Structure information

CCR5

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7O7F

SPECIES

Homo sapiens

RESOLUTION

3.150

PREFERRED CHAIN

C

REFERENCE

10.1126/SCIADV.ABG8685

PUBLICATION DATE

June 30, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CCL5 E18 N-term polar (charge-assisted hydrogen bond)
CCL5 P19 N-term Van der Waals
CCL5 C20 N-term Van der Waals
CCL5 C20 N-term hydrophobic
CCL5 K22 N-term Van der Waals
CCL5 K26 1.28x28 TM1 polar (charge-assisted hydrogen bond)
CCL5 A30 1.32x32 TM1 Van der Waals
CCL5 A30 1.32x32 TM1 hydrophobic
CCL5 Y37 1.39x39 TM1 Van der Waals
CCL5 W86 2.60x60 TM2 Van der Waals
CCL5 W86 2.60x60 TM2 hydrophobic
CCL5 Y89 2.63x63 TM2 Van der Waals
CCL5 Y89 2.63x63 TM2 hydrophobic
CCL5 Y108 3.32x32 TM3 Van der Waals
CCL5 Y108 3.32x32 TM3 hydrophobic
CCL5 F109 3.33x33 TM3 Van der Waals
CCL5 F109 3.33x33 TM3 hydrophobic
CCL5 Q170 ECL2 Van der Waals
CCL5 E172 ECL2 Van der Waals
CCL5 S179 45.51x51 ECL2 Van der Waals
CCL5 S180 45.52x52 ECL2 polar (hydrogen bond with backbone)
CCL5 S180 45.52x52 ECL2 Van der Waals
CCL5 H181 ECL2 polar (hydrogen bond)
CCL5 H181 ECL2 Van der Waals
CCL5 F182 ECL2 Van der Waals
CCL5 F182 ECL2 hydrophobic
CCL5 Y184 ECL2 hydrophobic
CCL5 Y184 ECL2 Van der Waals
CCL5 Y187 5.31x32 TM5 Van der Waals
CCL5 Y187 5.31x32 TM5 polar (hydrogen bond)
CCL5 Q188 5.32x33 TM5 Van der Waals
CCL5 Q188 5.32x33 TM5 polar (hydrogen bond)
CCL5 K191 5.35x36 TM5 polar (charge-assisted hydrogen bond)
CCL5 Q194 5.38x39 TM5 Van der Waals
CCL5 T195 5.39x40 TM5 polar (hydrogen bond)
CCL5 L255 6.55x55 TM6 Van der Waals
CCL5 L255 6.55x55 TM6 hydrophobic
CCL5 N258 6.58x58 TM6 Van der Waals
CCL5 C269 7.25x24 TM7 hydrophobic
CCL5 D276 7.32x31 TM7 Van der Waals
CCL5 Q280 7.36x35 TM7 polar (hydrogen bond)
CCL5 Q280 7.36x35 TM7 Van der Waals
CCL5 E283 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

CCL5

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Residue Diagrams

M N G V F G F I F V L S Y L P P L L R A 1 L N L A I S D L F F L L T V P F W A H Y 2 L I I F F I G S F F G I F Y L G T L L Q 3 G V V T S V I T W V V A V F A S L P G 4 Y C I V M V L L P L V L G L I V I K L T Q 5 F T I M I V Y F L F W A P Y N I V L L L 6 I P N I C C H T M G L T E T V Q M A Q 7
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ICL1 K R L K ICL1ECL1 Q W D F ECL1ICL2 A V F A L K A R ICL2ECL2 R S Q K E G L H Y T C S S H F P Y S ECL2ICL3 R ICL3ECL3 L N ECL3N-term M D Y Q V S S P I Y D I N Y Y T S E P C Q N-termC-term K H I A K R F C K C C S I F Q Q E A P E R A S S V Y T R S T G E Q E I S V G L C-term K I N V K Q I A A R L L P P L Y S L V F I F G F V G N M L V I L I L I N C S M T D I Y L L N L A I S D L F F L L T V P F W A H Y A A A G N T M C Q L L T G L Y F I G F F S G I F F I I L L T I D R Y L A V V H T V T F G V V T S V I T W V V A V F A S L P G I I F T Q Y Q F W K N F Q T L K I V I L G L V L P L L V M V I C Y S G I L K T L L R C N E K K R H R A V R L I F T I M I V Y F L F W A P Y N I V L L L N T F Q E F F G N C S S S N R L D Q A M Q V T E T L G M T H C C I N P I I Y A F V G E K L L V F R N Y F F Q
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR5
TM1
1x28 1.28x28 K26
1x32 1.32x32 A30
1x39 1.39x39 Y37
TM2
2x60 2.60x60 W86
2x63 2.63x63 Y89
TM3
3x32 3.32x32 Y108
3x33 3.33x33 F109
ECL2
45x51 45.51x51 S179
45x52 45.52x52 S180
TM5
5x32 5.31x32 Y187
5x33 5.32x33 Q188
5x36 5.35x36 K191
5x39 5.38x39 Q194
5x40 5.39x40 T195
TM6
6x55 6.55x55 L255
6x58 6.58x58 N258
TM7
7x24 7.25x24 C269
7x31 7.32x31 D276
7x35 7.36x35 Q280
7x38 7.39x38 E283