PDB
5N2R
Resolution
2.8 Å
Released
July 26, 2017
Receptor
A2A
Class
A
Species
Homo sapiens
Ligand
Function
PSB36
Antagonist
Reference
10.1016/j.str.2017.06.012

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
PSB36 I66 2.64x63 TM2 Van der Waals
PSB36 S67 2.65x64 TM2 Van der Waals
PSB36 V84 3.32x32 TM3 hydrophobic
PSB36 L85 3.33x33 TM3 Van der Waals
PSB36 F168 45.52x52 ECL2 hydrophobic
PSB36 F168 45.52x52 ECL2 aromatic (face-to-face)
PSB36 E169 ECL2 hydrophobic
PSB36 M174 5.35x37 TM5 hydrophobic
PSB36 M177 5.38x40 TM5 Van der Waals
PSB36 W246 6.48x48 TM6 hydrophobic
PSB36 L249 6.51x51 TM6 hydrophobic
PSB36 I252 6.54x54 TM6 hydrophobic
PSB36 N253 6.55x55 TM6 polar (hydrogen bond)
PSB36 N253 6.55x55 TM6 polar (hydrogen bond)
PSB36 T256 6.58x58 TM6 hydrophobic
PSB36 H264 ECL3 Van der Waals
PSB36 M270 7.35x34 TM7 hydrophobic
PSB36 Y271 7.36x35 TM7 Van der Waals
PSB36 I274 7.39x38 TM7 hydrophobic
PSB36 A277 7.42x41 TM7 hydrophobic
PSB36 H278 7.43x42 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
Helix box plot — Download: PNG | SVG V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7

GPCRdb(A)
GPCRdb(A)
A2A receptor
TM2
2x63 2.64x63 I66
2x64 2.65x64 S67
TM3
3x32 3.32x32 V84
3x33 3.33x33 L85
ECL2
45x52 45.52x52 F168
TM5
5x37 5.35x37 M174
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x54 6.54x54 I252
6x55 6.55x55 N253
6x58 6.58x58 T256
TM7
7x34 7.35x34 M270
7x35 7.36x35 Y271
7x38 7.39x38 I274
7x41 7.42x41 S277
7x42 7.43x42 H278