CCR5 (ccr5_human)

FAMILY

Class A (Rhodopsin) Protein receptors Chemokine receptors CCR5

GENE

CCR5

ORGANISM

Human (Homo sapiens)

ALT. NAMES

C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5, CHEMR13, HIV-1 fusion coreceptor, CD195

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
D
Y
Q
V
S
S
P
I
Y
10
                   
D
I
N
Y
Y
T
S
E
P
C
20
  TM1            
Q
K
I
N
V
K
Q
I
A
A
30
                   
R
L
L
P
P
L
Y
S
L
V
40
                   
F
I
F
G
F
V
G
N
M
L
50
                   
V
I
L
I
L
I
N
C
K
R
60
ICL1 TM2      
L
K
S
M
T
D
I
Y
L
L
70
                   
N
L
A
I
S
D
L
F
F
L
80
                   
L
T
V
P
F
W
A
H
Y
A
90
    ECL1 TM3  
A
A
Q
W
D
F
G
N
T
M
100
                   
C
Q
L
L
T
G
L
Y
F
I
110
                   
G
F
F
S
G
I
F
F
I
I
120
                   
L
L
T
I
D
R
Y
L
A
V
130
    ICL2        
V
H
A
V
F
A
L
K
A
R
140
TM4              
T
V
T
F
G
V
V
T
S
V
150
                   
I
T
W
V
V
A
V
F
A
S
160
                   
L
P
G
I
I
F
T
R
S
Q
170
ECL2            
K
E
G
L
H
Y
T
C
S
S
180
          TM5    
H
F
P
Y
S
Q
Y
Q
F
W
190
                   
K
N
F
Q
T
L
K
I
V
I
200
                   
L
G
L
V
L
P
L
L
V
M
210
                   
V
I
C
Y
S
G
I
L
K
T
220
        ICL3 TM6
L
L
R
C
R
N
E
K
K
R
230
                 
H
R
A
V
R
L
I
F
T
I
240
                   
M
I
V
Y
F
L
F
W
A
P
250
                   
Y
N
I
V
L
L
L
N
T
F
260
          ECL3 TM7
Q
E
F
F
G
L
N
N
C
S
270
               
S
S
N
R
L
D
Q
A
M
Q
280
                   
V
T
E
T
L
G
M
T
H
C
290
                   
C
I
N
P
I
I
Y
A
F
V
300
H8                
G
E
K
F
R
N
Y
L
L
V
310
      C-term  
F
F
Q
K
H
I
A
K
R
F
320
                   
C
K
C
C
S
I
F
Q
Q
E
330
                   
A
P
E
R
A
S
S
V
Y
T
340
                   
R
S
T
G
E
Q
E
I
S
V
350
   
G
L

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 K R L K ICL1ECL1 Q W D F ECL1ICL2 A V F A L K A R ICL2ECL2 R S Q K E G L H Y T C S S H F P Y S ECL2ICL3 R ICL3ECL3 L N ECL3N-term M D Y Q V S S P I Y D I N Y Y T S E P C Q N-termC-term K H I A K R F C K C C S I F Q Q E A P E R A S S V Y T R S T G E Q E I S V G L C-term K I N V K Q I A A R L L P P L Y S L V F I F G F V G N M L V I L I L I N C S M T D I Y L L N L A I S D L F F L L T V P F W A H Y A A A G N T M C Q L L T G L Y F I G F F S G I F F I I L L T I D R Y L A V V H T V T F G V V T S V I T W V V A V F A S L P G I I F T Q Y Q F W K N F Q T L K I V I L G L V L P L L V M V I C Y S G I L K T L L R C N E K K R H R A V R L I F T I M I V Y F L F W A P Y N I V L L L N T F Q E F F G N C S S S N R L D Q A M Q V T E T L G M T H C C I N P I I Y A F V G E K L L V F R N Y F F Q
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

M N G V F G F I F V L S Y L P P L L R A 1 L N L A I S D L F F L L T V P F W A H Y 2 L I I F F I G S F F G I F Y L G T L L Q 3 G V V T S V I T W V V A V F A S L P G 4 Y C I V M V L L P L V L G L I V I K L T Q 5 F T I M I V Y F L F W A P Y N I V L L L 6 I P N I C C H T M G L T E T V Q M A Q 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

956 mutation data points available.

PHYSIOLOGICAL LIGANDS

CCL3 (Mouse), CCL7 (Human), CCL13 (Human), CCL11 (Rat), CCL16 (Human), CCL11 (Mouse), CCL8 (Human), CCL2 (Rat), CCL5 (Mouse), CCL14 (Human), CCL4 (Mouse), CCL5 (Human), CCL4 (Human), CCL3 (Rat), CCL3 (Human), CCL7 (Rat), CCL11 (Human), CCL2 (Human), CCL4 (Rat), CCL8 (Mouse), CCL7 (Mouse), CCL2 (Mouse)

STRUCTURE MODELS

ccr5_human inactive,

ccr5_human active

STRUCTURES

Found 11 structure(s) - view all details on the Structures page

PDBs: 4MBS, 6AKX, 6AKY, 6MEO, 6MET, 7F1T, 5UIW, 7F1Q, 7F1R, 7F1S, 7O7F