SMO (smo_human)
FAMILY
Class F (Frizzled) Protein receptors Frizzled SMO
GENE
SMO (SMOH)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Protein smoothened, Protein Gx
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
A
|
A
|
R
|
P
|
A
|
R
|
G
|
P
|
10 |
E
|
L
|
P
|
L
|
L
|
G
|
L
|
L
|
L
|
L
|
20 |
L
|
L
|
L
|
G
|
D
|
P
|
G
|
R
|
G
|
A
|
30 |
A
|
S
|
S
|
G
|
N
|
A
|
T
|
G
|
P
|
G
|
40 |
P
|
R
|
S
|
A
|
G
|
G
|
S
|
A
|
R
|
R
|
50 |
S
|
A
|
A
|
V
|
T
|
G
|
P
|
P
|
P
|
P
|
60 |
L
|
S
|
H
|
C
|
G
|
R
|
A
|
A
|
P
|
C
|
70 |
E
|
P
|
L
|
R
|
Y
|
N
|
V
|
C
|
L
|
G
|
80 |
S
|
V
|
L
|
P
|
Y
|
G
|
A
|
T
|
S
|
T
|
90 |
L
|
L
|
A
|
G
|
D
|
S
|
D
|
S
|
Q
|
E
|
100 |
E
|
A
|
H
|
G
|
K
|
L
|
V
|
L
|
W
|
S
|
110 |
G
|
L
|
R
|
N
|
A
|
P
|
R
|
C
|
W
|
A
|
120 |
V
|
I
|
Q
|
P
|
L
|
L
|
C
|
A
|
V
|
Y
|
130 |
M
|
P
|
K
|
C
|
E
|
N
|
D
|
R
|
V
|
E
|
140 |
L
|
P
|
S
|
R
|
T
|
L
|
C
|
Q
|
A
|
T
|
150 |
R
|
G
|
P
|
C
|
A
|
I
|
V
|
E
|
R
|
E
|
160 |
R
|
G
|
W
|
P
|
D
|
F
|
L
|
R
|
C
|
T
|
170 |
P
|
D
|
R
|
F
|
P
|
E
|
G
|
C
|
T
|
N
|
180 |
E
|
V
|
Q
|
N
|
I
|
K
|
F
|
N
|
S
|
S
|
190 |
G
|
Q
|
C
|
E
|
V
|
P
|
L
|
V
|
R
|
T
|
200 |
D
|
N
|
P
|
K
|
S
|
W
|
Y
|
E
|
D
|
V
|
210 |
E
|
G
|
C
|
G
|
I
|
Q
|
C
|
Q
|
N
|
P
|
220 |
TM1 | |||||||||
L
|
F
|
T
|
E
|
A
|
E
|
H
|
Q
|
D
|
M
|
230 |
H
|
S
|
Y
|
I
|
A
|
A
|
F
|
G
|
A
|
V
|
240 |
T
|
G
|
L
|
C
|
T
|
L
|
F
|
T
|
L
|
A
|
250 |
ICL1 | |||||||||
T
|
F
|
V
|
A
|
D
|
W
|
R
|
N
|
S
|
N
|
260 |
TM2 | |||||||||
R
|
Y
|
P
|
A
|
V
|
I
|
L
|
F
|
Y
|
V
|
270 |
N
|
A
|
C
|
F
|
F
|
V
|
G
|
S
|
I
|
G
|
280 |
ECL1 | |||||||||
W
|
L
|
A
|
Q
|
F
|
M
|
D
|
G
|
A
|
R
|
290 |
R
|
E
|
I
|
V
|
C
|
R
|
A
|
D
|
G
|
T
|
300 |
M
|
R
|
L
|
G
|
E
|
P
|
T
|
S
|
N
|
E
|
310 |
TM3 | |||||||||
T
|
L
|
S
|
C
|
V
|
I
|
I
|
F
|
V
|
I
|
320 |
V
|
Y
|
Y
|
A
|
L
|
M
|
A
|
G
|
V
|
V
|
330 |
W
|
F
|
V
|
V
|
L
|
T
|
Y
|
A
|
W
|
H
|
340 |
ICL2 | |||||||||
T
|
S
|
F
|
K
|
A
|
L
|
G
|
T
|
T
|
Y
|
350 |
TM4 | |||||||||
Q
|
P
|
L
|
S
|
G
|
K
|
T
|
S
|
Y
|
F
|
360 |
H
|
L
|
L
|
T
|
W
|
S
|
L
|
P
|
F
|
V
|
370 |
L
|
T
|
V
|
A
|
I
|
L
|
A
|
V
|
A
|
Q
|
380 |
ECL2 | |||||||||
V
|
D
|
G
|
D
|
S
|
V
|
S
|
G
|
I
|
C
|
390 |
TM5 | |||||||||
F
|
V
|
G
|
Y
|
K
|
N
|
Y
|
R
|
Y
|
R
|
400 |
A
|
G
|
F
|
V
|
L
|
A
|
P
|
I
|
G
|
L
|
410 |
V
|
L
|
I
|
V
|
G
|
G
|
Y
|
F
|
L
|
I
|
420 |
R
|
G
|
V
|
M
|
T
|
L
|
F
|
S
|
I
|
K
|
430 |
ICL3 | TM6 | ||||||||
S
|
N
|
H
|
P
|
G
|
L
|
L
|
S
|
E
|
K
|
440 |
A
|
A
|
S
|
K
|
I
|
N
|
E
|
T
|
M
|
L
|
450 |
R
|
L
|
G
|
I
|
F
|
G
|
F
|
L
|
A
|
F
|
460 |
G
|
F
|
V
|
L
|
I
|
T
|
F
|
S
|
C
|
H
|
470 |
F
|
Y
|
D
|
F
|
F
|
N
|
Q
|
A
|
E
|
W
|
480 |
E
|
R
|
S
|
F
|
R
|
D
|
Y
|
V
|
L
|
C
|
490 |
ECL3 | |||||||||
Q
|
A
|
N
|
V
|
T
|
I
|
G
|
L
|
P
|
T
|
500 |
K
|
Q
|
P
|
I
|
P
|
D
|
C
|
E
|
I
|
K
|
510 |
TM7 | |||||||||
N
|
R
|
P
|
S
|
L
|
L
|
V
|
E
|
K
|
I
|
520 |
N
|
L
|
F
|
A
|
M
|
F
|
G
|
T
|
G
|
I
|
530 |
H8 | |||||||||
A
|
M
|
S
|
T
|
W
|
V
|
W
|
T
|
K
|
A
|
540 |
T
|
L
|
L
|
I
|
W
|
R
|
R
|
T
|
W
|
C
|
550 |
C-term | |||||||||
R
|
L
|
T
|
G
|
Q
|
S
|
D
|
D
|
E
|
P
|
560 |
K
|
R
|
I
|
K
|
K
|
S
|
K
|
M
|
I
|
A
|
570 |
K
|
A
|
F
|
S
|
K
|
R
|
H
|
E
|
L
|
L
|
580 |
Q
|
N
|
P
|
G
|
Q
|
E
|
L
|
S
|
F
|
S
|
590 |
M
|
H
|
T
|
V
|
S
|
H
|
D
|
G
|
P
|
V
|
600 |
A
|
G
|
L
|
A
|
F
|
D
|
L
|
N
|
E
|
P
|
610 |
S
|
A
|
D
|
V
|
S
|
S
|
A
|
W
|
A
|
Q
|
620 |
H
|
V
|
T
|
K
|
M
|
V
|
A
|
R
|
R
|
G
|
630 |
A
|
I
|
L
|
P
|
Q
|
D
|
I
|
S
|
V
|
T
|
640 |
P
|
V
|
A
|
T
|
P
|
V
|
P
|
P
|
E
|
E
|
650 |
Q
|
A
|
N
|
L
|
W
|
L
|
V
|
E
|
A
|
E
|
660 |
I
|
S
|
P
|
E
|
L
|
Q
|
K
|
R
|
L
|
G
|
670 |
R
|
K
|
K
|
K
|
R
|
R
|
K
|
R
|
K
|
K
|
680 |
E
|
V
|
C
|
P
|
L
|
A
|
P
|
P
|
P
|
E
|
690 |
L
|
H
|
P
|
P
|
A
|
P
|
A
|
P
|
S
|
T
|
700 |
I
|
P
|
R
|
L
|
P
|
Q
|
L
|
P
|
R
|
Q
|
710 |
K
|
C
|
L
|
V
|
A
|
A
|
G
|
A
|
W
|
G
|
720 |
A
|
G
|
D
|
S
|
C
|
R
|
Q
|
G
|
A
|
W
|
730 |
T
|
L
|
V
|
S
|
N
|
P
|
F
|
C
|
P
|
E
|
740 |
P
|
S
|
P
|
P
|
Q
|
D
|
P
|
F
|
L
|
P
|
750 |
S
|
A
|
P
|
A
|
P
|
V
|
A
|
W
|
A
|
H
|
760 |
G
|
R
|
R
|
Q
|
G
|
L
|
G
|
P
|
I
|
H
|
770 |
S
|
R
|
T
|
N
|
L
|
M
|
D
|
T
|
E
|
L
|
780 |
M
|
D
|
A
|
D
|
S
|
D
|
F
|