Structure information

ETB receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6IGL

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

A

PUBLICATION DATE

Nov. 21, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
IRL 1620 I94 N-term hydrophobic
IRL 1620 N158 2.61x60 TM2 polar (hydrogen bond)
IRL 1620 K161 2.64x63 TM2 polar (charge-assisted hydrogen bond)
IRL 1620 E165 2.68x67 TM2 polar (hydrogen bond with backbone)
IRL 1620 Q181 3.32x32 TM3 polar (hydrogen bond)
IRL 1620 Q181 3.32x32 TM3 polar (hydrogen bond)
IRL 1620 K182 3.33x33 TM3 polar (charge-charge)
IRL 1620 E236 4.60x61 TM4 polar (charge-charge)
IRL 1620 M245 ECL2 hydrophobic
IRL 1620 Y247 ECL2 aromatic (face-to-face)
IRL 1620 L252 ECL2 hydrophobic
IRL 1620 I254 ECL2 hydrophobic
IRL 1620 K273 5.38x39 TM5 polar (charge-charge)
IRL 1620 L277 5.42x43 TM5 hydrophobic
IRL 1620 W336 6.48x48 TM6 hydrophobic
IRL 1620 L339 6.51x51 TM6 hydrophobic
IRL 1620 R343 6.55x55 TM6 polar (charge-charge)
IRL 1620 R343 6.55x55 TM6 polar (charge-charge)
IRL 1620 Y350 6.62x62 TM6 polar (charge-assisted hydrogen bond)
IRL 1620 Y350 6.62x62 TM6 polar (charge-assisted hydrogen bond)
IRL 1620 Q352 ECL3 polar (charge-assisted hydrogen bond)
IRL 1620 Q352 ECL3 polar (charge-assisted hydrogen bond)
IRL 1620 R357 7.24x23 TM7 polar (charge-charge)
IRL 1620 L361 7.28x27 TM7 hydrophobic
IRL 1620 L365 7.32x31 TM7 hydrophobic
IRL 1620 D368 7.35x34 TM7 polar (charge-charge)
IRL 1620 D368 7.35x34 TM7 polar (charge-charge)
IRL 1620 Y369 7.36x35 TM7 polar (hydrogen bond)
IRL 1620 I372 7.39x38 TM7 hydrophobic

Ligands

IRL 1620

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Residue Diagrams

S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7
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ICL1 K C M R N ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
ETB receptor
TM2
2x60 2.61x60 N158
2x63 2.64x63 K161
TM3
3x32 3.32x32 Q181
3x33 3.33x33 K182
TM4
4x61 4.60x61 E236
TM5
5x39 5.38x39 K273
5x43 5.42x43 L277
TM6
6x48 6.48x48 W336
6x51 6.51x51 L339
6x55 6.55x55 R343
6x62 6.62x62 Y350
TM7
7x23 7.24x23 R357
7x27 7.28x27 L361
7x31 7.32x31 L365
7x34 7.35x34 D368
7x35 7.36x35 Y369
7x38 7.39x38 I372