PDB
7IPA
Resolution
2.3 Å
Released
May 20, 2026
Receptor
A2A
Class
A
Species
Homo sapiens
Ligands
FU336-32
theophylline
Function
Unknown
Antagonist
Reference
—
FU336-32 theophylline

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
FU336-32 N36 12.49x49 ICL1 polar (hydrogen bond with backbone)
FU336-32 N36 12.49x49 ICL1 Van der Waals
FU336-32 N39 2.37x37 TM2 polar (hydrogen bond)
FU336-32 N39 2.37x37 TM2 polar (hydrogen bond)
FU336-32 T41 2.39x39 TM2 polar (hydrogen bond)
FU336-32 T41 2.39x39 TM2 Van der Waals
FU336-32 N42 2.40x40 TM2 polar (hydrogen bond)
FU336-32 N42 2.40x40 TM2 polar (hydrogen bond)
FU336-32 V45 2.43x43 TM2 hydrophobic
FU336-32 V45 2.43x43 TM2 Van der Waals
FU336-32 I98 3.46x46 TM3 Van der Waals
FU336-32 R102 3.50x50 TM3 polar (charge-assisted hydrogen bond)
theophylline F168 45.52x52 ECL2 aromatic (face-to-face)
FU336-32 A231 6.33x33 TM6 Van der Waals
FU336-32 A231 6.33x33 TM6 hydrophobic
FU336-32 A235 6.37x37 TM6 hydrophobic
FU336-32 A235 6.37x37 TM6 Van der Waals
theophylline L249 6.51x51 TM6 hydrophobic
theophylline N253 6.55x55 TM6 polar (hydrogen bond)
theophylline N253 6.55x55 TM6 polar (hydrogen bond)
theophylline I274 7.39x38 TM7 hydrophobic
theophylline I274 7.39x38 TM7 Van der Waals
FU336-32 I292 8.47x47 H8 hydrophobic
FU336-32 I292 8.47x47 H8 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
Helix box plot — Download: PNG | SVG V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7

GPCRdb(A)
GPCRdb(A)
A2A receptor
ICL1
12x49 12.49x49 N36
TM2
2x37 2.37x37 N39
2x39 2.39x39 T41
2x40 2.40x40 N42
2x43 2.43x43 V45
TM3
3x46 3.46x46 I98
3x50 3.50x50 R102
ECL2
45x52 45.52x52 F168
TM6
6x33 6.33x33 A231
6x37 6.37x37 L235
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x38 7.39x38 I274
H8
8x47 8.47x47 I292