Structure information

ETB receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6IGL

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-018-07094-0

PUBLICATION DATE

Nov. 21, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
sovateltide I94 N-term hydrophobic
sovateltide I157 2.60x59 TM2 hydrophobic
sovateltide N158 2.61x60 TM2 polar (hydrogen bond)
sovateltide K161 2.64x63 TM2 polar (charge-assisted hydrogen bond)
sovateltide E165 2.68x67 TM2 Van der Waals
sovateltide E165 2.68x67 TM2 polar (hydrogen bond with backbone)
sovateltide P178 3.29x29 TM3 Van der Waals
sovateltide Q181 3.32x32 TM3 Van der Waals
sovateltide Q181 3.32x32 TM3 polar (hydrogen bond)
sovateltide K182 3.33x33 TM3 polar (charge-assisted hydrogen bond)
sovateltide V185 3.36x36 TM3 hydrophobic
sovateltide V185 3.36x36 TM3 Van der Waals
sovateltide E236 4.60x61 TM4 polar (charge-assisted hydrogen bond)
sovateltide M245 ECL2 Van der Waals
sovateltide M245 ECL2 hydrophobic
sovateltide Y247 ECL2 aromatic (face-to-face)
sovateltide Y247 ECL2 Van der Waals
sovateltide L252 ECL2 hydrophobic
sovateltide L252 ECL2 Van der Waals
sovateltide I254 ECL2 Van der Waals
sovateltide I254 ECL2 hydrophobic
sovateltide L256 45.51x51 ECL2 hydrophobic
sovateltide K273 5.38x39 TM5 polar (charge-assisted hydrogen bond)
sovateltide L277 5.42x43 TM5 Van der Waals
sovateltide L277 5.42x43 TM5 hydrophobic
sovateltide W336 6.48x48 TM6 hydrophobic
sovateltide W336 6.48x48 TM6 Van der Waals
sovateltide L339 6.51x51 TM6 Van der Waals
sovateltide L339 6.51x51 TM6 hydrophobic
sovateltide R343 6.55x55 TM6 polar (charge-assisted hydrogen bond)
sovateltide K346 6.58x58 TM6 Van der Waals
sovateltide Y350 6.62x62 TM6 polar (hydrogen bond)
sovateltide Y350 6.62x62 TM6 Van der Waals
sovateltide Q352 ECL3 Van der Waals
sovateltide Q352 ECL3 polar (hydrogen bond)
sovateltide R357 7.24x23 TM7 polar (charge-assisted hydrogen bond)
sovateltide L361 7.28x27 TM7 hydrophobic
sovateltide L361 7.28x27 TM7 Van der Waals
sovateltide L365 7.32x31 TM7 hydrophobic
sovateltide L365 7.32x31 TM7 Van der Waals
sovateltide D368 7.35x34 TM7 polar (charge-assisted hydrogen bond)
sovateltide Y369 7.36x35 TM7 polar (hydrogen bond)
sovateltide Y369 7.36x35 TM7 Van der Waals
sovateltide I372 7.39x38 TM7 hydrophobic
sovateltide I372 7.39x38 TM7 Van der Waals

Ligands

sovateltide

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Residue Diagrams

S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7
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ICL1 K C M R N ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
ETB receptor
TM2
2x59 2.60x59 I157
2x60 2.61x60 N158
2x63 2.64x63 K161
TM3
3x29 3.29x29 P178
3x32 3.32x32 Q181
3x33 3.33x33 K182
3x36 3.36x36 V185
TM4
4x61 4.60x61 E236
ECL2
45x51 45.51x51 L256
TM5
5x39 5.38x39 K273
5x43 5.42x43 L277
TM6
6x48 6.48x48 W336
6x51 6.51x51 L339
6x55 6.55x55 R343
6x58 6.58x58 K346
6x62 6.62x62 Y350
TM7
7x23 7.24x23 R357
7x27 7.28x27 L361
7x31 7.32x31 L365
7x34 7.35x34 D368
7x35 7.36x35 Y369
7x38 7.39x38 I372