Structure information

CCR5

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6MEO

SPECIES

Homo sapiens

RESOLUTION

3.900

PREFERRED CHAIN

B

PUBLICATION DATE

Dec. 12, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Envelope glycoprotein gp160 M1 N-term hydrophobic
Envelope glycoprotein gp160 D2 N-term polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 Y3 N-term hydrophobic
Envelope glycoprotein gp160 V5 N-term hydrophobic
Envelope glycoprotein gp160 D11 N-term polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 D11 N-term polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 Y15 N-term polar (hydrogen bond)
Envelope glycoprotein gp160 Y15 N-term polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 K22 N-term polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 K22 N-term polar (charge-charge)
Envelope glycoprotein gp160 K29 1.31x31 TM1 polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 K29 1.31x31 TM1 polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 Q33 1.35x35 TM1 polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 Q40 1.42x42 TM1 polar (hydrogen bond)
Envelope glycoprotein gp160 S42 1.44x44 TM1 polar (hydrogen bond)
Envelope glycoprotein gp160 F43 1.45x45 TM1 hydrophobic
Envelope glycoprotein gp160 L44 1.46x46 TM1 polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 L44 1.46x46 TM1 polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 K46 1.48x48 TM1 polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 K46 1.48x48 TM1 polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 P48 1.50x50 TM1 polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 R59 1.61x61 TM1 polar (charge-charge)
Envelope glycoprotein gp160 R59 1.61x61 TM1 polar (charge-charge)
Envelope glycoprotein gp160 W86 2.60x60 TM2 hydrophobic
Envelope glycoprotein gp160 E172 ECL2 polar (charge-charge)
Envelope glycoprotein gp160 E172 ECL2 polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 T177 ECL2 polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 C178 45.50x50 ECL2 polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 S179 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 S180 45.52x52 ECL2 polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 S180 45.52x52 ECL2 polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 F182 ECL2 hydrophobic
Envelope glycoprotein gp160 Y187 5.31x32 TM5 hydrophobic
Envelope glycoprotein gp160 Y251 6.51x51 TM6 polar (hydrogen bond)
Envelope glycoprotein gp160 Y251 6.51x51 TM6 polar (hydrogen bond)
Envelope glycoprotein gp160 N258 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 D276 7.32x31 TM7 polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 M279 7.35x34 TM7 polar (hydrogen bond)
Envelope glycoprotein gp160 M279 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 M279 7.35x34 TM7 polar (hydrogen bond)
Envelope glycoprotein gp160 E283 7.39x38 TM7 polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 E283 7.39x38 TM7 polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 E283 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

Envelope glycoprotein gp160

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Residue Diagrams

M N G V F G F I F V L S Y L P P L L R A 1 L N L A I S D L F F L L T V P F W A H Y 2 L I I F F I G S F F G I F Y L G T L L Q 3 G V V T S V I T W V V A V F A S L P G 4 Y C I V M V L L P L V L G L I V I K L T Q 5 F T I M I V Y F L F W A P Y N I V L L L 6 I P N I C C H T M G L T E T V Q M A Q 7
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ICL1 K R L K ICL1ECL1 Q W D F ECL1ICL2 A V F A L K A R ICL2ECL2 R S Q K E G L H Y T C S S H F P Y S ECL2ICL3 R N E ICL3ECL3 L N ECL3N-term M D Y Q V S S P I Y D I N Y Y T S E P C Q N-termC-term K H I A K R F C K C C S I F Q Q E A P E R A S S V Y T R S T G E Q E I S V G L C-term K I N V K Q I A A R L L P P L Y S L V F I F G F V G N M L V I L I L I N C S M T D I Y L L N L A I S D L F F L L T V P F W A H Y A A A G N T M C Q L L T G L Y F I G F F S G I F F I I L L T I D R Y L A V V H T V T F G V V T S V I T W V V A V F A S L P G I I F T Q Y Q F W K N F Q T L K I V I L G L V L P L L V M V I C Y S G I L K T L L R C K K R H R A V R L I F T I M I V Y F L F W A P Y N I V L L L N T F Q E F F G N C S S S N R L D Q A M Q V T E T L G M T H C C I N P I I Y A F V G E K L L V F R N Y F F Q
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR5
TM1
1x31 1.31x31 A29
1x35 1.35x35 L33
1x42 1.42x42 V40
1x44 1.44x44 I42
1x45 1.45x45 F43
1x46 1.46x46 G44
1x48 1.48x48 V46
1x50 1.50x50 N48
TM2
2x60 2.60x60 W86
ECL2
45x50 45.50x50 C178
45x51 45.51x51 S179
45x52 45.52x52 S180
TM5
5x32 5.31x32 Y187
TM6
6x51 6.51x51 Y251
6x58 6.58x58 N258
TM7
7x31 7.32x31 D276
7x34 7.35x34 M279
7x38 7.39x38 E283