PDB
7EJX
Resolution
2.4 Å
Released
April 13, 2022
Receptor
GPR88
Class
A
Species
Homo sapiens
Ligand
Function
compound 2 [PMID: 24793972]
Allosteric agonist
Reference
10.1038/S41467-022-30081-5

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Ligand Amino Acid Generic Number Segment Interaction Type
compound 2 [PMID: 24793972] L209 5.55x55 TM5 hydrophobic
compound 2 [PMID: 24793972] L213 5.59x59 TM5 hydrophobic
compound 2 [PMID: 24793972] I215 5.61x61 TM5 hydrophobic
compound 2 [PMID: 24793972] V216 5.62x62 TM5 hydrophobic
compound 2 [PMID: 24793972] V219 5.65x65 TM5 hydrophobic
compound 2 [PMID: 24793972] R220 5.66x66 TM5 Van der Waals
compound 2 [PMID: 24793972] L281 ICL3 hydrophobic
compound 2 [PMID: 24793972] S282 ICL3 polar (hydrogen bond with backbone)
compound 2 [PMID: 24793972] G283 6.34x34 TM6 Van der Waals
compound 2 [PMID: 24793972] L284 6.35x35 TM6 hydrophobic
compound 2 [PMID: 24793972] V286 6.37x37 TM6 hydrophobic
compound 2 [PMID: 24793972] L287 6.38x38 TM6 hydrophobic
compound 2 [PMID: 24793972] C290 6.41x41 TM6 hydrophobic
compound 2 [PMID: 24793972] C291 6.42x42 TM6 Van der Waals
compound 2 [PMID: 24793972] L294 6.45x45 TM6 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R K L Q ICL1ECL1 T G S A E P P A D W ECL1ICL2 P A A T Y Q A L Y ICL2ECL2 P P W A P R P G A A P P ECL2ICL3 L N F H L L H Q L P G C A A A A A A F P G A Q H A P G P G G A A H P A Q A Q P L P P A L H P R R A Q R R L S ICL3ECL3 L P V ECL3N-term M T N S S S T S T S S T T G G S L L L L C E N-termC-term G V G D A A A A A V A A T A V P A V S Q A Q L G T R A A G Q H W C-term E E E S W A G R R I P V S L L Y S G L A I G G T L A N G M V I Y L V S S F T T S N A F I V N G C A A D L S V C A L W M P Q E A V L G L L P D G A G G S Y R L L R G G L L G L G L T V S L L S H C L V A L N R Y L L I T R Q R R H T A G M L A L S W A L A L G L V L L L R V H Y P A L L A A A A L L A Q T A L L L H C Y L G I V R R V R V S V K R V S V G L S V L L L C C V F L L A T Q P L V W V S L A S G F S P W G V Q A A S W L L C C A L S A L N P L L Y T W N E E V R S F R R S V L P
Helix box plot — Download: PNG | SVG G N A L T G G I A L G S Y L L S V P I R 1 V N G C A A D L S V C L A W M P Q E A V L 2 L C H S L L S V T L G L G L L G G R L L 3 T A G M L A L S W A L A L G L V L L L 4 Y C H L L L A T Q A L L A A A A L L A P Y 5 L L L C C V F L L A T Q P L V W V S L A 6 L P N L A S L A C C L L W S A A Q V G 7

GPCRdb(A)
GPCRdb(A)
GPR88
TM5
5x55 5.55x55 L209
5x59 5.59x59 L213
5x61 5.61x61 I215
5x62 5.62x62 V216
5x65 5.65x65 V219
5x66 5.66x66 R220
TM6
6x34 6.34x34 G283
6x35 6.35x35 L284
6x37 6.37x37 V286
6x38 6.38x38 L287
6x41 6.41x41 C290
6x42 6.42x42 C291
6x45 6.45x45 L294