Structure information

V2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7KH0

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

PUBLICATION DATE

May 26, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Argipressin R32 N-term polar (hydrogen bond with backbone)
Argipressin D33 1.28x28 TM1 polar (hydrogen bond with backbone)
Argipressin M120 3.33x33 TM3 hydrophobic
Argipressin T190 ECL2 polar (charge-assisted hydrogen bond)
Argipressin T190 ECL2 polar (hydrogen bond)
Argipressin C192 45.50x50 ECL2 polar (hydrogen bond with backbone)
Argipressin A194 45.52x52 ECL2 polar (hydrogen bond with backbone)
Argipressin A194 45.52x52 ECL2 polar (hydrogen bond with backbone)
Argipressin C195 ECL2 polar (hydrogen bond with backbone)
Argipressin C195 ECL2 polar (hydrogen bond)
Argipressin C195 ECL2 polar (hydrogen bond with backbone)
Argipressin F287 6.51x51 TM6 hydrophobic
Argipressin Q291 6.55x55 TM6 polar (hydrogen bond)
Argipressin Q291 6.55x55 TM6 polar (charge-assisted hydrogen bond)
Argipressin M311 7.39x38 TM7 polar (hydrogen bond with backbone)
Argipressin L312 7.40x39 TM7 polar (hydrogen bond with backbone)
Argipressin A314 7.42x41 TM7 hydrophobic

Ligands

Argipressin

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Residue Diagrams

G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7
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ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
V2 receptor
TM1
1x28 1.28x28 D33
TM3
3x33 3.33x33 M120
ECL2
45x50 45.50x50 C192
45x52 45.52x52 A194
TM6
6x51 6.51x51 F287
6x55 6.55x55 Q291
TM7
7x38 7.39x38 M311
7x39 7.40x39 L312
7x41 7.42x41 A314