5.2 | O=C(O)[C@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158835 | 80895 | 0 | None | 5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 490 | 8 | 1 | 4 | 5.2 | O=C(O)[C@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072044 | 80897 | 0 | None | 5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 524 | 8 | 1 | 4 | 5.9 | O=C(O)[C@H](Cc1ccccc1Cl)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158837 | 80897 | 0 | None | 5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 524 | 8 | 1 | 4 | 5.9 | O=C(O)[C@H](Cc1ccccc1Cl)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072050 | 80899 | 0 | None | 5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1ccccc1F)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158839 | 80899 | 0 | None | 5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1ccccc1F)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072118 | 80901 | 0 | None | 5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158841 | 80901 | 0 | None | 5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 22397445 | 81827 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 499 | 4 | 1 | 4 | 5.0 | O=C(c1c[nH]c(=O)c2ccccc12)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171020 | 81827 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 499 | 4 | 1 | 4 | 5.0 | O=C(c1c[nH]c(=O)c2ccccc12)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 57718837 | 115512 | 0 | None | -1 | 3 | Mouse | 8.0 | pKi | = | 8 | Binding | ChEMBL | 414 | 7 | 1 | 2 | 6.4 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355932 | 115512 | 0 | None | -1 | 3 | Mouse | 8.0 | pKi | = | 8 | Binding | ChEMBL | 414 | 7 | 1 | 2 | 6.4 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 59295946 | 83599 | 0 | None | 5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 612 | 11 | 5 | 8 | 1.7 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NCCO)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207281 | 83599 | 0 | None | 5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 612 | 11 | 5 | 8 | 1.7 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NCCO)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 56965995 | 128750 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 497 | 6 | 2 | 5 | 3.3 | CNC(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| CHEMBL3670796 | 128750 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 497 | 6 | 2 | 5 | 3.3 | CNC(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| 69260946 | 80882 | 1 | None | -19 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.5 | O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158823 | 80882 | 1 | None | -19 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.5 | O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71462103 | 80890 | 1 | None | -2 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 492 | 8 | 1 | 5 | 5.2 | O=C(O)COc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158830 | 80890 | 1 | None | -2 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 492 | 8 | 1 | 5 | 5.2 | O=C(O)COc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 17963227 | 81819 | 0 | None | -39 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 539 | 5 | 0 | 5 | 5.1 | Cc1ccc(S(=O)(=O)N(C)C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171013 | 81819 | 0 | None | -39 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 539 | 5 | 0 | 5 | 5.1 | Cc1ccc(S(=O)(=O)N(C)C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 9910169 | 81824 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 422 | 7 | 1 | 4 | 4.3 | COc1cccc(C(=O)NCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171018 | 81824 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 422 | 7 | 1 | 4 | 4.3 | COc1cccc(C(=O)NCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963336 | 81851 | 0 | None | -5 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 536 | 5 | 1 | 6 | 4.3 | N#Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171044 | 81851 | 0 | None | -5 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 536 | 5 | 1 | 6 | 4.3 | N#Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 118721192 | 115521 | 0 | None | 4 | 2 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 458 | 8 | 1 | 4 | 6.0 | CCOC(=O)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355941 | 115521 | 0 | None | 4 | 2 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 458 | 8 | 1 | 4 | 6.0 | CCOC(=O)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 10300214 | 83784 | 0 | None | -6 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 492 | 9 | 2 | 5 | 5.0 | O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C1CCC1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208416 | 83784 | 0 | None | -6 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 492 | 9 | 2 | 5 | 5.0 | O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C1CCC1 | 10.1016/j.bmcl.2012.09.113 | ||
| 44389685 | 64402 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 459 | 4 | 1 | 2 | 6.3 | Cc1ccccc1NC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181894 | 64402 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 459 | 4 | 1 | 2 | 6.3 | Cc1ccccc1NC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 17989653 | 81050 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 301 | 2 | 1 | 3 | 3.2 | Fc1ccc2c(c1)nc(CC(F)(F)F)n2C1CCNCC1 | 10.1016/j.bmc.2012.09.013 | ||
| CHEMBL2159765 | 81050 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 301 | 2 | 1 | 3 | 3.2 | Fc1ccc2c(c1)nc(CC(F)(F)F)n2C1CCNCC1 | 10.1016/j.bmc.2012.09.013 | ||
| 44389678 | 122808 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 574 | 6 | 1 | 5 | 4.6 | CS(=O)(=O)N[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL361620 | 122808 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 574 | 6 | 1 | 5 | 4.6 | CS(=O)(=O)N[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44389669 | 62268 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 458 | 5 | 0 | 2 | 5.8 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cccc(Cl)c3Cl)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178286 | 62268 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 458 | 5 | 0 | 2 | 5.8 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cccc(Cl)c3Cl)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44401055 | 68340 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 454 | 7 | 2 | 4 | 4.6 | COc1ccc(C(CNC(=O)Nc2ccc(F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL192162 | 68340 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 454 | 7 | 2 | 4 | 4.6 | COc1ccc(C(CNC(=O)Nc2ccc(F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401192 | 70241 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 529 | 7 | 1 | 3 | 6.4 | CC(C)(C)c1ccc(C(CNC(=O)Cc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL194943 | 70241 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 529 | 7 | 1 | 3 | 6.4 | CC(C)(C)c1ccc(C(CNC(=O)Cc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401227 | 134718 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 421 | 9 | 1 | 4 | 4.5 | COc1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL372496 | 134718 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 421 | 9 | 1 | 4 | 4.5 | COc1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401173 | 69518 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 466 | 8 | 2 | 5 | 4.5 | COc1ccc(NC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193871 | 69518 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 466 | 8 | 2 | 5 | 4.5 | COc1ccc(NC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44400953 | 68939 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.8 | Cc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL192751 | 68939 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.8 | Cc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401108 | 69483 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 420 | 5 | 2 | 3 | 4.1 | Cc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193732 | 69483 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 420 | 5 | 2 | 3 | 4.1 | Cc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C)CC2)cc1 | 10.1021/jm040827u | ||
| 44401062 | 69707 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 502 | 9 | 1 | 4 | 5.6 | CN(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193975 | 69707 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 502 | 9 | 1 | 4 | 5.6 | CN(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 118721204 | 115544 | 0 | None | 5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 532 | 9 | 3 | 2 | 6.7 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355964 | 115544 | 0 | None | 5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 532 | 9 | 3 | 2 | 6.7 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| 11477767 | 62698 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 511 | 5 | 0 | 4 | 5.7 | CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178818 | 62698 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 511 | 5 | 0 | 4 | 5.7 | CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44391171 | 131274 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 294 | 1 | 0 | 2 | 4.7 | Clc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL369351 | 131274 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 294 | 1 | 0 | 2 | 4.7 | Clc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| 25024650 | 115540 | 0 | None | -21 | 3 | Mouse | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355960 | 115540 | 0 | None | -21 | 3 | Mouse | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721203 | 115543 | 0 | None | -1 | 3 | Mouse | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355963 | 115543 | 0 | None | -1 | 3 | Mouse | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721194 | 115524 | 0 | None | -229 | 3 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.4 | COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355944 | 115524 | 0 | None | -229 | 3 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.4 | COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 25024651 | 115536 | 0 | None | -69 | 3 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355956 | 115536 | 0 | None | -69 | 3 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44389719 | 62691 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 408 | 5 | 0 | 2 | 4.6 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(F)cc3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178771 | 62691 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 408 | 5 | 0 | 2 | 4.6 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(F)cc3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44389750 | 165536 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 469 | 4 | 1 | 2 | 6.0 | O=C(c1cccc2[nH]ccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL425875 | 165536 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 469 | 4 | 1 | 2 | 6.0 | O=C(c1cccc2[nH]ccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44401247 | 69082 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 492 | 6 | 2 | 3 | 5.7 | O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(F)cc1 | 10.1021/jm040827u | ||
| CHEMBL193332 | 69082 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 492 | 6 | 2 | 3 | 5.7 | O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(F)cc1 | 10.1021/jm040827u | ||
| 44401111 | 68065 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 480 | 6 | 2 | 3 | 5.9 | CC(C)(C)c1ccc(C(CNC(=O)Nc2ccc(F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL191719 | 68065 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 480 | 6 | 2 | 3 | 5.9 | CC(C)(C)c1ccc(C(CNC(=O)Nc2ccc(F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44400945 | 70779 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 455 | 7 | 1 | 3 | 5.2 | CC(C)(C)c1ccc(C(CNC(=O)Cc2ccccc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL195473 | 70779 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 455 | 7 | 1 | 3 | 5.2 | CC(C)(C)c1ccc(C(CNC(=O)Cc2ccccc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401128 | 70770 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 462 | 6 | 2 | 3 | 5.8 | CC(C)(C)c1ccc(C(CNC(=O)Nc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL195427 | 70770 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 462 | 6 | 2 | 3 | 5.8 | CC(C)(C)c1ccc(C(CNC(=O)Nc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44400972 | 165440 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 337 | 7 | 1 | 3 | 3.1 | Cc1ccc(CCNCC(c2ccccc2)N2CCN(C)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL425377 | 165440 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 337 | 7 | 1 | 3 | 3.1 | Cc1ccc(CCNCC(c2ccccc2)N2CCN(C)CC2)cc1 | 10.1021/jm040827u | ||
| 44401053 | 70723 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 371 | 8 | 1 | 4 | 3.0 | COc1ccc(C(CNCCc2ccc(F)cc2)N2CCN(C)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL195197 | 70723 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 371 | 8 | 1 | 4 | 3.0 | COc1ccc(C(CNCCc2ccc(F)cc2)N2CCN(C)CC2)cc1 | 10.1021/jm040827u | ||
| 44401255 | 69514 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 5.5 | COc1ccccc1CCNCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| CHEMBL193850 | 69514 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 5.5 | COc1ccccc1CCNCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| 44389674 | 62304 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 469 | 4 | 1 | 2 | 6.0 | O=C(c1ccc2[nH]ccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178367 | 62304 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 469 | 4 | 1 | 2 | 6.0 | O=C(c1ccc2[nH]ccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 71451391 | 80857 | 0 | None | 12 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 472 | 8 | 1 | 4 | 4.5 | Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158781 | 80857 | 0 | None | 12 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 472 | 8 | 1 | 4 | 4.5 | Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 10005242 | 80878 | 0 | None | 3 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)C(c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158819 | 80878 | 0 | None | 3 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)C(c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 23102749 | 81822 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 525 | 6 | 1 | 5 | 4.3 | Cc1c(Cl)ccc(OC2CCN(C3CCN(S(=O)(=O)NC(=O)c4ccccc4)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171016 | 81822 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 525 | 6 | 1 | 5 | 4.3 | Cc1c(Cl)ccc(OC2CCN(C3CCN(S(=O)(=O)NC(=O)c4ccccc4)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 59295926 | 83803 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 474 | 7 | 2 | 6 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cnnc2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208435 | 83803 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 474 | 7 | 2 | 6 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cnnc2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 59295914 | 83670 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 638 | 9 | 4 | 8 | 2.2 | CC1(O)CN(S(=O)(=O)c2ccc3c(C(=O)NC[C@@H](O)CN4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)c[nH]c(=O)c3c2)C1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207655 | 83670 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 638 | 9 | 4 | 8 | 2.2 | CC1(O)CN(S(=O)(=O)c2ccc3c(C(=O)NC[C@@H](O)CN4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)c[nH]c(=O)c3c2)C1 | 10.1016/j.bmcl.2012.09.112 | ||
| 11952525 | 115538 | 0 | None | 21 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 562 | 10 | 0 | 5 | 8.0 | CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355958 | 115538 | 0 | None | 21 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 562 | 10 | 0 | 5 | 8.0 | CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 11952526 | 115533 | 0 | None | -24 | 3 | Mouse | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 534 | 9 | 1 | 4 | 7.5 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355953 | 115533 | 0 | None | -24 | 3 | Mouse | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 534 | 9 | 1 | 4 | 7.5 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44391160 | 122772 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 413 | 1 | 1 | 4 | 5.6 | CC(C)(C)c1csc2nc3n(c(=N)c12)CC/C3=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL361430 | 122772 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 413 | 1 | 1 | 4 | 5.6 | CC(C)(C)c1csc2nc3n(c(=N)c12)CC/C3=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| 44401004 | 70226 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 471 | 8 | 1 | 3 | 5.5 | Fc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL194885 | 70226 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 471 | 8 | 1 | 3 | 5.5 | Fc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 44389699 | 63587 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 445 | 4 | 1 | 3 | 5.1 | Nc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL180599 | 63587 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 445 | 4 | 1 | 3 | 5.1 | Nc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 71462102 | 80876 | 0 | None | -6 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 4.4 | O=C(O)C(c1ccccc1)N1CCO[C@@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158817 | 80876 | 0 | None | -6 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 4.4 | O=C(O)C(c1ccccc1)N1CCO[C@@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71455217 | 81849 | 0 | None | -3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171042 | 81849 | 0 | None | -3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963141 | 81856 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 491 | 5 | 1 | 5 | 4.1 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171049 | 81856 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 491 | 5 | 1 | 5 | 4.1 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71459825 | 83785 | 0 | None | 3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 433 | 8 | 2 | 5 | 3.9 | N#Cc1ccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208417 | 83785 | 0 | None | 3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 433 | 8 | 2 | 5 | 3.9 | N#Cc1ccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1016/j.bmcl.2012.09.113 | ||
| 71463288 | 83789 | 0 | None | -6 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 441 | 8 | 1 | 5 | 5.0 | COc1cccc(SC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208421 | 83789 | 0 | None | -6 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 441 | 8 | 1 | 5 | 5.0 | COc1cccc(SC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 44400992 | 69614 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.8 | O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1cc(Cl)cc(Cl)c1 | 10.1021/jm040827u | ||
| CHEMBL193931 | 69614 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.8 | O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1cc(Cl)cc(Cl)c1 | 10.1021/jm040827u | ||
| 44389747 | 168637 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 424 | 5 | 0 | 2 | 5.1 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cccc(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL440750 | 168637 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 424 | 5 | 0 | 2 | 5.1 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cccc(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44401135 | 69310 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 8 | 1 | 3 | 6.8 | FC(F)(F)c1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193507 | 69310 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 8 | 1 | 3 | 6.8 | FC(F)(F)c1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 118721187 | 115516 | 0 | None | -1 | 3 | Mouse | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.2 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355936 | 115516 | 0 | None | -1 | 3 | Mouse | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.2 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721188 | 115517 | 0 | None | -2 | 3 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 439 | 8 | 2 | 3 | 5.3 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355937 | 115517 | 0 | None | -2 | 3 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 439 | 8 | 2 | 3 | 5.3 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721200 | 115534 | 0 | None | -275 | 3 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 558 | 9 | 1 | 6 | 7.0 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355954 | 115534 | 0 | None | -275 | 3 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 558 | 9 | 1 | 6 | 7.0 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401202 | 69786 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 542 | 6 | 2 | 3 | 6.5 | O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(C(F)(F)F)cc1 | 10.1021/jm040827u | ||
| CHEMBL194025 | 69786 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 542 | 6 | 2 | 3 | 6.5 | O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(C(F)(F)F)cc1 | 10.1021/jm040827u | ||
| 44401183 | 69810 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 459 | 8 | 1 | 3 | 5.5 | FC(F)(F)c1ccc(CCNCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL194040 | 69810 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 459 | 8 | 1 | 3 | 5.5 | FC(F)(F)c1ccc(CCNCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44389709 | 63374 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 445 | 4 | 1 | 3 | 5.1 | Nc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL180122 | 63374 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 445 | 4 | 1 | 3 | 5.1 | Nc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44389688 | 64214 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 495 | 4 | 0 | 3 | 6.3 | C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181460 | 64214 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 495 | 4 | 0 | 3 | 6.3 | C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44391330 | 63690 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 322 | 2 | 0 | 2 | 5.5 | CCC1C/C(=C\c2ccccc2Cl)C2=Nc3ccccc3CN21 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL180721 | 63690 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 322 | 2 | 0 | 2 | 5.5 | CCC1C/C(=C\c2ccccc2Cl)C2=Nc3ccccc3CN21 | 10.1016/j.bmcl.2004.11.039 | ||
| 44389721 | 63952 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 481 | 4 | 0 | 3 | 6.1 | O=C(c1nccc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL180988 | 63952 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 481 | 4 | 0 | 3 | 6.1 | O=C(c1nccc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44391276 | 122438 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 278 | 1 | 0 | 2 | 4.2 | Fc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL360738 | 122438 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 278 | 1 | 0 | 2 | 4.2 | Fc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| 44391297 | 131967 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 2 | 0 | 2 | 4.6 | CCc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL369778 | 131967 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 2 | 0 | 2 | 4.6 | CCc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| 44391307 | 167749 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 337 | 2 | 0 | 3 | 4.7 | CN(C)c1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL434151 | 167749 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 337 | 2 | 0 | 3 | 4.7 | CN(C)c1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 | 10.1016/j.bmcl.2004.11.039 | ||
| 118721191 | 115520 | 0 | None | -331 | 3 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 444 | 8 | 1 | 3 | 6.5 | COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355940 | 115520 | 0 | None | -331 | 3 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 444 | 8 | 1 | 3 | 6.5 | COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 70790201 | 128756 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 440 | 5 | 0 | 4 | 3.7 | Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)N(C)c3ccccn3)CC2)ccc1Cl | nan | ||
| CHEMBL3670803 | 128756 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 440 | 5 | 0 | 4 | 3.7 | Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)N(C)c3ccccn3)CC2)ccc1Cl | nan | ||
| 44389695 | 63599 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 424 | 5 | 0 | 2 | 5.1 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL180651 | 63599 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 424 | 5 | 0 | 2 | 5.1 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44389712 | 62766 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 442 | 5 | 0 | 2 | 5.3 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3F)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178916 | 62766 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 442 | 5 | 0 | 2 | 5.3 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3F)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44401086 | 70187 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.5 | O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(C(F)(F)F)cc1 | 10.1021/jm040827u | ||
| CHEMBL194715 | 70187 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.5 | O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(C(F)(F)F)cc1 | 10.1021/jm040827u | ||
| 44401251 | 69083 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 498 | 7 | 2 | 4 | 5.4 | COc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193334 | 69083 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 498 | 7 | 2 | 4 | 5.4 | COc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 11283679 | 64031 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.1 | CO[C@@H]1CN(C2CCN(C(=O)c3ccc4cccnc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181273 | 64031 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.1 | CO[C@@H]1CN(C2CCN(C(=O)c3ccc4cccnc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 17963315 | 81840 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 511 | 5 | 1 | 5 | 4.4 | O=C(NS(=O)(=O)c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171033 | 81840 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 511 | 5 | 1 | 5 | 4.4 | O=C(NS(=O)(=O)c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 59296109 | 83796 | 0 | None | 12 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 3.0 | CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208428 | 83796 | 0 | None | 12 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 3.0 | CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296077 | 83594 | 0 | None | 5 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 547 | 8 | 3 | 7 | 2.5 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(S(C)(=O)=O)ccc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207276 | 83594 | 0 | None | 5 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 547 | 8 | 3 | 7 | 2.5 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(S(C)(=O)=O)ccc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 44400973 | 127001 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 504 | 7 | 2 | 4 | 5.5 | COc1ccc(C(CNC(=O)Nc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL366231 | 127001 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 504 | 7 | 2 | 4 | 5.5 | COc1ccc(C(CNC(=O)Nc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 69260851 | 80883 | 1 | None | -2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.5 | O=C(O)c1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158824 | 80883 | 1 | None | -2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.5 | O=C(O)c1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 10143016 | 81861 | 0 | None | -3 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 525 | 6 | 1 | 5 | 4.5 | O=C(NS(=O)(=O)Cc1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171215 | 81861 | 0 | None | -3 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 525 | 6 | 1 | 5 | 4.5 | O=C(NS(=O)(=O)Cc1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71454365 | 83786 | 0 | None | 1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 4.6 | O[C@@H](CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)COc1ccc2ncsc2c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208418 | 83786 | 0 | None | 1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 4.6 | O[C@@H](CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)COc1ccc2ncsc2c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296073 | 83790 | 0 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 483 | 8 | 2 | 6 | 3.0 | N#Cc1cccc(S(=O)(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208422 | 83790 | 0 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 483 | 8 | 2 | 6 | 3.0 | N#Cc1cccc(S(=O)(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 44401172 | 123672 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 445 | 10 | 1 | 5 | 4.4 | COc1ccccc1CCNCC(c1ccccc1OC)N1CCN(c2ccccc2)CC1 | 10.1021/jm040827u | ||
| CHEMBL363409 | 123672 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 445 | 10 | 1 | 5 | 4.4 | COc1ccccc1CCNCC(c1ccccc1OC)N1CCN(c2ccccc2)CC1 | 10.1021/jm040827u | ||
| 25024651 | 115536 | 0 | None | 39 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355956 | 115536 | 0 | None | 39 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44391296 | 64972 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 328 | 1 | 0 | 2 | 5.0 | FC(F)(F)c1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL182889 | 64972 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 328 | 1 | 0 | 2 | 5.0 | FC(F)(F)c1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| 44389722 | 63953 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 538 | 5 | 1 | 4 | 5.2 | CC(=O)N[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL180989 | 63953 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 538 | 5 | 1 | 4 | 5.2 | CC(=O)N[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44401052 | 69736 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 496 | 9 | 1 | 4 | 5.5 | CN(C)c1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193991 | 69736 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 496 | 9 | 1 | 4 | 5.5 | CN(C)c1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 56967062 | 128769 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 531 | 6 | 1 | 5 | 4.0 | Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)n1 | nan | ||
| CHEMBL3670816 | 128769 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 531 | 6 | 1 | 5 | 4.0 | Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)n1 | nan | ||
| 44391318 | 65371 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 328 | 1 | 0 | 2 | 5.3 | Clc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL183441 | 65371 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 328 | 1 | 0 | 2 | 5.3 | Clc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 | 10.1016/j.bmcl.2004.11.039 | ||
| 118721199 | 115529 | 0 | None | 2 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 440 | 8 | 2 | 3 | 5.9 | CCc1[nH]c2cc(C(=O)O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355949 | 115529 | 0 | None | 2 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 440 | 8 | 2 | 3 | 5.9 | CCc1[nH]c2cc(C(=O)O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 25024650 | 115540 | 0 | None | -338 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355960 | 115540 | 0 | None | -338 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401235 | 69499 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 504 | 7 | 2 | 4 | 5.5 | COc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193810 | 69499 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 504 | 7 | 2 | 4 | 5.5 | COc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44400995 | 70755 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 505 | 7 | 2 | 4 | 5.9 | CN(C)c1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL195353 | 70755 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 505 | 7 | 2 | 4 | 5.9 | CN(C)c1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401188 | 69474 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 428 | 9 | 1 | 4 | 4.4 | CN(C)c1ccc(CCNCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193656 | 69474 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 428 | 9 | 1 | 4 | 4.4 | CN(C)c1ccc(CCNCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401047 | 70786 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 462 | 7 | 2 | 3 | 5.7 | Cc1ccc(NC(=O)NCC(CC(C)C)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL195495 | 70786 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 462 | 7 | 2 | 3 | 5.7 | Cc1ccc(NC(=O)NCC(CC(C)C)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1021/jm040827u | ||
| 118721190 | 115519 | 0 | None | 5 | 3 | Mouse | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 416 | 7 | 2 | 3 | 5.3 | OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355939 | 115519 | 0 | None | 5 | 3 | Mouse | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 416 | 7 | 2 | 3 | 5.3 | OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 11214422 | 123144 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 511 | 5 | 0 | 4 | 5.7 | CO[C@@H]1CN(C2CCN(C(=O)c3cccc4cccnc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL362040 | 123144 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 511 | 5 | 0 | 4 | 5.7 | CO[C@@H]1CN(C2CCN(C(=O)c3cccc4cccnc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44391258 | 121879 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 328 | 1 | 0 | 2 | 5.3 | Clc1cccc(Cl)c1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL360075 | 121879 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 328 | 1 | 0 | 2 | 5.3 | Clc1cccc(Cl)c1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| 67114884 | 128755 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 539 | 6 | 1 | 6 | 3.1 | Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N4CCOCC4)ccn3)CC2)ccc1Cl | nan | ||
| CHEMBL3670802 | 128755 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 539 | 6 | 1 | 6 | 3.1 | Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N4CCOCC4)ccn3)CC2)ccc1Cl | nan | ||
| 71072115 | 80846 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 515 | 8 | 1 | 5 | 5.1 | N#Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158770 | 80846 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 515 | 8 | 1 | 5 | 5.1 | N#Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072081 | 80849 | 0 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158773 | 80849 | 0 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072113 | 80850 | 0 | None | 3 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158774 | 80850 | 0 | None | 3 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 11444350 | 80853 | 0 | None | 7 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 558 | 8 | 1 | 4 | 6.3 | O=C(O)[C@H](Cc1cccc(C(F)(F)F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158777 | 80853 | 0 | None | 7 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 558 | 8 | 1 | 4 | 6.3 | O=C(O)[C@H](Cc1cccc(C(F)(F)F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71449584 | 80884 | 1 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)Cc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158825 | 80884 | 1 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)Cc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69347719 | 80891 | 1 | None | 3 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1CN1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158831 | 80891 | 1 | None | 3 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1CN1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71460419 | 80898 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 524 | 8 | 1 | 4 | 5.9 | O=C(O)[C@H](Cc1ccc(Cl)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158838 | 80898 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 524 | 8 | 1 | 4 | 5.9 | O=C(O)[C@H](Cc1ccc(Cl)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 17963334 | 81845 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171038 | 81845 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 59296064 | 83791 | 0 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 447 | 7 | 2 | 5 | 3.5 | N#Cc1cccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208423 | 83791 | 0 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 447 | 7 | 2 | 5 | 3.5 | N#Cc1cccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 59295960 | 83683 | 0 | None | 12 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 532 | 8 | 4 | 6 | 2.6 | NC(=O)c1c(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207667 | 83683 | 0 | None | 12 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 532 | 8 | 4 | 6 | 2.6 | NC(=O)c1c(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| 118721197 | 115527 | 0 | None | 19 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.2 | CCc1[nH]c2cc(OC)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355947 | 115527 | 0 | None | 19 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.2 | CCc1[nH]c2cc(OC)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44389730 | 64267 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 442 | 5 | 0 | 2 | 5.3 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(F)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181678 | 64267 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 442 | 5 | 0 | 2 | 5.3 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(F)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 70790198 | 128749 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 454 | 6 | 1 | 4 | 4.2 | CCc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| CHEMBL3670795 | 128749 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 454 | 6 | 1 | 4 | 4.2 | CCc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| 44401056 | 69505 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 492 | 7 | 2 | 4 | 5.8 | COc1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193827 | 69505 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 492 | 7 | 2 | 4 | 5.8 | COc1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 71462389 | 81831 | 0 | None | -1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 476 | 5 | 1 | 4 | 4.8 | O=C(O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171024 | 81831 | 0 | None | -1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 476 | 5 | 1 | 4 | 4.8 | O=C(O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71462390 | 81833 | 0 | None | -6 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 500 | 5 | 1 | 6 | 4.3 | O=C(c1ccc(-c2nn[nH]n2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171026 | 81833 | 0 | None | -6 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 500 | 5 | 1 | 6 | 4.3 | O=C(c1ccc(-c2nn[nH]n2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 59296114 | 83793 | 0 | None | -12 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 3.4 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cn2cc(F)ccc2n1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208425 | 83793 | 0 | None | -12 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 3.4 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cn2cc(F)ccc2n1 | 10.1016/j.bmcl.2012.09.113 | ||
| 67114949 | 128763 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 539 | 7 | 1 | 5 | 4.4 | Cc1cc(C(=O)N(C)C(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670810 | 128763 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 539 | 7 | 1 | 5 | 4.4 | Cc1cc(C(=O)N(C)C(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 56967064 | 128773 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 537 | 7 | 1 | 5 | 4.2 | Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C4CC4)n3)CC2)ccc1Cl | nan | ||
| CHEMBL3670820 | 128773 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 537 | 7 | 1 | 5 | 4.2 | Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C4CC4)n3)CC2)ccc1Cl | nan | ||
| 59295939 | 83798 | 0 | None | 12 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 461 | 7 | 3 | 4 | 4.1 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208430 | 83798 | 0 | None | 12 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 461 | 7 | 3 | 4 | 4.1 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296000 | 83800 | 0 | None | 7 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 478 | 6 | 3 | 6 | 3.1 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)n1c(=O)[nH]c2ccccc21 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208432 | 83800 | 0 | None | 7 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 478 | 6 | 3 | 6 | 3.1 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)n1c(=O)[nH]c2ccccc21 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296104 | 83801 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 503 | 7 | 2 | 5 | 3.8 | CN(C[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C(=O)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208433 | 83801 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 503 | 7 | 2 | 5 | 3.8 | CN(C[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C(=O)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 59295974 | 83688 | 0 | None | 19 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 581 | 8 | 3 | 7 | 3.2 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4cc(S(C)(=O)=O)ccc34)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207672 | 83688 | 0 | None | 19 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 581 | 8 | 3 | 7 | 3.2 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4cc(S(C)(=O)=O)ccc34)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| 11179794 | 63962 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 511 | 5 | 0 | 4 | 5.7 | CO[C@@H]1CN(C2CCN(C(=O)c3nccc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181034 | 63962 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 511 | 5 | 0 | 4 | 5.7 | CO[C@@H]1CN(C2CCN(C(=O)c3nccc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44389770 | 123303 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 552 | 6 | 1 | 4 | 5.5 | CC(=O)NC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL362401 | 123303 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 552 | 6 | 1 | 4 | 5.5 | CC(=O)NC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44400954 | 126534 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 518 | 6 | 2 | 3 | 7.1 | CC(C)(C)c1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL365584 | 126534 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 518 | 6 | 2 | 3 | 7.1 | CC(C)(C)c1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 118721186 | 115515 | 0 | None | -2 | 3 | Mouse | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 5.9 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355935 | 115515 | 0 | None | -2 | 3 | Mouse | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 5.9 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44400982 | 70781 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 477 | 9 | 1 | 4 | 5.8 | COc1ccccc1CCNCC(c1ccc(C(C)(C)C)cc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| CHEMBL195480 | 70781 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 477 | 9 | 1 | 4 | 5.8 | COc1ccccc1CCNCC(c1ccc(C(C)(C)C)cc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| 44401252 | 70472 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 323 | 7 | 1 | 3 | 2.8 | CN1CCN(C(CNCCc2ccccc2)c2ccccc2)CC1 | 10.1021/jm040827u | ||
| CHEMBL195093 | 70472 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 323 | 7 | 1 | 3 | 2.8 | CN1CCN(C(CNCCc2ccccc2)c2ccccc2)CC1 | 10.1021/jm040827u | ||
| 44401225 | 69617 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 515 | 8 | 1 | 3 | 7.1 | CC(C)(C)c1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193938 | 69617 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 515 | 8 | 1 | 3 | 7.1 | CC(C)(C)c1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401067 | 167861 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 450 | 7 | 2 | 4 | 4.8 | COc1ccc(C(CNC(=O)Nc2ccc(C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL434918 | 167861 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 450 | 7 | 2 | 4 | 4.8 | COc1ccc(C(CNC(=O)Nc2ccc(C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44389690 | 64336 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 426 | 5 | 0 | 2 | 4.8 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(F)cc(F)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181827 | 64336 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 426 | 5 | 0 | 2 | 4.8 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(F)cc(F)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 11386642 | 62760 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 507 | 5 | 0 | 3 | 6.5 | C=C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178887 | 62760 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 507 | 5 | 0 | 3 | 6.5 | C=C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 56966925 | 128745 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 483 | 6 | 2 | 5 | 3.0 | CNC(=O)c1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| CHEMBL3670791 | 128745 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 483 | 6 | 2 | 5 | 3.0 | CNC(=O)c1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| 24937092 | 115537 | 0 | None | -2 | 2 | Mouse | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 500 | 10 | 0 | 5 | 6.4 | CCOC(=O)Cn1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc21 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355957 | 115537 | 0 | None | -2 | 2 | Mouse | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 500 | 10 | 0 | 5 | 6.4 | CCOC(=O)Cn1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc21 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721186 | 115515 | 0 | None | -29 | 3 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 5.9 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355935 | 115515 | 0 | None | -29 | 3 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 5.9 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401109 | 70737 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 515 | 8 | 1 | 3 | 6.8 | CC(C)(C)c1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL195293 | 70737 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 515 | 8 | 1 | 3 | 6.8 | CC(C)(C)c1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 56966998 | 128767 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 527 | 7 | 1 | 6 | 3.3 | COc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670814 | 128767 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 527 | 7 | 1 | 6 | 3.3 | COc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 118721194 | 115524 | 0 | None | -5 | 3 | Mouse | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.4 | COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355944 | 115524 | 0 | None | -5 | 3 | Mouse | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.4 | COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 71460416 | 80852 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 520 | 9 | 1 | 5 | 5.3 | COc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158776 | 80852 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 520 | 9 | 1 | 5 | 5.3 | COc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71456725 | 80886 | 1 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)Cc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158827 | 80886 | 1 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)Cc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072057 | 80900 | 0 | None | 5 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1cccc(F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158840 | 80900 | 0 | None | 5 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1cccc(F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 17963332 | 81847 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 541 | 6 | 1 | 6 | 4.4 | COc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171040 | 81847 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 541 | 6 | 1 | 6 | 4.4 | COc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963153 | 81853 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4Cl)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171046 | 81853 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4Cl)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 59295982 | 83600 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 568 | 8 | 4 | 7 | 2.1 | NS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207282 | 83600 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 568 | 8 | 4 | 7 | 2.1 | NS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| 44391331 | 64503 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 394 | 4 | 0 | 2 | 6.3 | CCCCC1C/C(=C\c2ccccc2Br)C2=Nc3ccccc3CN21 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL181984 | 64503 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 394 | 4 | 0 | 2 | 6.3 | CCCCC1C/C(=C\c2ccccc2Br)C2=Nc3ccccc3CN21 | 10.1016/j.bmcl.2004.11.039 | ||
| 44389698 | 64039 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 458 | 5 | 0 | 2 | 5.8 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(Cl)ccc3Cl)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181290 | 64039 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 458 | 5 | 0 | 2 | 5.8 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(Cl)ccc3Cl)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 69347980 | 80892 | 1 | None | -5 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)c1cccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158832 | 80892 | 1 | None | -5 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)c1cccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71458869 | 81829 | 0 | None | -2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 506 | 7 | 1 | 5 | 4.6 | O=C(O)COc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171022 | 81829 | 0 | None | -2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 506 | 7 | 1 | 5 | 4.6 | O=C(O)COc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71449857 | 81830 | 0 | None | -10 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 476 | 5 | 1 | 4 | 4.8 | O=C(O)c1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171023 | 81830 | 0 | None | -10 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 476 | 5 | 1 | 4 | 4.8 | O=C(O)c1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71463287 | 83787 | 0 | None | -79 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 420 | 7 | 1 | 5 | 4.1 | N#Cc1cccc(OC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208419 | 83787 | 0 | None | -79 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 420 | 7 | 1 | 5 | 4.1 | N#Cc1cccc(OC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296085 | 83794 | 0 | None | -2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 506 | 8 | 2 | 7 | 3.1 | CS(=O)(=O)c1ccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)s1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208426 | 83794 | 0 | None | -2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 506 | 8 | 2 | 7 | 3.1 | CS(=O)(=O)c1ccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)s1 | 10.1016/j.bmcl.2012.09.113 | ||
| 71458870 | 81838 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 504 | 5 | 1 | 4 | 5.2 | Cc1ccc(C(=O)N2CCC(N3CC[C@@H](Oc4ccc(Cl)c(C)c4Cl)C[C@H]3C(=O)O)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171031 | 81838 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 504 | 5 | 1 | 4 | 5.2 | Cc1ccc(C(=O)N2CCC(N3CC[C@@H](Oc4ccc(Cl)c(C)c4Cl)C[C@H]3C(=O)O)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 44389832 | 63593 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 511 | 5 | 0 | 4 | 5.7 | CO[C@@H]1CN(C2CCN(C(=O)c3ccnc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL180621 | 63593 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 511 | 5 | 0 | 4 | 5.7 | CO[C@@H]1CN(C2CCN(C(=O)c3ccnc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44391176 | 122096 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 385 | 1 | 1 | 4 | 4.9 | Cc1sc2nc3n(c(=N)c2c1C)CC/C3=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL360268 | 122096 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 385 | 1 | 1 | 4 | 4.9 | Cc1sc2nc3n(c(=N)c2c1C)CC/C3=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| 57718837 | 115512 | 0 | None | -45 | 3 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 414 | 7 | 1 | 2 | 6.4 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355932 | 115512 | 0 | None | -45 | 3 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 414 | 7 | 1 | 2 | 6.4 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721189 | 115518 | 0 | None | -7 | 3 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 400 | 6 | 1 | 2 | 6.1 | Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355938 | 115518 | 0 | None | -7 | 3 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 400 | 6 | 1 | 2 | 6.1 | Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 11952524 | 115531 | 0 | None | -3 | 3 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 490 | 8 | 0 | 3 | 7.8 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355951 | 115531 | 0 | None | -3 | 3 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 490 | 8 | 0 | 3 | 7.8 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 11952525 | 115538 | 0 | None | -21 | 3 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 562 | 10 | 0 | 5 | 8.0 | CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355958 | 115538 | 0 | None | -21 | 3 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 562 | 10 | 0 | 5 | 8.0 | CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721201 | 115535 | 0 | None | 2 | 2 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 548 | 10 | 1 | 4 | 7.6 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1Cc1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355955 | 115535 | 0 | None | 2 | 2 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 548 | 10 | 1 | 4 | 7.6 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1Cc1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44389688 | 64214 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 495 | 4 | 0 | 3 | 6.3 | C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181460 | 64214 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 495 | 4 | 0 | 3 | 6.3 | C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44401117 | 69862 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 413 | 7 | 1 | 3 | 4.2 | Cc1ccc(CC(=O)NCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL194070 | 69862 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 413 | 7 | 1 | 3 | 4.2 | Cc1ccc(CC(=O)NCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 44391277 | 65455 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 369 | 1 | 1 | 4 | 4.4 | Cc1oc2nc3n(c(=N)c2c1C)CC/C3=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL183478 | 65455 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 369 | 1 | 1 | 4 | 4.4 | Cc1oc2nc3n(c(=N)c2c1C)CC/C3=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| 118721205 | 115545 | 0 | None | -67 | 3 | Mouse | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 653 | 11 | 3 | 5 | 7.2 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355965 | 115545 | 0 | None | -67 | 3 | Mouse | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 653 | 11 | 3 | 5 | 7.2 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44391236 | 122607 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 357 | 1 | 1 | 4 | 4.3 | N=c1c2ccsc2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL361149 | 122607 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 357 | 1 | 1 | 4 | 4.3 | N=c1c2ccsc2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| 11360133 | 122804 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 351 | 1 | 1 | 3 | 4.2 | N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL361606 | 122804 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 351 | 1 | 1 | 3 | 4.2 | N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| 44389704 | 62174 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 509 | 5 | 0 | 3 | 6.7 | CC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178136 | 62174 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 509 | 5 | 0 | 3 | 6.7 | CC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44391252 | 65513 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 397 | 2 | 1 | 4 | 5.2 | N=c1c2c(C3CC3)csc2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL183520 | 65513 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 397 | 2 | 1 | 4 | 5.2 | N=c1c2c(C3CC3)csc2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| 44391317 | 65171 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 336 | 2 | 0 | 2 | 5.7 | C(=C1\CCN2Cc3ccccc3N=C12)\c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL183052 | 65171 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 336 | 2 | 0 | 2 | 5.7 | C(=C1\CCN2Cc3ccccc3N=C12)\c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2004.11.039 | ||
| 44400990 | 165698 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 454 | 7 | 2 | 3 | 5.5 | CC(C)CC(CNC(=O)Nc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| CHEMBL426822 | 165698 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 454 | 7 | 2 | 3 | 5.5 | CC(C)CC(CNC(=O)Nc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| 11466397 | 62550 | 0 | None | -407 | 4 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 511 | 5 | 1 | 4 | 5.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178447 | 62550 | 0 | None | -407 | 4 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 511 | 5 | 1 | 4 | 5.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 71451392 | 80862 | 0 | None | 31 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | C[C@](Cc1ccccc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158786 | 80862 | 0 | None | 31 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | C[C@](Cc1ccccc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71458868 | 81820 | 0 | None | 6 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 568 | 6 | 1 | 6 | 4.8 | Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)NS(=O)(=O)c4ccc(N(C)C)cc4)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171014 | 81820 | 0 | None | 6 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 568 | 6 | 1 | 6 | 4.8 | Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)NS(=O)(=O)c4ccc(N(C)C)cc4)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 59295958 | 83598 | 0 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccc(F)cc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207280 | 83598 | 0 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccc(F)cc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 59296100 | 83674 | 0 | None | 7 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 460 | 7 | 3 | 5 | 3.0 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]nc2C(F)(F)F)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207659 | 83674 | 0 | None | 7 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 460 | 7 | 3 | 5 | 3.0 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]nc2C(F)(F)F)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 59296090 | 83678 | 0 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.3 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)cc1C(F)(F)F | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207662 | 83678 | 0 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.3 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)cc1C(F)(F)F | 10.1016/j.bmcl.2012.09.112 | ||
| 10653 | 2256 | 6 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 511 | 6 | 1 | 5 | 3.6 | O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C | nan | ||
| 59534386 | 2256 | 6 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 511 | 6 | 1 | 5 | 3.6 | O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C | nan | ||
| CHEMBL3670800 | 2256 | 6 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 511 | 6 | 1 | 5 | 3.6 | O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C | nan | ||
| DB15269 | 2256 | 6 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 511 | 6 | 1 | 5 | 3.6 | O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C | nan | ||
| 11466397 | 62550 | 0 | None | -1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 511 | 5 | 1 | 4 | 5.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178447 | 62550 | 0 | None | -1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 511 | 5 | 1 | 4 | 5.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 11466397 | 62550 | 0 | None | -1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 511 | 5 | 1 | 4 | 5.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178447 | 62550 | 0 | None | -1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 511 | 5 | 1 | 4 | 5.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 56966926 | 128757 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 537 | 8 | 2 | 5 | 4.1 | Cc1cc(C(=O)NCC2CC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670804 | 128757 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 537 | 8 | 2 | 5 | 4.1 | Cc1cc(C(=O)NCC2CC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 71072104 | 80851 | 0 | None | 15 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 520 | 9 | 1 | 5 | 5.3 | COc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158775 | 80851 | 0 | None | 15 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 520 | 9 | 1 | 5 | 5.3 | COc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 66615678 | 80856 | 0 | None | 19 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 488 | 8 | 1 | 4 | 5.0 | Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158780 | 80856 | 0 | None | 19 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 488 | 8 | 1 | 4 | 5.0 | Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 59296039 | 83795 | 0 | None | 15 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 467 | 8 | 3 | 6 | 3.2 | COc1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)ccc1N | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208427 | 83795 | 0 | None | 15 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 467 | 8 | 3 | 6 | 3.2 | COc1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)ccc1N | 10.1016/j.bmcl.2012.09.113 | ||
| 59295984 | 83597 | 0 | None | 3 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 487 | 7 | 3 | 5 | 3.3 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207279 | 83597 | 0 | None | 3 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 487 | 7 | 3 | 5 | 3.3 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 59296048 | 83602 | 0 | None | 6 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 9 | 4 | 7 | 2.4 | CNS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207284 | 83602 | 0 | None | 6 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 9 | 4 | 7 | 2.4 | CNS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| 59295969 | 83603 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 608 | 10 | 4 | 7 | 2.9 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NC3CC3)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207285 | 83603 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 608 | 10 | 4 | 7 | 2.9 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NC3CC3)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 71454296 | 83681 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 521 | 7 | 2 | 6 | 3.3 | Cn1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c(C(F)(F)F)cc1=O | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207665 | 83681 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 521 | 7 | 2 | 6 | 3.3 | Cn1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c(C(F)(F)F)cc1=O | 10.1016/j.bmcl.2012.09.112 | ||
| 59296094 | 83685 | 0 | None | 31 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 7 | 3 | 6 | 2.7 | N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207669 | 83685 | 0 | None | 31 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 7 | 3 | 6 | 2.7 | N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| 44389737 | 123344 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 481 | 4 | 0 | 3 | 6.1 | O=C(c1ccc2ncccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL362649 | 123344 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 481 | 4 | 0 | 3 | 6.1 | O=C(c1ccc2ncccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 66906657 | 115522 | 0 | None | 12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 6.2 | CCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355942 | 115522 | 0 | None | 12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 6.2 | CCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 68849581 | 80877 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 4.4 | O=C(O)C(c1ccccc1)N1CCO[C@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158818 | 80877 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 4.4 | O=C(O)C(c1ccccc1)N1CCO[C@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69348078 | 80879 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)[C@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158820 | 80879 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)[C@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69272932 | 80887 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 492 | 8 | 1 | 5 | 5.2 | O=C(O)COc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158828 | 80887 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 492 | 8 | 1 | 5 | 5.2 | O=C(O)COc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072034 | 80896 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 490 | 8 | 1 | 4 | 5.2 | O=C(O)[C@@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158836 | 80896 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 490 | 8 | 1 | 4 | 5.2 | O=C(O)[C@@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 17963208 | 81841 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 529 | 5 | 1 | 5 | 4.5 | O=C(NS(=O)(=O)c1ccc(F)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171034 | 81841 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 529 | 5 | 1 | 5 | 4.5 | O=C(NS(=O)(=O)c1ccc(F)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71453505 | 81848 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 554 | 6 | 1 | 6 | 4.5 | CN(C)c1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171041 | 81848 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 554 | 6 | 1 | 6 | 4.5 | CN(C)c1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963347 | 81852 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 579 | 5 | 1 | 5 | 5.4 | O=C(NS(=O)(=O)c1cccc(C(F)(F)F)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171045 | 81852 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 579 | 5 | 1 | 5 | 5.4 | O=C(NS(=O)(=O)c1cccc(C(F)(F)F)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71452601 | 83792 | 0 | None | -100 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 434 | 8 | 1 | 5 | 4.5 | N#Cc1cccc(OC[C@@H](O)CCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208424 | 83792 | 0 | None | -100 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 434 | 8 | 1 | 5 | 4.5 | N#Cc1cccc(OC[C@@H](O)CCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296098 | 83684 | 0 | None | 15 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 446 | 7 | 3 | 6 | 2.0 | N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207668 | 83684 | 0 | None | 15 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 446 | 7 | 3 | 6 | 2.0 | N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2012.09.112 | ||
| 44391213 | 122349 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 365 | 1 | 0 | 3 | 4.3 | C/N=c1/c2ccccc2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL360560 | 122349 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 365 | 1 | 0 | 3 | 4.3 | C/N=c1/c2ccccc2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| 118721198 | 115528 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 439 | 8 | 2 | 3 | 5.3 | CCc1[nH]c2cc(C(N)=O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355948 | 115528 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 439 | 8 | 2 | 3 | 5.3 | CCc1[nH]c2cc(C(N)=O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401177 | 68058 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 490 | 9 | 1 | 4 | 5.9 | CN(C)c1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL191693 | 68058 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 490 | 9 | 1 | 4 | 5.9 | CN(C)c1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401182 | 70725 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 476 | 7 | 2 | 3 | 6.0 | Cc1cc(C)cc(NC(=O)NCC(CC(C)C)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1021/jm040827u | ||
| CHEMBL195202 | 70725 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 476 | 7 | 2 | 3 | 6.0 | Cc1cc(C)cc(NC(=O)NCC(CC(C)C)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1021/jm040827u | ||
| 25056325 | 70833 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 496 | 7 | 2 | 3 | 6.5 | Cc1ccc(NC(=O)NCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL195610 | 70833 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 496 | 7 | 2 | 3 | 6.5 | Cc1ccc(NC(=O)NCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 136229178 | 81832 | 0 | None | -19 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 516 | 5 | 1 | 6 | 4.5 | O=C(c1ccc(-c2noc(=O)[nH]2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171025 | 81832 | 0 | None | -19 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 516 | 5 | 1 | 6 | 4.5 | O=C(c1ccc(-c2noc(=O)[nH]2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71452602 | 83804 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 433 | 8 | 2 | 5 | 3.9 | N#Cc1cccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208436 | 83804 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 433 | 8 | 2 | 5 | 3.9 | N#Cc1cccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 118721185 | 115514 | 0 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 6.5 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355934 | 115514 | 0 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 6.5 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721204 | 115544 | 0 | None | -28 | 3 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 532 | 9 | 3 | 2 | 6.7 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355964 | 115544 | 0 | None | -28 | 3 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 532 | 9 | 3 | 2 | 6.7 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44391329 | 121826 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 344 | 2 | 0 | 3 | 4.9 | FC(F)(F)Oc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL359918 | 121826 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 344 | 2 | 0 | 3 | 4.9 | FC(F)(F)Oc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| 11477767 | 62698 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 511 | 5 | 0 | 4 | 5.7 | CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178818 | 62698 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 511 | 5 | 0 | 4 | 5.7 | CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44400948 | 70727 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 510 | 7 | 2 | 3 | 6.8 | Cc1cc(C)cc(NC(=O)NCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)c1 | 10.1021/jm040827u | ||
| CHEMBL195214 | 70727 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 510 | 7 | 2 | 3 | 6.8 | Cc1cc(C)cc(NC(=O)NCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)c1 | 10.1021/jm040827u | ||
| 118721189 | 115518 | 0 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 400 | 6 | 1 | 2 | 6.1 | Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355938 | 115518 | 0 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 400 | 6 | 1 | 2 | 6.1 | Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44389738 | 64140 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 525 | 6 | 0 | 4 | 6.1 | CCO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181379 | 64140 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 525 | 6 | 0 | 4 | 6.1 | CCO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 118721206 | 115546 | 0 | None | -97 | 3 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 667 | 11 | 2 | 6 | 7.3 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355966 | 115546 | 0 | None | -97 | 3 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 667 | 11 | 2 | 6 | 7.3 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44389868 | 64308 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 588 | 7 | 1 | 5 | 4.9 | CS(=O)(=O)NC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181789 | 64308 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 588 | 7 | 1 | 5 | 4.9 | CS(=O)(=O)NC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44401160 | 69122 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 436 | 6 | 2 | 4 | 3.8 | COc1ccccc1NC(=O)NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C)CC1 | 10.1021/jm040827u | ||
| CHEMBL193369 | 69122 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 436 | 6 | 2 | 4 | 3.8 | COc1ccccc1NC(=O)NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C)CC1 | 10.1021/jm040827u | ||
| 118721206 | 115546 | 0 | None | 19 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 667 | 11 | 2 | 6 | 7.3 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355966 | 115546 | 0 | None | 19 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 667 | 11 | 2 | 6 | 7.3 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44389784 | 63994 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.1 | CO[C@@H]1CN(C2CCN(C(=O)c3cnc4ccccc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181137 | 63994 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.1 | CO[C@@H]1CN(C2CCN(C(=O)c3cnc4ccccc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44401083 | 124019 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 5.8 | COc1ccccc1C(CNCCc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| CHEMBL364047 | 124019 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 5.8 | COc1ccccc1C(CNCCc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| 44401154 | 69921 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 477 | 9 | 1 | 4 | 5.8 | COc1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL194161 | 69921 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 477 | 9 | 1 | 4 | 5.8 | COc1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401031 | 69692 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 503 | 8 | 1 | 3 | 7.1 | CC(C)(C)c1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193973 | 69692 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 503 | 8 | 1 | 3 | 7.1 | CC(C)(C)c1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401011 | 134717 | 0 | None | - | 1 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 510 | 8 | 1 | 4 | 5.0 | CN(C)c1ccc(C(CNC(=O)Cc2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL372493 | 134717 | 0 | None | - | 1 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 510 | 8 | 1 | 4 | 5.0 | CN(C)c1ccc(C(CNC(=O)Cc2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 44391247 | 122981 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 307 | 1 | 1 | 3 | 4.1 | N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1Cl | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL361761 | 122981 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 307 | 1 | 1 | 3 | 4.1 | N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1Cl | 10.1016/j.bmcl.2004.11.039 | ||
| 44389910 | 63026 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.1 | CO[C@@H]1CN(C2CCN(C(=O)c3ccc4cnccc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL179490 | 63026 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.1 | CO[C@@H]1CN(C2CCN(C(=O)c3ccc4cnccc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44391177 | 64138 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 411 | 1 | 1 | 4 | 5.2 | N=c1c2c3c(sc2nc2n1CC/C2=C\c1ccccc1Br)CCCC3 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL181367 | 64138 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 411 | 1 | 1 | 4 | 5.2 | N=c1c2c3c(sc2nc2n1CC/C2=C\c1ccccc1Br)CCCC3 | 10.1016/j.bmcl.2004.11.039 | ||
| 44401206 | 126535 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 447 | 8 | 1 | 3 | 5.8 | CC(C)(C)c1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL365596 | 126535 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 447 | 8 | 1 | 3 | 5.8 | CC(C)(C)c1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 118721205 | 115545 | 0 | None | -870 | 3 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 653 | 11 | 3 | 5 | 7.2 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355965 | 115545 | 0 | None | -870 | 3 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 653 | 11 | 3 | 5 | 7.2 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401063 | 132578 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 444 | 7 | 2 | 4 | 4.7 | COc1ccccc1C(CNC(=O)Nc1ccc(C)cc1)N1CCN(c2ccccc2)CC1 | 10.1021/jm040827u | ||
| CHEMBL370244 | 132578 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 444 | 7 | 2 | 4 | 4.7 | COc1ccccc1C(CNC(=O)Nc1ccc(C)cc1)N1CCN(c2ccccc2)CC1 | 10.1021/jm040827u | ||
| 44391192 | 63556 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 301 | 2 | 1 | 3 | 4.0 | CCc1ccccc1/C=C1\CCn2c1nc1ccccc1c2=N | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL180446 | 63556 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 301 | 2 | 1 | 3 | 4.0 | CCc1ccccc1/C=C1\CCn2c1nc1ccccc1c2=N | 10.1016/j.bmcl.2004.11.039 | ||
| 44401248 | 135464 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 504 | 7 | 2 | 4 | 5.5 | COc1ccccc1NC(=O)NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| CHEMBL373158 | 135464 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 504 | 7 | 2 | 4 | 5.5 | COc1ccccc1NC(=O)NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| 118721189 | 115518 | 0 | None | -1 | 3 | Mouse | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 400 | 6 | 1 | 2 | 6.1 | Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355938 | 115518 | 0 | None | -1 | 3 | Mouse | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 400 | 6 | 1 | 2 | 6.1 | Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721196 | 115526 | 0 | None | -4 | 3 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 5.9 | CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355946 | 115526 | 0 | None | -4 | 3 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 5.9 | CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721197 | 115527 | 0 | None | -19 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.2 | CCc1[nH]c2cc(OC)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355947 | 115527 | 0 | None | -19 | 2 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.2 | CCc1[nH]c2cc(OC)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 57718829 | 115530 | 0 | None | 2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 428 | 7 | 0 | 3 | 6.4 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1C | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355950 | 115530 | 0 | None | 2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 428 | 7 | 0 | 3 | 6.4 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1C | 10.1016/j.bmcl.2014.11.063 | ||
| 44389752 | 63777 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 481 | 4 | 0 | 3 | 6.1 | O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL180813 | 63777 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 481 | 4 | 0 | 3 | 6.1 | O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 118721198 | 115528 | 0 | None | -1 | 2 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 439 | 8 | 2 | 3 | 5.3 | CCc1[nH]c2cc(C(N)=O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355948 | 115528 | 0 | None | -1 | 2 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 439 | 8 | 2 | 3 | 5.3 | CCc1[nH]c2cc(C(N)=O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44400950 | 68325 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 449 | 6 | 2 | 4 | 4.2 | CN1CCN(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(N(C)C)cc2)CC1 | 10.1021/jm040827u | ||
| CHEMBL192045 | 68325 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 449 | 6 | 2 | 4 | 4.2 | CN1CCN(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(N(C)C)cc2)CC1 | 10.1021/jm040827u | ||
| 10151756 | 80874 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.1 | O=C(O)C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158815 | 80874 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.1 | O=C(O)C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69274365 | 80885 | 1 | None | -7 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)Cc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158826 | 80885 | 1 | None | -7 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)Cc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71449585 | 80888 | 0 | None | -7 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 492 | 8 | 1 | 5 | 5.2 | O=C(O)COc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158829 | 80888 | 0 | None | -7 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 492 | 8 | 1 | 5 | 5.2 | O=C(O)COc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| 17963196 | 81843 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 541 | 6 | 1 | 6 | 4.4 | COc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171036 | 81843 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 541 | 6 | 1 | 6 | 4.4 | COc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 118721202 | 115542 | 0 | None | -77 | 3 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355962 | 115542 | 0 | None | -77 | 3 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44391212 | 65512 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 303 | 2 | 1 | 4 | 3.5 | COc1ccc(/C=C2\CCn3c2nc2ccccc2c3=N)cc1 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL183519 | 65512 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 303 | 2 | 1 | 4 | 3.5 | COc1ccc(/C=C2\CCn3c2nc2ccccc2c3=N)cc1 | 10.1016/j.bmcl.2004.11.039 | ||
| 44401088 | 165797 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 483 | 9 | 1 | 4 | 5.4 | COc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL427357 | 165797 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 483 | 9 | 1 | 4 | 5.4 | COc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 44389675 | 62532 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 525 | 6 | 0 | 4 | 6.0 | COC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178438 | 62532 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 525 | 6 | 0 | 4 | 6.0 | COC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 71449859 | 81836 | 0 | None | -10 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 600 | 10 | 1 | 8 | 5.1 | O=C(O)CCCCn1nnc(-c2ccc(C(=O)N3CCC(N4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)CC3)cc2)n1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171029 | 81836 | 0 | None | -10 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 600 | 10 | 1 | 8 | 5.1 | O=C(O)CCCCn1nnc(-c2ccc(C(=O)N3CCC(N4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)CC3)cc2)n1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71462391 | 81839 | 0 | None | -1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 554 | 6 | 1 | 6 | 3.9 | CS(=O)(=O)c1cccc(C(=O)N2CC[C@@H](N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)[C@H](C(=O)O)C2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171032 | 81839 | 0 | None | -1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 554 | 6 | 1 | 6 | 3.9 | CS(=O)(=O)c1cccc(C(=O)N2CC[C@@H](N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)[C@H](C(=O)O)C2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 118721205 | 115545 | 0 | None | 67 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 653 | 11 | 3 | 5 | 7.2 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355965 | 115545 | 0 | None | 67 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 653 | 11 | 3 | 5 | 7.2 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| 67115149 | 128761 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 4.5 | CCC(C)NC(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| CHEMBL3670808 | 128761 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 4.5 | CCC(C)NC(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| 68028908 | 128770 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 539 | 7 | 1 | 5 | 4.5 | Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C(C)C)n3)CC2)ccc1Cl | nan | ||
| CHEMBL3670817 | 128770 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 539 | 7 | 1 | 5 | 4.5 | Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C(C)C)n3)CC2)ccc1Cl | nan | ||
| 68029259 | 128764 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 537 | 7 | 2 | 5 | 4.2 | Cc1cc(C(=O)NC2CCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670811 | 128764 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 537 | 7 | 2 | 5 | 4.2 | Cc1cc(C(=O)NC2CCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 118721191 | 115520 | 0 | None | 12 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 444 | 8 | 1 | 3 | 6.5 | COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355940 | 115520 | 0 | None | 12 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 444 | 8 | 1 | 3 | 6.5 | COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 67115103 | 128759 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 4.3 | Cc1cc(C(=O)NCC(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670806 | 128759 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 4.3 | Cc1cc(C(=O)NCC(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 56966996 | 128760 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 547 | 8 | 2 | 5 | 3.9 | Cc1cc(C(=O)NCC(F)F)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670807 | 128760 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 547 | 8 | 2 | 5 | 3.9 | Cc1cc(C(=O)NCC(F)F)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 118721200 | 115534 | 0 | None | 15 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 558 | 9 | 1 | 6 | 7.0 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355954 | 115534 | 0 | None | 15 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 558 | 9 | 1 | 6 | 7.0 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 67115023 | 128754 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 523 | 6 | 1 | 5 | 3.9 | Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N4CCCC4)ccn3)CC2)ccc1Cl | nan | ||
| CHEMBL3670801 | 128754 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 523 | 6 | 1 | 5 | 3.9 | Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N4CCCC4)ccn3)CC2)ccc1Cl | nan | ||
| 118721194 | 115524 | 0 | None | 5 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.4 | COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355944 | 115524 | 0 | None | 5 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.4 | COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 11952526 | 115533 | 0 | None | 24 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 534 | 9 | 1 | 4 | 7.5 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355953 | 115533 | 0 | None | 24 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 534 | 9 | 1 | 4 | 7.5 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44389744 | 123355 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 458 | 5 | 0 | 2 | 5.8 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL362700 | 123355 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 458 | 5 | 0 | 2 | 5.8 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 66906657 | 115522 | 0 | None | -12 | 2 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 6.2 | CCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355942 | 115522 | 0 | None | -12 | 2 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 6.2 | CCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721199 | 115529 | 0 | None | -2 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 440 | 8 | 2 | 3 | 5.9 | CCc1[nH]c2cc(C(=O)O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355949 | 115529 | 0 | None | -2 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 440 | 8 | 2 | 3 | 5.9 | CCc1[nH]c2cc(C(=O)O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721188 | 115517 | 0 | None | -8 | 3 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 439 | 8 | 2 | 3 | 5.3 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355937 | 115517 | 0 | None | -8 | 3 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 439 | 8 | 2 | 3 | 5.3 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401189 | 69500 | 0 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 429 | 8 | 1 | 4 | 3.9 | COc1ccc(C(CNC(=O)Cc2ccccc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193818 | 69500 | 0 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 429 | 8 | 1 | 4 | 3.9 | COc1ccc(C(CNC(=O)Cc2ccccc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 44391800 | 63942 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 484 | 6 | 0 | 3 | 4.9 | COc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Br)cc3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL180939 | 63942 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 484 | 6 | 0 | 3 | 4.9 | COc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Br)cc3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44389675 | 62532 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 525 | 6 | 0 | 4 | 6.0 | COC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178438 | 62532 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 525 | 6 | 0 | 4 | 6.0 | COC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 25024850 | 115541 | 0 | None | -6 | 3 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355961 | 115541 | 0 | None | -6 | 3 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 | 10.1016/j.bmcl.2014.11.063 | ||
| 68028909 | 128768 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 553 | 9 | 1 | 5 | 4.7 | CCCCc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670815 | 128768 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 553 | 9 | 1 | 5 | 4.7 | CCCCc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 118721195 | 115525 | 0 | None | -9 | 3 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 6.5 | CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355945 | 115525 | 0 | None | -9 | 3 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 6.5 | CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44400977 | 69613 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 420 | 7 | 2 | 3 | 4.8 | CC(C)CC(CNC(=O)Nc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| CHEMBL193916 | 69613 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 420 | 7 | 2 | 3 | 4.8 | CC(C)CC(CNC(=O)Nc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| 44400944 | 69973 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 442 | 9 | 1 | 4 | 4.8 | Cc1ccc(CCNCC(c2ccc(N(C)C)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL194435 | 69973 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 442 | 9 | 1 | 4 | 4.8 | Cc1ccc(CCNCC(c2ccc(N(C)C)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 118721188 | 115517 | 0 | None | 2 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 439 | 8 | 2 | 3 | 5.3 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355937 | 115517 | 0 | None | 2 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 439 | 8 | 2 | 3 | 5.3 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44391312 | 65256 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 304 | 3 | 0 | 3 | 4.4 | CCOc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL183229 | 65256 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 304 | 3 | 0 | 3 | 4.4 | CCOc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| 44389735 | 121810 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 481 | 4 | 0 | 3 | 6.1 | O=C(c1cnc2ccccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL359850 | 121810 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 481 | 4 | 0 | 3 | 6.1 | O=C(c1cnc2ccccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 118721195 | 115525 | 0 | None | 1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 6.5 | CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355945 | 115525 | 0 | None | 1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 6.5 | CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44389736 | 62507 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 513 | 5 | 0 | 3 | 6.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CF)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178422 | 62507 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 513 | 5 | 0 | 3 | 6.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CF)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44389725 | 123138 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 482 | 4 | 0 | 4 | 5.5 | O=C(c1cnnc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL362017 | 123138 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 482 | 4 | 0 | 4 | 5.5 | O=C(c1cnnc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 56966927 | 128747 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 456 | 6 | 1 | 5 | 3.6 | COc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| CHEMBL3670793 | 128747 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 456 | 6 | 1 | 5 | 3.6 | COc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| 118721193 | 115523 | 0 | None | -69 | 3 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 398 | 7 | 2 | 3 | 5.2 | OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355943 | 115523 | 0 | None | -69 | 3 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 398 | 7 | 2 | 3 | 5.2 | OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 11952525 | 115538 | 0 | None | -38 | 3 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 562 | 10 | 0 | 5 | 8.0 | CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355958 | 115538 | 0 | None | -38 | 3 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 562 | 10 | 0 | 5 | 8.0 | CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401129 | 126256 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 391 | 7 | 1 | 3 | 3.8 | CN1CCN(C(CNCCc2ccccc2)c2ccc(C(F)(F)F)cc2)CC1 | 10.1021/jm040827u | ||
| CHEMBL365369 | 126256 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 391 | 7 | 1 | 3 | 3.8 | CN1CCN(C(CNCCc2ccccc2)c2ccc(C(F)(F)F)cc2)CC1 | 10.1021/jm040827u | ||
| 44401175 | 126709 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 5.5 | COc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL365806 | 126709 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 5.5 | COc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401037 | 70736 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.5 | O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccccc1 | 10.1021/jm040827u | ||
| CHEMBL195291 | 70736 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.5 | O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccccc1 | 10.1021/jm040827u | ||
| 118721195 | 115525 | 0 | None | -1 | 3 | Mouse | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 6.5 | CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355945 | 115525 | 0 | None | -1 | 3 | Mouse | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 6.5 | CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44389765 | 168770 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.1 | CO[C@@H]1CN(C2CCN(C(=O)c3ccc4nccnc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL441848 | 168770 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.1 | CO[C@@H]1CN(C2CCN(C(=O)c3ccc4nccnc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 118721192 | 115521 | 0 | None | -4 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 458 | 8 | 1 | 4 | 6.0 | CCOC(=O)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355941 | 115521 | 0 | None | -4 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 458 | 8 | 1 | 4 | 6.0 | CCOC(=O)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401146 | 69918 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 459 | 8 | 1 | 3 | 5.5 | FC(F)(F)c1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL194135 | 69918 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 459 | 8 | 1 | 3 | 5.5 | FC(F)(F)c1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401256 | 70890 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 471 | 9 | 1 | 4 | 5.7 | COc1ccccc1CCNCC(c1ccc(C(C)(C)C)cc1)N1CCN(c2ccccc2)CC1 | 10.1021/jm040827u | ||
| CHEMBL195657 | 70890 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 471 | 9 | 1 | 4 | 5.7 | COc1ccccc1CCNCC(c1ccc(C(C)(C)C)cc1)N1CCN(c2ccccc2)CC1 | 10.1021/jm040827u | ||
| 25024650 | 115540 | 0 | None | 21 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355960 | 115540 | 0 | None | 21 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721202 | 115542 | 0 | None | 15 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355962 | 115542 | 0 | None | 15 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 | 10.1016/j.bmcl.2014.11.063 | ||
| 9914506 | 80845 | 0 | None | 3 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 515 | 8 | 1 | 5 | 5.1 | N#Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158769 | 80845 | 0 | None | 3 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 515 | 8 | 1 | 5 | 5.1 | N#Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 68938028 | 80848 | 0 | None | 6 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158772 | 80848 | 0 | None | 6 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 66615705 | 80855 | 0 | None | 19 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158779 | 80855 | 0 | None | 19 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69826668 | 81828 | 0 | None | 5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 524 | 5 | 0 | 5 | 4.9 | Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)c4cccc(S(C)(=O)=O)c4)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171021 | 81828 | 0 | None | 5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 524 | 5 | 0 | 5 | 4.9 | Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)c4cccc(S(C)(=O)=O)c4)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 71457010 | 81846 | 0 | None | 10 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 545 | 5 | 1 | 5 | 5.1 | O=C(NS(=O)(=O)c1ccccc1Cl)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171039 | 81846 | 0 | None | 10 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 545 | 5 | 1 | 5 | 5.1 | O=C(NS(=O)(=O)c1ccccc1Cl)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 70790202 | 128762 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 553 | 8 | 1 | 5 | 4.8 | CCC(C)N(C)C(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| CHEMBL3670809 | 128762 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 553 | 8 | 1 | 5 | 4.8 | CCC(C)N(C)C(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| 57718837 | 115512 | 0 | None | 1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 414 | 7 | 1 | 2 | 6.4 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355932 | 115512 | 0 | None | 1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 414 | 7 | 1 | 2 | 6.4 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 56966997 | 128765 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 555 | 6 | 1 | 5 | 3.8 | Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Br)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670812 | 128765 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 555 | 6 | 1 | 5 | 3.8 | Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Br)c(C)c3)CC2)n1 | nan | ||
| 11466397 | 62550 | 0 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 511 | 5 | 1 | 4 | 5.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178447 | 62550 | 0 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 511 | 5 | 1 | 4 | 5.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 10003872 | 69939 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 449 | 9 | 1 | 4 | 5.1 | COc1ccc(C(CNCCc2cc(C)cc(C)c2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL194283 | 69939 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 449 | 9 | 1 | 4 | 5.1 | COc1ccc(C(CNCCc2cc(C)cc(C)c2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 71451390 | 80854 | 0 | None | 7 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 474 | 8 | 1 | 4 | 4.7 | O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158778 | 80854 | 0 | None | 7 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 474 | 8 | 1 | 4 | 4.7 | O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 22397436 | 81825 | 0 | None | -6 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 510 | 5 | 0 | 5 | 4.5 | CS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171019 | 81825 | 0 | None | -6 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 510 | 5 | 0 | 5 | 4.5 | CS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963258 | 81844 | 0 | None | -2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 554 | 6 | 1 | 6 | 4.5 | CN(C)c1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171037 | 81844 | 0 | None | -2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 554 | 6 | 1 | 6 | 4.5 | CN(C)c1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71451671 | 81835 | 0 | None | -31 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 519 | 8 | 2 | 5 | 5.0 | O=C(O)CCNc1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171028 | 81835 | 0 | None | -31 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 519 | 8 | 2 | 5 | 5.0 | O=C(O)CCNc1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71451670 | 81823 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 455 | 7 | 1 | 4 | 4.2 | COc1ccc(C(=O)NCCN2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171017 | 81823 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 455 | 7 | 1 | 4 | 4.2 | COc1ccc(C(=O)NCCN2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 44389751 | 64313 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 442 | 5 | 0 | 2 | 5.3 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(F)cc(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181794 | 64313 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 442 | 5 | 0 | 2 | 5.3 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(F)cc(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 44401136 | 70432 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 495 | 9 | 1 | 3 | 6.8 | Cc1cc(C)cc(CCNCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)c1 | 10.1021/jm040827u | ||
| CHEMBL195081 | 70432 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 495 | 9 | 1 | 3 | 6.8 | Cc1cc(C)cc(CCNCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)c1 | 10.1021/jm040827u | ||
| 44401132 | 68294 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 474 | 5 | 2 | 3 | 5.1 | CN1CCN(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C(F)(F)F)cc2)CC1 | 10.1021/jm040827u | ||
| CHEMBL191824 | 68294 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 474 | 5 | 2 | 3 | 5.1 | CN1CCN(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C(F)(F)F)cc2)CC1 | 10.1021/jm040827u | ||
| 118721191 | 115520 | 0 | None | -12 | 3 | Mouse | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 444 | 8 | 1 | 3 | 6.5 | COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355940 | 115520 | 0 | None | -12 | 3 | Mouse | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 444 | 8 | 1 | 3 | 6.5 | COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 25024849 | 115539 | 0 | None | -97 | 3 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355959 | 115539 | 0 | None | -97 | 3 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401012 | 68328 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 454 | 7 | 2 | 4 | 4.6 | COc1ccccc1C(CNC(=O)Nc1ccc(F)cc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| CHEMBL192066 | 68328 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 454 | 7 | 2 | 4 | 4.6 | COc1ccccc1C(CNC(=O)Nc1ccc(F)cc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| 44401145 | 69894 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 420 | 6 | 2 | 3 | 4.8 | Cc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL194086 | 69894 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 420 | 6 | 2 | 3 | 4.8 | Cc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 25024849 | 115539 | 0 | None | 13 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355959 | 115539 | 0 | None | 13 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401048 | 69506 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 473 | 8 | 1 | 3 | 5.8 | Cc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193828 | 69506 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 473 | 8 | 1 | 3 | 5.8 | Cc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 11952526 | 115533 | 0 | None | -1122 | 3 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 534 | 9 | 1 | 4 | 7.5 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355953 | 115533 | 0 | None | -1122 | 3 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 534 | 9 | 1 | 4 | 7.5 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401209 | 69461 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 418 | 6 | 2 | 3 | 4.5 | O=C(NCC(c1ccccc1)N1CCN(c2ccccc2)CC1)Nc1ccc(F)cc1 | 10.1021/jm040827u | ||
| CHEMBL193592 | 69461 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 418 | 6 | 2 | 3 | 4.5 | O=C(NCC(c1ccccc1)N1CCN(c2ccccc2)CC1)Nc1ccc(F)cc1 | 10.1021/jm040827u | ||
| 44389683 | 131128 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 458 | 5 | 0 | 2 | 5.8 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL369287 | 131128 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 458 | 5 | 0 | 2 | 5.8 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 118721196 | 115526 | 0 | None | -6 | 3 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 5.9 | CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355946 | 115526 | 0 | None | -6 | 3 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 5.9 | CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 24937215 | 115532 | 0 | None | -9 | 3 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 472 | 9 | 1 | 4 | 5.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355952 | 115532 | 0 | None | -9 | 3 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 472 | 9 | 1 | 4 | 5.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O | 10.1016/j.bmcl.2014.11.063 | ||
| 44401226 | 70763 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 429 | 9 | 1 | 4 | 4.7 | COc1ccc(C(CNCCc2ccc(C)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL195406 | 70763 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 429 | 9 | 1 | 4 | 4.7 | COc1ccc(C(CNCCc2ccc(C)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 56966929 | 128753 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 553 | 6 | 1 | 6 | 3.4 | Cc1cc(C(=O)N2CCOCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670799 | 128753 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 553 | 6 | 1 | 6 | 3.4 | Cc1cc(C(=O)N2CCOCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 11753159 | 542 | 3 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 7679 | 542 | 3 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158814 | 542 | 3 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 11753159 | 542 | 3 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 7679 | 542 | 3 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2158814 | 542 | 3 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 17963183 | 81850 | 0 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 545 | 5 | 1 | 5 | 5.1 | O=C(NS(=O)(=O)c1cccc(Cl)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171043 | 81850 | 0 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 545 | 5 | 1 | 5 | 5.1 | O=C(NS(=O)(=O)c1cccc(Cl)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 59296024 | 83595 | 0 | None | 9 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 547 | 8 | 3 | 7 | 2.5 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3ccc(S(C)(=O)=O)cc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207277 | 83595 | 0 | None | 9 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 547 | 8 | 3 | 7 | 2.5 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3ccc(S(C)(=O)=O)cc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 59296111 | 83673 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 480 | 7 | 3 | 5 | 3.4 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C(F)(F)F | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207658 | 83673 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 480 | 7 | 3 | 5 | 3.4 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C(F)(F)F | 10.1016/j.bmcl.2012.09.112 | ||
| 56966995 | 128758 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 523 | 6 | 1 | 5 | 3.8 | Cc1cc(C(=O)N2CCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670805 | 128758 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 523 | 6 | 1 | 5 | 3.8 | Cc1cc(C(=O)N2CCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 118721184 | 115513 | 0 | None | 1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 6.2 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355933 | 115513 | 0 | None | 1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 6.2 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 25024850 | 115541 | 0 | None | 6 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355961 | 115541 | 0 | None | 6 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401005 | 70227 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 459 | 9 | 1 | 5 | 3.9 | COc1ccccc1CC(=O)NCC(c1ccccc1OC)N1CCN(c2ccccc2)CC1 | 10.1021/jm040827u | ||
| CHEMBL194886 | 70227 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 459 | 9 | 1 | 5 | 3.9 | COc1ccccc1CC(=O)NCC(c1ccccc1OC)N1CCN(c2ccccc2)CC1 | 10.1021/jm040827u | ||
| 44401025 | 69334 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 496 | 9 | 1 | 4 | 5.5 | CN(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193535 | 69334 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 496 | 9 | 1 | 4 | 5.5 | CN(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 11466397 | 62550 | 0 | None | -83 | 4 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 511 | 5 | 1 | 4 | 5.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178447 | 62550 | 0 | None | -83 | 4 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 511 | 5 | 1 | 4 | 5.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 24937215 | 115532 | 0 | None | 1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 472 | 9 | 1 | 4 | 5.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355952 | 115532 | 0 | None | 1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 472 | 9 | 1 | 4 | 5.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O | 10.1016/j.bmcl.2014.11.063 | ||
| 70790203 | 128776 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 525 | 6 | 1 | 5 | 4.0 | Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3cc(C)c(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670823 | 128776 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 525 | 6 | 1 | 5 | 4.0 | Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3cc(C)c(Cl)c(C)c3)CC2)n1 | nan | ||
| 44391235 | 64914 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 376 | 1 | 0 | 4 | 4.1 | N#C/N=c1/c2ccccc2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL182719 | 64914 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 376 | 1 | 0 | 4 | 4.1 | N#C/N=c1/c2ccccc2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| 118721185 | 115514 | 0 | None | -1 | 3 | Mouse | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 6.5 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355934 | 115514 | 0 | None | -1 | 3 | Mouse | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 6.5 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 25056323 | 70892 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 5.8 | COc1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL195671 | 70892 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 5.8 | COc1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401069 | 68768 | 0 | None | - | 1 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 473 | 7 | 1 | 3 | 5.3 | O=C(Cc1cc(Cl)cc(Cl)c1)NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| CHEMBL192384 | 68768 | 0 | None | - | 1 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 473 | 7 | 1 | 3 | 5.3 | O=C(Cc1cc(Cl)cc(Cl)c1)NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| 44401110 | 68312 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 477 | 9 | 1 | 4 | 5.8 | COc1ccc(C(CNCCc2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL191959 | 68312 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 477 | 9 | 1 | 4 | 5.8 | COc1ccc(C(CNCCc2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 59296041 | 83686 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 558 | 8 | 3 | 8 | 2.1 | CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(C#N)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207670 | 83686 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 558 | 8 | 3 | 8 | 2.1 | CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(C#N)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| 25024651 | 115536 | 0 | None | -39 | 3 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355956 | 115536 | 0 | None | -39 | 3 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721185 | 115514 | 0 | None | -19 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 6.5 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355934 | 115514 | 0 | None | -19 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 6.5 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 69347707 | 80893 | 1 | None | -5 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158833 | 80893 | 1 | None | -5 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69260079 | 80894 | 2 | None | -63 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 463 | 6 | 1 | 5 | 4.8 | O=C(O)c1cccnc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158834 | 80894 | 2 | None | -63 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 463 | 6 | 1 | 5 | 4.8 | O=C(O)c1cccnc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71457009 | 81837 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 504 | 5 | 1 | 4 | 5.2 | Cc1ccc(C(=O)N2CCC(N3CC[C@H](Oc4ccc(Cl)c(C)c4Cl)C[C@@H]3C(=O)O)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171030 | 81837 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 504 | 5 | 1 | 4 | 5.2 | Cc1ccc(C(=O)N2CCC(N3CC[C@H](Oc4ccc(Cl)c(C)c4Cl)C[C@@H]3C(=O)O)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963199 | 81858 | 0 | None | 1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 493 | 5 | 1 | 5 | 3.7 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(F)c(F)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171050 | 81858 | 0 | None | 1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 493 | 5 | 1 | 5 | 3.7 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(F)c(F)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 44401203 | 69787 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 424 | 6 | 2 | 3 | 4.6 | O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(F)cc1 | 10.1021/jm040827u | ||
| CHEMBL194026 | 69787 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 424 | 6 | 2 | 3 | 4.6 | O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(F)cc1 | 10.1021/jm040827u | ||
| 118721204 | 115544 | 0 | None | -5 | 3 | Mouse | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 532 | 9 | 3 | 2 | 6.7 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355964 | 115544 | 0 | None | -5 | 3 | Mouse | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 532 | 9 | 3 | 2 | 6.7 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| 25024850 | 115541 | 0 | None | -107 | 3 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355961 | 115541 | 0 | None | -107 | 3 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721184 | 115513 | 0 | None | -1 | 3 | Mouse | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 6.2 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355933 | 115513 | 0 | None | -1 | 3 | Mouse | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 6.2 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 11952524 | 115531 | 0 | None | -9 | 3 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 490 | 8 | 0 | 3 | 7.8 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355951 | 115531 | 0 | None | -9 | 3 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 490 | 8 | 0 | 3 | 7.8 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721193 | 115523 | 0 | None | 1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 398 | 7 | 2 | 3 | 5.2 | OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355943 | 115523 | 0 | None | 1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 398 | 7 | 2 | 3 | 5.2 | OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44389684 | 62653 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 468 | 5 | 0 | 2 | 5.2 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Br)cc3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178576 | 62653 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 468 | 5 | 0 | 2 | 5.2 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Br)cc3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 118721206 | 115546 | 0 | None | -19 | 3 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 667 | 11 | 2 | 6 | 7.3 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355966 | 115546 | 0 | None | -19 | 3 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 667 | 11 | 2 | 6 | 7.3 | CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| 11952524 | 115531 | 0 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 490 | 8 | 0 | 3 | 7.8 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355951 | 115531 | 0 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 490 | 8 | 0 | 3 | 7.8 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 56966928 | 128748 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 440 | 5 | 1 | 4 | 3.9 | Cc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| CHEMBL3670794 | 128748 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 440 | 5 | 1 | 4 | 3.9 | Cc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 | nan | ||
| 44389677 | 62758 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 481 | 4 | 0 | 3 | 6.1 | O=C(c1cccc2cccnc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178875 | 62758 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 481 | 4 | 0 | 3 | 6.1 | O=C(c1cccc2cccnc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 56965997 | 128746 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 440 | 5 | 1 | 4 | 3.9 | Cc1cccc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670792 | 128746 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 440 | 5 | 1 | 4 | 3.9 | Cc1cccc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 118721201 | 115535 | 0 | None | -2 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 548 | 10 | 1 | 4 | 7.6 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1Cc1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355955 | 115535 | 0 | None | -2 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 548 | 10 | 1 | 4 | 7.6 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1Cc1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 11466397 | 62550 | 0 | None | 1 | 4 | Rhesus macaque | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 511 | 5 | 1 | 4 | 5.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178447 | 62550 | 0 | None | 1 | 4 | Rhesus macaque | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 511 | 5 | 1 | 4 | 5.3 | O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 11477767 | 62698 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 511 | 5 | 0 | 4 | 5.7 | CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL178818 | 62698 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 511 | 5 | 0 | 4 | 5.7 | CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 67115945 | 128774 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 525 | 7 | 1 | 5 | 3.9 | CCc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C)n3)CC2)ccc1Cl | nan | ||
| CHEMBL3670821 | 128774 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 525 | 7 | 1 | 5 | 3.9 | CCc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C)n3)CC2)ccc1Cl | nan | ||
| 56967065 | 128775 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 521 | 6 | 1 | 5 | 3.3 | C#Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670822 | 128775 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 521 | 6 | 1 | 5 | 3.3 | C#Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 71072052 | 80847 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 515 | 8 | 1 | 5 | 5.1 | N#Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158771 | 80847 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 515 | 8 | 1 | 5 | 5.1 | N#Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71453204 | 80858 | 0 | None | 12 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 488 | 8 | 1 | 4 | 5.0 | Cc1cc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158782 | 80858 | 0 | None | 12 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 488 | 8 | 1 | 4 | 5.0 | Cc1cc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 17963363 | 81842 | 0 | None | 2 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 545 | 5 | 1 | 5 | 5.1 | O=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171035 | 81842 | 0 | None | 2 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 545 | 5 | 1 | 5 | 5.1 | O=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963226 | 81855 | 0 | None | 3 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 505 | 5 | 1 | 5 | 4.4 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4C)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171048 | 81855 | 0 | None | 3 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 505 | 5 | 1 | 5 | 4.4 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4C)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 59295994 | 83802 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cc(=O)[nH]c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208434 | 83802 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cc(=O)[nH]c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 59295925 | 83687 | 0 | None | 2 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 567 | 8 | 3 | 7 | 2.9 | CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207671 | 83687 | 0 | None | 2 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 567 | 8 | 3 | 7 | 2.9 | CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| 56966999 | 128771 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 495 | 6 | 1 | 5 | 3.1 | Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(F)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670818 | 128771 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 495 | 6 | 1 | 5 | 3.1 | Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(F)c(C)c3)CC2)n1 | nan | ||
| 118721200 | 115534 | 0 | None | -15 | 3 | Mouse | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 558 | 9 | 1 | 6 | 7.0 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355954 | 115534 | 0 | None | -15 | 3 | Mouse | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 558 | 9 | 1 | 6 | 7.0 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 67115364 | 123918 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 483 | 6 | 2 | 5 | 3.0 | CNC(=O)c1cccc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3639696 | 123918 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 483 | 6 | 2 | 5 | 3.0 | CNC(=O)c1cccc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 44391319 | 64007 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 328 | 1 | 0 | 2 | 5.3 | Clc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)cc1Cl | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL181195 | 64007 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 328 | 1 | 0 | 2 | 5.3 | Clc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)cc1Cl | 10.1016/j.bmcl.2004.11.039 | ||
| 118721190 | 115519 | 0 | None | -40 | 3 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 416 | 7 | 2 | 3 | 5.3 | OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355939 | 115519 | 0 | None | -40 | 3 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 416 | 7 | 2 | 3 | 5.3 | OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 24937215 | 115532 | 0 | None | -1 | 3 | Mouse | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 472 | 9 | 1 | 4 | 5.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355952 | 115532 | 0 | None | -1 | 3 | Mouse | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 472 | 9 | 1 | 4 | 5.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O | 10.1016/j.bmcl.2014.11.063 | ||
| 25024849 | 115539 | 0 | None | -13 | 3 | Mouse | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355959 | 115539 | 0 | None | -13 | 3 | Mouse | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44391170 | 65388 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 399 | 1 | 1 | 3 | 4.1 | N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1I | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL183461 | 65388 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 399 | 1 | 1 | 3 | 4.1 | N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1I | 10.1016/j.bmcl.2004.11.039 | ||
| 44400991 | 69470 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 471 | 9 | 1 | 4 | 5.7 | COc1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193633 | 69470 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 471 | 9 | 1 | 4 | 5.7 | COc1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 43957010 | 68295 | 7 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 399 | 6 | 2 | 4 | 3.0 | CN1CCN(C(CNC(=O)Nc2ccc(F)cc2)c2ccc(N(C)C)cc2)CC1 | 10.1021/jm040827u | ||
| CHEMBL191828 | 68295 | 7 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 399 | 6 | 2 | 4 | 3.0 | CN1CCN(C(CNC(=O)Nc2ccc(F)cc2)c2ccc(N(C)C)cc2)CC1 | 10.1021/jm040827u | ||
| 118721186 | 115515 | 0 | None | 2 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 5.9 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355935 | 115515 | 0 | None | 2 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 5.9 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401085 | 134979 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 527 | 8 | 1 | 3 | 6.5 | FC(F)(F)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL372858 | 134979 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 527 | 8 | 1 | 3 | 6.5 | FC(F)(F)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 118721202 | 115542 | 0 | None | -15 | 3 | Mouse | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355962 | 115542 | 0 | None | -15 | 3 | Mouse | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 535 | 9 | 1 | 5 | 6.9 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 | 10.1016/j.bmcl.2014.11.063 | ||
| 68846936 | 80875 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)C(c1ccccc1)N1CCCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158816 | 80875 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)C(c1ccccc1)N1CCCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.08.103 | ||
| 23102733 | 81821 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 511 | 6 | 1 | 5 | 4.0 | O=C(NS(=O)(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1)c1ccccc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171015 | 81821 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 511 | 6 | 1 | 5 | 4.0 | O=C(NS(=O)(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1)c1ccccc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71449858 | 81834 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 582 | 9 | 1 | 6 | 4.8 | O=C(O)CCCS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171027 | 81834 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 582 | 9 | 1 | 6 | 4.8 | O=C(O)CCCS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71461541 | 83805 | 0 | None | 15 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 513 | 9 | 3 | 6 | 2.7 | CS(=O)(=O)c1ccccc1C(=O)NCC(O)CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208437 | 83805 | 0 | None | 15 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 513 | 9 | 3 | 6 | 2.7 | CS(=O)(=O)c1ccccc1C(=O)NCC(O)CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.bmcl.2012.09.113 | ||
| 44391240 | 123141 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 432 | 2 | 0 | 2 | 6.7 | Fc1ccc(C2C/C(=C\c3ccccc3Br)C3=Nc4ccccc4CN32)cc1 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL362032 | 123141 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 432 | 2 | 0 | 2 | 6.7 | Fc1ccc(C2C/C(=C\c3ccccc3Br)C3=Nc4ccccc4CN32)cc1 | 10.1016/j.bmcl.2004.11.039 | ||
| 44389732 | 64017 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 420 | 6 | 0 | 3 | 4.5 | COc1ccc(CC2CCN(C3CCN(C(=O)Cc4ccccc4C)CC3)CC2)cc1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181230 | 64017 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 420 | 6 | 0 | 3 | 4.5 | COc1ccc(CC2CCN(C3CCN(C(=O)Cc4ccccc4C)CC3)CC2)cc1 | 10.1016/j.bmcl.2005.01.016 | ||
| 71450777 | 83788 | 0 | None | -63 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 5.2 | N#Cc1cccc(OCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208420 | 83788 | 0 | None | -63 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 5.2 | N#Cc1cccc(OCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 56965994 | 128766 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 525 | 7 | 1 | 5 | 3.9 | CCc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| CHEMBL3670813 | 128766 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 525 | 7 | 1 | 5 | 3.9 | CCc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 | nan | ||
| 56965996 | 128751 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 497 | 6 | 1 | 5 | 3.3 | Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)ccn3)CC2)ccc1Cl | nan | ||
| CHEMBL3670797 | 128751 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 497 | 6 | 1 | 5 | 3.3 | Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)ccn3)CC2)ccc1Cl | nan | ||
| 25056324 | 126424 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 459 | 8 | 1 | 3 | 5.8 | Clc1cc(Cl)cc(CCNCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)c1 | 10.1021/jm040827u | ||
| CHEMBL365551 | 126424 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 459 | 8 | 1 | 3 | 5.8 | Clc1cc(Cl)cc(CCNCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)c1 | 10.1021/jm040827u | ||
| 44401070 | 68769 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 414 | 6 | 2 | 3 | 4.7 | Cc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL192385 | 68769 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 414 | 6 | 2 | 3 | 4.7 | Cc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm040827u | ||
| 24937092 | 115537 | 0 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 500 | 10 | 0 | 5 | 6.4 | CCOC(=O)Cn1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc21 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355957 | 115537 | 0 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 500 | 10 | 0 | 5 | 6.4 | CCOC(=O)Cn1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc21 | 10.1016/j.bmcl.2014.11.063 | ||
| 44391282 | 122106 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 352 | 1 | 1 | 4 | 3.6 | N=c1c2cccnc2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL360308 | 122106 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 352 | 1 | 1 | 4 | 3.6 | N=c1c2cccnc2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| 136216709 | 78556 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 341 | 1 | 2 | 4 | 2.9 | N=c1c2nc[nH]c2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL2113024 | 78556 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 341 | 1 | 2 | 4 | 2.9 | N=c1c2nc[nH]c2nc2n1CC/C2=C\c1ccccc1Br | 10.1016/j.bmcl.2004.11.039 | ||
| 44387847 | 60172 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 504 | 7 | 2 | 4 | 5.8 | COc1ccc(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL175547 | 60172 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 504 | 7 | 2 | 4 | 5.8 | COc1ccc(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44387853 | 63115 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 515 | 8 | 1 | 3 | 6.8 | CC(C)(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL179752 | 63115 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 515 | 8 | 1 | 3 | 6.8 | CC(C)(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 57718829 | 115530 | 0 | None | -2 | 2 | Mouse | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 428 | 7 | 0 | 3 | 6.4 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1C | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355950 | 115530 | 0 | None | -2 | 2 | Mouse | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 428 | 7 | 0 | 3 | 6.4 | CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1C | 10.1016/j.bmcl.2014.11.063 | ||
| 118721196 | 115526 | 0 | None | 4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 5.9 | CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355946 | 115526 | 0 | None | 4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 412 | 7 | 2 | 3 | 5.9 | CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44389790 | 64441 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.1 | CO[C@@H]1CN(C2CCN(C(=O)c3cnnc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181929 | 64441 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.1 | CO[C@@H]1CN(C2CCN(C(=O)c3cnnc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2005.01.016 | ||
| 56967063 | 128772 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 565 | 6 | 1 | 5 | 4.4 | Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C(F)(F)F)c3)CC2)n1 | nan | ||
| CHEMBL3670819 | 128772 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 565 | 6 | 1 | 5 | 4.4 | Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C(F)(F)F)c3)CC2)n1 | nan | ||
| 118721184 | 115513 | 0 | None | -14 | 3 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 6.2 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355933 | 115513 | 0 | None | -14 | 3 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 6.2 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44400974 | 134767 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 485 | 8 | 1 | 4 | 5.2 | COc1ccccc1CC(=O)NCC(c1ccc(C(C)(C)C)cc1)N1CCN(c2ccccc2)CC1 | 10.1021/jm040827u | ||
| CHEMBL372725 | 134767 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 485 | 8 | 1 | 4 | 5.2 | COc1ccccc1CC(=O)NCC(c1ccc(C(C)(C)C)cc1)N1CCN(c2ccccc2)CC1 | 10.1021/jm040827u | ||
| 44400949 | 68814 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 477 | 8 | 1 | 3 | 5.7 | Fc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL192412 | 68814 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 477 | 8 | 1 | 3 | 5.7 | Fc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401155 | 69830 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 504 | 7 | 2 | 4 | 5.8 | COc1ccccc1C(CNC(=O)Nc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| CHEMBL194044 | 69830 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 504 | 7 | 2 | 4 | 5.8 | COc1ccccc1C(CNC(=O)Nc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm040827u | ||
| 44401094 | 70785 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 391 | 7 | 1 | 3 | 3.8 | CN1CCN(C(CNCCc2ccc(C(F)(F)F)cc2)c2ccccc2)CC1 | 10.1021/jm040827u | ||
| CHEMBL195488 | 70785 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 391 | 7 | 1 | 3 | 3.8 | CN1CCN(C(CNCCc2ccc(C(F)(F)F)cc2)c2ccccc2)CC1 | 10.1021/jm040827u | ||
| 11397231 | 81051 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 469 | 7 | 0 | 4 | 6.2 | Fc1ccc(SCCCN2CCC(n3c(CC(F)(F)F)nc4cc(F)ccc43)CC2)cc1 | 10.1016/j.bmc.2012.09.013 | ||
| CHEMBL2159766 | 81051 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 469 | 7 | 0 | 4 | 6.2 | Fc1ccc(SCCCN2CCC(n3c(CC(F)(F)F)nc4cc(F)ccc43)CC2)cc1 | 10.1016/j.bmc.2012.09.013 | ||
| 9797962 | 65343 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 338 | 1 | 0 | 2 | 4.8 | Brc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL183429 | 65343 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 338 | 1 | 0 | 2 | 4.8 | Brc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 | 10.1016/j.bmcl.2004.11.039 | ||
| 44401032 | 69785 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 492 | 7 | 2 | 4 | 5.8 | COc1ccc(C(CNC(=O)Nc2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL194022 | 69785 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 492 | 7 | 2 | 4 | 5.8 | COc1ccc(C(CNC(=O)Nc2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401234 | 69498 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 435 | 9 | 1 | 4 | 4.8 | COc1ccc(C(CNCCc2ccc(C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL193809 | 69498 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 435 | 9 | 1 | 4 | 4.8 | COc1ccc(C(CNCCc2ccc(C)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 118721193 | 115523 | 0 | None | -1 | 3 | Mouse | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 398 | 7 | 2 | 3 | 5.2 | OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355943 | 115523 | 0 | None | -1 | 3 | Mouse | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 398 | 7 | 2 | 3 | 5.2 | OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44401089 | 123541 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 5.5 | COc1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL363181 | 123541 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 5.5 | COc1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44391268 | 63568 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 312 | 1 | 0 | 2 | 4.8 | Fc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 | 10.1016/j.bmcl.2004.11.039 | ||
| CHEMBL180493 | 63568 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 312 | 1 | 0 | 2 | 4.8 | Fc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 | 10.1016/j.bmcl.2004.11.039 | ||
| 44387857 | 60709 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 542 | 6 | 2 | 3 | 6.8 | O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1cc(Cl)cc(Cl)c1 | 10.1021/jm040827u | ||
| CHEMBL176281 | 60709 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 542 | 6 | 2 | 3 | 6.8 | O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1cc(Cl)cc(Cl)c1 | 10.1021/jm040827u | ||
| 44389729 | 64018 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 458 | 5 | 0 | 2 | 5.8 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(Cl)cc(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| CHEMBL181232 | 64018 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 458 | 5 | 0 | 2 | 5.8 | Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(Cl)cc(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2005.01.016 | ||
| 118721187 | 115516 | 0 | None | -10 | 3 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.2 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355936 | 115516 | 0 | None | -10 | 3 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.2 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721187 | 115516 | 0 | None | 1 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.2 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355936 | 115516 | 0 | None | 1 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 6.2 | CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44400978 | 135353 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 530 | 6 | 2 | 3 | 6.8 | CC(C)(C)c1ccc(C(CNC(=O)Nc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL373092 | 135353 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 530 | 6 | 2 | 3 | 6.8 | CC(C)(C)c1ccc(C(CNC(=O)Nc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 118721203 | 115543 | 0 | None | 1 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355963 | 115543 | 0 | None | 1 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| 44400983 | 70794 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 436 | 7 | 2 | 4 | 4.5 | COc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL195533 | 70794 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 436 | 7 | 2 | 4 | 4.5 | COc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 44401176 | 68059 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 517 | 7 | 2 | 4 | 5.9 | CN(C)c1ccc(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| CHEMBL191696 | 68059 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 517 | 7 | 2 | 4 | 5.9 | CN(C)c1ccc(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm040827u | ||
| 118721190 | 115519 | 0 | None | -5 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 416 | 7 | 2 | 3 | 5.3 | OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355939 | 115519 | 0 | None | -5 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 416 | 7 | 2 | 3 | 5.3 | OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.11.063 | ||
| 118721203 | 115543 | 0 | None | -10 | 3 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| CHEMBL3355963 | 115543 | 0 | None | -10 | 3 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 563 | 10 | 0 | 6 | 7.4 | CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 | 10.1016/j.bmcl.2014.11.063 | ||
| 795 | 568 | 3 | None | - | 1 | Human | 8.3 | pKd | None | 8.3 | Binding | Guide to Pharmacology | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 12450563 | ||
| 796 | 568 | 3 | None | - | 1 | Human | 8.3 | pKd | None | 8.3 | Binding | Guide to Pharmacology | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 12450563 | ||
| 9913085 | 568 | 3 | None | - | 1 | Human | 8.3 | pKd | None | 8.3 | Binding | Guide to Pharmacology | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 12450563 | ||
| CHEMBL20921 | 568 | 3 | None | - | 1 | Human | 8.3 | pKd | None | 8.3 | Binding | Guide to Pharmacology | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 12450563 | ||
| 11753159 | 542 | 3 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 23031591 | ||
| 7679 | 542 | 3 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 23031591 | ||
| CHEMBL2158814 | 542 | 3 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 23031591 | ||
| 10653 | 2256 | 6 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 511 | 6 | 1 | 5 | 3.6 | O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C | None | ||
| 59534386 | 2256 | 6 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 511 | 6 | 1 | 5 | 3.6 | O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C | None | ||
| CHEMBL3670800 | 2256 | 6 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 511 | 6 | 1 | 5 | 3.6 | O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C | None | ||
| DB15269 | 2256 | 6 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 511 | 6 | 1 | 5 | 3.6 | O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C | None | ||
| 3492 | 685 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O | 12067561 | ||
| 9868459 | 685 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O | 12067561 | ||
| CHEMBL50593 | 685 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 451 | 10 | 3 | 4 | 4.5 | CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O | 12067561 | ||
| 3530 | 3462 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@@H](NC(=O)c1ccc2c(c1)cccc2)Cc1ccc(cc1)N(=O)=O | None | ||
| 5311092 | 3462 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 378 | 6 | 1 | 5 | 3.3 | COC(=O)[C@@H](NC(=O)c1ccc2c(c1)cccc2)Cc1ccc(cc1)N(=O)=O | None | ||
| 795 | 568 | 3 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 12450563 | ||
| 796 | 568 | 3 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 12450563 | ||
| 9913085 | 568 | 3 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 12450563 | ||
| CHEMBL20921 | 568 | 3 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 12450563 | ||
| 758 | 851 | 0 | None | -3 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | None | None | None | None | 8642344 | ||||
| 759 | 854 | 0 | None | 6 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | None | None | None | None | 8642344 | ||||
| 787 | 812 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 8642344 | ||||
| 769 | 813 | 0 | None | 446 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | Guide to Pharmacology | None | None | None | None | 8642344 | ||||
| 771 | 825 | 0 | None | 1 | 2 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 8642344 | ||||