Structure information

SMO

PROTEIN CLASS

Class F (Frizzled)

PDB CODE

4QIN

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

A

REFERENCE

10.1038/NCOMMS5355

PUBLICATION DATE

July 23, 2014

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
SAG1.5 N219 N-term polar (hydrogen bond)
SAG1.5 N219 N-term polar (hydrogen bond)
SAG1.5 P220 N-term Van der Waals
SAG1.5 L221 N-term hydrophobic
SAG1.5 L221 N-term Van der Waals
SAG1.5 M301 ECL1 Van der Waals
SAG1.5 M301 ECL1 hydrophobic
SAG1.5 L303 ECL1 hydrophobic
SAG1.5 L303 ECL1 Van der Waals
SAG1.5 D384 ECL2 Van der Waals
SAG1.5 Y394 ECL2 Van der Waals
SAG1.5 Y394 ECL2 hydrophobic
SAG1.5 K395 ECL2 Van der Waals
SAG1.5 D473 6.54x54 TM6 polar (charge-assisted hydrogen bond)
SAG1.5 Q477 6.58x58 TM6 Van der Waals
SAG1.5 W480 6.61x61 TM6 polar (hydrogen bond with backbone)
SAG1.5 W480 6.61x61 TM6 Van der Waals
SAG1.5 E481 6.62x62 TM6 polar (hydrogen bond with backbone)
SAG1.5 E481 6.62x62 TM6 Van der Waals
SAG1.5 F484 6.65x65 TM6 hydrophobic
SAG1.5 F484 6.65x65 TM6 Van der Waals
SAG1.5 P513 ECL3 hydrophobic
SAG1.5 P513 ECL3 Van der Waals
SAG1.5 E518 7.38x38 TM7 Van der Waals

Ligands

SAG1.5

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Residue Diagrams

L T C L G T V A G F A A I Y S H M D Q H 1 F Y V N A C F F V G S I G W L A Q F 2 V V F W V V G A M L A Y Y V I V F I I V 3 T S Y F H L L T W S L P F V L T V A I L 4 L F Y G G V I L V L G I P A L V F G A R Y 5 G I F G F L A F G F V L I T F S C H F Y 6 T S M A I G T G F M A F L N I K E V L L 7
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ICL1 W R N S N ICL1ECL1 M D G A R R E I V C R A D G T M R L G E P T S N E T ECL1ICL2 L G T T Y Q P L S G ICL2ECL2 Q V D G D S V S G I C F V G Y K ECL2ICL3 P G L L ICL3ECL3 G L P T K Q P I P D C E I K N R P ECL3N-term M A A A R P A R G P E L P L L G L L L L L L L G D P G R G A A S S G N A T G P G P R S A G G S A R R S A A V T G P P P P L S H C G R A A P C E P L R Y N V C L G S V L P Y G A T S T L L A G D S D S Q E E A H G K L V L W S G L R N A P R C W A V I Q P L L C A V Y M P K C E N D R V E L P S R T L C Q A T R G P C A I V E R E R G W P D F L R C T P D R F P E G C T N E V Q N I K F N S S G Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F N-termC-term G Q S D D E P K R I K K S K M I A K A F S K R H E L L Q N P G Q E L S F S M H T V S H D G P V A G L A F D L N E P S A D V S S A W A Q H V T K M V A R R G A I L P Q D I S V T P V A T P V P P E E Q A N L W L V E A E I S P E L Q K R L G R K K K R R K R K K E V C P L A P P P E L H P P A P A P S T I P R L P Q L P R Q K C L V A A G A W G A G D S C R Q G A W T L V S N P F C P E P S P P Q D P F L P S A P A P V A W A H G R R Q G L G P I H S R T N L M D T E L M D A D S D F C-term T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D R Y P A V I L F Y V N A C F F V G S I G W L A Q F L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A K T S Y F H L L T W S L P F V L T V A I L A V A N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T I S L L V E K I N L F A M F G T G I A M S T W V W T K A W R R L T T L L I T W C R
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Residue Table


GPCRdb(A)
GPCRdb(F)
SMO
TM6
6x58 6.54x54 D473
6x62 6.58x58 Q477
6x65 6.61x61 W480
6x66 6.62x62 E481
6x69 6.65x65 F484
TM7
7x35 7.38x38 E518