Structure information

V2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7BB7

SPECIES

Homo sapiens

RESOLUTION

4.400

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIADV.ABG5628

PUBLICATION DATE

June 2, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
vasopressin R32 N-term polar (charge-assisted hydrogen bond)
vasopressin D33 1.28x28 TM1 polar (charge-assisted hydrogen bond)
vasopressin Q96 2.61x60 TM2 Van der Waals
vasopressin Q119 3.32x32 TM3 Van der Waals
vasopressin Q119 3.32x32 TM3 polar (hydrogen bond)
vasopressin M120 3.33x33 TM3 hydrophobic
vasopressin M120 3.33x33 TM3 Van der Waals
vasopressin M123 3.36x36 TM3 hydrophobic
vasopressin M123 3.36x36 TM3 Van der Waals
vasopressin Y124 3.37x37 TM3 Van der Waals
vasopressin F178 4.64x65 TM4 Van der Waals
vasopressin F178 4.64x65 TM4 hydrophobic
vasopressin W193 45.51x51 ECL2 hydrophobic
vasopressin W193 45.51x51 ECL2 Van der Waals
vasopressin A194 45.52x52 ECL2 Van der Waals
vasopressin A194 45.52x52 ECL2 hydrophobic
vasopressin F307 7.35x34 TM7 hydrophobic
vasopressin F307 7.35x34 TM7 Van der Waals
vasopressin M311 7.39x38 TM7 hydrophobic
vasopressin M311 7.39x38 TM7 Van der Waals

Ligands

vasopressin

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Residue Diagrams

G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7
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ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
V2 receptor
TM1
1x28 1.28x28 D33
TM2
2x60 2.61x60 Q96
TM3
3x32 3.32x32 Q119
3x33 3.33x33 M120
3x36 3.36x36 M123
3x37 3.37x37 Y124
TM4
4x65 4.64x65 F178
ECL2
45x51 45.51x51 W193
45x52 45.52x52 A194
TM7
7x34 7.35x34 F307
7x38 7.39x38 M311