Structure information

β1-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5A8E

SPECIES

Meleagris gallopavo

RESOLUTION

2.400

PREFERRED CHAIN

A

PUBLICATION DATE

Sept. 30, 2015

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
7-methylcyanopindolol D121 3.32x32 TM3 polar (charge-charge)
7-methylcyanopindolol D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
7-methylcyanopindolol V122 3.33x33 TM3 hydrophobic
7-methylcyanopindolol V125 3.36x36 TM3 hydrophobic
7-methylcyanopindolol F201 45.52x52 ECL2 aromatic (edge-to-face)
7-methylcyanopindolol T203 ECL2 polar (hydrogen bond)
7-methylcyanopindolol S211 5.42x43 TM5 polar (hydrogen bond)
7-methylcyanopindolol F306 6.51x51 TM6 hydrophobic
7-methylcyanopindolol F307 6.52x52 TM6 aromatic (edge-to-face)
7-methylcyanopindolol N310 6.55x55 TM6 polar (hydrogen bond)
7-methylcyanopindolol N329 7.39x38 TM7 polar (hydrogen bond)
7-methylcyanopindolol N329 7.39x38 TM7 polar (hydrogen bond)
7-methylcyanopindolol N329 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

7-methylcyanopindolol

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Residue Diagrams

V N G A V I L L V V L A M L L S M G A E 1 T S L A C A D L V M G L L V V P F G A T L 2 V C L T E I S A T V C L V D L S T W C E 3 A K V I I C T V W A I S A L V S F L P I 4 Y V F I M I L L P I Y F S I I S S A I A Y 5 G I I M G V F T L C W L P F F L V N I V 6 I P N F A S N A Y G L W N F F V F L W 7
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ICL1 Q R L Q ICL1ECL1 T W L W ECL1ICL2 P F R Y Q S L M ICL2ECL2 W W R D E D P Q A L K C Y Q D P G C C D F V T ECL2ICL3 G R F Y G S Q E Q P Q P P P L P Q H Q P I L G N G R A S K ICL3ECL3 R D L V ECL3N-term M G D G W L P P D C G P H N R S G G G G A T A A P T G S R Q V S N-termC-term F P R K A D R R L H A G G Q P A P L P G G F I S T L G S P E H S P G G T W S D C N G G T R G G S E S S L E E R H S K T S R S E S K M E R E K N I L A T T R F Y C T F L G N G D K A V F C T V L R I V K L F E D A T C T C P H T H K L K M K W R F K Q H Q A C-term A E L L S Q Q W E A G M S L L M A L V V L L I V A G N V L V I A A I G R T T L T N L F I T S L A C A D L V M G L L V V P F G A T L V V R G G S F L C E C W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S T R A R A K V I I C T V W A I S A L V S F L P I M M H N R A Y A I A S S I I S F Y I P L L I M I F V Y L R V Y R E A K E Q I R K I D R C E R K T S R V M A M R E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N P D W L F V F F N W L G Y A N S A F N P I I Y C R S P D F K R F R K A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β1-adrenoceptor
TM3
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 V125
ECL2
45x52 45.52x52 F201
TM5
5x43 5.42x43 S211
TM6
6x51 6.51x51 F306
6x52 6.52x52 F307
6x55 6.55x55 N310
TM7
7x38 7.39x38 N329