Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

3PWH

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

A

PUBLICATION DATE

Sept. 7, 2011

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ZM241385 A63 2.61x60 TM2 polar (hydrogen bond with backbone)
ZM241385 F168 45.52x52 ECL2 aromatic (face-to-face)
ZM241385 E169 ECL2 polar (charge-assisted hydrogen bond)
ZM241385 M177 5.38x40 TM5 hydrophobic
ZM241385 L249 6.51x51 TM6 hydrophobic
ZM241385 H250 6.52x52 TM6 aromatic (face-to-edge)
ZM241385 N253 6.55x55 TM6 polar (hydrogen bond)
ZM241385 Y271 7.36x35 TM7 hydrophobic
ZM241385 I274 7.39x38 TM7 hydrophobic

Ligands

ZM241385

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM2
2x60 2.61x60 A63
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
TM7
7x35 7.36x35 Y271
7x38 7.39x38 I274