Structure information

5-HT1B receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7C61

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

PUBLICATION DATE

July 29, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Ergotamine D129 3.32x32 TM3 polar (charge-charge)
Ergotamine I130 3.33x33 TM3 hydrophobic
Ergotamine C133 3.36x36 TM3 hydrophobic
Ergotamine T134 3.37x37 TM3 polar (hydrogen bond)
Ergotamine V200 45.51x51 ECL2 hydrophobic
Ergotamine V201 45.52x52 ECL2 hydrophobic
Ergotamine F370 6.51x51 TM6 hydrophobic
Ergotamine F371 6.52x52 TM6 aromatic (edge-to-face)
Ergotamine F391 7.35x34 TM7 hydrophobic

Ligands

Ergotamine

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Residue Diagrams

A N S L T T A L T I L A L L M V L L V K 1 A S L A V T D L L V S L I V M P I S T M Y 2 V C L H L I S A T C C T I D S S L W F D 3 A A V M I A L V W V F S I S I S L P P F 4 Y L A I L L L T P F Y F A G V T S Y V T Y 5 G I I L G A F I V C W L P F F I I S L V 6 I P N I L S N L Y G L W T F F D F I A 7
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ICL1 R K L H ICL1ECL1 R W T L ECL1ICL2 A V E Y S A K R ICL2ECL2 R Q A K A E E E V S E C V V N T D ECL2ICL3 N R T G K R L T R A Q L I T D S P G S T S S V T S I N S R V P D V P S E S G S P V Y V N Q V K V R V S D A L L E K K ICL3ECL3 C K D A C W F ECL3N-term M E E P G A Q C A P P P P A G S E T W V P Q A N L S S A P S Q N C S A K D Y I Y Q D S I N-termC-term R F K C T S C-term S L P W K V L L V M L L A L I T L A T T L S N A F V I A T V Y R T T P A N Y L I A S L A V T D L L V S I L V M P I S T M Y T V T G G Q V V C D F W L S S D I T C C T A S I L H L C V I A L D R Y W A I T D T P K R A A V M I A L V W V F S I S I S L P P F F W H I L Y T V Y S T V G A F Y F P T L L L I A L Y G R I Y V E A R S R I L K Q T P K L M A A R E R K A T K T L G I I L G A F I V C W L P F F I I S L V M P I H L A I F D F F T W L G Y L N S L I N P I I Y T M S N E D F H K F K Q A L I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1B receptor
TM3
3x32 3.32x32 D129
3x33 3.33x33 I130
3x36 3.36x36 C133
3x37 3.37x37 T134
ECL2
45x51 45.51x51 V200
45x52 45.52x52 V201
TM6
6x51 6.51x51 F330
6x52 6.52x52 F331
TM7
7x34 7.35x34 F351