Structure information

OT receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7QVM

SPECIES

Homo sapiens

RESOLUTION

3.250

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-31325-0

PUBLICATION DATE

Aug. 10, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
oxytocin E42 1.35x35 TM1 polar (charge-assisted hydrogen bond)
oxytocin Q92 2.57x56 TM2 Van der Waals
oxytocin Q96 2.61x60 TM2 Van der Waals
oxytocin Q96 2.61x60 TM2 polar (hydrogen bond)
oxytocin D100 2.65x64 TM2 polar (charge-assisted hydrogen bond)
oxytocin K116 3.29x29 TM3 polar (charge-assisted hydrogen bond)
oxytocin Q119 3.32x32 TM3 Van der Waals
oxytocin Q171 4.60x61 TM4 polar (hydrogen bond)
oxytocin Q171 4.60x61 TM4 Van der Waals
oxytocin F175 4.64x65 TM4 hydrophobic
oxytocin F175 4.64x65 TM4 Van der Waals
oxytocin W188 45.51x51 ECL2 hydrophobic
oxytocin W188 45.51x51 ECL2 Van der Waals
oxytocin I204 5.42x43 TM5 hydrophobic
oxytocin I204 5.42x43 TM5 Van der Waals
oxytocin F291 6.51x51 TM6 Van der Waals
oxytocin F291 6.51x51 TM6 hydrophobic
oxytocin Q295 6.55x55 TM6 polar (hydrogen bond)
oxytocin Q295 6.55x55 TM6 Van der Waals
oxytocin S298 6.58x58 TM6 Van der Waals
oxytocin K306 ECL3 Van der Waals
oxytocin I312 7.36x35 TM7 Van der Waals
oxytocin I312 7.36x35 TM7 hydrophobic
oxytocin L316 7.40x39 TM7 polar (hydrogen bond with backbone)
oxytocin L316 7.40x39 TM7 Van der Waals
oxytocin A318 7.42x41 TM7 Van der Waals

Ligands

oxytocin

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Residue Diagrams

A N G S L A L L L I L C L V A V E V R A 1 K H L S I A D L V V A F V Q V L P Q L L W 2 L L L L Y T S A F M G V V Q L Y K V L R 3 D R L A V L A T W L G C L V A S A P Q 4 Y C A A L V I V P V I Y V A L T I W T I Y 5 F I I V L A F I V C W T P F F F V Q M W 6 W P N C C S N L S A L L M V I I F A S 7
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ICL1 R Q K H ICL1ECL1 R F Y G ECL1ICL2 P L R S L ICL2ECL2 S L R E V A D G V F D C W A V F I Q P ECL2ICL3 A A A E A P E G A A A G D G G R V A L A R V S S V ICL3ECL3 D A N A P ECL3N-term M E G A L A A N W S A E A A N A S A A P P G A E G N R T A G P P R R N-termC-term S Y L K G R R L G E T S A S K K S N S S S F V L S H R S S S Q R S C S Q P S T A C-term N E A L A R V E V A V L C L I L L L A L S G N A C V L L A L R T T S R L F F F M K H L S I A D L V V A V F Q V L P Q L L W D I T F P D L L C R L V K Y L Q V V G M F A S T Y L L L L M S L D R C L A I C Q R R R T D R L A V L A T W L G C L V A S A P Q V H I F W G P K A Y I T W I T L A V Y I V P V I V L A A C Y G L I S F K I W Q N L R L K T A A A K L I S K A K I R T V K M T F I I V L A F I V C W T P F F F V Q M W S V W K E A S A F I I V M L L A S L N S C C N P W I Y M L F T G H L V Q C S A L F H E R F L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OT receptor
TM1
1x35 1.35x35 E42
TM2
2x56 2.57x56 Q92
2x60 2.61x60 Q96
2x64 2.65x64 D100
TM3
3x29 3.29x29 K116
3x32 3.32x32 Q119
TM4
4x61 4.60x61 Q171
4x65 4.64x65 F175
ECL2
45x51 45.51x51 W188
TM5
5x43 5.42x43 I204
TM6
6x51 6.51x51 F291
6x55 6.55x55 Q295
6x58 6.58x58 S298
TM7
7x35 7.36x35 I312
7x39 7.40x39 L316
7x41 7.42x41 A318