Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6GT3

SPECIES

Homo sapiens

RESOLUTION

2.000

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

June 26, 2019

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AZD4635 V84 3.32x32 TM3 hydrophobic
AZD4635 L85 3.33x33 TM3 hydrophobic
AZD4635 F168 45.52x52 ECL2 aromatic (face-to-face)
AZD4635 E169 ECL2 polar (charge-assisted hydrogen bond)
AZD4635 M177 5.38x40 TM5 hydrophobic
AZD4635 W246 6.48x48 TM6 hydrophobic
AZD4635 L249 6.51x51 TM6 hydrophobic
AZD4635 H250 6.52x52 TM6 polar (hydrogen bond)
AZD4635 N253 6.55x55 TM6 polar (hydrogen bond)
AZD4635 N253 6.55x55 TM6 polar (hydrogen bond)
AZD4635 I274 7.39x38 TM7 hydrophobic

Ligands

AZD4635

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM3
3x32 3.32x32 V84
3x33 3.33x33 L85
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
TM7
7x38 7.39x38 I274