avacopan [1090]



avacopan


SMILES Cc1ccc(NC(=O)[C@H]2CCCN(C(=O)c3c(C)cccc3F)[C@H]2c2ccc(NC3CCCC3)cc2)cc1C(F)(F)F
InChIKey PUKBOVABABRILL-YZNIXAGQSA-N

Chemical Properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Log P 8.048
Molecular weight (Da) 581.3
Stereochemistry info partial

Database connections

Structure pdb 6C1R
Model (Boltz2) C5a1

Bioactivities

Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database
Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database

avacopan


Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Distribution across phases (no. indications)

Phase I 0
Phase II 3
Phase III 0
Phase IV 3

Database connections

Structure pdb 6C1R
Model (Boltz2) C5a1

Sankey plot

Drug Information

Target Disease
Gene Protein Receptor family Ligand type Class Name Phase ICD11 ATC Association score