Structure information

ghrelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F9Z

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-021-25364-2

PUBLICATION DATE

Aug. 18, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
GHRP-6 D99 2.60x60 TM2 polar (charge-assisted hydrogen bond)
GHRP-6 L103 2.64x64 TM2 hydrophobic
GHRP-6 L103 2.64x64 TM2 Van der Waals
GHRP-6 Y106 2.67x67 TM2 hydrophobic
GHRP-6 Y106 2.67x67 TM2 Van der Waals
GHRP-6 Q120 3.29x29 TM3 polar (hydrogen bond)
GHRP-6 E124 3.33x33 TM3 polar (charge-assisted hydrogen bond)
GHRP-6 I178 4.60x61 TM4 Van der Waals
GHRP-6 I178 4.60x61 TM4 hydrophobic
GHRP-6 L181 4.63x64 TM4 hydrophobic
GHRP-6 L181 4.63x64 TM4 Van der Waals
GHRP-6 R199 45.51x51 ECL2 Van der Waals
GHRP-6 P200 45.52x52 ECL2 hydrophobic
GHRP-6 P200 45.52x52 ECL2 Van der Waals
GHRP-6 M213 5.39x39 TM5 hydrophobic
GHRP-6 M213 5.39x39 TM5 Van der Waals
GHRP-6 F279 6.51x51 TM6 hydrophobic
GHRP-6 R283 6.55x55 TM6 Van der Waals
GHRP-6 F286 6.58x58 TM6 hydrophobic
GHRP-6 F286 6.58x58 TM6 Van der Waals
GHRP-6 Q302 7.32x31 TM7 polar (hydrogen bond)
GHRP-6 Q302 7.32x31 TM7 polar (hydrogen bond)
GHRP-6 N305 7.35x34 TM7 polar (hydrogen bond)
GHRP-6 N305 7.35x34 TM7 polar (hydrogen bond)
GHRP-6 S308 7.38x37 TM7 polar (hydrogen bond)
GHRP-6 F309 7.39x38 TM7 hydrophobic
GHRP-6 F309 7.39x38 TM7 Van der Waals
GHRP-6 F312 7.42x41 TM7 hydrophobic
GHRP-6 F312 7.42x41 TM7 Van der Waals

Ligands

GHRP-6

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Residue Diagrams

L N G A I G V V F L A V C T A T V G A L 1 S S M A F S D L L I F L C M P L D L V R 2 A T I T L V T A Y T C S E S V F Q F L K 3 V K L V I F V I W A V A F C S A G P I 4 Y L V T L C F V P L F F F I S S V W V M 5 A V V V F A F I L C W L P F H V G R Y L 6 I P N I A A S L Y F L V F S V L N C Y 7
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ICL1 R E L R ICL1ECL1 R P W N F ECL1ICL2 P L R A K V V V ICL2ECL2 G V E H E N G T D P W D T N E C R P T E F A V R S ECL2ICL3 A V V G A ICL3ECL3 P G S ECL3N-term M W N A T P S E E P G F N L T L A D L D W D A S P G N D S L G D E L L Q L F N-termC-term F S Q R K L S T L K D E S S R A W T E S S I N T C-term P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F T K G R V K L V I F V I W A V A F C S A G P I F V L V G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R R G D S L R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K V F R E P Y R V A L L G F
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Residue Table


GPCRdb(A)
GPCRdb(A)
ghrelin receptor
TM2
2x60 2.60x60 D99
2x64 2.64x64 L103
2x67 2.67x67 Y106
TM3
3x29 3.29x29 Q120
3x33 3.33x33 E124
TM4
4x61 4.60x61 I178
4x64 4.63x64 L181
ECL2
45x51 45.51x51 R199
45x52 45.52x52 P200
TM5
5x39 5.39x39 M213
TM6
6x51 6.51x51 F279
6x55 6.55x55 R283
6x58 6.58x58 F286
TM7
7x31 7.32x31 Q302
7x34 7.35x34 N305
7x37 7.38x37 S308
7x38 7.39x38 F309
7x41 7.42x41 F312