Structure information

GPR88

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7EJX

SPECIES

Homo sapiens

RESOLUTION

2.400

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-30081-5

PUBLICATION DATE

April 13, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
compound 2 [PMID: 24793972] L213 5.59x59 TM5 hydrophobic
compound 2 [PMID: 24793972] I215 5.61x61 TM5 hydrophobic
compound 2 [PMID: 24793972] V216 5.62x62 TM5 hydrophobic
compound 2 [PMID: 24793972] V219 5.65x65 TM5 hydrophobic
compound 2 [PMID: 24793972] S282 ICL3 polar (hydrogen bond with backbone)
compound 2 [PMID: 24793972] S282 ICL3 Van der Waals
compound 2 [PMID: 24793972] G283 6.34x34 TM6 Van der Waals
compound 2 [PMID: 24793972] L284 6.35x35 TM6 Van der Waals
compound 2 [PMID: 24793972] L284 6.35x35 TM6 hydrophobic
compound 2 [PMID: 24793972] V286 6.37x37 TM6 hydrophobic
compound 2 [PMID: 24793972] V286 6.37x37 TM6 Van der Waals
compound 2 [PMID: 24793972] L287 6.38x38 TM6 hydrophobic
compound 2 [PMID: 24793972] L287 6.38x38 TM6 Van der Waals
compound 2 [PMID: 24793972] C290 6.41x41 TM6 Van der Waals
compound 2 [PMID: 24793972] C290 6.41x41 TM6 hydrophobic

Ligands

compound 2 [PMID: 24793972]

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Residue Diagrams

G N A L T G G I A L G S Y L L S V P I R 1 V N G C A A D L S V C L A W M P Q E A V L 2 L C H S L L S V T L G L G L L G G R L L 3 T A G M L A L S W A L A L G L V L L L 4 Y C H L L L A T Q A L L A A A A L L A P Y 5 L L L C C V F L L A T Q P L V W V S L A 6 L P N L A S L A C C L L W S A A Q V G 7
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ICL1 R K L Q ICL1ECL1 T G S A E P P A D W ECL1ICL2 P A A T Y Q A L Y ICL2ECL2 P P W A P R P G A A P P ECL2ICL3 L N F H L L H Q L P G C A A A A A A F P G A Q H A P G P G G A A H P A Q A Q P L P P A L H P R R A Q R R L S ICL3ECL3 L P V ECL3N-term M T N S S S T S T S S T T G G S L L L L C E N-termC-term G V G D A A A A A V A A T A V P A V S Q A Q L G T R A A G Q H W C-term E E E S W A G R R I P V S L L Y S G L A I G G T L A N G M V I Y L V S S F T T S N A F I V N G C A A D L S V C A L W M P Q E A V L G L L P D G A G G S Y R L L R G G L L G L G L T V S L L S H C L V A L N R Y L L I T R Q R R H T A G M L A L S W A L A L G L V L L L R V H Y P A L L A A A A L L A Q T A L L L H C Y L G I V R R V R V S V K R V S V G L S V L L L C C V F L L A T Q P L V W V S L A S G F S P W G V Q A A S W L L C C A L S A L N P L L Y T W N E E V R S F R R S V L P
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR88
TM5
5x59 5.59x59 L213
5x61 5.61x61 I215
5x62 5.62x62 V216
5x65 5.65x65 V219
TM6
6x34 6.34x34 G283
6x35 6.35x35 L284
6x37 6.37x37 V286
6x38 6.38x38 L287
6x41 6.41x41 C290