Structure information

V2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7KH0

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-021-00483-Z

PUBLICATION DATE

May 26, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
vasopressin R32 N-term Van der Waals
vasopressin R32 N-term polar (hydrogen bond with backbone)
vasopressin D33 1.28x28 TM1 polar (hydrogen bond with backbone)
vasopressin D33 1.28x28 TM1 Van der Waals
vasopressin Q92 2.57x56 TM2 Van der Waals
vasopressin Q96 2.61x60 TM2 Van der Waals
vasopressin K116 3.29x29 TM3 Van der Waals
vasopressin Q119 3.32x32 TM3 Van der Waals
vasopressin M120 3.33x33 TM3 Van der Waals
vasopressin M120 3.33x33 TM3 hydrophobic
vasopressin Q174 4.60x61 TM4 Van der Waals
vasopressin T190 ECL2 polar (hydrogen bond)
vasopressin T190 ECL2 Van der Waals
vasopressin C192 45.50x50 ECL2 polar (hydrogen bond with backbone)
vasopressin C192 45.50x50 ECL2 Van der Waals
vasopressin W193 45.51x51 ECL2 hydrophobic
vasopressin W193 45.51x51 ECL2 Van der Waals
vasopressin A194 45.52x52 ECL2 polar (hydrogen bond with backbone)
vasopressin A194 45.52x52 ECL2 Van der Waals
vasopressin C195 ECL2 polar (hydrogen bond with backbone)
vasopressin C195 ECL2 polar (hydrogen bond)
vasopressin V206 5.39x40 TM5 Van der Waals
vasopressin V206 5.39x40 TM5 hydrophobic
vasopressin F287 6.51x51 TM6 Van der Waals
vasopressin F287 6.51x51 TM6 hydrophobic
vasopressin F288 6.52x52 TM6 Van der Waals
vasopressin F288 6.52x52 TM6 hydrophobic
vasopressin Q291 6.55x55 TM6 polar (hydrogen bond)
vasopressin Q291 6.55x55 TM6 polar (hydrogen bond)
vasopressin Q291 6.55x55 TM6 Van der Waals
vasopressin A294 6.58x58 TM6 Van der Waals
vasopressin A295 6.59x59 TM6 Van der Waals
vasopressin E303 ECL3 Van der Waals
vasopressin M311 7.39x38 TM7 polar (hydrogen bond with backbone)
vasopressin M311 7.39x38 TM7 Van der Waals
vasopressin L312 7.40x39 TM7 Van der Waals
vasopressin L312 7.40x39 TM7 polar (hydrogen bond with backbone)
vasopressin A314 7.42x41 TM7 hydrophobic
vasopressin A314 7.42x41 TM7 Van der Waals

Ligands

vasopressin

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Residue Diagrams

G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7
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ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
V2 receptor
TM1
1x28 1.28x28 D33
TM2
2x56 2.57x56 Q92
2x60 2.61x60 Q96
TM3
3x29 3.29x29 K116
3x32 3.32x32 Q119
3x33 3.33x33 M120
TM4
4x61 4.60x61 Q174
ECL2
45x50 45.50x50 C192
45x51 45.51x51 W193
45x52 45.52x52 A194
TM5
5x40 5.39x40 V206
TM6
6x51 6.51x51 F287
6x52 6.52x52 F288
6x55 6.55x55 Q291
6x58 6.58x58 A294
6x59 6.59x59 A295
TM7
7x38 7.39x38 M311
7x39 7.40x39 L312
7x41 7.42x41 A314