GPCRdb

alprenolol

Agent/drug
Bioactivity

alprenolol

SMILES	C=CCc1ccccc1OCC(O)CNC(C)C
InChIKey	PAZJSJFMUHDSTF-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	2
Rotatable bonds	8
Molecular weight (Da)	249.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	α_1A β₂ 5-HT_1A 5-HT_1B

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Human	Adrenoceptors	A	pKd	6.75	7.69	8.37	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.55	8.55	8.55	ChEMBL
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	8.38	8.67	8.96	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKd	8.01	8.01	8.01	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	9.00	9.00	9.00	Guide to Pharmacology
β₂	ADRB2	Human	Adrenoceptors	A	pKd	8.84	9.12	9.53	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.92	9.04	9.30	ChEMBL
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	9.24	9.27	9.30	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	6.77	8.11	8.92	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKd	8.02	8.02	8.02	Drug Central
β₃	ADRB3	Human	Adrenoceptors	A	pKd	6.86	6.99	7.12	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	7.46	7.46	7.46	PDSP Ki database
β₃	ADRB3	Human	Adrenoceptors	A	pKd	8.16	8.16	8.16	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	7.70	7.70	7.70	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.12	8.12	8.12	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.67	7.67	7.67	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.93	6.93	6.93	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	7.00	7.08	7.15	PDSP Ki database

Showing 1 to 20 of 24 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Human	Adrenoceptors	A	pIC50	7.86	8.09	8.31	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pIC50	8.26	8.56	8.94	ChEMBL
β₂	ADRB2	Bovine	Adrenoceptors	A	pIC50	8.07	8.07	8.07	Drug Central
β₂	ADRB2	Bovine	Adrenoceptors	A	pIC50	8.53	8.53	8.53	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	6.20	6.20	6.20	ChEMBL

Showing 1 to 5 of 5 entries

alprenolol

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	α_1A β₂ 5-HT_1A 5-HT_1B

Compound is not listed as a drug.