Structure information

OX2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6TPN

SPECIES

Homo sapiens

RESOLUTION

2.610

PREFERRED CHAIN

A

REFERENCE

10.1021/acs.jmedchem.9b01787

PUBLICATION DATE

Jan. 1, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
HTL6641 P131 3.29x29 TM3 hydrophobic
HTL6641 Q134 3.32x32 TM3 polar (hydrogen bond)
HTL6641 Q134 3.32x32 TM3 Van der Waals
HTL6641 T135 3.33x33 TM3 Van der Waals
HTL6641 V138 3.36x36 TM3 hydrophobic
HTL6641 V138 3.36x36 TM3 Van der Waals
HTL6641 Q187 4.60x61 TM4 polar (hydrogen bond)
HTL6641 Q187 4.60x61 TM4 Van der Waals
HTL6641 C210 45.50x50 ECL2 Van der Waals
HTL6641 H224 5.39x40 TM5 Van der Waals
HTL6641 F227 5.42x43 TM5 Van der Waals
HTL6641 F227 5.42x43 TM5 aromatic (face-to-face)
HTL6641 Y317 6.48x48 TM6 Van der Waals
HTL6641 Y317 6.48x48 TM6 hydrophobic
HTL6641 I320 6.51x51 TM6 Van der Waals
HTL6641 I320 6.51x51 TM6 polar (hydrogen bond with backbone)
HTL6641 S321 6.52x52 TM6 Van der Waals
HTL6641 N324 6.55x55 TM6 Van der Waals
HTL6641 N324 6.55x55 TM6 polar (hydrogen bond)
HTL6641 H350 7.39x38 TM7 Van der Waals

Ligands

HTL6641

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Residue Diagrams

V N G I L A V V F V I I Y G A I L V W E 1 V N L S L A D V L V T T I C L P A T L V V 2 C S L T L V S V S V S V T Q L Y P I V K 3 A R N S I V I I W I V S C I I M I P Q 4 Y A L V M L C L P A M Y T V L F F C I H Y 5 M I V L L V F A I C Y L P I S I L N V L 6 I P N A A S N A Y V L W H S F T F W A 7
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ICL1 H H M R ICL1ECL1 T W F F ECL1ICL2 P L M F K S ICL2ECL2 E C S T V F P G L A N K T T L F T V C D E R W G G E ECL2ICL3 G T S S V V Q R K W K P L Q P V S Q P R G P G Q P T K S R M S A ICL3ECL3 G M F A H T E ECL3N-term M S G T K L E D S P P C R N W S S A S E L N E T Q E P F L N P T D Y D D E E F L R Y L W R E Y L H P K E N-termC-term G V H H R Q E D R L T R G R T S T E S R K S L T T Q I S N F D N I S K L S E Q V V L T S I S T L P A A N G A G P L Q N W C-term Y E W V L I A G Y I I V F V V A L I G N V L V C V A V W K N T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H T A K R A R N S I V I I W I V S C I I M I P Q A I V M I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C R Q I P V A A E I K Q I R A R R K T A R M L M I V L L V F A I C Y L P I S I L N V L K R V F D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C C L F R E E A F S C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OX2 receptor
TM3
3x29 3.29x29 P131
3x32 3.32x32 Q134
3x33 3.33x33 T135
3x36 3.36x36 V138
TM4
4x61 4.60x61 Q187
ECL2
45x50 45.50x50 C210
TM5
5x40 5.39x40 H224
5x43 5.42x43 F227
TM6
6x48 6.48x48 Y317
6x51 6.51x51 I320
6x52 6.52x52 S321
6x55 6.55x55 N324
TM7
7x38 7.39x38 H350