GPCRdb

SR142948A

Agent/drug
Bioactivity

SR142948A

SMILES	COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)C)cc1C(C)C
InChIKey	LWULHXVBLMWCHO-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	8
Hydrogen bond donors	2
Rotatable bonds	13
Molecular weight (Da)	685.4

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	6Z4Q

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

NTS₁	NTR1	Rat	Neurotensin	A	pKi	8.70	8.77	8.85	ChEMBL
NTS₁	NTR1	Human	Neurotensin	A	pKi	8.96	8.98	9.00	ChEMBL
NTS₂	NTR2	Rat	Neurotensin	A	pKi	8.15	8.20	8.24	ChEMBL
NTS₂	NTR2	Human	Neurotensin	A	pKi	7.13	7.13	7.13	ChEMBL

Showing 1 to 4 of 4 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

NTS₁	NTR1	Human	Neurotensin	A	pIC50	8.90	8.90	8.90	Guide to Pharmacology
NTS₁	NTR1	Human	Neurotensin	A	pEC50	5.00	5.00	5.00	ChEMBL
NTS₁	NTR1	Human	Neurotensin	A	pIC50	7.30	8.64	9.62	ChEMBL
NTS₂	NTR2	Rat	Neurotensin	A	pEC50	7.66	7.70	7.75	ChEMBL

Showing 1 to 4 of 4 entries

SR142948A

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	6Z4Q

Compound is not listed as a drug.