Structure information

C5a1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6C1R

SPECIES

Homo sapiens

RESOLUTION

2.200

PREFERRED CHAIN

B

PUBLICATION DATE

May 30, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Avacopan L211 3.41x41 TM3 hydrophobic
Avacopan A214 3.44x44 TM3 hydrophobic
Avacopan A218 3.48x48 TM3 hydrophobic
Avacopan F221 3.51x51 TM3 aromatic (face-to-edge)
Avacopan W299 5.49x49 TM5 polar (hydrogen bond)
Avacopan W299 5.49x49 TM5 aromatic (edge-to-face)
Avacopan T303 5.53x53 TM5 polar (hydrogen bond with backbone)
Avacopan C307 5.57x57 TM5 hydrophobic

Ligands

Avacopan

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Residue Diagrams

A N G L V G V L F V V A F I V L A L I D 1 L N L A V A D F L S C L A L P I L F T S 2 T A L L L I S A Y M N L L I L S P L I S 3 A W I A C A V A W G L A L L L T I P S 4 Y C I T L T L L P W L F G L V L R V I A V 5 V A V V A S F F I F W L P Y Q V T G I M 6 I P N I C C N I Y A F S V C L S D L K 7
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ICL1 A K R ICL1ECL1 H H W P F ECL1ICL2 P I W C Q N F R ICL2ECL2 V V R E E Y F P P K V L C G V D Y S H ECL2ICL3 R A T R S ICL3ECL3 E P S ECL3N-term M D S F N Y T T P D Y G H Y D D K D T L D L N T P V D K T S N T L N-termC-term G R L R K S L P S L L R N V L T E E S V V R E S K S F T R S T V D T M A Q K T Q A V C-term R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K G A G L A W I A C A V A W G L A L L L T I P S F L Y R D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q
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Residue Table


GPCRdb(A)
GPCRdb(A)
C5a1 receptor
TM3
3x41 3.41x41 L125
3x44 3.44x44 A128
3x48 3.48x48 A132
3x51 3.51x51 F135
TM5
5x49 5.49x49 W213
5x53 5.53x53 T217
5x57 5.57x57 C221