Structure information

CCR5

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5UIW

SPECIES

Homo sapiens

RESOLUTION

2.200

PREFERRED CHAIN

A

PUBLICATION DATE

June 28, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
5P7-CCL5 S17 N-term polar (hydrogen bond with backbone)
5P7-CCL5 P19 N-term hydrophobic
5P7-CCL5 C20 N-term polar (hydrogen bond with backbone)
5P7-CCL5 C20 N-term polar (hydrogen bond with backbone)
5P7-CCL5 A29 1.31x31 TM1 hydrophobic
5P7-CCL5 W86 2.60x60 TM2 hydrophobic
5P7-CCL5 F109 3.33x33 TM3 hydrophobic
5P7-CCL5 Q170 ECL2 polar (hydrogen bond)
5P7-CCL5 K171 ECL2 polar (charge-charge)
5P7-CCL5 K171 ECL2 polar (charge-charge)
5P7-CCL5 E172 ECL2 polar (hydrogen bond with backbone)
5P7-CCL5 E172 ECL2 polar (charge-assisted hydrogen bond)
5P7-CCL5 E172 ECL2 polar (charge-assisted hydrogen bond)
5P7-CCL5 S179 45.51x51 ECL2 polar (hydrogen bond)
5P7-CCL5 S179 45.51x51 ECL2 polar (hydrogen bond)
5P7-CCL5 S179 45.51x51 ECL2 polar (hydrogen bond)
5P7-CCL5 S180 45.52x52 ECL2 polar (hydrogen bond with backbone)
5P7-CCL5 F182 ECL2 polar (hydrogen bond with backbone)
5P7-CCL5 Y184 ECL2 hydrophobic
5P7-CCL5 Y187 5.31x32 TM5 polar (hydrogen bond)
5P7-CCL5 K191 5.35x36 TM5 polar (charge-assisted hydrogen bond)
5P7-CCL5 N258 6.58x58 TM6 polar (hydrogen bond)
5P7-CCL5 C269 7.25x24 TM7 hydrophobic
5P7-CCL5 D276 7.32x31 TM7 polar (charge-charge)
5P7-CCL5 E283 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

5P7-CCL5

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Residue Diagrams

M N G V F G F I F V L S Y L P P L L R A 1 L N L A I S D L F F L L T V P F W A H Y 2 L I I F F I G S F F G I F Y L G T L L Q 3 G V V T S V I T W V V A V F A S L P G 4 Y C I V M V L L P L V L G L I V I K L T Q 5 F T I M I V Y F L F W A P Y N I V L L L 6 I P N I C C H T M G L T E T V Q M A Q 7
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ICL1 K R L K ICL1ECL1 Q W D F ECL1ICL2 A V F A L K A R ICL2ECL2 R S Q K E G L H Y T C S S H F P Y S ECL2ICL3 R N E ICL3ECL3 L N ECL3N-term M D Y Q V S S P I Y D I N Y Y T S E P C Q N-termC-term K H I A K R F C K C C S I F Q Q E A P E R A S S V Y T R S T G E Q E I S V G L C-term K I N V K Q I A A R L L P P L Y S L V F I F G F V G N M L V I L I L I N C S M T D I Y L L N L A I S D L F F L L T V P F W A H Y A A A G N T M C Q L L T G L Y F I G F F S G I F F I I L L T I D R Y L A V V H T V T F G V V T S V I T W V V A V F A S L P G I I F T Q Y Q F W K N F Q T L K I V I L G L V L P L L V M V I C Y S G I L K T L L R C K K R H R A V R L I F T I M I V Y F L F W A P Y N I V L L L N T F Q E F F G N C S S S N R L D Q A M Q V T E T L G M T H C C I N P I I Y A F V G E K L L V F R N Y F F Q
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR5
TM1
1x31 1.31x31 A29
TM2
2x60 2.60x60 W86
TM3
3x33 3.33x33 F109
ECL2
45x51 45.51x51 S179
45x52 45.52x52 S180
TM5
5x32 5.31x32 Y187
5x36 5.35x36 K191
TM6
6x58 6.58x58 N258
TM7
7x24 7.25x24 C269
7x31 7.32x31 D276
7x38 7.39x38 E283