Structure information

CCR5

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4MBS

SPECIES

Homo sapiens

RESOLUTION

2.710

PREFERRED CHAIN

A

PUBLICATION DATE

Sept. 11, 2013

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Maraviroc Y37 1.39x39 TM1 aromatic (edge-to-face)
Maraviroc Y37 1.39x39 TM1 polar (hydrogen bond)
Maraviroc W86 2.60x60 TM2 hydrophobic
Maraviroc Y108 3.32x32 TM3 aromatic (edge-to-face)
Maraviroc F109 3.33x33 TM3 aromatic (face-to-edge)
Maraviroc F112 3.36x36 TM3 aromatic (face-to-edge)
Maraviroc T195 5.39x40 TM5 polar (hydrogen bond)
Maraviroc I198 5.42x43 TM5 hydrophobic
Maraviroc Y251 6.51x51 TM6 polar (hydrogen bond)
Maraviroc L255 6.55x55 TM6 hydrophobic
Maraviroc T259 6.59x59 TM6 polar (hydrogen bond)
Maraviroc E283 7.39x38 TM7 polar (charge-charge)

Ligands

Maraviroc

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

M N G V F G F I F V L S Y L P P L L R A 1 L N L A I S D L F F L L T V P F W A H Y 2 L I I F F I G S F F G I F Y L G T L L Q 3 G V V T S V I T W V V A V F A S L P G 4 Y C I V M V L L P L V L G L I V I K L T Q 5 F T I M I V Y F L F W A P Y N I V L L L 6 I P N I C C H T M G L T E T V Q M A Q 7
Download: PNG | SVG
ICL1 K R L K ICL1ECL1 Q W D F ECL1ICL2 A V F A L K A R ICL2ECL2 R S Q K E G L H Y T C S S H F P Y S ECL2ICL3 R N E ICL3ECL3 L N ECL3N-term M D Y Q V S S P I Y D I N Y Y T S E P C Q N-termC-term K H I A K R F C K C C S I F Q Q E A P E R A S S V Y T R S T G E Q E I S V G L C-term K I N V K Q I A A R L L P P L Y S L V F I F G F V G N M L V I L I L I N C S M T D I Y L L N L A I S D L F F L L T V P F W A H Y A A A G N T M C Q L L T G L Y F I G F F S G I F F I I L L T I D R Y L A V V H T V T F G V V T S V I T W V V A V F A S L P G I I F T Q Y Q F W K N F Q T L K I V I L G L V L P L L V M V I C Y S G I L K T L L R C K K R H R A V R L I F T I M I V Y F L F W A P Y N I V L L L N T F Q E F F G N C S S S N R L D Q A M Q V T E T L G M T H C C I N P I I Y A F V G E K L L V F R N Y F F Q
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
CCR5
TM1
1x39 1.39x39 Y37
TM2
2x60 2.60x60 W86
TM3
3x32 3.32x32 Y108
3x33 3.33x33 F109
3x36 3.36x36 F112
TM5
5x40 5.39x40 T195
5x43 5.42x43 I198
TM6
6x51 6.51x51 Y251
6x55 6.55x55 L255
6x59 6.59x59 T259
TM7
7x38 7.39x38 E283