Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5NM2

SPECIES

Homo sapiens

RESOLUTION

1.950

PREFERRED CHAIN

A

PUBLICATION DATE

Sept. 27, 2017

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
139180-30-6 L85 3.33x33 TM3 hydrophobic
139180-30-6 F168 45.52x52 ECL2 aromatic (face-to-face)
139180-30-6 E169 ECL2 polar (charge-assisted hydrogen bond)
139180-30-6 M177 5.38x40 TM5 hydrophobic
139180-30-6 W246 6.48x48 TM6 hydrophobic
139180-30-6 L249 6.51x51 TM6 hydrophobic
139180-30-6 H250 6.52x52 TM6 aromatic (face-to-edge)
139180-30-6 N253 6.55x55 TM6 polar (hydrogen bond)
139180-30-6 N253 6.55x55 TM6 polar (hydrogen bond)
139180-30-6 N253 6.55x55 TM6 polar (hydrogen bond)
139180-30-6 H264 ECL3 aromatic (face-to-edge)
139180-30-6 M270 7.35x34 TM7 hydrophobic

Ligands

139180-30-6

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM3
3x33 3.33x33 L85
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
TM7
7x34 7.35x34 M270